WO2017206016A1 - Anti-inflammation and swelling-relief traditional chinese ointment for external application - Google Patents

Anti-inflammation and swelling-relief traditional chinese ointment for external application Download PDF

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WO2017206016A1
WO2017206016A1 PCT/CN2016/083896 CN2016083896W WO2017206016A1 WO 2017206016 A1 WO2017206016 A1 WO 2017206016A1 CN 2016083896 W CN2016083896 W CN 2016083896W WO 2017206016 A1 WO2017206016 A1 WO 2017206016A1
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traditional chinese
parts
chinese medicine
swelling
inflammatory
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PCT/CN2016/083896
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French (fr)
Chinese (zh)
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吴克
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江苏奇力康皮肤药业有限公司
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Priority to PCT/CN2016/083896 priority Critical patent/WO2017206016A1/en
Priority to CN201680000512.5A priority patent/CN108495645B/en
Publication of WO2017206016A1 publication Critical patent/WO2017206016A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • the invention relates to a traditional Chinese medicine ointment. More specifically, the present invention relates to a traditional Chinese medicine ointment having an external application of anti-inflammatory and swelling.
  • the external Chinese medicine ointment is an external semi-solid dosage form which is easily mixed on the skin surface and is prepared by mixing the medicinal material extract with a suitable medium, and has the advantages of good adhesion, spreadability, convenient use and the like.
  • TCM external application ointment uses the synergistic effect of drugs to form a large compound of multi-flavor drugs, in order to exert the good effect of the drug, the traditional Chinese medicine ointment is applied to the surface of the plaster to stimulate the nerve endings, through the reflection, dilation of blood vessels, and promotion of local blood Circulation, improve the nutrition of the surrounding tissues, so as to achieve the purpose of swelling, anti-inflammatory and analgesic.
  • the drug penetrates the subcutaneous tissue through the skin in the affected area, and the relative advantage of the drug concentration is locally generated, thereby exerting a strong pharmacological effect.
  • the traditional external application of anti-inflammatory and swelling Chinese medicine ointment has the following disadvantages: (1) Only the efficacy of traditional Chinese medicine is considered when formulating the ointment, but its toxicity and irritation are neglected, which may aggravate the discomfort of the patient; (2) the traditional external application of ointment The transdermal absorption effect is poor, and the ideal therapeutic effect is not achieved; (3) The traditional Chinese medicine ointment mostly uses sesame oil to extract the traditional Chinese medicine component, and it is easy to extract the active ingredient or the active ingredient in the medicinal material due to the excessive temperature.
  • the inventors of the present invention have found that by properly combining nine kinds of Chinese herbal medicines, they are non-irritating to the skin, and are processed according to the characteristics of each Chinese herbal medicine and the extraction of active ingredients.
  • a transdermal enhancer composed of a suitable ratio of menthol, borneol, PEG, and octanol is also added to the traditional Chinese medicine ointment of the present invention, which significantly increases the therapeutic effect of the traditional Chinese medicine external application ointment. Based on this finding, the present invention has been completed.
  • Still another object of the present invention is to provide an external application of an anti-inflammatory and swelling traditional Chinese medicine ointment, which can quickly reduce inflammation and reduce swelling, has remarkable curative effect, is convenient to use, and is non-irritating to the skin.
  • an externally applied anti-inflammatory and anti-inflammatory Chinese medicine ointment comprising, by weight, consisting of the following grouping ratios:
  • sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed, Chuanxiong and VB 5 can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling-reducing effects.
  • Seabuckthorn oil in seabuckthorn fruit nucleus can resist anti-inflammatory muscles and promote tissue regeneration.
  • Phellodendron has strong inhibitory effect on various pathogenic bacteria, and has astringent and anti-inflammatory effects.
  • the habitat can be used for stagnation of blood circulation and blood circulation.
  • Huayu Chrysanthemum has excellent anti-inflammatory and anti-inflammatory effects, relieves pain and swelling, promotes wound healing, and promotes cell regeneration and skin metabolism.
  • Forsythia treats heat-clearing and detoxifying, swelling and dispersing; Uncaria can be used for Shujinhuo It can reduce swelling and analgesia; pumpkin seeds have anti-inflammatory and analgesic effects; Chuanxiong can be used for activating blood circulation and phlegm and relieving pain; proper addition of VB 5 can be used to soothe the skin and promote the recovery of skin health.
  • the transdermal enhancer comprises 30-40% by weight of menthol, 30-40% by weight of borneol, 15-20% by weight of PEG and 10-15% by weight of octanol.
  • menthol can change the permeability of the stratum corneum, reduce the resistance of the drug to penetration through the skin, and improve the diffusion system of the drug in the stratum corneum of the skin.
  • the borneol can synergize with menthol to effectively increase the absorption of the drug by the skin; PEG and octanol can fuse and mix traditional Chinese medicine with menthol and borneol, which not only increases the solubility of the drug, but also significantly improves the long-term effect of the penetration-promoting effect.
  • the molecular weight of the PEG is 400-600. Under this molecular weight, the PEG has good compatibility with drugs and other excipients, and has an optimal promoting effect on the transdermal efficiency of the drug.
