WO2017047240A1 - Dispositif d'analyse automatisé - Google Patents

Dispositif d'analyse automatisé Download PDF

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Publication number
WO2017047240A1
WO2017047240A1 PCT/JP2016/071948 JP2016071948W WO2017047240A1 WO 2017047240 A1 WO2017047240 A1 WO 2017047240A1 JP 2016071948 W JP2016071948 W JP 2016071948W WO 2017047240 A1 WO2017047240 A1 WO 2017047240A1
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Prior art keywords
reaction container
reaction
unit
reaction vessel
automatic analyzer
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PCT/JP2016/071948
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English (en)
Japanese (ja)
Inventor
央 上路
Original Assignee
株式会社 日立ハイテクノロジーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 株式会社 日立ハイテクノロジーズ filed Critical 株式会社 日立ハイテクノロジーズ
Priority to JP2017539747A priority Critical patent/JP6698665B2/ja
Priority to CN201680050816.2A priority patent/CN108027380B/zh
Priority to CN202011029124.4A priority patent/CN112129963B/zh
Publication of WO2017047240A1 publication Critical patent/WO2017047240A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present invention relates to an automatic analyzer that automatically analyzes a component contained in a biological sample such as blood, and more particularly to an automatic analyzer that includes a disposal unit that houses a used reaction container.
  • light from a light source has a single or multiple wavelengths obtained by irradiating the reaction mixture, which is the sample to be analyzed, mixed with the sample.
  • Automatic analyzers that measure the amount of transmitted light and scattered light are widely used.
  • Automatic analyzers include devices for biochemical analysis that perform quantitative and qualitative analysis of target components in biological samples in the fields of biochemical tests and hematology tests, and blood coagulation that measures the coagulation ability of blood samples. There are devices for analysis.
  • reaction container for storing the reaction solution used for the analysis for disposal.
  • reaction containers etc. are collected in the disposal part by natural fall, the reaction containers accumulate in a specific place of the disposal part, which spills out, and furthermore this spilled out If the reaction container is picked up by a human hand, it may cause a secondary infection.
  • Patent Document 1 as a technique for preventing such accumulation of reaction containers and the like in a specific place, after collecting used chips and vessels into a disposable storage container by natural fall, the storage container itself is removed.
  • An apparatus having a mechanism for leveling a chip and a vessel accommodated therein by vibrating back and forth, left and right or up and down by a reciprocating linear motion is described.
  • An object of the present invention relates to realizing highly reliable analysis that prevents accumulation of used reaction vessels while maintaining space saving and suppresses the influence on measurement results due to noise such as vibration.
  • a sample dispensing mechanism that dispenses a sample into a reaction container, a reagent dispensing mechanism that dispenses a reagent into the reaction container, and a reaction container holding unit that holds the reaction container;
  • a measurement unit including a light source for irradiating light to the mixed solution of the sample and the reagent contained in the held reaction container, and a detection unit for detecting the irradiated light, and the measurement is completed
  • a reaction container discarding unit that discards the reaction container, a reaction container transfer mechanism that transfers the reaction container from the reaction container holding unit to the reaction container disposal unit, and discards the reaction container to the reaction container disposal unit, and the reaction container
  • a control unit for controlling the operation of the transfer mechanism, wherein the control unit is configured to prevent the reaction vessel discarding unit from being continuously discarded at a predetermined position in the reaction vessel discarding unit. Characterized by controlling the operation That automatic analyzer, and to provide an analytical method using the device.
  • the reaction container transfer mechanism operates so as not to overlap the point and timing of disposal to the disposal part of the reaction container, the used reaction container in the disposal part is maintained while saving space. It is possible to realize highly reliable analysis that prevents accumulation at a specific location and suppresses the influence of noise such as vibration on measurement results.
  • the figure which shows the basic composition of the automatic analyzer which concerns on this Embodiment The figure which shows the structure of the reaction container disposal part which does not have a cover part based on this Embodiment (1st Embodiment). The figure which shows the structure of the reaction container disposal part which has a cover part provided with the several opening part based on this Embodiment (2nd Embodiment). The figure which shows the structure of the reaction container disposal part which has a cover part provided with the groove-shaped opening part which concerns on this Embodiment (3rd Embodiment). The figure which shows the structure of the reaction container disposal part which is equipped with the cover part provided with the several opening part based on this Embodiment (4th Embodiment), and has the storage space divided into plurality inside.
