CN116270915A - Sweet wormwood herb paste and preparation method and application thereof - Google Patents
Sweet wormwood herb paste and preparation method and application thereof Download PDFInfo
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- CN116270915A CN116270915A CN202310334944.1A CN202310334944A CN116270915A CN 116270915 A CN116270915 A CN 116270915A CN 202310334944 A CN202310334944 A CN 202310334944A CN 116270915 A CN116270915 A CN 116270915A
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- sweet wormwood
- oil
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Abstract
The invention relates to the technical field of pharmaceutical preparations, in particular to sweet wormwood herb paste and a preparation method and application thereof. The sweet wormwood herb paste is prepared from a phase A, a phase B and a phase C, wherein the phase A, the phase B and the phase C comprise the following raw materials: phase A: matrix, menthol, camphor and borneol; and B phase: radix Arnebiae extract, columba grass oil and myrrha oil; and C phase: ligusticum wallichii oil, peppermint leaf oil, methyl salicylate, artemisia annua extract, centella asiatica extract and berberis thunbergii extract. The invention also provides a preparation method of the sweet wormwood herb paste and application of the sweet wormwood herb paste in preparation of medicines for refreshing, removing mites or repelling mosquitoes. The sweet wormwood herb paste is mainly prepared from sweet wormwood herb extract, lithospermum extract and methyl salicylate, is scientific in synergistic collocation, has a good antibacterial and mite-inhibiting effect, has no adverse reaction, can be suitable for improving different symptoms caused by different diseases, can improve headache, common cold, refreshment, heatstroke and nasal obstruction, removes fatigue and reduces tiredness, and has the curative effects of resisting bacteria, diminishing inflammation and relieving itching.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to sweet wormwood herb paste and a preparation method and application thereof.
Background
The medical ointment generally comprises ointment, plaster and ointment prescription (commonly called as soft extract), and the external ointment is also called as ointment and is generally mixed by adding medicine fine powder into a matrix.
At present, the external ointment is prepared into medicaments with specific curative effects according to specific disease symptoms, such as adding specific medicaments into a matrix according to common symptoms such as bacteriostasis, mite removal, mosquito bite, refreshment, heatstroke, nasal obstruction, fatigue removal, and sleepiness reduction, and the like, has single functionality and no applicability to multiple symptoms, and certain external ointments have the effect of improving the symptoms, but have poor medicinal effects, relapse is easier to occur, and adverse reactions can occur when part of external ointments are used.
Artemisinin exists in artemisinin plants in most areas of China, has the effects of malaria resistance, tumor resistance, fungus resistance and immunoregulation, and the development of external ointment with novel artemisinin effect and application are urgent problems to be solved.
Disclosure of Invention
In order to solve the technical problems, the invention provides sweet wormwood herb paste and a preparation method and application thereof. The sweet wormwood herb ointment is mainly prepared from sweet wormwood herb extract, lithospermum extract and methyl salicylate, is scientific in synergistic collocation, has a good antibacterial and mite-inhibiting effect, has no adverse reaction, can be suitable for improving different symptoms caused by different diseases, and has a good curative effect.
The invention aims to provide sweet wormwood herb paste.
The invention also aims to provide a preparation method of the sweet wormwood herb paste.
The invention further aims at providing an application of the sweet wormwood herb paste.
According to the purpose of the invention, the sweet wormwood herb paste is prepared from an A phase, a B phase and a C phase, wherein the A phase, the B phase and the C phase comprise the following raw materials:
phase A: matrix, menthol, camphor and borneol;
and B phase: radix Arnebiae extract, columba grass oil and myrrha oil;
and C phase: ligusticum wallichii oil, peppermint leaf oil, methyl salicylate, artemisia annua extract, centella asiatica extract and berberis thunbergii extract.
The sweet wormwood herb paste is preferably prepared from the following raw materials in parts by weight:
phase A: 55-65 parts of matrix, 15-20 parts of menthol, 3-7 parts of camphor and 1.5-5.5 parts of borneol;
the phase B is as follows: 0.000001 to 0.00002 part of lithospermum extract, 0.000001 to 0.00002 part of citronella oil and 0.000001 to 0.00002 part of myrrh oil;
and C phase: 3 to 7 parts of ligusticum wallichii oil, 1.5 to 5.5 parts of mint leaf oil, 1 to 3 parts of methyl salicylate, 0.5 to 1.5 parts of artemisia annua extract, 0.05 to 0.5 part of centella asiatica extract and 0.05 to 0.5 part of berberis thunbergii extract.