  • the sea buckthorn core, the yellow cedar, the raw land, the hook vine, the chuanxiong, respectively, are pulverized, mixed, and then extracted with 85% ethanol as a solvent at 80 ° C for 3 times to promote the dissolution of the active ingredient of the traditional Chinese medicine. .
  • the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized, mixed, and then extracted with 70% ethanol as a solvent at 55 to 60 ° C for 2 times, chamomile flowers, forsythia and pumpkin.
  • the ethanol reflux extraction temperature of the child should not be too high, otherwise it will increase the dissolution of the ineffective components and reduce the efficacy.
  • the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 ⁇ m, thereby ensuring the leaching of the active ingredient of the traditional Chinese medicine and preventing the fine particle size of the traditional Chinese medicine from affecting the filtration.
  • the 85% ethanol is 5-8 times of the mixed volume of Hippophae rhamnoides, Cork, S. chinensis, Uncaria and Chuanxiong, and the time of each extraction is 1-2 h, suitable ratio of material to liquid and extraction time Ensure the mass transfer driving force and increase the extraction rate of effective substances.
  • the chamomile flower, forsythia, and pumpkin seed are respectively pulverized to 28 to 32 ⁇ m, so that the active ingredient of the traditional Chinese medicine can be sufficiently dissolved to ensure a balance between the dissolution rate of the active ingredient and the pulverization energy.
  • the 70% ethanol is 4-5 times of the chamomile flower, forsythia and pumpkin seeds, and the time of each extraction is 0.3-0.7 h to ensure the active ingredient of the traditional Chinese medicine.
  • transdermal enhancer consisting of a suitable ratio of menthol, borneol, PEG and octanol in the present invention effectively changes the permeability of the stratum corneum of the skin, reduces the resistance of the drug to penetration through the skin, and improves the drug in The diffusion system of the stratum corneum of the skin, and the prolongation effect is long-lasting;
  • the present invention replaces the traditional sesame oil extraction method, and adopts different alcohol reflux processes for extraction according to different properties of the Chinese herbal medicine, thereby ensuring sufficient extraction of the active ingredients and avoiding excessive impurities of the traditional Chinese medicine paste caused by excessive extraction temperature. Poor efficacy.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 15 parts of sea buckthorn core; 10 parts of Phellodendron; 8 parts of habitat; 8 parts of chamomile flower; 5 parts of forsythia; Parts; 5 parts of pumpkin seeds; 3 parts of Chuanxiong; 3 parts of VB 5 ; 3 parts of transdermal enhancer.
  • the transdermal enhancer comprises 30% by weight of menthol, 40% by weight of borneol, 20% by weight of PEG400 and 10% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 20 ⁇ m, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the mixture is refluxed at 80 ° C for 3 times.
  • the first time, each extraction is 1h; the chamomile flowers, forsythia, and pumpkin seeds are respectively pulverized to 28 ⁇ m, mixed, and then sequentially mixed with 4 times of chrysanthemum, forsythia and pumpkin seeds.
  • 70% ethanol was used as a solvent, and the extraction was carried out twice at 55 ° C, and the extraction time was 0.3 h.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 20 parts of sea buckthorn core; 15 parts of Phellodendron; 12 parts of habitat; 12 parts of chamomile flower; 15 parts of forsythia; Parts; 10 parts of pumpkin seeds; 7 parts of Chuanxiong; 5 parts of VB 5 ; 5 parts of transdermal enhancer.
  • the transdermal enhancer comprises 40% by weight of menthol, 35% by weight of borneol, 15% by weight of PEG600 and 10% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 25 ⁇ m, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. Times, each extraction time is 2h.
  • the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized to 32 ⁇ m, mixed, and then sequentially mixed with 70% ethanol of 5 times chamomile, forsythia and pumpkin seed volume, and refluxed at 60 ° C. 2 times, the time of each extraction is 0.7h.
  • the transdermal enhancer comprises 35 wt% menthol, 35 wt% borneol, 15 wt% PEG 500, and 15 wt% octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 23 ⁇ m, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the co-extraction is carried out at 80 ° C under reflux.
  • the extraction time is 2h, 1.5h and 1h respectively; the chamomile flower, forsythia,
  • the pumpkin seeds were pulverized to 30 ⁇ m, mixed, and then, with 4.5 times the volume of chamomile, forsythia and pumpkin seeds, 70% ethanol as solvent, and refluxed at 58 ° C for 2 times, the extraction time was 0.5 h and 0.7h.
  • the transdermal enhancer comprises 32% by weight of menthol, 38% by weight of borneol, 18% by weight of PEG400 and 12% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 22 ⁇ m, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times.
  • the extraction time was 1.5h, 1.5h and 1h respectively; the chamomile flowers, forsythia and pumpkin seeds were pulverized to 29 ⁇ m, mixed, and then 4 times chamomile, forsythia and pumpkin mixture
  • the volume of 70% ethanol was used as a solvent, and the extraction was carried out twice at 58 ° C, and the extraction time was 0.7 h and 0.4 h, respectively.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 17 parts of sea buckthorn kernel; 13 parts of cork; 9 parts of habitat; 11 parts of chamomile flower; 10 parts of forsythia; Servings; 8 parts of pumpkin seeds; 6 parts of Chuanxiong; 5 parts of VB 5 ; 4 parts of transdermal enhancer.
