WO2017134144A1 - Procédé de formation d'une cartouche de médicament et cartouche de médicament formée par le procédé - Google Patents

Procédé de formation d'une cartouche de médicament et cartouche de médicament formée par le procédé Download PDF

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Publication number
WO2017134144A1
WO2017134144A1 PCT/EP2017/052218 EP2017052218W WO2017134144A1 WO 2017134144 A1 WO2017134144 A1 WO 2017134144A1 EP 2017052218 W EP2017052218 W EP 2017052218W WO 2017134144 A1 WO2017134144 A1 WO 2017134144A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston
cartridge
medicament cartridge
proximal
medicament
Prior art date
Application number
PCT/EP2017/052218
Other languages
English (en)
Inventor
Henrik Bengtsson
Dan NØRTOFT SØRENSEN
Lasse FREDERIKSEN
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2017134144A1 publication Critical patent/WO2017134144A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the present invention relates to an assembly of components for a drug delivery device that allows a user to select a single or multiple doses of an injectable liquid drug and to dispense the selected dose of the product and to apply said product to a patient, preferably by injection.
  • the present invention relates to a method of forming a piston assembly for use in such drug delivery devices.
  • Drug delivery devices allowing for multiple dosing of a required dosage of a liquid medicinal product, such as liquid drugs, and further providing administration of the liquid to a patient, are as such well-known in the art. Generally, such devices have substantially the same purpose as that of an ordinary syringe.
  • Drug delivery devices of this kind have to meet a number of user specific requirements. For instance in case of those with diabetes, many users will be physically infirm and may also have impaired vision. Therefore, these devices need to be robust in construction, yet easy to use, both in terms of the manipulation of the parts and understanding by a user of its operation. Further, the dose setting must be easy and unambiguous and where the device is to be disposable rather than reusable, the device should be inexpensive to manufacture and easy to dispose. In order to meet these requirements, the number of parts and steps required to assemble the device and an overall number of material types the device is made from have to be kept to a minimum .
  • the liquid drug to be administered is provided in a medicament cartridge that has a moveable piston or bung mechanically interacting with a piston rod driven by an expelling mechanism of the drug delivery device.
  • a piston bearing is typically located between the piston rod and the piston.
  • an end-user has to conduct a so-called priming of the expelling mechanism in order to ensure that already with an initial dose setting and a first subsequent dose dispensing step, an accurate amount of the liquid drug is dispensed in a predefined way.
  • An initial dose setting and expelling of a minor dose may in certain situations also be required for removing any air present in the medicament cartridge and/or a connected needle and for performing a flow check.
  • WO 2014/060369 Al refers to the particular problem of uncontrolled movement of the piston of a held cartridge between dose administrations and proposes to establish a connection between a piston rod foot and the piston of a held cartridge for example by use of a spike that inserts into the piston or by using glue. This is to mitigate the potential issue of an air gap being formed between a piston rod and a piston of a held cartridge which may be caused by accidental dislodgment between the piston and the piston rod.
  • the present invention relates to a method of forming a piston assembly for a medicament cartridge for cooperation with a medical injection device wherein the medicament cartridge comprises a tubular cartridge barrel extending along an axis, the piston assembly configured for being received in the tubular barrel of the medicament cartridge and for being slideably displaceable towards a distal end thereof to expel medicament through an outlet.
  • the method comprises the steps of:
  • step c) of applying a surface treatment heat is applied to melt said surface area.
  • the present invention relates to a method of forming a medicament cartridge for a medical injection device wherein the medicament cartridge comprises a tubular cartridge barrel extending along an axis and a piston assembly at least partly received in the cartridge barrel, the piston assembly being slideably displaceable towards a distal end of the cartridge barrel to expel medicament through an outlet.
  • the method comprising the steps of: a) providing the cartridge barrel,
  • a piston at least partly made of an elastomeric material, the piston comprising a distal end configured for fluid contact with medicament in the cartridge, a proximal end having a proximal contact surface, and a sealing periphery disposed between the distal and proximal end,
  • step e) of applying a surface heat treatment of the proximal contact surface of the piston is performed subsequent to step c) of positioning the piston in the cartridge barrel, whereby full flexibility of the manufacturing process is enabled .
