WO2017206016A1 - Pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème - Google Patents

Pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème Download PDF

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Publication number
WO2017206016A1
WO2017206016A1 PCT/CN2016/083896 CN2016083896W WO2017206016A1 WO 2017206016 A1 WO2017206016 A1 WO 2017206016A1 CN 2016083896 W CN2016083896 W CN 2016083896W WO 2017206016 A1 WO2017206016 A1 WO 2017206016A1
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WO
WIPO (PCT)
Prior art keywords
traditional chinese
parts
chinese medicine
swelling
inflammatory
Prior art date
Application number
PCT/CN2016/083896
Other languages
English (en)
Chinese (zh)
Inventor
吴克
Original Assignee
江苏奇力康皮肤药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏奇力康皮肤药业有限公司 filed Critical 江苏奇力康皮肤药业有限公司
Priority to CN201680000512.5A priority Critical patent/CN108495645B/zh
Priority to PCT/CN2016/083896 priority patent/WO2017206016A1/fr
Publication of WO2017206016A1 publication Critical patent/WO2017206016A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • the invention relates to a traditional Chinese medicine ointment. More specifically, the present invention relates to a traditional Chinese medicine ointment having an external application of anti-inflammatory and swelling.
  • the external Chinese medicine ointment is an external semi-solid dosage form which is easily mixed on the skin surface and is prepared by mixing the medicinal material extract with a suitable medium, and has the advantages of good adhesion, spreadability, convenient use and the like.
  • TCM external application ointment uses the synergistic effect of drugs to form a large compound of multi-flavor drugs, in order to exert the good effect of the drug, the traditional Chinese medicine ointment is applied to the surface of the plaster to stimulate the nerve endings, through the reflection, dilation of blood vessels, and promotion of local blood Circulation, improve the nutrition of the surrounding tissues, so as to achieve the purpose of swelling, anti-inflammatory and analgesic.
  • the drug penetrates the subcutaneous tissue through the skin in the affected area, and the relative advantage of the drug concentration is locally generated, thereby exerting a strong pharmacological effect.
  • the traditional external application of anti-inflammatory and swelling Chinese medicine ointment has the following disadvantages: (1) Only the efficacy of traditional Chinese medicine is considered when formulating the ointment, but its toxicity and irritation are neglected, which may aggravate the discomfort of the patient; (2) the traditional external application of ointment The transdermal absorption effect is poor, and the ideal therapeutic effect is not achieved; (3) The traditional Chinese medicine ointment mostly uses sesame oil to extract the traditional Chinese medicine component, and it is easy to extract the active ingredient or the active ingredient in the medicinal material due to the excessive temperature.
  • the inventors of the present invention have found that by properly combining nine kinds of Chinese herbal medicines, they are non-irritating to the skin, and are processed according to the characteristics of each Chinese herbal medicine and the extraction of active ingredients.
  • a transdermal enhancer composed of a suitable ratio of menthol, borneol, PEG, and octanol is also added to the traditional Chinese medicine ointment of the present invention, which significantly increases the therapeutic effect of the traditional Chinese medicine external application ointment. Based on this finding, the present invention has been completed.
  • Still another object of the present invention is to provide an external application of an anti-inflammatory and swelling traditional Chinese medicine ointment, which can quickly reduce inflammation and reduce swelling, has remarkable curative effect, is convenient to use, and is non-irritating to the skin.
  • an externally applied anti-inflammatory and anti-inflammatory Chinese medicine ointment comprising, by weight, consisting of the following grouping ratios:
  • sea buckthorn core, cork, raw land, chamomile flower, forsythia, uncaria, pumpkin seed, Chuanxiong and VB 5 can produce strong and long-lasting heat-clearing, anti-inflammatory and swelling-reducing effects.
  • Seabuckthorn oil in seabuckthorn fruit nucleus can resist anti-inflammatory muscles and promote tissue regeneration.
  • Phellodendron has strong inhibitory effect on various pathogenic bacteria, and has astringent and anti-inflammatory effects.
  • the habitat can be used for stagnation of blood circulation and blood circulation.
  • Huayu Chrysanthemum has excellent anti-inflammatory and anti-inflammatory effects, relieves pain and swelling, promotes wound healing, and promotes cell regeneration and skin metabolism.