  • FIG. 1 shows a basic configuration of an automatic analyzer according to the present embodiment.
  • the automatic analyzer 100 mainly includes a sample disk 102, a reagent disk 104, a sample dispensing mechanism 105, a sample dispensing mechanism cleaning unit 106, a reaction container installation unit 108, a reaction container transfer mechanism 109, a reaction container.
  • a supply unit 110 a detection unit 111, a reagent dispensing mechanism 112, a reagent dispensing mechanism cleaning unit 113, a reaction container discarding unit 114, an operation unit 115, a control unit 116, a storage unit 117, an interface 118, and the like.
  • the sample disk 102 is a disk-shaped unit that can be rotated clockwise or counterclockwise, and a plurality of sample containers 101 holding samples or quality control samples can be arranged on the circumference thereof.
  • the reagent disk 104 is a disk-shaped unit that can be rotated clockwise and counterclockwise, and contains a reagent containing a component that reacts with a component of each inspection item included in the sample.
  • a plurality of reagent containers 103 can be arranged on the circumference thereof.
  • the reagent disk 104 can be configured to be able to cool the reagent in the arranged reagent container 103 by providing a cold insulation mechanism or the like.
  • the sample dispensing mechanism 105 sucks the sample in the sample container 101 held on the sample disk 102 and discharges it into the reaction container 107 installed in the sample dispensing port 119.
  • the operation of the sample dispensing mechanism 105 is controlled based on an instruction from the control unit 116 in accordance with an operation of a sample syringe pump (not shown).
  • the sample dispensing mechanism washing unit 106 is a mechanism for washing the sample dispensing mechanism 105 with washing water.
  • the timing of water washing is controlled based on an instruction from the control unit 116.
  • the reagent dispensing mechanism 112 sucks the reagent in the reagent container 103 held on the reagent disk 104 and installs the reagent in the reaction container 107 in which the sample is dispensed, which is installed in the reaction container installation unit 108 of the detection unit 111. Do dispensing.
  • the operation of the reagent dispensing mechanism 112 is controlled based on an instruction from the control unit 116 in accordance with an operation of a reagent syringe pump (not shown).
  • the reagent dispensing mechanism washing unit 113 is a mechanism for washing the reagent dispensing mechanism 112 with washing water.
  • the timing of water washing is controlled based on an instruction from the control unit 116.
  • the reaction container supply unit 110 is configured to hold a plurality of reaction containers 107 before analysis.
  • the reaction container transfer mechanism 109 transfers the reaction container 107 used for analysis from the reaction container supply unit 110 to the sample dispensing port 119 and carries it in.
  • the reaction container 107 after the sample is dispensed is unloaded from the sample dispensing port 119, and transferred to and loaded into the reaction container installation unit 108 of the detection unit 111.
  • the reaction vessel 107 is taken out from the reaction vessel setting unit 108, transferred to the reaction vessel discarding unit 114, and discarded.
  • the detection unit 111 includes one or more reaction container installation units 108 for installing the reaction container 107 (in this embodiment, six cases are shown as an example), a light source and a photodiode (not shown).
  • An optical system including a detection unit (photosensor).
  • the light source is produced by a reaction that occurs in the reaction solution by irradiating light to the reaction vessel 107 that contains the reaction solution that is a mixed solution of the sample to be analyzed and the reagent inserted in the reaction vessel installation unit 108. Measurement of light intensity such as scattered light and transmitted light obtained by the material. For example, when detecting scattered light, each reaction container installation part 108 has the light source arrange
  • the detection unit performs light / current conversion on the received scattered light, thereby outputting a photometric signal indicating the received light intensity to an A / D converter (not shown).
  • the light intensity measurement signal A / D converted by the A / D converter is sent to the control unit 116 and the storage unit 117 via the interface 118.
  • the amount of fibrinogen (Fbg) in the sample can be determined.
  • other blood coagulation test items such as prothrombin time (PT) and activated partial thromboplastin time (APTT) can be analyzed. .
  • PT prothrombin time
  • APTT activated partial thromboplastin time
  • the reaction container discarding unit 114 is a unit for discarding the reaction container 107 that has been used for analysis. More specifically, it has an opening which is a waste outlet into which the reaction vessel 114 is charged, and a storage box (not shown) arranged below the opening.