  • Large-scale manufacturing may involve manufacturing of a standardized cartridge to be used in many different types of applications, e.g . wherein the same type of cartridge may be used both in configurations wherein the piston bearing is bonded to the piston of the cartridge as well as in configurations wherein a piston bearing is not bonded to the piston. Hence, a cost effective manufacturing of medicament cartridges may be obtained.
  • the medicament cartridge forms a pre-filled cartridge accommodating a medicament.
  • the step of filling the medicament cartridge is performed prior to the step of applying a surface heat treatment.
  • the softened material By positioning the distal surface of the piston bearing in abutting contact with the proximal surface of the piston, the softened material will create a bond between the distal surface of the piston and the distal surface of the piston bearing when allowed to harden.
  • a portion of the piston forming the proximal end of the piston, or alternatively the entire piston, may in some embodiments be made from an elastomeric composition such as bromobutyl or chlorobutyl rubber.
  • Suitable materials for the piston bearing may include thermoplastic polymers such as polypropylene.
  • the proximal contact surface of the piston may define a substantially planar surface.
  • the distal contact surface of the piston bearing may form a substantially planar surface.
  • said surface heat treatment is performed exclusively on the piston causing a melting of a surface area of the proximal contact surface of the piston.
  • the piston has been subjected to a vulcanization process prior to the step of applying a surface heat treatment of the proximal contact surface of the piston.
  • the proximal surface of the piston bearing is configured for attachment to a piston rod so that when the piston bearing is attached to the piston rod, the piston bearing is prevented from moving in the distal direction relative to the piston rod .
  • Said attachment may further be formed so that the piston bearing is prevented from moving in the proximal direction relative to the piston rod.
  • the proximal surface of the piston bearing is formed so as to cooperate and attach relative to the piston rod so that the piston rod and the piston bearing are axially fixed relative to each other while allowing the piston rod to rotate freely relative to the piston bearing.
  • the piston bearing is an integral part of a piston rod of an injection device, such as forming part of a unitary piston rod .
  • the proximal end of the piston may define a rim portion engaging or adapted to engage the tubular barrel of the medicament cartridge.
  • said surface heat treatment may involve melting a surface area of the proximal surface of the piston at locations radially spaced apart from said rim portion, such as 1-2 mm from the outermost portions of the piston.
  • the piston prior to step e), the piston is arranged fully inside the tubular barrel of the medicament cartridge, and in step e) the surface heat treatment is performed while the piston is disposed inside the tubular cartridge barrel . This enables the attachment process to be performed on a prefilled medicament cartridge during assembly operations of an injection device introducing flexibility in the production process.
  • the method comprises a step, prior to step e), of arranging the piston in an axial position inside the tubular barrel where the proximal contact surface of the piston is located distally to a proximal end face of the tubular barrel, such as wherein the proximal contact surface of the piston is located more than 2 mm from the proximal face of the tubular cartridge barrel .
  • the attachment between the piston and the piston bearing is carried out before the piston is introduced into the tubular barrel of the medicament cartridge.
  • heat may be applied by local energy deposition to melt said surface area.
  • heat is applied by non-contact energy deposition.
  • heat is applied by establishing surface contact between a heated heating member and said surface area.
  • Energy deposition may be performed by radiating said surface area or illuminating said surface area by means of an illumination source, such as by a laser.
  • heat is applied by depositing ultrasonic energy at said surface area.
  • step f) may be performed prior to step e) of applying a surface heat treatment.
  • the step of depositing ultrasonic energy by generating ultrasonic energy at said surface area may involve coupling an ultrasonic emitter to a proximal surface portion of the piston bearing.
  • At least one of the piston and the piston bearing comprises a material or compound that is inductively heatable and wherein heat is applied by inductively heating said surface area .