  • Forsythia treats heat-clearing and detoxifying, swelling and dispersing; Uncaria can be used for Shujinhuo It can reduce swelling and analgesia; pumpkin seeds have anti-inflammatory and analgesic effects; Chuanxiong can be used for activating blood circulation and phlegm and relieving pain; proper addition of VB 5 can be used to soothe the skin and promote the recovery of skin health.
  • the transdermal enhancer comprises 30-40% by weight of menthol, 30-40% by weight of borneol, 15-20% by weight of PEG and 10-15% by weight of octanol.
  • menthol can change the permeability of the stratum corneum, reduce the resistance of the drug to penetration through the skin, and improve the diffusion system of the drug in the stratum corneum of the skin.
  • the borneol can synergize with menthol to effectively increase the absorption of the drug by the skin; PEG and octanol can fuse and mix traditional Chinese medicine with menthol and borneol, which not only increases the solubility of the drug, but also significantly improves the long-term effect of the penetration-promoting effect.
  • the molecular weight of the PEG is 400-600. Under this molecular weight, the PEG has good compatibility with drugs and other excipients, and has an optimal promoting effect on the transdermal efficiency of the drug.
  • the sea buckthorn core, the yellow cedar, the raw land, the hook vine, the chuanxiong, respectively, are pulverized, mixed, and then extracted with 85% ethanol as a solvent at 80 ° C for 3 times to promote the dissolution of the active ingredient of the traditional Chinese medicine. .
  • the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized, mixed, and then extracted with 70% ethanol as a solvent at 55 to 60 ° C for 2 times, chamomile flowers, forsythia and pumpkin.
  • the ethanol reflux extraction temperature of the child should not be too high, otherwise it will increase the dissolution of the ineffective components and reduce the efficacy.
  • the sea buckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to 20 to 25 ⁇ m, thereby ensuring the leaching of the active ingredient of the traditional Chinese medicine and preventing the fine particle size of the traditional Chinese medicine from affecting the filtration.
  • the 85% ethanol is 5-8 times of the mixed volume of Hippophae rhamnoides, Cork, S. chinensis, Uncaria and Chuanxiong, and the time of each extraction is 1-2 h, suitable ratio of material to liquid and extraction time Ensure the mass transfer driving force and increase the extraction rate of effective substances.
  • the chamomile flower, forsythia, and pumpkin seed are respectively pulverized to 28 to 32 ⁇ m, so that the active ingredient of the traditional Chinese medicine can be sufficiently dissolved to ensure a balance between the dissolution rate of the active ingredient and the pulverization energy.
  • the 70% ethanol is 4-5 times of the chamomile flower, forsythia and pumpkin seeds, and the time of each extraction is 0.3-0.7 h to ensure the active ingredient of the traditional Chinese medicine.
  • transdermal enhancer consisting of a suitable ratio of menthol, borneol, PEG and octanol in the present invention effectively changes the permeability of the stratum corneum of the skin, reduces the resistance of the drug to penetration through the skin, and improves the drug in The diffusion system of the stratum corneum of the skin, and the prolongation effect is long-lasting;
  • the present invention replaces the traditional sesame oil extraction method, and adopts different alcohol reflux processes for extraction according to different properties of the Chinese herbal medicine, thereby ensuring sufficient extraction of the active ingredients and avoiding excessive impurities of the traditional Chinese medicine paste caused by excessive extraction temperature. Poor efficacy.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 15 parts of sea buckthorn core; 10 parts of Phellodendron; 8 parts of habitat; 8 parts of chamomile flower; 5 parts of forsythia; Parts; 5 parts of pumpkin seeds; 3 parts of Chuanxiong; 3 parts of VB 5 ; 3 parts of transdermal enhancer.
  • the transdermal enhancer comprises 30% by weight of menthol, 40% by weight of borneol, 20% by weight of PEG400 and 10% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 20 ⁇ m, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the mixture is refluxed at 80 ° C for 3 times.
  • the first time, each extraction is 1h; the chamomile flowers, forsythia, and pumpkin seeds are respectively pulverized to 28 ⁇ m, mixed, and then sequentially mixed with 4 times of chrysanthemum, forsythia and pumpkin seeds.