  • the operation unit 115 has an input terminal such as a keyboard and mouse as an input means and an operation screen displayed on the display unit, and inputs analysis items of the sample to be analyzed from the keyboard and operation screen, and inputs them to the control unit 116.
  • an input terminal such as a keyboard and mouse as an input means and an operation screen displayed on the display unit, and inputs analysis items of the sample to be analyzed from the keyboard and operation screen, and inputs them to the control unit 116.
  • the control unit 116 is based on the input from the operation unit 115, the sample disk 102, the reagent disk 104, the sample dispensing mechanism 105, the sample dispensing mechanism cleaning unit 106, the reaction container transfer mechanism 109, the detection unit 111, and the reagent dispensing mechanism 112. Then, the operation of the reagent dispensing mechanism cleaning unit 113 is controlled, and the overall control of the operation and condition setting of various components constituting the automatic analyzer 100 is performed. In addition, the control unit processes the measurement signal input from the detection unit 111 via the interface 118, performs calculation for obtaining the concentration of the target component and the blood coagulation time based on the detection result, and data processing such as specifying an abnormal part. Etc. Details will be described later.
  • the storage unit 117 stores input information from the operation unit 115, operation information of the sample disk 102 and the like, reagent, sample information, and the like.
  • the interface 118 mediates operation information of the sample disk 102 and the like, input information from the operation unit 115, operation information from the control unit 116, and information stored in the storage unit 117.
  • the sample analysis in the automatic analyzer 100 is performed in the order of sample dispensing, reagent dispensing, photometry, disposal of the reaction vessel 107, and data processing.
  • the basic analysis flow is described in detail below.
  • a plurality of reagent containers 103 are arranged side by side on the circumference.
  • the target reagent container 103 Upon receiving an analysis item selection and analysis start instruction from the operation unit 115, the target reagent container 103 is set according to the analysis item. It is rotated clockwise or counterclockwise to the bottom of the reagent dispensing mechanism 112 and conveyed.
  • a predetermined amount of the reagent in the reagent container 103 is dispensed by a reagent syringe (not shown) connected to the reagent dispensing mechanism 112.
  • a plurality of reaction vessels 107 are arranged vertically and horizontally on the reaction vessel supply unit 110.
  • the reaction container transfer mechanism 109 transfers and carries the reaction container 107 from the reaction container supply unit 110 to the reaction container installation unit 108 via the reagent dispensing port 119 in a predetermined order.
  • a plurality of sample containers 101 are arranged on the circumference of the sample disk 102 and rotated clockwise or counterclockwise according to the order of the samples to be analyzed, and conveyed to the bottom of the sample dispensing mechanism 105. To do.
  • the sample in the sample container 101 is dispensed into a reaction container 107 installed in the sample dispensing port 119 by a sample syringe (not shown) connected to the sample dispensing mechanism 105.
  • the reagent dispensing mechanism 112 aspirates the reagent from the reagent container 103 and dispenses it into the reaction container 107 containing the sample installed in the reaction container installation unit 108 of the detection unit 111.
  • the progress of the reaction in the reaction solution which is a mixed solution of the sample and the reagent contained in the reaction vessel 107, is collected by the detection unit configured by the photodiode described above, and is detected by the detection unit. Detected at 111.
  • the detected data, use detection unit number, use sample type and installation position on the sample disk 102, use reagent type and installation position on the reagent disk 104 are stored in the storage unit 117.
  • reaction vessel 107 When the reaction and measurement of the reaction liquid held in the reaction vessel 107 is completed, the reaction vessel 107 is discarded to the reaction vessel disposal unit 114 by the reaction vessel transfer mechanism 109 while holding the mixed solution after the reaction.
  • FIG. 2 is a diagram showing a configuration of a reaction container discarding unit that does not have a lid according to the present embodiment.
  • the reaction container discarding unit 114 shown in FIG. 1 includes an open storage box 201 in the present embodiment.
  • the reaction container transfer mechanism 202 transports the used reaction container 203, which has been analyzed, to the storage box 201 via the transport path 204 and discards it.
  • the reaction container transfer mechanism 202 arbitrarily determines a disposal point on the storage box 201 so that the disposal operation of the reaction container 203 is not continuously performed at a predetermined position. be able to. If it is on the storage box 201, there is no restriction
  • the reaction container 203 is prevented from accumulating at a specific location in the storage box 201 while suppressing the influence of noise due to vibration. be able to.