  • Such method may involve performing step f) prior to step e). In other embodiments step e) is performed prior to step f).
  • step f) axial pressure is applied between the piston and the piston bearing. Said axial pressure may be applied while the deposited energy dissipates ensuring an effective bond between the piston and the piston bearing . In certain embodiments, axial pressure is maintained for a pre-defined period subsequent to finalization of step e) of surface heat treatment, such predefined period being selected between 0.2 and 4 seconds, such as between 0.4 and 1 second, such as between 0.5 and 2 seconds.
  • the present invention relates to a piston assembly formed in by the method according to the first aspect described above.
  • the present invention relates to a medicament cartridge comprising a piston assembly, where the medicament cartridge is formed in accordance with one of the methods according to the second aspect described above.
  • the medicament cartridge may comprise a tubular barrel made from glass. Said glass barrel may comprise siliconized wall areas at the inner surface of the cartridge barrel .
  • the medicament cartridge may be prefilled with a medicament.
  • a distal end of the tubular barrel connects to an outlet which may be provided with a seal in the form of a pierceable septum configured for being pierced and penetrated by an injection needle.
  • the present invention relates to an injection device for receiving a medicament cartridge in accordance with the fourth aspect.
  • the injection device may be configured for expelling a multitude of individual doses performed as separate dose administrations, wherein the individual doses may be provided by a fixed dose amount or a variable dose amount. In other forms the injection device may be configured for expelling only a single dose from a held medicament cartridge.
  • the injection device may be configured for attachment to an injection needle that couples to the medicament cartridge of the device.
  • the injection device may be provided as a disposable device wherein a pre-filled medicament cartridge is irremovably received in the injection device, or alternatively, as a durable device intended for replacement of an empty medicament cartridge.
  • the injection device comprises an expelling mechanism that couples to a piston rod wherein the piston rod is adapted to rotate as it is forced distally during dose expelling.
  • the attachment between the piston bearing and the piston rod allows free rotation of the piston rod, as the piston rod rotates during dose expelling.
  • insulin is meant to encompass any drug-containing flowable medicine capable of being passed through a delivery means such as a cannula or hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension, and which has a blood glucose controlling effect, e.g. human insulin and analogues thereof as well as non-insulins such as GLP-1 and analogues thereof.
  • a delivery means such as a cannula or hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension, and which has a blood glucose controlling effect, e.g. human insulin and analogues thereof as well as non-insulins such as GLP-1 and analogues thereof.
  • a delivery means such as a cannula or hollow needle in a controlled manner, such as a liquid, solution, gel or fine suspension, and which has a blood glucose controlling effect
  • human insulin and analogues thereof as well as non-insulins such as GLP-1 and analogues thereof.
  • fig . 1 is a schematic representation of a prior art pen device with a protective cap attached and with a needle attached to the cartridge,
  • fig . 2 shows a detailed view the piston drive components of a prior art pen device of fig. 1,
  • fig . 3 is a cross sectional view of a piston assembly according to the invention with a cartridge body and a piston rod,
  • fig . 4 schematically depicts a first embodiment of a heating process according to the invention wherein a laser source irradiates a proximal surface portion of the piston
  • fig . 5 schematically depicts a second embodiment of a heating process according to the invention wherein a hot rod applies heat to a proximal surface portion of the piston
  • fig . 6 schematically depicts a third embodiment of a heating process according to the invention wherein an ultrasonic horn deposits heat between a piston and a piston bearing .
  • Fig. 1 is a schematical representation of a prior art drug delivery device in the form of a pen-formed injection device 100, i.e. a so-called "injection pen".
  • the injection pen 100 includes a dose setting and expelling mechanism for repetitively performing individual dosage administrations, such as expelling apportioned dosages of insulin.
  • Injection pen 100 comprises a medicament filled cartridge 101 which is accommodated in a distal part of the injection pen.
  • the injection pen 100 includes a housing that defines a central longitudinal axis.
  • the proximal part 104 of the device holds a mechanism 110 for setting and injecting specific doses of a medicament from the cartridge 101.