  • the transdermal enhancer comprises 36% by weight of menthol, 33% by weight of borneol, 17% by weight of PEG500 and 14% by weight of octanol.
  • the seabuckthorn core, the yellow cypress, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter After 24 ⁇ m, the mixture was mixed with 85% ethanol of 7 times Chinese herbal medicine as solvent, and refluxed at 80 ° C for 3 times.
  • the extraction time was 1.5 h, 1 h and 2 h, respectively; the chamomile flower, forsythia, and pumpkin seeds were respectively After pulverizing to 31 ⁇ m, the mixture was mixed, and then 70 times of the volume of the mixture of chamomile flowers, forsythia and pumpkin seeds was used as a solvent, and the mixture was re-extracted twice at 59 ° C for 0.6 h and 0.5 h, respectively.

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Abstract

A traditional Chinese ointment for external application for anti-inflammation and swelling relief, consisting of the following components in parts by weight: 15-20 parts of seeds of Fructus hippophae, 10-15 parts of Cortex phellodendri, 8-12 parts of Radix rehmanniae, 8-12 parts of Cota tinctoria, 5-15 parts of Fructus forsythiae, 5-15 parts of Ramulus uncariae cum uncis, 5-10 parts of pumpkin seed, 3-7 parts of Ligusticum chuanxiong, 3-5 parts of VB5, and 3-5 parts of transdermal enhancer. The transdermal enhancer comprises 30-40 wt% of menthol, 30-40 wt% of Borneolum syntheticum, 15-20 wt% of PEG, and 10-15 wt% of octanol.

Description

外敷消炎消肿中药膏剂External application of anti-inflammatory and swelling Chinese medicine ointment 技术领域Technical field
本发明涉及一种中药膏剂。更具体地说，本发明涉及一种具有外敷消炎消肿的中药膏剂。The invention relates to a traditional Chinese medicine ointment. More specifically, the present invention relates to a traditional Chinese medicine ointment having an external application of anti-inflammatory and swelling.
背景技术Background technique
外用中药膏剂是药材提取物与适宜介质混合制成的易于涂布于皮肤表面的外用半固体剂型，具有较好的附着性、涂展性、使用携带方便等优点。中医外敷药膏通过运用药物互相协调为用的效能，组成多味药物的大复方，以发挥药物的良好效果，将中药膏剂贴于体表的膏药刺激神经末梢，通过反射，扩张血管，促进局部血液循环，改善周围组织的营养，从而达到消肿、消炎和镇痛的目的。同时药物在患处通过皮肤渗透皮下组织，在局部产生药物浓度的相对优势，从而发挥较强的药理作用。The external Chinese medicine ointment is an external semi-solid dosage form which is easily mixed on the skin surface and is prepared by mixing the medicinal material extract with a suitable medium, and has the advantages of good adhesion, spreadability, convenient use and the like. TCM external application ointment uses the synergistic effect of drugs to form a large compound of multi-flavor drugs, in order to exert the good effect of the drug, the traditional Chinese medicine ointment is applied to the surface of the plaster to stimulate the nerve endings, through the reflection, dilation of blood vessels, and promotion of local blood Circulation, improve the nutrition of the surrounding tissues, so as to achieve the purpose of swelling, anti-inflammatory and analgesic. At the same time, the drug penetrates the subcutaneous tissue through the skin in the affected area, and the relative advantage of the drug concentration is locally generated, thereby exerting a strong pharmacological effect.
但传统的外敷消炎消肿中药膏剂有如下缺点：(1)配制膏剂时仅考虑到中药的功效，而忽视了其毒性和刺激性，反而会加重患者的不适现象；(2)传统外敷膏剂的透皮吸收效果差，达不到理想的治疗效果；(3)传统中药膏剂多以麻油进行中药成分的提取，易因温度过高破坏药材内的有效成分或有效成分提取不完整。However, the traditional external application of anti-inflammatory and swelling Chinese medicine ointment has the following disadvantages: (1) Only the efficacy of traditional Chinese medicine is considered when formulating the ointment, but its toxicity and irritation are neglected, which may aggravate the discomfort of the patient; (2) the traditional external application of ointment The transdermal absorption effect is poor, and the ideal therapeutic effect is not achieved; (3) The traditional Chinese medicine ointment mostly uses sesame oil to extract the traditional Chinese medicine component, and it is easy to extract the active ingredient or the active ingredient in the medicinal material due to the excessive temperature.
发明内容Summary of the invention
作为各种广泛且细致的研究和实验的结果，本发明的发明人已经发现，通过将九种中草药进行合理配伍，对皮肤无刺激性，并根据每种中草药的特性进行处理和有效成分的提取，此外在本发明的中药膏剂中还添加由合适比例薄荷醇、冰片、PEG及辛醇组成的透皮促进剂，显著增加了本发明中药外敷膏剂的疗效。基于这种发现，完成了本发明。As a result of various extensive and meticulous research and experiments, the inventors of the present invention have found that by properly combining nine kinds of Chinese herbal medicines, they are non-irritating to the skin, and are processed according to the characteristics of each Chinese herbal medicine and the extraction of active ingredients. In addition, a transdermal enhancer composed of a suitable ratio of menthol, borneol, PEG, and octanol is also added to the traditional Chinese medicine ointment of the present invention, which significantly increases the therapeutic effect of the traditional Chinese medicine external application ointment. Based on this finding, the present invention has been completed.