  • the accumulation of the reaction vessels 203 in the storage box 201 can be leveled in the automatic analyzer that maintains the reliability of the measurement results and realizes space saving.
  • reaction container discarding unit that does not include a lid and has a storage box whose upper surface is open has been described.
  • configuration of a reaction container discarding unit including a storage box having a lid having a plurality of openings will be described with reference to FIG.
  • the reaction container transfer mechanism 302 conveys the used reaction container 303, which has been analyzed, to the plurality of openings 304 formed in the lid portion 305 of the storage box 301 via the conveyance path 306, Discard.
  • the number of the opening parts 304 formed in the cover part 305 is five is shown, this number is not limited and can be changed as needed.
  • the reaction container transfer mechanism 302 holds the used reaction container 303 installed on the reaction container installation unit 108 shown in FIG. It moves right above any one of the openings, and the reaction vessel 303 is discarded.
  • the order of discarding can be set according to a certain sequence, for example, opening 1 ⁇ opening 2 ⁇ opening 3 ⁇ opening 4 ⁇ opening 5 ⁇ opening 1 ⁇ ... It can also be changed as necessary. In this way, by changing the order of discarding the plurality of openings formed in accordance with a certain sequence, it is possible to prevent the reaction vessel 303 from being accumulated at a certain location in the storage box 301 and stored.
  • the height of the reaction vessel 303 can be made uniform.
  • the lid 305 it is possible to prevent fallen objects other than the reaction vessel 303 from falling into the storage box 301.
  • the reaction vessel 303 holds a reaction solution that is a mixed solution of a specimen and a reagent, and a precipitate produced after the reaction, but some specimens include a risk of dangerous infection. Yes. Therefore, if anything other than the reaction container 303 is collected in the storage box 301, there is a risk of secondary infection due to the user accessing the storage box 303.
  • by providing the lid portion 305 it is possible to prevent such a risk from being collected inside the storage box 301 other than the reaction vessel 303, and thus such a risk can be avoided.
  • the configuration of the reaction container discarding section having a lid portion having a groove-shaped opening according to the present embodiment will be described.
  • the configuration in which the plurality of openings 304 are formed in the lid portion 305 has been described.
  • the lid portion 405 is formed in a groove shape and includes a single disposal point.
  • One opening 404 is provided.
  • the reaction container transfer mechanism 402 has a single opening 404 formed in a groove shape in the lid 405 of the storage box 401 for the used reaction container 403 that has been analyzed via the transport path 406. And is discarded at a plurality of disposal points included in the opening 404.
  • the order of discarding can be set according to a certain sequence, for example, P1-> P2-> P3-> P4-> P5-> P6-> ... in the opening 404 in the figure, and if necessary, It can also be changed.
  • a plurality of disposal points are formed on one opening 405 by making the shape of the opening 405 into a groove shape instead of a circular shape matching the reaction container 403 as in the second embodiment. Can be included.
  • the reaction container transfer unit 402 can discard the reaction container 403 at any point as long as it is on the opening 404. After discarding the reaction container 403 at a certain point, the distance between the disposal points is increased by taking a longer moving distance. It is also possible to increase the distance, and conversely, it is possible to shorten the moving distance so that the distance between the disposal points is several millimeters.
  • the reaction vessel 403 can be discarded into the storage box 401 over a wide range on the single opening 404.
  • the heights of the reaction containers 403 in the storage box 401 can be made uniform.
  • the degree of freedom of the disposal point increases. Thereby, equalization of the height of the reaction container 403 in the storage box 401 can be executed with higher accuracy.
  • a configuration of a reaction container discarding section that includes a lid section having a plurality of openings and further has a storage space partitioned into a plurality of sections, and using this configuration, depending on the state of the sample An aspect of changing the storage space in the storage box for discarding the reaction container will be described with reference to FIG.
  • the reaction container transfer mechanism 502 conveys the used reaction container 503, which has been analyzed, to the plurality of openings 604 formed in the lid 505 of the storage box 501 via the conveyance path 506, It is discarded in one of a plurality of storage spaces partitioned by the partition member 505 in the storage box 501.
  • the interior of the storage box 501 is divided into two spaces, a first space 501a and a second space 501b, by the partition member 505.