The sweet wormwood herb paste is preferably prepared from the following raw materials in parts by weight:
phase A: 62.5 parts of matrix, 17.7 parts of menthol, 4.7 parts of camphor and 3.5 parts of borneol;
and B phase: 0.00001 part of lithospermum extract, 0.00001 part of citronella oil and 0.00001 part of myrrh oil;
and C phase: 5 parts of ligusticum wallichii oil, 1.5 parts of mint leaf oil, 1.9 parts of methyl salicylate, 1 part of artemisia annua extract, 0.1 part of centella asiatica extract and 0.1 part of berberis thunbergii extract.
The sweet wormwood paste, preferably, the matrix comprises petrolatum and beeswax, and the mass ratio of the petrolatum to the beeswax is (2.5-6): 1.
the sweet wormwood herb paste is preferable, and the content of active substances in the centella asiatica extract is more than or equal to 90%.
The sweet wormwood herb paste is preferable, and the content of active substances in the extract of the berberis thunbergii is more than or equal to 90%.
According to the purpose of the invention, the preparation method of the sweet wormwood herb paste comprises the following steps of:
(1) Mixing all the raw materials in phase A, homogenizing, heating to 75-80deg.C, and stirring for 55-60min to obtain phase A mixture;
(2) Adjusting the temperature of the phase A mixture to 55-60 ℃, then adding all the raw materials in the phase B into the phase A mixture, and stirring for 25-30min to obtain paste;
(3) Filtering the paste with filter cloth, adding phase C, and mixing to obtain herba Artemisiae Annuae paste.
In the preparation method of the sweet wormwood herb paste, preferably, the filter cloth is 200-mesh filter cloth.
According to the purpose of the invention, the sweet wormwood herb paste is applied to the preparation of the medicines for refreshing, removing mites or repelling mosquitoes.
The general roles that the various raw materials of the present invention play in the sweet wormwood paste of the present invention are shown in Table 1 below:
TABLE 1 general effects of raw materials
The medicine effect of each raw material in the sweet wormwood herb paste is as follows:
menthol: colorless needle-like or prismatic crystals or white crystalline powder; has special fragrance of herba Menthae, and cool and refreshing after initial burning. Has antipruritic and analgesic effects, and is commonly used for relieving pain and swelling; it is used for treating rhinitis, pharyngolaryngitis, allergic dermatitis, resuscitation, and refreshment.
Borneol: colorless transparent or white semitransparent flaky crisp crystals; fragrant smell, pungent and cool taste; has volatility. [ MEANS FOR SOLVING PROBLEMS ] it is pungent, bitter and slightly cold. It enters heart, spleen and lung meridians. [ Functions and indications ] induce resuscitation and refresh mind, clear heat and alleviate pain. Can be used for treating fever, unconsciousness, convulsion, apoplexy, phlegm syncope, qi stagnation syncope, middle-jiao coma, chest pain, conjunctival congestion, aphtha, laryngopharynx swelling and pain, and ear canal purulence. Has the effects of inducing resuscitation, removing the vital energy, improving eyesight, inducing resuscitation and refreshing mind. External use 'heat clearing, detumescence, itching relieving and pain relieving'. Can be used for treating halitosis, pyocutaneous disease, and furuncle due to blood heat and internal heat accumulation.
Ligusticum wallichii oil: the light brown to brown oily liquid is a mixture containing various effective components, and mainly comprises ligustilide (more than or equal to 15%), n-butylphthalide, ligustrazine, ferulic acid and the like. Has effects in relieving spasm, dilating blood vessel, relieving cough and asthma, and resisting cerebral ischemia. Promoting qi circulation, resolving stagnation, promoting blood circulation, relieving pain, dispelling pathogenic wind, removing dampness, removing fat, and reducing weight; can eliminate free radicals, has antioxidant effect, and can prevent aging; can effectively inhibit the activity of melanocyte, reduce melanin, and has whitening effect. The volatile oil is an important active ingredient of rhizoma Ligustici Chuanxiong, and contains about 1% of lactone compound; the volatile oil contains more compounds, the proportion of the compounds in the total volatile oil is 93.64%, the main components of the compounds are fumigating lactone (58.00%), cedrene (6.08%), 3-butylphthalide (5.29%), and some active ingredients such as a-phellandrene.