  • the mechanism includes an elongated piston rod 108 extending along the central longitudinal axis.
  • the cartridge 101 comprises a passage in a distal neck part forming an outlet which is sealed by a septum, i.e. a pierceable sealing member 105.
  • Cartridge 101 further comprises an axially slideably mounted piston 106 which is adapted to slide towards the distal part of the container 101 when a distally directed force is exerted on the piston 106.
  • medication is delivered through an injection needle 103 which may be releasably secured to the distal part of the injection pen.
  • the injection pen further comprises a dose dial 111 which may be manipulated by the hand of a user for selecting a dosage, the size of the selected dosage being visible in window 113.
  • the injection pen 100 further comprises an injection button 112 for injecting a selected dosage.
  • a distally directed force on the button 112 exerted by the hand of the user, activates the mechanism 110 of the pen for causing a dosing movement of the piston rod 108 and with it the piston 106 of cartridge 101.
  • Fig . 1 further shows a cap 115 which is adapted to be removably attached to the distal part of the injection pen. In the storage state, when the cap 115 is attached to the injection pen 100, the cap protects the cartridge 101 and the needle 103.
  • Fig. 2 further shows a detailed view of typical piston drive parts of an injection pen.
  • the piston rod 108 of the device transfers a drive force of the piston rod to the piston 106 by means of a piston bearing 107 hence distributing the driving load onto the proximal surface of the piston 106.
  • the injection pens shown in figs. 1 and 2 serve as example injection devices which may be utilized in connection with the different aspects of the present invention.
  • the piston bearing 107 is axially attached to the distal portion of the piston rod 108 whereas in other injection pens the piston bearing is loosely withheld or sandwiched between the distal portion of the piston rod and the piston.
  • Some prior art pens utilize a piston rod that rotates as it moved distally for expelling a dose. In such pens engagement surfaces between the piston rod and the piston bearing are typically formed to include a bearing surface allowing free rotation of the piston rod relative to the piston bearing. In other pens the piston rod does not rotate as it moves distally during expelling of a dose. In such pens, the piston bearing need not rotate relative to the piston rod .
  • a piston assembly according to a first embodiment is shown in fig. 3.
  • the piston assembly includes a piston 6 of a cartridge 1 and a piston bearing 7 where the piston 6 and the piston bearing 7 are attached to each other preventing the piston 6 from moving axially in the distal direction relative to the piston bearing 7.
  • by such attachment it is ensured that the piston bearing 7 will not tend to tilt should the piston 6 be arranged with a distance relative to the piston rod of an injection device or become dislodged relative to the piston rod .
  • the piston 6 is formed as a generally cylindrical member made from an elastomeric rubber composition such as bromobutyl or chlorobutyl rubbers.
  • the piston 6 is formed as a unitary molded component exhibiting a substantially flat proximal surface wherein only slight protrusions are formed . These protrusions are typically formed to prevent adherence between pistons when a multitude of pistons during manufacture are handled in bulk.
  • the piston 6 includes a distal face adapted to be in fluid contact with medicament of the cartridge 1. Between the distal face and the proximal surface of the piston 6 a number of sealing lips protrude from a radially outwards facing surface of the piston.
  • the piston bearing 7 is formed as a thin circular disc made from a thermoplastic polymer such as polypropylene.
  • the piston bearing 7 exhibits a near planar surface at the distal end and includes an attachment geometry 7c at the proximal end for attaching the piston bearing 7 to a corresponding attachment geometry 8c of piston rod 8.
  • the attachment geometry 7c forms a spherical socket which is configured to receive a complementary ball formed member of the piston rod 8.
  • the engagement prevents the piston bearing 7 from accidentally disengaging the piston rod 8 and is sufficient to withstand forces tending to move the piston 6 relative to the piston rod 8.
  • the connection 7c/8c forms an axial snap connection.
  • other attachment geometries 7c and 8c forming the same function of preventing distal movement of the piston bearing relative to the piston rod may be used instead.
  • Non-limiting examples may for be provided as an axial ratchet connection or a connection using magnets. In fig.
