WO2019163460A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2019163460A1
WO2019163460A1 PCT/JP2019/003307 JP2019003307W WO2019163460A1 WO 2019163460 A1 WO2019163460 A1 WO 2019163460A1 JP 2019003307 W JP2019003307 W JP 2019003307W WO 2019163460 A1 WO2019163460 A1 WO 2019163460A1
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WO
WIPO (PCT)
Prior art keywords
component
silica
granules
dentifrice composition
colored
Prior art date
Application number
PCT/JP2019/003307
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English (en)
Japanese (ja)
Inventor
剛太郎 飯泉
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to JP2020501626A priority Critical patent/JP7264146B2/ja
Priority to KR1020207019010A priority patent/KR20200125580A/ko
Publication of WO2019163460A1 publication Critical patent/WO2019163460A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes

Definitions

  • the present invention relates to a dentifrice composition in which colored granules are dispersed and blended, and the appearance aesthetics (uniformness and vividness of colored granules) are excellent.
  • the dentifrice composition is generally used by extruding the dentifrice composition from a tube container and placing it on a toothbrush at the time of use. At this time, first, the quality of the dentifrice composition is judged by its appearance. Sometimes. For this reason, designing an aesthetically pleasing appearance that the user likes is an important issue because it not only enhances the satisfaction when using the dentifrice composition, but also leads to continuous use.
  • Patent Document 1 Japanese Patent Publication No. 7-59491: Polishing silica, a dentifrice composition having a pearly feeling, containing a vehicle having the same refractive index as polishing silica, titanium mica, thickening silica and fatty acid alkanolamide
  • Patent Document 2 Japanese Patent Laid-Open No. 11-217320: A toothpaste composition having a pearl luster in which a magenta titanium is blended with a toothpaste composition having a specific transparency.
  • Patent Document 3 Japanese Patent Publication No. 2002-526393: Transparent liquid dentifrice formulation in which colored silica particles are blended with transparent dentifrice gel containing sorbitol, glycerol and polyethylene glycol in a specific ratio as a wetting agent.
  • Patent Document 4 Japanese Patent Publication No. 2006-514117: Translucent or transparent gel Multicolor striped dentifrice comprising a first layer containing colorant particles that creates a striped appearance in the phase and another second layer Narubutsu
  • the present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition in which colored granules are dispersed and blended, and the appearance aesthetics (uniformness and color vividness of the colored granules) are excellent. .
  • the present inventor has obtained a dentifrice composition containing colored granules as colored particles and silica as a base, and mica titanium and a specific sugar alcohol having a specific amount or less.
  • the dentifrice base has an appropriate translucent appearance, and the colored granules are uniformly dispersed and blended in the dentifrice base, improving the uniformity and vividness of the color, resulting in excellent appearance aesthetics. I found out.
  • the present invention has been made.
  • the colored granules on the surface of the preparation overlap with the colored granules even if the colored granules are uniformly dispersed and blended. And sometimes lacked a uniform appearance.
  • coloring granules are incorporated into a dentifrice base dentifrice base, especially an aqueous base containing water as a solvent, it is preferable to use a pigment that is difficult to elute as a coloring dye. In some cases, the vividness is not sufficient as compared with the ionic dye, and the color tone may be lowered when wet with the aqueous base.
  • the appearance of the colored granules (A) was improved, and the vividness of the color could be improved.
  • the dentifrice-based appearance has a transparent and translucent appearance, but the colored particles are uniformly dispersed and dispersed, and the colored particles The dentifrice composition which gave the vividness of the color which seemed to be vivid and emphasized, and was excellent in the aesthetics of the external appearance was able to be obtained.
  • the component (B) is used as a base, and the component (D) is used in a specific amount or less,
  • A) It is possible to design the appearance of the formulation that appears to have the components dispersed therein, especially an appropriate translucent appearance. Furthermore, by adding the component (C), the formulation surface not only gives a glossy feeling but also the color of the component (A) Brilliantly contributed to the design of a translucent appearance, and was able to give the above special effects specifically.