  • the blood sample that is the sample reacts with the reagent in a few seconds at the earliest, and the mixture begins to coagulate.
  • the specimen does not start to coagulate within a few seconds after mixing with the reagent, and may not coagulate even after several minutes.
  • the automatic analyzer has a maximum time for continuing the measurement, such as a maximum measurement time.
  • a maximum measurement time When this time has elapsed, the measurement is terminated without obtaining the blood coagulation time as the analysis result.
  • the specimen is held in the reaction container 503 almost as a liquid.
  • the storage container 501 is moved by the reaction container transfer mechanism 502 in the same manner as the other reaction container 503, that is, the reaction container 503 in which the blood coagulation reaction is completed and the mixture changed into a solid is stored in the reaction container 503 holding the liquid specimen. If it is discarded in the common space, the liquid in the reaction vessel 503 may spill and contaminate the storage box 501.
  • the reaction container 503 accommodated in a state in which the mixed liquid of the specimen and the reagent does not coagulate even when the maximum measurement time is reached is from the position 5 or 6 of the opening 504. Discard and collect in the first space 501a in the storage box 501. On the other hand, when the mixed solution of the specimen and the reagent is solidified and changed into a solid as usual, the reaction container 503 is discarded from any one of the positions 1 to 4 of the opening 504, and the inside of the storage box 501 is disposed. Collect in the second space 501b.
  • the control unit 116 Determines that the liquid mixture accommodated in the reaction vessel 503 used for this analysis is in a liquid state, and controls the operation of the reaction vessel transfer mechanism 502 so as to collect it in the first space 501a as described above. .
  • the liquid in the reaction container 503 can be obtained. And the solidified mixture can be recovered separately.
  • the contamination in the storage box 501 can be reduced. Further, it is possible to reduce the risk of contact with the liquid mixture spilled from the inside when the reaction vessel 503 is discarded.
  • reaction container discarding unit having a detector for detecting the accumulation state of the internal reaction vessel
  • the accumulation state of the reaction vessel in the storage box is detected
  • the reaction container transfer mechanism 602 conveys the used reaction container 603 whose analysis is completed to a plurality of openings 604 formed in the lid 605 of the storage box 601 via the conveyance path 606. Discard.
  • a plurality of detectors 607 capable of detecting the accumulation state of the collected reaction container 603 are installed inside the storage box 601.
  • the type of the detector 607 is not particularly limited as long as the presence of the reaction vessel 603 recovered from the corresponding opening 604 can be detected.
  • the detector 607 is desirably provided below the position of the corresponding opening 604.
  • the collection information of the reaction container 603 stored in the storage unit 117 is read (step 701).
  • the collection information of the reaction vessel 603 is information including the time when the previous reaction vessel 603 was discarded and the position of the opening 604 used.
  • the reaction vessel 603 is transferred by the reaction vessel transfer mechanism 602 and is continuously discarded in the storage box 601, the reaction vessel 603 is accumulated immediately below the used opening 604.
  • the detector 607 detects the presence of the accumulated reaction vessel 603 (step 702).
  • the number of detectors 607 that can be detected is not limited to one, and accumulation can be detected by a plurality of detectors 607. If the presence of the reaction vessel 603 is detected by at least one of the plurality of detectors 607, the process proceeds to step 703.
  • the reaction container 603 When the detector 607 detects the accumulation state of the reaction container 603 in the storage box 601, the reaction container 603 is most determined from the previous disposal time stored in the storage unit 117 and the position information of the detector 607. The opening 604 with less accumulation is determined (step 703).
  • the opening 604 with the smallest accumulation in the reaction vessel 603 corresponds to the opening 604 in which the presence of the reaction vessel 603 was not detected in step 702.
  • the opening at the location where the previous discard time acquired in step 701 and the current time are the most deviated.
  • the part 604 is determined to be the opening 604 in which the accumulation of the reaction vessel 603 is small.
  • the reaction container transfer mechanism 602 transfers the reaction container 603 to the determined position of the opening 604 and stores it through the opening 604. It is discarded in the box 601 (step 704).
  • the control unit 116 determines that the accumulation amount of the reaction vessel 603 is still small. In this case, among the plurality of openings 604, the opening 604 at the position where the previously used discard time and the current time are most different is determined as the next discard location.