本发明的一个目的是解决至少上述问题和/或缺陷，并提供至少后面将说 明的优点。It is an object of the present invention to address at least the above problems and/or disadvantages and to provide at least The advantages of Ming.
本发明还有一个目的是提供一种外敷消炎消肿中药膏剂，其能快速消炎消肿，疗效显著，使用方便，且对皮肤无刺激性。Still another object of the present invention is to provide an external application of an anti-inflammatory and swelling traditional Chinese medicine ointment, which can quickly reduce inflammation and reduce swelling, has remarkable curative effect, is convenient to use, and is non-irritating to the skin.
为了实现根据本发明的这些目的和其它优点，提供了一种外敷消炎消肿中药膏剂，按重量份计，由以下组分配比组成：In order to achieve these and other advantages in accordance with the present invention, there is provided an externally applied anti-inflammatory and anti-inflammatory Chinese medicine ointment comprising, by weight, consisting of the following grouping ratios:
Figure PCTCN2016083896-appb-000001
Figure PCTCN2016083896-appb-000001
在上述中药膏剂配方中，沙棘果核、黄柏、生地、春黄菊花、连翘、钩藤、南瓜子、川穹和VB5合用可产生强而持久的清热消炎消肿效能。沙棘果核中的沙棘油能抗炎生肌，有效促进组织再生；黄柏对多种致病细菌具有很强的抑制作用，且具有收敛和消炎的作用；生地可用于流畅血脉之瘀滞，活血化瘀；春黄菊花具有优异的抗炎消炎，止痛消肿，促进伤口愈合，同时具有促进细胞再生和皮肤新陈代谢等作用；连翘主治清热解毒、消肿散结；钩藤可用于舒筋活络、消肿镇痛；南瓜子具有消炎止痛作用；川芎可用于活血行气，祛风止痛；VB5的适当添加可用于舒缓皮肤，促进皮肤健康的恢复。In the above traditional Chinese medicine ointment formula, sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed, Chuanxiong and VB 5 can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling-reducing effects. Seabuckthorn oil in seabuckthorn fruit nucleus can resist anti-inflammatory muscles and promote tissue regeneration. Phellodendron has strong inhibitory effect on various pathogenic bacteria, and has astringent and anti-inflammatory effects. The habitat can be used for stagnation of blood circulation and blood circulation. Huayu Chrysanthemum has excellent anti-inflammatory and anti-inflammatory effects, relieves pain and swelling, promotes wound healing, and promotes cell regeneration and skin metabolism. Forsythia treats heat-clearing and detoxifying, swelling and dispersing; Uncaria can be used for Shujinhuo It can reduce swelling and analgesia; pumpkin seeds have anti-inflammatory and analgesic effects; Chuanxiong can be used for activating blood circulation and phlegm and relieving pain; proper addition of VB 5 can be used to soothe the skin and promote the recovery of skin health.
优选的是，其中，按重量份计，由以下组分配比组成：Preferably, wherein, by weight, it consists of the following group distribution ratios:
Figure PCTCN2016083896-appb-000002
Figure PCTCN2016083896-appb-000002
Figure PCTCN2016083896-appb-000003
Figure PCTCN2016083896-appb-000003
优选的是，其中，所述透皮促进剂包括30～40wt％的薄荷醇、30～40wt％的冰片、15～20wt％的PEG及10～15wt％的辛醇。薄荷醇的添加可改变角质层的通透性，减低药物经皮肤渗透的阻力，提高药物在皮肤角质层的扩散体系，冰片可与薄荷醇产生协同增效作用，有效增加皮肤对药物的吸收；PEG和辛醇可对中药和薄荷醇及冰片起到融合和混合的作用，既增加药物的溶解度，又可显著提高促渗效果的长久性。Preferably, the transdermal enhancer comprises 30-40% by weight of menthol, 30-40% by weight of borneol, 15-20% by weight of PEG and 10-15% by weight of octanol. The addition of menthol can change the permeability of the stratum corneum, reduce the resistance of the drug to penetration through the skin, and improve the diffusion system of the drug in the stratum corneum of the skin. The borneol can synergize with menthol to effectively increase the absorption of the drug by the skin; PEG and octanol can fuse and mix traditional Chinese medicine with menthol and borneol, which not only increases the solubility of the drug, but also significantly improves the long-term effect of the penetration-promoting effect.
优选的是，其中，所述PEG的分子量为400～600，在此分子量下，PEG与药物及其他辅料有良好的相容性，且对药物的透皮效率有最优的促进效果。Preferably, the molecular weight of the PEG is 400-600. Under this molecular weight, the PEG has good compatibility with drugs and other excipients, and has an optimal promoting effect on the transdermal efficiency of the drug.
优选的是，其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎后，混合，然后以85％的乙醇为溶剂，80℃回流提取3次，以促进中药有效成分的溶出。Preferably, the sea buckthorn core, the yellow cedar, the raw land, the hook vine, the chuanxiong, respectively, are pulverized, mixed, and then extracted with 85% ethanol as a solvent at 80 ° C for 3 times to promote the dissolution of the active ingredient of the traditional Chinese medicine. .