  • the piston 6 has been attached to the piston bearing 7 by a process using a surface heat treatment of the proximal surface of the piston 6 so as to melt an area of the piston which is later to become mated with the distal surface of the piston bearing 7. Subsequent to melting, when the material is soft and sticky, the piston bearing 7 is moved into abutting contact with the piston and pressure is exerted while the softened part of the piston becomes hardened . The result is a strong bond between the piston 6 and the piston bearing 7.
  • Fig. 4 schematically shows a first embodiment process for melting an area of the piston 6.
  • a light source 50 emits a radiation beam 51 which impinges a portion of the proximal surface of the piston 6.
  • Light energy is chosen having a wavelength that is absorbed by the surface of interest. Focused visible or invisible light or a laser beam is pointed towards the proximal surface of the piston 6 so that the surface is quickly elevated to above its transformation temperature whereby it becomes sticky.
  • Exemplary radiation times with a 30w laser may be provided in the order of 0.5 to 2 seconds to ensure sufficient melting of the surface of the piston while avoiding excessive heating of deeper located regions of the piston which could otherwise influence the sealing properties of the piston.
  • Fig. 5 schematically shows a second embodiment process for heating and melting an area of the proximal surface of the piston 6.
  • a heated mandrel 60 in the form of a rod is brought into contact with the proximal surface of the piston 6 to elevate the temperature and thus melt shallow regions of the piston.
  • the heated mandrel may be heated to an elevated temperature, preferably 300-400 Degrees Celsius, and maintained in contact with the piston for a short duration, e.g . in the order of 0.5 to 1 second. Elevated temperatures may offer reductions in process time but may result in increased generation of fumes.
  • heating may be performed by energy deposition using an ultrasonic horn which is applied at the proximal surface of the piston 6.
  • FIG. 6 schematically shows a third embodiment process for heating and melting a surface area between the piston 6 and the piston bearing 7.
  • the distal surface of the piston bearing 7 is initially brought into abutting contact with the proximal surface of the piston 6.
  • An ultrasonic horn 70 is applied to the proximal surface of the piston bearing 7 and energy is deposited and absorbed at the interface between the components in a manner contemplating a conventional ultrasonic welding process. The resulting rise in temperature makes one or both material portions of the piston 6 and the piston washer 7 sticky and a bond is made between the two components.
  • alternative means for applying heat causing a local melting of the piston and/or the piston bearing may include a hot air stream, a flame or a plasma beam which is pointed towards the surface area of interest until it gets sticky.
  • at least one of the piston and the piston bearing of the piston assembly may include a material or compound that is inductively heatable and wherein heat is applied by inductively heating the surface area intended to provide a bond between the piston and the piston bearing . Regions of the thermoplastic polymer elements or the elastomeric rubber of the piston adjoining the inductive heatable material or compound are thus caused to heat up resulting in a localized melting of the thermoplastic polymer or rubber material making it sticky and in turn causing a bond between the piston and the piston bearing to be established.
  • the piston and/or the piston bearing includes a metallic part or distributed metal particles that becomes inductively heated when an inductive field is applied to the part in question.
  • Still further alternatives may involve chemically melting of the surface area of interest for making the piston and the piston bearing adhere to each other for creating a bond between these components.
  • the injection device shown in fig . 1 provides a non-limiting example of a pen injector which may incorporate the piston assembly and the medicament cartridge as described herein and in accordance with the assembly methods described herein.