  • Comparative Example 1 in which the non-colored granules as the comparative component of the component (A) were blended was inferior in the uniformity of the granules and the vividness of the colors of the granules (both x ). Further, Comparative Examples 3 and 4 lacking the component (C) were inferior in vividness of the color of the colored granules (x), and Comparative Example 3 in which titanium oxide was blended had poor uniformity in the colored granules (x). (D) The comparative example 2 whose component amount exceeds a specific value and is too much was inferior in the uniformity of the colored granules ( ⁇ ). On the other hand, the dentifrice composition (Example) of the present invention was excellent in the uniformity of color granules and the vividness of the color (both ⁇ or ⁇ ).
  • the present invention provides the following dentifrice composition.
  • the component (B) is silica selected from abrasive silica and thickening silica.
  • (A) 0.01 to 2% by mass of component, (B) 5 to 40% by mass, (C) 0.01 to 2% by mass, and (D) 5 to 40% by mass of component The dentifrice composition according to any one of [1] to [5].
  • (E) The binder according to any one of [1] to [6], further containing 0.1 to 3.5% by mass of a binder selected from the following components (E-1) and (E-2): Dentifrice composition.
  • (E-1) One or two selected from sodium polyacrylate and carboxyvinyl polymer (E-2) One or more selected from xanthan gum, carrageenan and sodium carboxymethylcellulose
  • (E-2) One or more selected from xanthan gum, carrageenan and sodium carboxymethylcellulose
  • the dentifrice composition according to [8] which is a dentifrice composition in which (A) colored granules are dispersed and mixed in a translucent dentifrice base.
  • the present invention it is possible to provide a dentifrice composition in which colored granules are dispersed and blended, and the appearance aesthetics (uniformness and vividness of colored granules) are excellent.
  • the dentifrice composition of the present invention contains a sugar alcohol selected from (A) colored granules, (B) silica, (C) titanium mica, and (D) sorbitol and glycerin.
  • a sugar alcohol selected from (A) colored granules, (B) silica, (C) titanium mica, and (D) sorbitol and glycerin.
  • the uniform feeling of the colored granules is the visual sensation that appears as if the colored granules are uniformly dispersed throughout the dentifrice base of the preparation.
  • the vividness of the color of the colored granule is the visual sensation that the color of the colored granule is recognized as vivid and outstanding.
  • the colored granules contain granule base particles (core) and a pigment, and the granule substrate particles are colored with a pigment.
  • the granule base particles and the pigment are not particularly limited as long as they can be blended in the dentifrice composition.
  • a water-insoluble material can be used, and the pigment is preferably an organic pigment that does not dissolve in water, and a pigment can be preferably used.
  • the water-insoluble material is preferably selected from silica and zeolite, and may be used alone or in combination. Among these, silica is more preferable.
  • the pigment may be other than white, and a red pigment, a blue pigment, and a green pigment are particularly preferable. As these pigments, for example, the following commercially available pigments can be used. Red pigment C.I. I. Pigment Red 181 (C.I. 73360) C. I. Pigment Red 4 (C.I. 12085) C. I. Pigment Red 5 (C.I. 12490) C. I. Pigment Red 112 (C.I. 12370) C. I. Pigment Red 122 (C.I. 73915) C. I.
  • Pigment Red 254 (C.I. 56110) Blue pigment C.I. I. Pigment Blue 15 (C.I. 74160) C. I. Pigment Blue 15: 1 (C.I. 74160) C. I. Pigment Blue 15: 3 (C.I. 74160) C. I. Pigment Blue 15: 6 (C.I. 74160) C. I. Pigment Blue 80 (C.I. 77007) Green pigment C.I. I. Pigment Green 7 (C.I. 74260) C. I. Pigment Green 36 (C.I. 74265)
  • the colored granules are preferably colored silica granules, more preferably red silica granules, blue silica granules, and green silica granules.