优选的是，其中，所述春黄菊花、连翘、南瓜子分别经粉碎后，混合，然后以70％的乙醇为溶剂，55～60℃回流提取2次，春黄菊花、连翘和南瓜子的乙醇回流提取温度不能过高，否则会增加无效成分的溶出，降低药效。Preferably, the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized, mixed, and then extracted with 70% ethanol as a solvent at 55 to 60 ° C for 2 times, chamomile flowers, forsythia and pumpkin. The ethanol reflux extraction temperature of the child should not be too high, otherwise it will increase the dissolution of the ineffective components and reduce the efficacy.
优选的是，其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别粉碎至20～25μm，既保证中药有效成分的浸出，又防止中药粒径过细影响过滤。Preferably, the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 μm, thereby ensuring the leaching of the active ingredient of the traditional Chinese medicine and preventing the fine particle size of the traditional Chinese medicine from affecting the filtration.
优选的是，其中，所述85％的乙醇为沙棘果核、黄柏、生地、钩藤和川芎混合体积的5～8倍，每次提取的时间为1～2h，合适的料液比和提取时间保证传质推动力，提高有效物质的提取率。Preferably, the 85% ethanol is 5-8 times of the mixed volume of Hippophae rhamnoides, Cork, S. chinensis, Uncaria and Chuanxiong, and the time of each extraction is 1-2 h, suitable ratio of material to liquid and extraction time Ensure the mass transfer driving force and increase the extraction rate of effective substances.
优选的是，其中，所述春黄菊花、连翘、南瓜子分别粉碎至28～32μm，即可使中药的有效成分充分溶出，以保证有效成分溶出率与粉碎能耗之间的平衡。Preferably, the chamomile flower, forsythia, and pumpkin seed are respectively pulverized to 28 to 32 μm, so that the active ingredient of the traditional Chinese medicine can be sufficiently dissolved to ensure a balance between the dissolution rate of the active ingredient and the pulverization energy.
优选的是，其中，每次提取，所述70％的乙醇为所述春黄菊花、连翘和南瓜子的4～5倍，每次提取的时间为0.3～0.7h，以保证中药有效成分的溶 出率及批次间的溶出稳定性。Preferably, in each extraction, the 70% ethanol is 4-5 times of the chamomile flower, forsythia and pumpkin seeds, and the time of each extraction is 0.3-0.7 h to ensure the active ingredient of the traditional Chinese medicine. Dissolution Outlet rate and dissolution stability between batches.
本发明至少包括以下有益效果：The invention includes at least the following beneficial effects:
(1)本发明中药膏剂配方中，沙棘果核、黄柏、生地、春黄菊花、连翘、钩藤、南瓜子和川穹的合用可产生强而持久的清热消炎消肿效能，且作用温和，对皮肤无刺激性；(1) In the formula of the traditional Chinese medicine ointment, the combination of sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed and Chuanxiong can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling effect, and the effect is mild. Not irritating to the skin;
(2)本发明中由合适比例薄荷醇、冰片、PEG及辛醇组成的透皮促进剂的使用，有效改变了皮肤角质层的通透性，减低药物经皮肤渗透的阻力，提高了药物在皮肤角质层的扩散体系，且促渗作用持久；(2) The use of a transdermal enhancer consisting of a suitable ratio of menthol, borneol, PEG and octanol in the present invention effectively changes the permeability of the stratum corneum of the skin, reduces the resistance of the drug to penetration through the skin, and improves the drug in The diffusion system of the stratum corneum of the skin, and the prolongation effect is long-lasting;
(3)本发明替代传统的麻油提取方法，根据中草药的不同性质采用不同的醇回流工艺进行提取，既保证了有效成分的充分提取，又避免的提取温度过高而造成的中药膏剂杂质多，药效差。(3) The present invention replaces the traditional sesame oil extraction method, and adopts different alcohol reflux processes for extraction according to different properties of the Chinese herbal medicine, thereby ensuring sufficient extraction of the active ingredients and avoiding excessive impurities of the traditional Chinese medicine paste caused by excessive extraction temperature. Poor efficacy.
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。Other advantages, objects, and features of the invention will be set forth in part in the description in the description which
具体实施方式detailed description
下面结合具体实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。The present invention will be further described in detail below with reference to specific embodiments, so that those skilled in the art can refer to the description.
应当理解，本文所使用的诸如“具有”、“包含”以及“包括”术语并不配出一个或多个其它元件或其组合的存在或添加。It is to be understood that the terms "having", "comprising" and "comprising" are used in the <RTIgt;
<实例1><Example 1>
一种外敷消炎消肿中药膏剂，其按重量份计，由以下组分配比组成：沙棘果核15份；黄柏10份；生地8份；春黄菊花8份；连翘5份；钩藤5份；南瓜子5份；川芎3份；VB5 3份；透皮促进剂3份。An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 15 parts of sea buckthorn core; 10 parts of Phellodendron; 8 parts of habitat; 8 parts of chamomile flower; 5 parts of forsythia; Parts; 5 parts of pumpkin seeds; 3 parts of Chuanxiong; 3 parts of VB 5 ; 3 parts of transdermal enhancer.