Camphor: white crystalline powder or colorless semitransparent hard lump, is easy to grind into fine powder; has pungent and special smell, and is pungent in taste and cool after taste; is volatile at normal temperature. Pungent in flavor and warm in nature, it enters heart meridian.
Peppermint leaf oil: is derived from peppermint leaf, has effects of relieving and tranquilizing, diminishing inflammation, relieving acne marks, improving skin health state, and inhibiting various bacteria, viruses and fungi. The peppermint leaf oil contains L-menthol (menthol) 62.3-87.2%, menthone 8-12%, menthone acetate, camphene, limonene, isomenthone, pinene, menthenone, resin, small amount of tannic acid, caffeic acid, luteolin, glucoside and various free amino acids (such as threonine). The peppermint leaf oil also contains a plurality of anti-inflammatory components taking dihydroxyl 1,2 dihydronaphthalene dicarboxylic acid as a parent nucleus.
Methyl salicylate: the color of the oil is light yellow transparent liquid, and the oil has strong fragrance of wintergreen oil. Has the effects of dilating skin blood vessel, promoting local blood circulation, and reflectively affecting adjacent skin, muscle, nerve and joint, thereby relieving inflammation and pain. After methyl salicylate is removed from body, it becomes salicylic acid, which is a very good antipyretic, analgesic and anti-inflammatory drug, and it is a non-steroidal anti-inflammatory drug. Can be used for external preparation for treating local soft tissue inflammation or injury, such as scapulohumeral periarthritis, tenosynovitis, lumbar muscle strain, etc., and pain caused by acute and chronic arthritis; methyl salicylate reduces prostaglandin synthesis by inhibiting the cyclooxygenase pathway, thereby exerting anti-inflammatory and analgesic effects; the external application has local stimulation effect, can promote local blood circulation, and can produce skin vasodilation, skin color redness, etc.
Artemisia annua extract: also called sweet wormwood extract, has broad-spectrum antibacterial property, has strong antibacterial effect on staphylococcus epidermidis, catarrhalis and the like, has certain inhibition effect on staphylococcus aureus, pseudomonas aeruginosa and the like, and can prevent and treat related skin diseases. Contains ketone 44.97%, wherein the ketone is mainly 21% of ascarone, 13% of l-camphor, 4% of acetic acid ascarol ester, 1% of pinene, camphene, eucalyptol, some hemiterpene alcohols and the like. Artemisia japonica extract has excellent antimalarial effect and various other biological activities including antiparasitic, antiviral, antifungal, antibacterial, anti-inflammatory, anticancer, anti-fat, anti-osteoporosis, anti-asthma, anti-ulcer, antinociception and immunomodulation.
Centella asiatica extract: centella asiatica extract contains various triterpenes, which contain alpha-amyrin structure. The main component is asiaticoside, madecassoside, and the appearance is brown yellow to white fine powder, and the taste is slightly bitter. Has excellent effects on treating damp-heat jaundice, heatstroke diarrhea, stranguria with sandy stranguria, carbuncle swelling sore and traumatic injury.
Sub citronella oil: volatile oil components obtained by processing and extracting whole grass of citronella belonging to Gramineae; sex taste: pungent and warm, nontoxic; efficacy: antifungal, such as streptoverticillium venezuelae; dispelling wind, relieving exterior syndrome, removing blood stasis, dredging collaterals, and treating common cold, headache, stomach ache and rheumatalgia; exterior syndrome relieving, fever reducing, repercussive, analgesic, rheumatalgia treating, common cold and fever relieving etc.; dispelling wind-dampness, dispelling cold, and treating arthralgia and myalgia, and general pain due to wind-cold-dampness; the stem and leaf of citronella contains volatile oil 0.4-0.8%, wherein the main component is citral, and the content is 75-85%. Also contains a small amount of citronellal, geranyl alcohol and methyl heptenone. The citronella oil has strong antibacterial activity, and the essential oil is not only placed in a culture medium to play a role in bacteriostasis, but also the steam of the essential oil has remarkable antibacterial effect.