  • granule base particles a pulverized product or a granulated product can be used, and in addition to the above materials, known components that can be usually blended in granules may be added to the constituent components, specifically, A fragrance
  • the said granule base particle can be prepared by a normal method using the structural component of a raw material.
  • the amount of the pigment used is not particularly limited as long as the entire surface of the granule base particle can be coated, but is preferably 0.01% (mass%, the same applies hereinafter) or more with respect to the entire granule base particle of the colored granule. In particular, 0.02% or more is preferable from the viewpoint of manifesting the effects of the present invention.
  • the upper limit of the amount used is not particularly limited, but is usually preferably 10% or less, particularly preferably 5% or less.
  • the content of the pigment with respect to the entire colored granule is preferably 0.01 to 10%, more preferably 0.02 to 5%.
  • the average disintegration strength is preferably 10 to 100 g / piece, more preferably 15 to 50 g / piece. It is. Use of disintegrating granules within this range is preferable because it can sufficiently prevent discomfort due to the granules during brushing.
  • the average disintegration strength of the above granule was measured with a rheometer (Sun Rheometer CR-200D manufactured by Sun Science Co., Ltd.), one for 30 granules, and one for each of the granules (compressed at a rate of 10 mm / min). This is the average value of the values measured (sometimes the load when the granules disintegrate) (the same applies hereinafter).
  • the average particle size of the colored granules is preferably 150 to 800 ⁇ m, more preferably 200 to 500 ⁇ m. A larger average particle size is more suitable for visualizing the granules. However, when the average particle size is 800 ⁇ m or less, unpleasant discomfort due to the granules during brushing can be sufficiently prevented.
  • the average particle size of the granule is based on mass, and after sieving with a JIS sieve, the mass of the granule remaining on each sieve is measured, and the 50% particle size is calculated from this mass distribution (hereinafter referred to as the following). The same).
  • the colored granules as described above can be obtained by coating the surface of the granule base particles (core) with a pigment, and a usual method can be adopted as the preparation method. Moreover, a commercial item can also be utilized. Specific examples of commercially available products include colored silica granules (trade name: Sorbosil BFG54, red silica granules, pigment: CI Pigment Red 181, trade name: Sorbosil BFG51, blue silica granules, pigment: C manufactured by PQ Corporation. CI Pigment Blue 15: 1, trade name: Sorbosil BFG52, green silica granules, pigment: CI Pigment Green 7).
  • colored silica granules trade name: Sorbosil BFG54, red silica granules, pigment: CI Pigment Red 181, trade name: Sorbosil BFG51, blue silica granules, pigment: C manufactured by PQ Corporation
  • the blending amount of the colored granules is preferably 0.01 to 2%, more preferably 0.05 to 1% of the whole composition. Within the above range, the uniformity of the colored granules is sufficiently excellent, and a good usability can be sufficiently maintained.
  • non-colored silica can be used, and examples thereof include abrasive silica and thickening silica.
  • the average particle diameter of the silica of component (B) may be in the range usually used for abrasive silica and thickened silica, and is not particularly limited, but is preferably 3 to 30 ⁇ m, more preferably 3 to 25 ⁇ m (laser scattering) Measurement method, D50, volume basis).
  • the abrasive silica include silica gel, precipitated silica, zirconosilicate, aluminosilicate and the like.
  • a commercially available product can be used as such an abrasive silica, for example, abrasive silica made by Huber, trade name: Zedent 103 can be used.
  • examples of the thickening silica include gelling silica and gelling aluminum silica.
  • a commercially available product can be used as such a thickening silica, for example, Thickening Silicic Acid, Zeodent165, manufactured by Huber, can be used.
  • the blending amount of (B) silica is preferably 5 to 40% of the total composition, more preferably 10 to 35%, and still more preferably 15 to 30%. When the blending amount is 5% or more, the effect of the present invention is exhibited. When the blending amount is 40% or less, the uniformity of the colored granules is sufficiently excellent while sufficiently securing the preparation stability. In addition, when the abrasive silica is blended within the range satisfying the blending amount of the component (B), the preferred blending amount is 5 to 30%, more preferably 10 to 25% of the entire composition. .