其中，所述透皮促进剂包括30wt％的薄荷醇、40wt％的冰片、20wt％的PEG400及10wt％的辛醇。Wherein, the transdermal enhancer comprises 30% by weight of menthol, 40% by weight of borneol, 20% by weight of PEG400 and 10% by weight of octanol.
其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎至平均粒径为20μm后，混合，然后依次以5倍中药混合物的85％的乙醇为溶剂，80℃回流共提取3次，每次均提取1h；所述春黄菊花、连翘、南瓜子分别经粉碎至28μm后，混合，然后依次以4倍春黄菊花、连翘和南瓜子混合物体积的 70％的乙醇为溶剂，55℃回流提取2次，每次提取的时间均为0.3h。Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 20 μm, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the mixture is refluxed at 80 ° C for 3 times. The first time, each extraction is 1h; the chamomile flowers, forsythia, and pumpkin seeds are respectively pulverized to 28 μm, mixed, and then sequentially mixed with 4 times of chrysanthemum, forsythia and pumpkin seeds. 70% ethanol was used as a solvent, and the extraction was carried out twice at 55 ° C, and the extraction time was 0.3 h.
将本实例制备的中药膏剂应用于临床治疗：The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:
张某，男，35岁，因住所环境潮湿，背部生有大片小疙瘩，瘙痒发红，外敷本实例制备的中药膏剂，瘙痒症状得到有效缓解，3天后疙瘩消失，无疤痕，疗效满意。Zhang, male, 35 years old, due to the damp environment of the residence, a large piece of small sputum on the back, itching redness, external application of the traditional Chinese medicine ointment prepared in this example, the itching symptoms were effectively relieved, after 3 days, the sputum disappeared, no scar, and the effect was satisfactory.
<实例2><Example 2>
一种外敷消炎消肿中药膏剂，其按重量份计，由以下组分配比组成：沙棘果核20份；黄柏15份；生地12份；春黄菊花12份；连翘15份；钩藤15份；南瓜子10份；川芎7份；VB5 5份；透皮促进剂5份。An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 20 parts of sea buckthorn core; 15 parts of Phellodendron; 12 parts of habitat; 12 parts of chamomile flower; 15 parts of forsythia; Parts; 10 parts of pumpkin seeds; 7 parts of Chuanxiong; 5 parts of VB 5 ; 5 parts of transdermal enhancer.
其中，所述透皮促进剂包括40wt％的薄荷醇、35wt％的冰片、15wt％的PEG600及10wt％的辛醇。Wherein, the transdermal enhancer comprises 40% by weight of menthol, 35% by weight of borneol, 15% by weight of PEG600 and 10% by weight of octanol.
其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎至平均粒径为25μm后，混合，然后依次以8倍中药混合物的85％的乙醇为溶剂，80℃回流共提取3次，每次提取的时间均为2h。；所述春黄菊花、连翘、南瓜子分别经粉碎至32μm后，混合，然后依次以5倍春黄菊花、连翘和南瓜子混合物体积的70％的乙醇为溶剂，60℃回流共提取2次，每次提取的时间为0.7h。Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 25 μm, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. Times, each extraction time is 2h. The chamomile flower, forsythia, and pumpkin seeds are respectively pulverized to 32 μm, mixed, and then sequentially mixed with 70% ethanol of 5 times chamomile, forsythia and pumpkin seed volume, and refluxed at 60 ° C. 2 times, the time of each extraction is 0.7h.
将本实例制备的中药膏剂应用于临床治疗：The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:
刘某，女，67岁，因脑梗塞致偏瘫半年，久卧在床，骶尾部皮肤形成压之不褪色的红斑，外敷本实例制备的中药膏剂，同时均采取翻身、减压等措施，皮肤有清凉感，且无刺激性，并且红斑逐渐消失，7天后得到治愈。Liu, female, 67 years old, due to cerebral infarction, hemiplegia for half a year, lying in bed for a long time, the skin of the appendix is formed into a faint erythema, and the traditional Chinese medicine ointment prepared by this example is applied, and the measures of turning over and decompressing are taken at the same time. It has a refreshing sensation and is non-irritating, and the erythema gradually disappears and is cured after 7 days.
<实例3><Example 3>
一种外敷消炎消肿中药膏剂，其按重量份计，由以下组分配比组成：沙棘果核16份；黄柏12份；生地11份；春黄菊花12份；连翘7份；钩藤7份；南瓜子9份；川芎3份；VB5 5份；透皮促进剂4份。External application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 16 parts of sea buckthorn kernel; 12 parts of Phellodendron; 11 parts of habitat; 12 parts of chamomile flower; 7 parts of forsythia; Servings; 9 parts of pumpkin seeds; 3 parts of Chuanxiong; 5 parts of VB 5 ; 4 parts of transdermal enhancer.
其中，所述透皮促进剂包括35wt％的薄荷醇、35wt％的冰片、15wt％的PEG500及15wt％的辛醇。Wherein, the transdermal enhancer comprises 35 wt% menthol, 35 wt% borneol, 15 wt% PEG 500, and 15 wt% octanol.