  • Other types of injection devices may equally well use a piston assembly in accordance with the invention, such devices including devices wherein a piston rod does not rotate as it moves distally during dose expelling, and devices wherein a bearing forms an integral part of the piston rod.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un procédé de formation d'une cartouche de médicament (1) pour un dispositif d'injection médical comprenant les étapes consistant à : a) fournir un cylindre de cartouche (2), b) fournir un piston (6) au moins partiellement constitué d'un matériau élastomère, le piston (6) comprenant une extrémité distale conçue pour un contact fluidique avec le médicament dans la cartouche (1) et une extrémité proximale ayant une surface de contact proximale, c) positionner le piston (6) dans le cylindre de cartouche (2), d) fournir un palier de piston (7), le palier de piston comprenant une surface de contact distale pour mise en prise du piston (6) et d'une surface proximale (7c) conçue pour fixation à une tige de piston (8), e) appliquer un traitement thermique en surface sur la surface de contact proximale du piston (6) et/ou la surface de contact distale du palier de piston (7) entraînant la fusion d'une zone de surface d'au moins une surface parmi lesdites surfaces de contact pour adoucir le matériau disposé au niveau de la zone traitée en surface et f) positionner la surface distale du palier de piston (7) en contact de butée avec la surface proximale du piston (6) pour établir une liaison entre le palier de piston (7) et le piston (6).
PCT/EP2017/052218 2016-02-02 2017-02-02 Procédé de formation d'une cartouche de médicament et cartouche de médicament formée par le procédé WO2017134144A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16153981.2 2016-02-02
EP16153981 2016-02-02

Publications (1)

Publication Number Publication Date
WO2017134144A1 true WO2017134144A1 (fr) 2017-08-10

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE519758A (fr) *
WO1998011927A1 (fr) 1996-09-20 1998-03-26 Disetronic Licensing Ag Organe d'expulsion destine a faire avancer le bouchon d'une ampoule d'injection et bouchon correspondant
US20030014005A1 (en) * 2000-03-17 2003-01-16 Atsushi Chiba Syringe
WO2008127345A1 (fr) * 2006-07-11 2008-10-23 Eli Lilly And Company Piston de cartouche de médicament
JP2009061343A (ja) * 2008-12-26 2009-03-26 Nihon Medi Physics Co Ltd 薬液充填済み注射器内の放射性医薬品の有効成分の損失防止方法
CA2768000A1 (fr) * 2009-04-30 2010-11-04 Sanofi-Aventis Deutschland Gmbh Connexion ajustable axialement d'une tige de piston a un piston pour un mecanisme d'entrainement dans un dispositif d'administration de medicament
WO2011005880A2 (fr) * 2009-07-08 2011-01-13 Medtronic Minimed, Inc. Systèmes et procédés de remplissage de réservoir
EP2659925A1 (fr) * 2012-05-02 2013-11-06 Sanofi-Aventis Deutschland GmbH Piston pour cartouche à utiliser dans un dispositif d'administration de médicaments
WO2014060369A1 (fr) 2012-10-15 2014-04-24 Novo Nordisk A/S Dispositif d'injection entraîné par ressort

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE519758A (fr) *
WO1998011927A1 (fr) 1996-09-20 1998-03-26 Disetronic Licensing Ag Organe d'expulsion destine a faire avancer le bouchon d'une ampoule d'injection et bouchon correspondant
US20030014005A1 (en) * 2000-03-17 2003-01-16 Atsushi Chiba Syringe
WO2008127345A1 (fr) * 2006-07-11 2008-10-23 Eli Lilly And Company Piston de cartouche de médicament
JP2009061343A (ja) * 2008-12-26 2009-03-26 Nihon Medi Physics Co Ltd 薬液充填済み注射器内の放射性医薬品の有効成分の損失防止方法
CA2768000A1 (fr) * 2009-04-30 2010-11-04 Sanofi-Aventis Deutschland Gmbh Connexion ajustable axialement d'une tige de piston a un piston pour un mecanisme d'entrainement dans un dispositif d'administration de medicament
WO2011005880A2 (fr) * 2009-07-08 2011-01-13 Medtronic Minimed, Inc. Systèmes et procédés de remplissage de réservoir
EP2659925A1 (fr) * 2012-05-02 2013-11-06 Sanofi-Aventis Deutschland GmbH Piston pour cartouche à utiliser dans un dispositif d'administration de médicaments
WO2014060369A1 (fr) 2012-10-15 2014-04-24 Novo Nordisk A/S Dispositif d'injection entraîné par ressort

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