Myrrh oil: is gum resin of myrrh tree or myrrh tree of Burseraceae, and myrrh oil is oily component obtained by rectifying and purifying gum resin; sex taste: bitter and flat, and no toxicity. Enter heart, liver and kidney meridians; efficacy: pathogenic fungi inhibition; reducing cholesterolemia; has effects of dispelling blood stasis, detumescence and relieving pain; has effects of dispelling blood, relieving swelling, relieving pain, and promoting granulation; myrrh has pharmacological effects of diminishing inflammation, resisting bacteria, relieving pain, protecting liver, resisting tumor, etc., and the main components of d-pinene, dipentene, limonene, eugenol, m-cresol, cinnamaldehyde, formic acid, palmitic acid, etc. Has good effect of preventing tissue degeneration, especially in the case of wound gangrene. The cooling function can help skin ulcers and sores, and can improve wound and chapped skin of soup.
Radix Arnebiae extract: has anti-dermatophyte virus effect, and is used as anti-inflammatory agent in cosmetics in combination with its anti-inflammatory property; has effect in promoting cathepsin activity, and can enhance metabolism of skin cells, and has antioxidant and antiaging effects. Comprises shikonin, acetylshikonin, shikonin, isobutyryl shikonin, etc. Shikonin has anticancer, antiinflammatory, and antibacterial effects. It can be used for treating acute and chronic hepatitis, and liver cirrhosis (ascites). The dermatophagoides can be used for treating flat wart and psoriasis, and can be topically applied for treating burn and promoting wound healing. The eye drop can be used for treating herpes simplex keratitis, and has certain curative effects on epithelial dendritic keratitis and superficial dendritic keratitis. The oil can be used for treating infantile dermatitis, eczema, colpitis, cervicitis, etc. Toothpaste containing shikonin can be used for preventing and treating dental caries and gingivitis. Can also be used as colorant for medicine, cosmetics and food.
The application method of the sweet wormwood herb paste aims at headache and common cold: applying appropriate amount of herba Artemisiae Annuae paste on the middle acupoint, double temple acupoint, YINTANG acupoint, double FENGpond acupoint, DAZHUI acupoint, and cervical vertebra, and slightly massaging and applying uniformly; aiming at refreshment, heatstroke, nasal obstruction, fatigue removal and fatigue reduction: the sweet wormwood herb paste is smeared at the positions of the middle acupoint, the double temples acupoint, the Yintang acupoint, the double wind pond acupoint, the Dazhui acupoint, the double nostrils, the nebula wind and the like of the human body, and is smeared evenly by gentle massage; aiming at mosquito bites: and (3) applying a proper amount of sweet wormwood herb paste on the mosquito bitten part or the skin injury part of the shallow part due to itching, and uniformly applying.
The sweet wormwood herb paste has a certain stimulation effect on eyes, so that the sweet wormwood herb paste is prevented from contacting the eyes when in use; for wounds formed by damage of skin shallow parts caused by mosquito bites, the deep wounds of the skin are not recommended to be used; the pregnant women and infants are forbidden; frequency of use: 2-3 times per day.
Compared with the prior art, the invention has the beneficial effects that:
(1) The sweet wormwood paste mainly adopts various natural antibacterial components such as the sweet wormwood extract, the lithospermum extract, the centella asiatica extract, the methyl salicylate and the like, and the sweet wormwood paste has better antibacterial and mite-inhibiting effects when being used cooperatively, wherein the sweet wormwood extract not only has antibacterial effects, but also has extremely strong mite-preventing effects when being used cooperatively with the lithospermum extract and the methyl salicylate, has excellent mite-inhibiting effects, has the mite-inhibiting rate of 99 percent, has no adverse reaction when being used by a human body, can be suitable for improving different symptoms caused by different symptoms, and has good curative effects.