其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎至平均粒径为23μm后，混合，然后依次以7倍中药混合物的85％的乙醇为溶剂，80℃回流共提取3次，提取的时间分别为2h、1.5h和1h；所述春黄菊花、连翘、 南瓜子分别经粉碎至30μm后，混合，然后依次以4.5倍春黄菊花、连翘和南瓜子混合物体积的70％的乙醇为溶剂，58℃回流共提取2次，提取时间分别为0.5h和0.7h。Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 23 μm, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the co-extraction is carried out at 80 ° C under reflux. The extraction time is 2h, 1.5h and 1h respectively; the chamomile flower, forsythia, The pumpkin seeds were pulverized to 30 μm, mixed, and then, with 4.5 times the volume of chamomile, forsythia and pumpkin seeds, 70% ethanol as solvent, and refluxed at 58 ° C for 2 times, the extraction time was 0.5 h and 0.7h.
将本实例制备的中药膏剂应用于临床治疗：The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:
陈某，男，8岁，因水土不服身上生有片状红肿现象，并有瘙痒感，外敷本实例制备的中药膏剂，瘙痒症状得到有效缓解，3天后红肿现象消失，疗效满意。Chen, male, 8 years old, suffering from flaky redness and swelling, and itching sensation, external application of the traditional Chinese medicine ointment prepared in this example, the itching symptoms were effectively relieved, redness disappeared after 3 days, the effect was satisfactory.
<实例4><Example 4>
一种外敷消炎消肿中药膏剂，其按重量份计，由以下组分配比组成：沙棘果核18份；黄柏14份；生地10份；春黄菊花9份；连翘12份；钩藤12份；南瓜子7份；川芎5份；VB5 4份；透皮促进剂4份。External application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 18 parts of seabuckthorn fruit core; 14 parts of Phellodendron; 10 parts of habitat; 9 parts of chamomile flower; 12 parts of forsythia; parts; 7 parts by pumpkin seeds; Chuanxiong 5 parts; VB 5 parts of 4; 4 parts penetration enhancer.
其中，所述透皮促进剂包括32wt％的薄荷醇、38wt％的冰片、18wt％的PEG400及12wt％的辛醇。Wherein, the transdermal enhancer comprises 32% by weight of menthol, 38% by weight of borneol, 18% by weight of PEG400 and 12% by weight of octanol.
其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎至平均粒径为22μm后，混合，然后依次以6倍中药混合物的85％的乙醇为溶剂，80℃回流共提取3次，提取的时间分别为1.5h、1.5h和1h；所述春黄菊花、连翘、南瓜子分别经粉碎至29μm后，混合，然后依次以4倍春黄菊花、连翘和南瓜子混合物体积的70％的乙醇为溶剂，58℃回流共提取2次，提取时间分别为0.7h和0.4h。Wherein, the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 22 μm, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. The extraction time was 1.5h, 1.5h and 1h respectively; the chamomile flowers, forsythia and pumpkin seeds were pulverized to 29μm, mixed, and then 4 times chamomile, forsythia and pumpkin mixture The volume of 70% ethanol was used as a solvent, and the extraction was carried out twice at 58 ° C, and the extraction time was 0.7 h and 0.4 h, respectively.
将本实例制备的中药膏剂应用于临床治疗：The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:
李某，男，24岁，因运动过激软组织挫伤，腿部出现红肿疼痛现象，外敷本实例制备的中药膏剂，5天后红肿现象完全消失，疗效满意。Li Mou, male, 24 years old, suffered from redness and swelling in the legs due to exercise and soft tissue. The traditional Chinese medicine ointment prepared in this example was completely disappeared after 5 days, and the curative effect was satisfactory.
<实例5><Example 5>
一种外敷消炎消肿中药膏剂，其按重量份计，由以下组分配比组成：沙棘果核17份；黄柏13份；生地9份；春黄菊花11份；连翘10份；钩藤10份；南瓜子8份；川芎6份；VB5 5份；透皮促进剂4份。An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, which comprises, by weight, by the following group distribution ratio: 17 parts of sea buckthorn kernel; 13 parts of cork; 9 parts of habitat; 11 parts of chamomile flower; 10 parts of forsythia; Servings; 8 parts of pumpkin seeds; 6 parts of Chuanxiong; 5 parts of VB 5 ; 4 parts of transdermal enhancer.
其中，所述透皮促进剂包括36wt％的薄荷醇、33wt％的冰片、17wt％的PEG500及14wt％的辛醇。Wherein, the transdermal enhancer comprises 36% by weight of menthol, 33% by weight of borneol, 17% by weight of PEG500 and 14% by weight of octanol.
其中，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎至平均粒径 为24μm后，混合，然后以7倍中药混合物的85％的乙醇为溶剂，80℃回流提取3次，提取的时间分别为1.5h、1h和2h；所述春黄菊花、连翘、南瓜子分别经粉碎至31μm后，混合，然后依次5倍春黄菊花、连翘和南瓜子混合物体积的70％的乙醇为溶剂，59℃回流共提取2次，提取时间分别为0.6h和0.5h。Wherein, the seabuckthorn core, the yellow cypress, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter After 24 μm, the mixture was mixed with 85% ethanol of 7 times Chinese herbal medicine as solvent, and refluxed at 80 ° C for 3 times. The extraction time was 1.5 h, 1 h and 2 h, respectively; the chamomile flower, forsythia, and pumpkin seeds were respectively After pulverizing to 31 μm, the mixture was mixed, and then 70 times of the volume of the mixture of chamomile flowers, forsythia and pumpkin seeds was used as a solvent, and the mixture was re-extracted twice at 59 ° C for 0.6 h and 0.5 h, respectively.
