YU43302A - Supstituisani bisindolilmaleimidi za inhibiciju proliferacije ćelija - Google Patents

Supstituisani bisindolilmaleimidi za inhibiciju proliferacije ćelija

Info

Publication number
YU43302A
YU43302A YU43302A YUP43302A YU43302A YU 43302 A YU43302 A YU 43302A YU 43302 A YU43302 A YU 43302A YU P43302 A YUP43302 A YU P43302A YU 43302 A YU43302 A YU 43302A
Authority
YU
Yugoslavia
Prior art keywords
inhibition
cell proliferation
treatment
disclosed
control
Prior art date
Application number
YU43302A
Other languages
English (en)
Inventor
Nader Fotouhi
Emily Aijun Liu
Allen John Lovey
Giuseppe Frederico Weber
John Guilfoyle Mullin
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU43302A publication Critical patent/YU43302A/sh
Publication of RS50449B publication Critical patent/RS50449B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Opisani su novi supstituisani piroli opšte formule (I). Ova jedinjenja i njihove farmaceutski prihvatljive soli primenjuju se za dobijanje medikamenata u formi kontinualnog infuzionog rastvora za terapiju i/ili kontrolu poremećaja proliferacije ćelija, konkretno kancera. Takodje su opisane farmaceutske smeše koje sadrže prethodno naznačena jedinjenja.[Disclosed are novel substituted pyrroles having formula (I). These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and methods for the treatment and/or control of cancer.
YUP-433/02A 1999-12-16 2000-12-12 Supstituisani bisindolilmaleimidi za inhibiciju proliferacije ćelija RS50449B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17105199P 1999-12-16 1999-12-16

Publications (2)

Publication Number Publication Date
YU43302A true YU43302A (sh) 2005-03-15
RS50449B RS50449B (sr) 2010-03-02

Family

ID=22622296

Country Status (33)

Country Link
US (1) US6313143B1 (sh)
EP (1) EP1242408B1 (sh)
JP (2) JP2003516986A (sh)
KR (1) KR100507422B1 (sh)
CN (1) CN1229374C (sh)
AR (1) AR029415A1 (sh)
AT (1) ATE306484T1 (sh)
AU (1) AU783616B2 (sh)
BR (1) BRPI0016329B8 (sh)
CA (1) CA2392902C (sh)
CO (1) CO5050293A1 (sh)
CZ (1) CZ304130B6 (sh)
DE (1) DE60023182T2 (sh)
ES (1) ES2249314T3 (sh)
GC (1) GC0000265A (sh)
HK (1) HK1054385B (sh)
HR (1) HRP20020513B1 (sh)
HU (1) HU230003B1 (sh)
IL (2) IL150128A0 (sh)
JO (1) JO2296B1 (sh)
MA (1) MA26856A1 (sh)
MX (1) MXPA02005560A (sh)
MY (1) MY126998A (sh)
NO (1) NO322240B1 (sh)
NZ (1) NZ519173A (sh)
PE (1) PE20011034A1 (sh)
PL (1) PL200243B1 (sh)
RS (1) RS50449B (sh)
RU (1) RU2264398C2 (sh)
TW (1) TWI274752B (sh)
UY (1) UY26485A1 (sh)
WO (1) WO2001044234A1 (sh)
ZA (1) ZA200204258B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
MXPA04004026A (es) * 2001-10-29 2004-07-08 Nektar Therapeutics Al Corp Conjugados polimericos de inhibidores de la proteina quinasa c.
EP2521545B1 (en) * 2010-01-07 2019-11-27 Alkermes Pharma Ireland Limited Prodrugs of heteroaromatic compounds
EP2474541A1 (en) * 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB9416467D0 (en) * 1994-08-13 1994-10-05 Wellcome Found Compounds for use in medicine
DK0932399T3 (da) * 1996-03-12 2006-05-15 Pg Txl Co Lp Vandoplöselige paclitaxel-prodrugs
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
US6943194B1 (en) * 1998-01-09 2005-09-13 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthesis of phenstatin and prodrugs thereof
CZ299068B6 (cs) * 1998-03-17 2008-04-16 F. Hoffmann-La Roche Ag Substituovaný bisindolylmaleinimid a farmaceutický prostredek s jeho obsahem
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
AU781732B2 (en) * 1999-10-12 2005-06-09 F. Hoffmann-La Roche Ag Substituted pyrroles as antiproliferative agents for the treatment of cancer

Also Published As

Publication number Publication date
WO2001044234A1 (en) 2001-06-21
RU2264398C2 (ru) 2005-11-20
NO322240B1 (no) 2006-09-04
ES2249314T3 (es) 2006-04-01
BR0016329A (pt) 2002-08-27
EP1242408A1 (en) 2002-09-25
JP2007153905A (ja) 2007-06-21
CN1229374C (zh) 2005-11-30
CN1409709A (zh) 2003-04-09
HU230003B1 (en) 2015-04-28
IL150128A0 (en) 2002-12-01
ZA200204258B (en) 2003-08-28
KR100507422B1 (ko) 2005-08-10
JP2003516986A (ja) 2003-05-20
CO5050293A1 (es) 2001-06-27
MXPA02005560A (es) 2002-09-02
CA2392902C (en) 2009-01-13
TWI274752B (en) 2007-03-01
RU2002119209A (ru) 2004-01-10
JP4763623B2 (ja) 2011-08-31
DE60023182D1 (de) 2006-02-23
MY126998A (en) 2006-11-30
PL355856A1 (en) 2004-05-31
HRP20020513A2 (en) 2004-08-31
NO20022776L (no) 2002-06-11
EP1242408B1 (en) 2005-10-12
DE60023182T2 (de) 2006-07-06
AU783616B2 (en) 2005-11-17
HRP20020513B1 (en) 2006-10-31
ATE306484T1 (de) 2005-10-15
HK1054385A1 (en) 2003-11-28
BRPI0016329B8 (pt) 2021-05-25
RS50449B (sr) 2010-03-02
BR0016329B1 (pt) 2013-03-19
AU2008201A (en) 2001-06-25
UY26485A1 (es) 2001-06-29
JO2296B1 (en) 2005-09-12
HK1054385B (zh) 2006-02-17
MA26856A1 (fr) 2004-12-20
AR029415A1 (es) 2003-06-25
CZ304130B6 (cs) 2013-11-13
GC0000265A (en) 2006-11-01
PL200243B1 (pl) 2008-12-31
HUP0203696A3 (en) 2004-01-28
NZ519173A (en) 2004-06-25
KR20020063215A (ko) 2002-08-01
HUP0203696A2 (hu) 2003-03-28
PE20011034A1 (es) 2001-10-12
NO20022776D0 (no) 2002-06-11
US6313143B1 (en) 2001-11-06
CZ20022447A3 (cs) 2003-06-18
IL150128A (en) 2006-06-11
CA2392902A1 (en) 2001-06-21

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