  • a preferred blending amount of the thickening silica is 0 to 10%, particularly 1 to 10% of the whole composition.
  • Titanium mica gives glossiness to the surface of the dentifrice, has the effect of improving the vividness of the colored granules, and is also involved in improving the uniformity of the granules.
  • Titanium mica preferably has an average particle size of 10 to 200 ⁇ m, more preferably 50 to 150 ⁇ m, and still more preferably 80 to 120 ⁇ m. When it is within the above range, a sufficient blending effect can be obtained.
  • the average particle diameter of the mica titanium is D50, based on volume, and is a value measured by a laser scattering measurement method (the same applies hereinafter).
  • the compounding amount of titanium mica is preferably 0.01 to 2%, more preferably 0.05 to 2%, particularly preferably 0.05 to 1% of the entire composition.
  • the blending amount is 0.01% or more, the vividness of the colored granules is sufficiently excellent, and the uniformity of the colored granules is improved.
  • it is 2% or less, the vividness of the colored granules is excellent, and the stability of the preparation is also good.
  • the component (D) is a sugar alcohol selected from sorbitol and glycerin, and may be sorbitol or glycerin, or sorbitol and glycerin.
  • (D) component adjusts the transparency by dentifrice base (B) silica, and contributes to the improvement of the uniform feeling of a colored granule.
  • a commercial item can be used for the sugar alcohol.
  • sorbitol may be trade name; NEOSORB (manufactured by Rocket Co., Ltd.), and glycerin may be glycerin (manufactured by Sakamoto Pharmaceutical Co., Ltd.).
  • the blending amount of the component (D) is 40% or less of the entire composition, preferably 5 to 40%, more preferably 10 to 35%. If the blending amount exceeds 40%, the transparency is too high and deviates from the desired translucent range, and the uniformity of the colored granules becomes worse. If it is 5% or more, the dentifrice base becomes moderately translucent, and the uniformity of colored granules is sufficiently excellent.
  • the dentifrice composition of the present invention preferably further contains a binder selected from the following components (E-1) and (E-2) as the component (E).
  • a binder selected from the following components (E-1) and (E-2) as the component (E).
  • the component (E) is at least one selected from the following components (E-1) and (E-2), and it is particularly preferable to use the components (E-1) and (E-2) in combination.
  • (E-1) One or two kinds selected from sodium polyacrylate and carboxyvinyl polymer (E-2)
  • E-2) One or more kinds selected from xanthan gum, carrageenan and sodium carboxymethylcellulose (E-1)
  • sodium polyacrylate is preferable, and cross-linked sodium polyacrylate is more preferable.
  • the component (E-2) is particularly preferably xanthan gum. Commercially available products can be used for the components (E-1) and (E-2).
  • the component (E-1) improves the shape-retaining property of the preparation, and provides a sufficient shape-retaining property by ensuring an appropriate translucent appearance in the dentifrice base.
  • the component (E-2) improves the glossiness of the preparation surface, particularly the condensed skin, and gives sufficient glossiness.
  • the shape retention of the preparation and the preparation surface are further improved while ensuring an appropriate translucent appearance, and the uniform feel of the colored granules. In addition, the vividness of the color is further improved.
  • the blending amount is preferably 0.1 to 3.5%, particularly 0.4 to 3%, particularly 0.5 to 2% of the entire composition. Further, when the component (E-1) is blended within the range satisfying the blending amount of the component (E), the preferred blending amount is 0.05 to 1.5%, particularly 0.2 to When the component (E-2) is blended, the preferable blending amount is 0.05 to 2%, particularly 0.2 to 1.5% of the entire composition.
  • an organic binder other than the component (E) (components (E-1) and (E-2)) may be further added.
  • the organic binder include alginic acid derivatives, polyethylene glycol having an average molecular weight of 200,000 or more (average molecular weight described in Quasi-drug Raw Material Standard 2006), polyvinyl alcohol, and the like.