(2) The sweet wormwood paste disclosed by the invention is smeared on a required part and then uniformly smeared, can penetrate deeply into the skin surface layer, can be quickly absorbed by active ingredients, can play a role in medicine effect by taking the channels and collaterals of acupuncture points as channels, has quick medicine effect, can improve symptoms such as headache, common cold and the like, can improve symptoms such as refreshment, heatstroke, nasal obstruction, fatigue removal and poverty relief, and has good effects of resisting bacteria, diminishing inflammation and relieving itching.
(3) The sweet wormwood herb paste has reasonable raw material collocation, is indispensable, and the prepared finished product has good drug effect, has an inhibition effect on pathogenic bacteria and mites, and can improve skin symptoms caused by the pathogenic bacteria and mites.
(4) The invention adopts the sub-citronella oil, the peppermint leaf oil and the essence, has reasonable flavor collocation, is refreshing and refreshing after being used, and has the functions of refreshing and restoring consciousness and no fear of mosquitoes.
Drawings
Fig. 1 is a diagram of a report of bacteriostasis detection of a artemisia annua extract according to an embodiment of the present invention;
fig. 2 is a mite-inhibiting detection report chart of the artemisia annua extract provided by the specific embodiment of the invention.
Detailed Description
The principles and features of the present invention are described below with reference to the drawings, the examples are illustrated for the purpose of illustrating the invention and are not to be construed as limiting the scope of the invention.
Example 1
The embodiment provides sweet wormwood herb paste which is prepared from a phase A, a phase B and a phase C, wherein the phase A, the phase B and the phase C respectively comprise the following raw materials in parts by weight:
phase A: 50 parts of petrolatum, 12.5 parts of beeswax, 17.7 parts of menthol, 4.7 parts of camphor and 3.5 parts of borneol;
and B phase: 0.00001 part of lithospermum extract, 0.00001 part of citronella oil and 0.00001 part of myrrh oil;
and C phase: 5 parts of ligusticum wallichii oil, 1.5 parts of mint leaf oil, 1.9 parts of methyl salicylate, 1 part of artemisia annua extract, 0.1 part of centella asiatica extract and 0.1 part of berberis thunbergii extract.
The preparation method of the sweet wormwood herb paste comprises the following steps:
(1) Adding all the raw materials in the phase A into a stirring pot, mixing and homogenizing, heating to 75-80 ℃, starting stirring, stirring at a rotating speed of 15-20rpm, uniformly stirring and dissolving, and stirring for 55-60min to obtain a phase A mixture;
(2) Adjusting the temperature of the phase A mixture to 55-60 ℃, then sequentially adding all the raw materials in the phase B into the phase A mixture, and stirring for 25-30min to obtain paste;
(3) Filtering the paste with 200 mesh filter cloth, adding phase C, and mixing to obtain herba Artemisiae Annuae paste; sequentially filling, cooling, removing redundant paste, sealing, detecting semi-finished products, packaging, boxing, checking and warehousing the sweet wormwood paste to obtain a sweet wormwood paste product.
Example 2
The embodiment provides sweet wormwood herb paste which is prepared from a phase A, a phase B and a phase C, wherein the phase A, the phase B and the phase C respectively comprise the following raw materials in parts by weight:
phase A: 43 parts by mass of petrolatum, 12.5 parts by mass of beeswax, 17.7 parts of menthol, 4.7 parts of camphor and 3.5 parts of borneol;
and B phase: 0.00001 part of lithospermum extract, 0.00001 part of citronella oil and 0.00001 part of myrrh oil;
and C phase: 5 parts of ligusticum wallichii oil, 3.2 parts of mint leaf oil, 2.3 parts of methyl salicylate, 1 part of artemisia annua extract, 0.2 part of centella asiatica extract and 0.2 part of berberis thunbergii extract.
The preparation method of the sweet wormwood herb paste of the embodiment is the same as that of the embodiment 1.