  • 70% ethanol was used as a solvent, and the extraction was carried out twice at 55 ° C, and the extraction time was 0.3 h.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 20 parts of sea buckthorn core; 15 parts of Phellodendron; 12 parts of habitat; 12 parts of chamomile flower; 15 parts of forsythia; Parts; 10 parts of pumpkin seeds; 7 parts of Chuanxiong; 5 parts of VB 5 ; 5 parts of transdermal enhancer.
  • the transdermal enhancer comprises 40% by weight of menthol, 35% by weight of borneol, 15% by weight of PEG600 and 10% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 25 ⁇ m, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times. Times, each extraction time is 2h.
  • the chamomile flower, forsythia, and pumpkin seeds are respectively pulverized to 32 ⁇ m, mixed, and then sequentially mixed with 70% ethanol of 5 times chamomile, forsythia and pumpkin seed volume, and refluxed at 60 ° C. 2 times, the time of each extraction is 0.7h.
  • the transdermal enhancer comprises 35 wt% menthol, 35 wt% borneol, 15 wt% PEG 500, and 15 wt% octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 23 ⁇ m, mixed, and then 8 times of ethanol of the Chinese medicine mixture is used as a solvent, and the co-extraction is carried out at 80 ° C under reflux.
  • the extraction time is 2h, 1.5h and 1h respectively; the chamomile flower, forsythia,
  • the pumpkin seeds were pulverized to 30 ⁇ m, mixed, and then, with 4.5 times the volume of chamomile, forsythia and pumpkin seeds, 70% ethanol as solvent, and refluxed at 58 ° C for 2 times, the extraction time was 0.5 h and 0.7h.
  • the transdermal enhancer comprises 32% by weight of menthol, 38% by weight of borneol, 18% by weight of PEG400 and 12% by weight of octanol.
  • the seabuckthorn core, the yellow cedar, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter of 22 ⁇ m, mixed, and then 8 times of ethanol of 8 times of the Chinese medicine mixture is used as a solvent, and refluxed at 80 ° C for 3 times.
  • the extraction time was 1.5h, 1.5h and 1h respectively; the chamomile flowers, forsythia and pumpkin seeds were pulverized to 29 ⁇ m, mixed, and then 4 times chamomile, forsythia and pumpkin mixture
  • the volume of 70% ethanol was used as a solvent, and the extraction was carried out twice at 58 ° C, and the extraction time was 0.7 h and 0.4 h, respectively.
  • An external application of anti-inflammatory and swelling traditional Chinese medicine ointment which comprises, by weight, by the following group distribution ratio: 17 parts of sea buckthorn kernel; 13 parts of cork; 9 parts of habitat; 11 parts of chamomile flower; 10 parts of forsythia; Servings; 8 parts of pumpkin seeds; 6 parts of Chuanxiong; 5 parts of VB 5 ; 4 parts of transdermal enhancer.
  • the transdermal enhancer comprises 36% by weight of menthol, 33% by weight of borneol, 17% by weight of PEG500 and 14% by weight of octanol.
  • the seabuckthorn core, the yellow cypress, the raw land, the genus Uncaria, and the Chuanxiong are respectively pulverized to an average particle diameter After 24 ⁇ m, the mixture was mixed with 85% ethanol of 7 times Chinese herbal medicine as solvent, and refluxed at 80 ° C for 3 times.
  • the extraction time was 1.5 h, 1 h and 2 h, respectively; the chamomile flower, forsythia, and pumpkin seeds were respectively After pulverizing to 31 ⁇ m, the mixture was mixed, and then 70 times of the volume of the mixture of chamomile flowers, forsythia and pumpkin seeds was used as a solvent, and the mixture was re-extracted twice at 59 ° C for 0.6 h and 0.5 h, respectively.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème, constituée des composants suivants, en parties en poids : 15 à 20 parties de graines du fruit d'Hippophae rhamnoides, 10 à 15 parties de l'écorce de Phellodendron amurense ou de Phellodendron chinense, 8 à 12 parties de tubercule de Rehmannia glutinosa, 8 à 12 parties de Cota tinctoria, 5 à 15 parties de fruit de Forsythia suspensa,5 à 15 parties de rameaux à épines d'Uncaria rhynchophylla, 5 à 10 parties de graines de Cucurbita, 3 à 7 parties de Ligusticum striatum, 3 à 5 parties d'acide pantothénique (vitamine B5), et 3 à 5 parties d'un agent favorisant le passage transdermique. L'agent favorisant le passage transdermique comprend entre 30 et 40 % en poids de menthol, entre 30 et 40 % en poids d'un mélange de bornéol optiquement neutre et d'isobornéol (Bingpian de synthèse, ou "Borneolum syntheticum"), entre 15 et 20 % en poids de PEG, et entre 10 et 15 % en poids d'un octanol.
PCT/CN2016/083896 2016-05-30 2016-05-30 Pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème WO2017206016A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201680000512.5A CN108495645B (zh) 2016-05-30 2016-05-30 外敷消炎消肿中药膏剂
PCT/CN2016/083896 WO2017206016A1 (fr) 2016-05-30 2016-05-30 Pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/083896 WO2017206016A1 (fr) 2016-05-30 2016-05-30 Pommade traditionnelle chinoise pour application externe contre l'inflammation et pour soulager l'œdème