  • the dentifrice composition of the present invention can be prepared as a toothpaste.
  • arbitrary components can be mix
  • in the toothpaste in addition to the components (A), (B) and (C), especially silicate-based abrasives other than silica, wetting agents other than the component (D), surfactants, and further if necessary Sweeteners, preservatives, flavors and active ingredients can be blended.
  • the preparation method can be obtained by adopting a usual method and mixing the compounding component with a solvent such as water.
  • the dentifrice base containing the component other than the component (A) by a conventional method, (A) colored granules Can be prepared by dispersing and blending.
  • abrasive examples include the silicates as described above, such as zeolite, and the blending amount thereof is preferably 5% or less of the entire composition, and may be unblended (blending amount 0%). Calcium carbonate and calcium phosphate other than silicate as the abrasive may adversely affect the effects of the present invention, so it is better not to mix them.
  • the wetting agent examples include components other than the component (D) such as xylitol, erythritol, polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight described in Quasi-drug Raw Material Standard 2006), and propylene glycol.
  • the blending amount of the wetting agent other than the component (D) is preferably 0 to 8%, particularly preferably 0 to 5% of the whole composition.
  • the component (D) of the present invention also acts as a wetting agent.
  • Surfactants include amphoteric surfactants such as anionic surfactants such as sodium lauryl sulfate, which are common for dentifrices, nonionic surfactants such as polyoxyethylene hydrogenated castor oil, and fatty acid amidopropyl betaine which is a betaine type. Agents and cationic surfactants.
  • the blending amount is usually 0.001 to 10%, particularly 0.1 to 5% of the whole composition.
  • sweetener examples include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester, benzoic acid and salts thereof.
  • flavor can use the well-known fragrance
  • Natural fragrances such as coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powdered fragrance Etc.) fragrance, menthol, carvone Anethole, cineol, methyl salicylate, cin
  • the blending amount of the fragrance is not particularly limited, but the above fragrance material is preferably used in the composition in an amount of 0.000001 to 1%. It is preferable to use 000001 to 2%, particularly 0.1 to 2%.
  • Active ingredients are known medicinal ingredients for dentifrices such as bactericides, anti-inflammatory agents, enzymes, fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, condensed phosphates such as pyrophosphate and tripolyphosphate
  • An effective amount of salt, plant extract, anticalculus agent, anti-plaque agent can be blended within a range that does not interfere with the effects of the present invention.
  • the solvent is preferably water, and the water content in the dentifrice composition is preferably 20 to 50%.
  • the dentifrice base is preferably translucent, and (A) colored granules are preferably dispersed and blended in the translucent dentifrice base.
  • the dentifrice base excluding the component (A) (a composition obtained by removing the component (A) from the dentifrice composition) is more preferably translucent that satisfies at least (2) of the following conditions. It is particularly preferable to satisfy two or more. Three black lines with a width of about 1 mm were drawn on white paper at intervals of 2 mm, and the dentifrice composition was extruded from the container so as to straddle the lines, and viewed with the naked eye from above.
  • the line looks when (1) When the thickness of the dentifrice composition extruded on white paper is less than 4 mm, particularly 3 mm or less, the line is clearly visible. (2) When the thickness of the dentifrice composition is 4 mm or more and 9 mm or less, the lines are blurred but visible. (3) When the thickness of the dentifrice composition exceeds 9 mm, particularly 10 mm or more, no line is visible.
  • the dentifrice composition as described above, particularly the dentifrice-based properties, is a combination of the components (B), (C) and (D), preferably the blending amounts of the components (C) and (D) are in the above ranges, respectively. It can be obtained by adjusting.
  • water-insoluble particles other than the components (A), (B) and (C), and a wetting agent other than the component (D) can be blended within a range that does not impair the above properties.
  • Dentifrice compositions having the compositions shown in Tables 1 to 4 were prepared by conventional methods, and the appearance of the formulations was evaluated by the following methods. The results are shown in Tables 1 to 4.