Example 3
The embodiment provides sweet wormwood herb paste which is prepared from a phase A, a phase B and a phase C, wherein the phase A, the phase B and the phase C respectively comprise the following raw materials in parts by weight:
phase A: 53 parts by mass of petrolatum, 11 parts by mass of beeswax, 17.7 parts of menthol, 4.7 parts of camphor and 3.5 parts of borneol;
and B phase: 0.00001 part of lithospermum extract, 0.00001 part of citronella oil and 0.00001 part of myrrh oil;
and C phase: 4.5 parts of ligusticum wallichii oil, 3.5 parts of peppermint leaf oil, 2.3 parts of methyl salicylate, 1 part of artemisia annua extract, 0.3 part of centella asiatica extract and 0.3 part of berberis thunbergii extract.
The preparation method of the sweet wormwood herb paste of the embodiment is the same as that of the embodiment 1.
Comparative example 1
This comparative example differs from example 1 in that: the Artemisia annua extract and the lithospermum extract are not added.
Comparative example 2
This comparative example differs from example 1 in that: radix Arnebiae extract is not added.
Comparative example 3
This comparative example differs from example 1 in that: no Artemisia annua extract is added.
Comparative example 4
This comparative example differs from example 1 in that: no methyl salicylate was added.
Comparative example 5
This comparative example differs from example 1 in that: no centella asiatica extract was added.
Comparative example 6
The comparative example provides a commercial grass paste (Jin Wofo brand) which is mainly prepared from the following raw materials: liquid paraffin, ethylhexyl palmitate, beeswax, microcrystalline wax, CI 61565, CI 12700, carbon black, essence, menthol, clove oil, borneol, camphor and extract of Berberis holly leaf.
Artemisia annua ointment efficacy test
The samples provided in example 1 and comparative examples 1 to 5 were subjected to antibacterial tests according to WS/T650-2019 "antibacterial and bacteriostatic Effect evaluation method", and the antibacterial effects of the samples on Staphylococcus aureus, pseudomonas aeruginosa and Candida albicans (Candida albicans) were tested;
the samples provided in example 1 and comparative examples 1-5 were subjected to mite-inhibiting tests according to the NY/T1151.2-2006 mite-killing detection standard;
the results of the bacteriostasis and mite-inhibiting rates of example 1 and comparative examples 1 to 5 are shown in Table 2.
TABLE 2
As can be seen from the results of the bacteriostasis rate and the mite inhibition rate of table 1, the sweet wormwood herb paste of the embodiment 1 has better bacteriostasis effect on pathogenic bacteria of staphylococcus aureus, pseudomonas aeruginosa and candida albicans, especially the bacteriostasis rate of the pathogenic bacteria is more than or equal to 90%, and the mite inhibition rate of the sweet wormwood herb paste of the embodiment 1 is 99%, compared with the green wormwood herb paste of the comparative example 5, the sweet wormwood herb paste has better bacteriostasis and mite removal effects; the antibacterial and mite-inhibiting results of comparative examples 1-5 show that the antibacterial and mite-inhibiting effects of the sweet wormwood extract, the centella asiatica extract, the lithospermum extract and the methyl salicylate can be improved, and the antibacterial and mite-inhibiting effects of the sweet wormwood extract are poor, and any one of the sweet wormwood extract, the lithospermum extract, the centella asiatica extract and the methyl salicylate can be independently used, so that the compound sweet wormwood extract, the lithospermum extract, the centella asiatica extract and the methyl salicylate have synergistic effects in antibacterial and mite-inhibiting effects, and have better curative effects of resisting bacteria, diminishing inflammation and relieving itching; based on the accompanying figures 1 and 2, the bacteriostasis detection report of the artemisia annua extract shows that: the artemisia annua extract has a strong antibacterial effect on malassezia furfur with the antibacterial rate of more than 99%; the mite-inhibiting detection report shows that: the artemisia annua extract has a good mite-inhibiting effect, and the inhibiting rate is up to 99%; like comparative example 2, comparative example 4 and comparative column 5, although the artemisia annua extract is added, the bacteriostasis and mite inhibition effects are poor, the lithospermum extract, the centella asiatica extract and the methyl salicylate are added, and the lithospermum extract, the centella asiatica extract and the methyl salicylate are compounded to realize the same bacteriostasis and mite inhibition effects by independently adopting the artemisia annua extract, so that the using amount of the artemisia annua is greatly reduced, and meanwhile, the prepared artemisia annua ointment has better bacteriostasis and mite inhibition effects.