将本实例制备的中药膏剂应用于临床治疗：The traditional Chinese medicine ointment prepared in this example is applied to clinical treatment:
谢某，女，42岁，胳膊被蜜蜂蜇伤，蜂刺被拔出后，出现红肿疼痛现象，外敷本实例制备的中药膏剂，疼痛症状得到有效缓解，4天后红肿消失，无疤痕，疗效满意。Xie Mou, female, 42 years old, her arm was bruised by a bee. After the bee sting was pulled out, there was redness and swelling. The traditional Chinese medicine ointment prepared in this example was used to relieve the pain symptoms. After 4 days, the redness disappeared without scars. .
可见，由本发明制备得到的外敷消炎消肿中药膏剂作用迅速，可产生强而持久的清热消炎消肿效能，且作用温和，对皮肤无刺激性。It can be seen that the external application of anti-inflammatory and anti-inflammatory traditional Chinese medicine ointment prepared by the invention has rapid action, can produce strong and lasting anti-inflammatory and anti-inflammatory effect, and has mild effect and no irritation to skin.
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用。它完全可以被适用于各种适合本发明的领域。对于熟悉本领域的人员而言，可容易地实现另外的修改。因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的实施例。 Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the embodiments. It can be applied to a wide variety of fields suitable for the present invention. Additional modifications can be readily implemented by those skilled in the art. The present invention is therefore not limited to the specific details and embodiments shown and described herein.

Claims (10)

  1. 一种外敷消炎消肿中药膏剂，其特征在于，按重量份计，由以下组分配比组成：An external application of anti-inflammatory and swelling traditional Chinese medicine ointment, characterized in that, by weight, it consists of the following group distribution ratios:
    Figure PCTCN2016083896-appb-100001
    Figure PCTCN2016083896-appb-100001
  2. 如权利要求1所述的外敷消炎消肿中药膏剂，其特征在于，按重量份计，由以下组分配比组成：The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, which is composed of the following group distribution ratios by weight:
    Figure PCTCN2016083896-appb-100002
    Figure PCTCN2016083896-appb-100002
  3. 如权利要求1所述的外敷消炎消肿中药膏剂，其特征在于，所述透皮促进剂包括30～40wt％的薄荷醇、30～40wt％的冰片、15～20wt％的PEG及10～15wt％的辛醇。 The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the transdermal enhancer comprises 30 to 40% by weight of menthol, 30 to 40% by weight of borneol, 15 to 20% by weight of PEG and 10 to 15% by weight. % octanol.
  4. 如权利要求3所述的外敷消炎消肿中药膏剂，其特征在于，所述PEG的分子量为400～600。The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 3, wherein the PEG has a molecular weight of 400 to 600.
  5. 如权利要求1所述的外敷消炎消肿中药膏剂，其特征在于，所述沙棘果核、黄柏、生地、钩藤、川芎分别经粉碎后，混合，然后以85％的乙醇为溶剂，80℃回流提取3次。The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are separately pulverized, mixed, and then 85% ethanol is used as a solvent, 80 ° C Extracted back to 3 times.
  6. 如权利要求1所述的外敷消炎消肿中药膏剂，其特征在于，所述春黄菊花、连翘、南瓜子分别经粉碎后，混合，然后以70％的乙醇为溶剂，55～60℃回流提取2次。The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 1, wherein the chamomile flower, forsythia, and pumpkin are respectively pulverized, mixed, and then refluxed with 70% ethanol as a solvent at 55 to 60 ° C. Extract 2 times.
  7. 如权利要求5所述的外敷消炎消肿中药膏剂，其特征在于，所述沙棘果核、黄柏、生地、钩藤、川芎分别粉碎至20～25μm。The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 5, wherein the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 μm.
  8. 如权利要求5所述的外敷消炎消肿中药膏剂，其特征在于，每次提取，所述85％的乙醇为沙棘果核、黄柏、生地、钩藤和川芎混合体积的5～8倍，每次提取的时间为1～2h。The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 5, characterized in that, in each extraction, the 85% ethanol is 5-8 times of the mixed volume of sea buckthorn core, cork, raw land, Uncaria and Chuanxiong, each time The extraction time is 1 to 2 hours.
  9. 如权利要求6所述的外敷消炎消肿中药膏剂，其特征在于，所述春黄菊花、连翘、南瓜子分别粉碎至28～32μm。The externally applied anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 6, wherein the chamomile flower, forsythia, and pumpkin are pulverized to 28 to 32 μm, respectively.
  10. 如权利要求6所述的外敷消炎消肿中药膏剂，其特征在于，每次提取，所述70％的乙醇为所述春黄菊花、连翘和南瓜子混合体积的4～5倍，每次提取的时间为0.3～0.7h。 The external application anti-inflammatory and swelling traditional Chinese medicine ointment according to claim 6, wherein each 70% of the ethanol is 4 to 5 times of the mixed volume of the chamomile flower, forsythia and pumpkin seeds, each time The extraction time is 0.3 to 0.7 h.
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