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WO2017206016A1 true WO2017206016A1 (fr) 2017-12-07

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3735258A4 (fr) * 2018-01-02 2021-10-13 Skinkick, Llc Compositions topiques de soins de la peau
CN113893315A (zh) * 2021-11-25 2022-01-07 顾帆 一种蚊虫叮咬消炎消肿止痒膏及其制备方法

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CN1090504A (zh) * 1993-10-13 1994-08-10 李昆文 外用药消痼净
CN1698745A (zh) * 2005-05-24 2005-11-23 朱瑜琪 一种外用消炎制剂的中药组合物
CN104056018A (zh) * 2014-06-25 2014-09-24 姬光勤 通络消炎止痛膏
CN104225410A (zh) * 2014-08-20 2014-12-24 王冀 一种治疗日光性皮炎的药膏
CN105211367A (zh) * 2015-09-29 2016-01-06 安徽省天旭茶业有限公司 一种消炎抗菌活血枇杷花琥珀茶及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090504A (zh) * 1993-10-13 1994-08-10 李昆文 外用药消痼净
CN1698745A (zh) * 2005-05-24 2005-11-23 朱瑜琪 一种外用消炎制剂的中药组合物
CN104056018A (zh) * 2014-06-25 2014-09-24 姬光勤 通络消炎止痛膏
CN104225410A (zh) * 2014-08-20 2014-12-24 王冀 一种治疗日光性皮炎的药膏
CN105211367A (zh) * 2015-09-29 2016-01-06 安徽省天旭茶业有限公司 一种消炎抗菌活血枇杷花琥珀茶及其制备方法

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BAI, ZAIXIAN ET AL.: "The Medicine and Health Effect of Shaji", LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH, vol. 10, no. 02, 10 February 1999 (1999-02-10), pages 147 - 148 *
LIU, YUNXI ET AL.: "Two Kinds of European Conventional Chamomiles", WORLD PHYTOMEDICINES, vol. 11, no. 03, 31 December 1996 (1996-12-31), pages 116 - 118 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3735258A4 (fr) * 2018-01-02 2021-10-13 Skinkick, Llc Compositions topiques de soins de la peau
CN113893315A (zh) * 2021-11-25 2022-01-07 顾帆 一种蚊虫叮咬消炎消肿止痒膏及其制备方法

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CN108495645B (zh) 2021-04-20

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