  • the dentifrice compositions of Examples and Comparative Examples 1 and 2 were all translucent in terms of the dentifrice base satisfying the following conditions, and colored granules were dispersed and blended in the dentifrice base.
  • the dentifrice composition of Comparative Example 3 was transparent, and the dentifrice composition of Comparative Example 4 was opaque.
  • the uniform feeling of the colored granules is a visual sensation that appears as if the colored granules are uniformly dispersed and scattered throughout the dentifrice base of the preparation.
  • the vividness of the color of the colored granule is the visual sensation that the color of the colored granule is recognized as vivid and outstanding.
  • a dentifrice composition having the composition shown in Table 5 was prepared in the same manner as described above and evaluated in the same manner. As a result, both the uniformity of color granules and the vividness of the color were excellent.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Epidemiology (AREA)
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  • Cosmetics (AREA)

Abstract

L'invention fournit une composition de dentifrice dans laquelle des granules colorées sont dispersées et mélangées, et qui se révèle d'une apparence excellente en termes de propriétés esthétiques (sensation d'uniformité des granules colorées et vivacité des couleurs). Plus précisément, l'invention concerne une composition de dentifrice qui comprend (A) les granules colorées, (B) une silice, (C) un mica titane, (D) un ou deux éléments choisis parmi un sorbitol et une glycérine. Ladite composition de dentifrice comprend en outre (E) un agent de liaison choisi parmi les composants （Ｅ－１） et （Ｅ－２） suivants. （Ｅ－１） : un ou deux éléments choisis parmi un polyacrylate de sodium et un polymère carboxyvinylique ; （Ｅ－２） : un ou plusieurs éléments choisis parmi une gomme de xanthane, une carraghénine et une carboxyméthylcellulose sodique
PCT/JP2019/003307 2018-02-26 2019-01-31 Composition de dentifrice WO2019163460A1 (fr)

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JP2007217334A (ja) * 2006-02-16 2007-08-30 Kao Corp 歯磨剤
JP2010150146A (ja) * 2008-12-24 2010-07-08 Lion Corp 歯磨剤組成物
JP2014125440A (ja) * 2012-12-26 2014-07-07 Lion Corp 口腔用組成物
JP2015124150A (ja) * 2013-12-25 2015-07-06 ライオン株式会社 歯磨剤組成物

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JP3117049B2 (ja) 1993-08-23 2000-12-11 ダイワ精工株式会社 中通し釣竿
JP4584367B2 (ja) 1998-01-29 2010-11-17 花王株式会社 練歯磨組成物
DE19845247A1 (de) 1998-10-01 2000-04-06 Henkel Kgaa Flüssiges Zahnreinigungsgel
US20040101492A1 (en) 2002-11-26 2004-05-27 The Procter & Gamble Company Multicolored striped dentifrice composition
JP5320776B2 (ja) * 2008-03-07 2013-10-23 ライオン株式会社 歯磨製品
JP5597969B2 (ja) * 2009-11-06 2014-10-01 ライオン株式会社 歯磨剤組成物
JP5516796B2 (ja) * 2013-05-23 2014-06-11 ライオン株式会社 歯磨組成物
WO2015167488A1 (fr) * 2014-04-30 2015-11-05 Colgate-Palmolive Company Composition de soin buccal contenant de la silice et du citrate de zinc
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JPS6366114A (ja) * 1986-09-08 1988-03-24 Lion Corp 歯磨組成物
JP2007217334A (ja) * 2006-02-16 2007-08-30 Kao Corp 歯磨剤
JP2010150146A (ja) * 2008-12-24 2010-07-08 Lion Corp 歯磨剤組成物
JP2014125440A (ja) * 2012-12-26 2014-07-07 Lion Corp 口腔用組成物
JP2015124150A (ja) * 2013-12-25 2015-07-06 ライオン株式会社 歯磨剤組成物

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CN110192986A (zh) 2019-09-03
KR20200125580A (ko) 2020-11-04
JP7264146B2 (ja) 2023-04-25

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