WO2022026592A3 - Antibody molecules to coronavirus and uses thereof - Google Patents

Antibody molecules to coronavirus and uses thereof Download PDF

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Publication number
WO2022026592A3
WO2022026592A3 PCT/US2021/043525 US2021043525W WO2022026592A3 WO 2022026592 A3 WO2022026592 A3 WO 2022026592A3 US 2021043525 W US2021043525 W US 2021043525W WO 2022026592 A3 WO2022026592 A3 WO 2022026592A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody molecules
coronavirus
spike protein
covid
cov
Prior art date
Application number
PCT/US2021/043525
Other languages
French (fr)
Other versions
WO2022026592A2 (en
Inventor
Jane C. Hirsh
Ishan Capila
Original Assignee
Celltas Bio, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltas Bio, Inc. filed Critical Celltas Bio, Inc.
Publication of WO2022026592A2 publication Critical patent/WO2022026592A2/en
Publication of WO2022026592A3 publication Critical patent/WO2022026592A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Antibody molecules that specifically bind to a coronavirus spike protein (e.g., SARS-CoV-2 spike protein) are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as COVID-19.
PCT/US2021/043525 2020-07-28 2021-07-28 Antibody molecules to coronavirus and uses thereof WO2022026592A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063057857P 2020-07-28 2020-07-28
US63/057,857 2020-07-28

Publications (2)

Publication Number Publication Date
WO2022026592A2 WO2022026592A2 (en) 2022-02-03
WO2022026592A3 true WO2022026592A3 (en) 2022-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/043525 WO2022026592A2 (en) 2020-07-28 2021-07-28 Antibody molecules to coronavirus and uses thereof

Country Status (1)

Country Link
WO (1) WO2022026592A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023156187A1 (en) * 2022-02-16 2023-08-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts High affinity antibodies against the sars-cov-2 receptor binding domain

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