  • a plurality of openings 604 are similarly provided. Among these, the opening 604 at the position where the discard time used last time and the current time are most different is determined as the next discard location (step 705). After determining the opening 604 for discarding the reaction vessel 603, the process proceeds to step 704.
  • the position of the used opening 604 and the discarded time are stored in the storage unit 117 (step 706).
  • the collection information regarding the opening 604 stored at the previous use is overwritten and stored, and the discarding operation is terminated.
  • the storage box 601 can be disposed. It can be determined more accurately whether or not the heights of the recovered reaction vessels 603 can be made uniform.
  • the present embodiment can be applied to a configuration having a plurality of disposal points in one opening 604 as in the third embodiment described above.
  • an apparatus for performing blood coagulation analysis which is an example of an automatic analyzer, has been described using, in particular, a stand-alone type configuration that is operated as a single independent apparatus.
  • clinical analyzers have several types of bioanalytical analysis, immunological analysis, blood coagulation analysis, etc.
  • FIG. 8 is a diagram showing a basic configuration of an automatic analyzer including a two-module blood coagulation analyzer according to the present embodiment.
  • the module type automatic analyzer 800 includes a first blood coagulation analysis unit 812 and a second blood coagulation analysis, which are a plurality of analysis units that analyze a reaction solution that is a mixed solution of a sample and a reagent.
  • the unit 817 includes transport lines 804 and 805 for transporting a sample rack 801 on which a sample container for storing the sample is mounted.
  • a rack sorting mechanism 809 that sorts the destination of the upper rack, and the sorted sample label Information such as a rack return mechanism 808 that moves the rack 801 to the rack storage unit 803, an emergency sample rack input unit 810 that inputs a sample rack 801
  • the transport system of the first blood coagulation analysis unit 812 arranged along the transport line 804 is a reading unit (first blood coagulation unit for collating analysis request information for the sample stored in the sample rack 901 from the transport line 804.
  • the 1st dispensing line 813 and the 1st rack handling mechanism 815 which conveys the sample rack 801 after sample dispensing to the conveyance lines 804 and 805 are provided.
  • the transport system of the second blood coagulation analyzer 817 arranged along the transport line 804 is also accommodated in the sample rack 801 from the transport line 804 in the same manner as the transport system of the first blood coagulation analyzer 812 described above.
  • a reading unit (second blood coagulation analysis unit) 821 for collating analysis request information for a sample a second rack carry-in mechanism 819 for receiving the sample rack 801 from the transfer line 804, and a sampling area where the sample is dispensed
  • a second rack handling mechanism 820 that transports the sample rack 801 after sample dispensing to the transport line 805.
  • the second rack handling mechanism 820 transports the sample rack 801 after sample dispensing to the transport line 805.
  • control unit 822 performs the blood coagulation based on the detection results such as the above-described transport operation of the sample rack 801, the dispensing operation of the sample and the reagent, the sorting of the sample rack 801 based on the read information, and the loading / unloading operation.
  • control unit 822 includes various data related to analysis conditions, an input unit 825 such as a keyboard for inputting instructions from the operator, information read from input information, samples, reagents, and information about detection results.
  • control unit 822 is connected to each component unit and controls the entire automatic analyzer. However, each component unit may be provided with an independent control unit.
  • reaction container transfer mechanism 830 in the first blood coagulation analysis unit 812 the reaction container discarding unit 829 in the second blood coagulation analysis unit 817, and the reaction container transfer mechanism 831, the first described above.
  • the fifth embodiment can be applied.
  • a sample dispensing port 916 that can be disposed, a standby unit 911 that includes a plurality of standby ports 910 that accommodate reaction vessels in a standby state, a reaction vessel magazine 902 in which a plurality of reaction vessels 901 are stocked, and a reaction vessel 901 are transferred, A reaction container transfer mechanism 912 that carries in and out of each position as required, and a pretreated sample that has been temperature adjusted to 37 ° C. and subjected to processing such as sample and dilution immediately before the measurement of blood coagulation time
  • a preheat unit 909 having a plurality of preheat ports 908 for raising the temperature of the sample, and an analysis port 910 for measuring the blood coagulation time by adjusting the temperature to 37 ° C.