The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and scope of the invention are intended to be included within the scope of the invention.
Claims (9)
1. The sweet wormwood herb paste is characterized by being prepared from an A phase, a B phase and a C phase, wherein the A phase, the B phase and the C phase comprise the following raw materials:
phase A: matrix, menthol, camphor and borneol;
and B phase: radix Arnebiae extract, columba grass oil and myrrha oil;
and C phase: ligusticum wallichii oil, peppermint leaf oil, methyl salicylate, artemisia annua extract, centella asiatica extract and berberis thunbergii extract.
2. The sweet wormwood paste according to claim 1, wherein the sweet wormwood paste is prepared from the following raw materials in parts by mass:
phase A: 55-65 parts of matrix, 15-20 parts of menthol, 3-7 parts of camphor and 1.5-5.5 parts of borneol;
the phase B is as follows: 0.000001 to 0.00002 part of lithospermum extract, 0.000001 to 0.00002 part of citronella oil and 0.000001 to 0.00002 part of myrrh oil;
and C phase: 3 to 7 parts of ligusticum wallichii oil, 1.5 to 5.5 parts of mint leaf oil, 1 to 3 parts of methyl salicylate, 0.5 to 1.5 parts of artemisia annua extract, 0.05 to 0.5 part of centella asiatica extract and 0.05 to 0.5 part of berberis thunbergii extract.
3. The sweet wormwood paste according to claim 1, wherein the sweet wormwood paste is prepared from the following raw materials in parts by mass:
phase A: 62.5 parts of matrix, 17.7 parts of menthol, 4.7 parts of camphor and 3.5 parts of borneol;
and B phase: 0.00001 part of lithospermum extract, 0.00001 part of citronella oil and 0.00001 part of myrrh oil;
and C phase: 5 parts of ligusticum wallichii oil, 1.5 parts of mint leaf oil, 1.9 parts of methyl salicylate, 1 part of artemisia annua extract, 0.1 part of centella asiatica extract and 0.1 part of berberis thunbergii extract.
4. A sweet wormwood paste according to any one of claims 1-3, wherein the matrix comprises petrolatum and beeswax, the mass ratio of petrolatum to beeswax being (2.5-6): 1.
5. the sweet wormwood paste according to any one of claims 1-3, wherein the content of active substances in centella asiatica extract is not less than 90%.
6. An artemisia apiacea paste according to any one of claims 1-3, wherein the content of active substances in the extract of berberis thunbergii is not less than 90%.
7. A method for preparing the sweet wormwood herb paste according to any one of claims 1-4, which comprises the following steps:
(1) Mixing all the raw materials in phase A, homogenizing, heating to 75-80deg.C, and stirring for 55-60min to obtain phase A mixture;
(2) Adjusting the temperature of the phase A mixture to 55-60 ℃, then adding all the raw materials in the phase B into the phase A mixture, and stirring for 25-30min to obtain paste;
(3) Filtering the paste with filter cloth, adding phase C, and mixing to obtain herba Artemisiae Annuae paste.
8. The method according to claim 5, wherein the filter cloth is a 200 mesh filter cloth.
9. Use of the sweet wormwood herb paste of any one of claims 1-4 in the preparation of a medicament for refreshing, removing mites or repelling mosquitoes.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849556A (en) * | 2010-05-28 | 2010-10-06 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849556A (en) * | 2010-05-28 | 2010-10-06 | 杨凌农科大无公害农药研究服务中心 | Plant source synergistic complex acaricide and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 叶兴法: "风痛灵微生物限度检查方法的验证", 西北药学杂志, vol. 24, no. 02, pages 140 - 141 * |
| 护肤界卷王: "抗衰，不甘示弱的植物成分"积雪草", pages 2 - 3, Retrieved from the Internet <URL:https://baijiahao.***.com/s?id=1757251331011761741&wfr=spider&for=pc> * |
| 美姐: "真.上头！头疼找它，1招提神醒脑 ! 真是爽的不要不要的~~", pages 18 - 19, Retrieved from the Internet <URL:https://roll.sohu.com/a/585795319_240886> * |
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