  • a plurality of analysis units 907, a reagent cassette 903 containing a reagent bottle in which a reagent is sealed are arranged circumferentially, a reagent disk 904 whose temperature is adjusted to about 10 ° C., and a reagent cassette supply unit 913
  • Container disposal unit 923 and sample dispensing mechanism washing unit 91 for washing the sample dispensing mechanism When provided with a first reagent system cleaning unit 920 for cleaning the first reagent dispensing system, a second reagent dispensing mechanism cleaning unit 922 for cleaning the second reagent dispensing mechanism 921, a.
  • the measurement of the blood coagulation time is obtained by calculation in the control unit 922 based on the detected light data.
  • the first to fifth embodiments described above can be applied to the configuration of the reaction container discarding unit 923 and the reaction container transfer mechanism 912 in the drawing.
  • each of the above-described configurations, functions, processing units, processing means, and the like may be realized by hardware by designing a part or all of them with, for example, an integrated circuit.
  • Each of the above-described configurations, functions, and the like may be realized by software by the processor interpreting and executing a program that realizes each function.
  • Information such as programs, tables, and files for realizing each function can be stored in a memory, a hard disk, a storage device such as an SSD (Solid State Drive), or a storage medium such as an IC card, an SD card, or a DVD.
  • information lines and control lines indicate what is considered necessary for explanation, and not all information lines and control lines on the product are necessarily shown. In practice, it can be considered that almost all the components are connected to each other.
  • Reagent cassette 904 ... Reagent disc 905 ... Reagent information reading part 906 ... Analysis port 907 ... Analysis unit 908 ... Preheat port 909 ... Preheat unit 910 ... Standby port 911 ... Standby unit 912 ... Reaction container transfer mechanism 913 ... Reagent cassette supply unit 914 ... Reagent Cassette storage unit 915... Reagent cassette transfer mechanism 916... Sample dispensing port 917... Sample dispensing mechanism 918. 919 ... First reagent dispensing mechanism 920 ... First reagent dispensing mechanism washing unit 921 ... Second reagent dispensing mechanism 922 ... Second reagent dispensing mechanism washing unit 923 ... Reaction container Waste department

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Abstract

La présente invention concerne un dispositif d'analyse automatisé qui irradie de la lumière depuis une source de lumière sur une solution mixte contenant un échantillon et un réactif dans une cuve de réaction, et analyse l'échantillon sur la base d'informations liées à la lumière résultante. Des cuves de réaction jetables sont collectées conjointement après analyse dans une unité d'élimination, mais si les cuves de réaction sont regroupées dans une partie de l'unité d'élimination, il existe un risque que le contenu puisse se déverser, par exemple. En outre, si l'élimination unité elle-même est amenée à vibrer afin de rendre la hauteur des cuves de réaction plus uniforme, le bruit résultant de la vibration peut affecter les résultats de mesure, de manière à dégrader la fiabilité des analyses. Ce dispositif d'analyse automatisé est pourvu de : une unité d'élimination de cuve de réaction pour l'élimination de cuves de réaction pour lesquelles la mesure est terminée; un mécanisme de transfert de cuve de réaction qui transfère les cuves de réaction à partir d'une unité de maintien de cuve de réaction vers l'unité d'élimination de cuve de réaction et élimine les cuves de réaction dans l'unité d'élimination de réaction; et une unité de commande. L'unité de commande commande le fonctionnement du mécanisme de transfert de cuves de réaction de telle manière que l'élimination des cuves de réaction dans l'unité d'élimination de cuves de réaction ne se produise pas en continu à un certain emplacement. Par conséquent, la présente invention concerne un dispositif d'analyse automatisé avec lequel il est possible qu'une accumulation de cuves de réaction utilisées soit rendue uniforme, tout en maintenant une fiabilité élevée des analyses.
PCT/JP2016/071948 2015-09-17 2016-07-27 Dispositif d'analyse automatisé WO2017047240A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2017539747A JP6698665B2 (ja) 2015-09-17 2016-07-27 自動分析装置
CN201680050816.2A CN108027380B (zh) 2015-09-17 2016-07-27 自动分析装置
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CN111551707B (zh) * 2020-07-13 2020-11-03 宁波海壹生物科技有限公司 一种用于化学发光免疫分析仪的丢杯装置
CN111551707A (zh) * 2020-07-13 2020-08-18 宁波海壹生物科技有限公司 一种用于化学发光免疫分析仪的丢杯装置
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