WO2017014597A1 - Composition cosmétique permettant d'améliorer le blanchissement de la peau contenant un extrait de graines de schisandra chinensis - Google Patents

Composition cosmétique permettant d'améliorer le blanchissement de la peau contenant un extrait de graines de schisandra chinensis Download PDF

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WO2017014597A1
WO2017014597A1 PCT/KR2016/008042 KR2016008042W WO2017014597A1 WO 2017014597 A1 WO2017014597 A1 WO 2017014597A1 KR 2016008042 W KR2016008042 W KR 2016008042W WO 2017014597 A1 WO2017014597 A1 WO 2017014597A1
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acid
skin
cosmetic composition
weeks
skin whitening
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PCT/KR2016/008042
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English (en)
Korean (ko)
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진영원
이상국
박헌주
김지혜
Original Assignee
동국대학교 산학협력단
서울대학교 산학협력단
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Priority claimed from KR1020160093457A external-priority patent/KR101896609B1/ko
Publication of WO2017014597A1 publication Critical patent/WO2017014597A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to a cosmetic composition, and more particularly to a cosmetic composition showing the skin whitening effect, including Schizandra seed extract.
  • melanin is a major pigment that determines the color of the skin, which is produced in melanocytes (melanocytes).
  • melanin is a dark brown pigment formed by a polymerization oxidation reaction by an enzyme such as tyrosinase present in melanocytes, using tyrosine, an amino acid present in vivo, as a substrate.
  • the melanin thus formed is transferred to epidermal cells called keratinocytes through dendritic processes of melanocytes.
  • Korean Unexamined Patent Publication No. 2009-0022750 discloses a cosmetic composition for improving whitening based on a complex extract of Schisandra chinensis, Schisandra chinensis and Licorice.
  • Cosmetic composition for improving skin whitening comprising Schizandra seed extract.
  • the Schizandra seed extract is contained in a concentration of less than 5 mg / ml 1 mg / ml or more with respect to the entire composition, cosmetic composition for improving skin whitening.
  • the cosmetic composition skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisturizing cream, hand cream, foundation, essence, nutrition Essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser having a formulation selected from the group, cosmetic composition for improving skin whitening.
  • the cosmetic composition for improving skin whitening of the present invention has an excellent skin whitening effect by including Schizandra seed extract as an active ingredient, and thus has an excellent effect of preventing or improving or treating the deposition of pigments.
  • the cosmetic composition for improving skin whitening of the present invention includes a Schisandra chinensis extract, which is a natural product-derived material, which is not toxic and does not cause side effects such as skin irritation and inflammation even when applied to the human body.
  • 1 is a graph showing the melanin production inhibition rate according to the concentration of Schizandra seed extract according to an embodiment of the present invention.
  • FIG. 2 is a view showing a visual evaluation analysis result of artificial pigmentation site after applying the cream containing Schizandra seed extract according to an embodiment of the present invention and the cream not including Schizandra seed extract.
  • Figure 3 is a view showing the result of analyzing the melamine level after applying a cream containing Schizandra seed extract and Schizandra seed extract according to an embodiment of the present invention as an active ingredient.
  • FIG. 4 is a view showing the result of analyzing the skin erection index after applying the cream containing the Schizandra chinensis seed extract according to an embodiment of the present invention as an active ingredient and the cream containing Schizandra seed extract.
  • FIG. 5 is a view showing a result of comparing the skin color after applying the cream containing the Schisandra chinensis seed extract according to an embodiment of the present invention as an active ingredient and the cream containing Schisandra chinensis extract.
  • the present invention relates to a cosmetic composition for improving skin whitening, and more particularly, to a cosmetic composition for improving skin whitening having excellent skin whitening effect while minimizing side effects such as skin irritation by including Schizandra seed extract as an active ingredient.
  • Melanin is a dark brown pigment produced in melanocytes, as described above, determines the skin color of humans, and can be expected to have an effect of brightening the skin by inhibiting the synthesis of melanin pigment.
  • Schisandra chinensis seed extract exhibits the effect of inhibiting the production of melanin pigment, A composition for improving skin whitening has been developed.
  • Schizandra's scientific name is Schizandra It is chinensis , a deciduous broad-leaved vine, with the leaves displaced, ovate or obovate, with sharply pointed and serrated ends, with a little hair on the back vein.
  • the flower is reddish white and blooms in June-July.
  • Fruits are used for food, and they grow in the shape of spikes at the ends of branches. They ripen red in August to September.
  • Jirisan, Jeonbuk, and Gangwon-do are the main production areas, and are wild throughout the country except Chungnam and Chungbuk, and geographically distributed in Japan, Sakhalin, Manchuria, and China.
  • Schisandra chinensis seed is not limited to the type of Schisandra chinensis, any of Schisandra chinensis seed can be used without limitation in its source, such as using cultivated or purchased commercially.
  • the "extract” is the extract itself, such as the extract obtained by the Schizandra seed extracting treatment, the diluent or concentrate of the extract, the dried product obtained by drying the extract, the crude or purified product of the extract, or a mixture thereof. It includes extracts of all formulations that can be formed using extracts.
  • Skin whitening in the present invention means any action that inhibits the synthesis of melanin to inhibit or prevent skin deposition of melanin.
  • Skin pigmentation as used herein means any action or condition in which the skin becomes dark due to increased synthesis of melanin.
  • the concentration of Schisandra chinensis extract is not particularly limited, but may be included, for example, in a concentration of 1 mg / ml or more and less than 5 mg / ml with respect to the entire composition.
  • concentration of Schisandra chinensis extract is contained less than 1 mg / ml with respect to the entire composition may be melanin production inhibitory effect, when containing more than 5 mg / ml may have a whitening effect but may exhibit cytotoxicity, cosmetic composition When applied to preferably contains less than 5 mg / ml.
  • Schisandra chinensis seed extract may be included in 0.001 to 90% by weight, preferably 0.001 to 70% by weight based on the total weight of the cosmetic composition. Can be. In the above range can maximize the skin whitening effect.
  • Schizandra seed extract may be included more preferably 0.001 to 50% by weight based on the total weight of the cosmetic composition.
  • the method of extracting Schizandra seeds is not particularly limited and may be extracted according to methods commonly used in the art.
  • the extraction method may include, but are not limited to, a compression method and a purification method. These methods may be carried out alone or in combination of two or more methods.
  • Schizandra seed extract according to the present invention has the effect of effectively inhibiting the production of melanin, and specifically, the cosmetic composition for improving skin whitening of the present invention exhibits the skin whitening effect by inhibiting melanin production by including Schizandra seed extract.
  • the cosmetic composition for improving skin whitening of the present invention exhibits the effect of reducing the total amount of melanin synthesized by including the Schizandra chinensis seed extract, thereby showing the effect of improving skin whitening.
  • the composition comprising the Schisandra chinensis seed extract of the present invention can be used in a variety of cosmetics, face wash and shampoo for the skin whitening effect.
  • the cosmetic composition is a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nourishing lotion, a massage cream, a nourishing cream, a moisturizing cream, a hand cream , Foundation, essence, nutrition essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.
  • Cosmetics of the present invention may include a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids and seaweed extract.
  • the water-soluble vitamin may be any compound that can be formulated in cosmetics, but, for example, preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H and the like, and salts thereof (thiamine hydrochloride, sodium ascorbate salt) and derivatives (ascorbic acid-2-sodium phosphate salt, ascorbic acid-2-magnesium phosphate salt, etc.) can also be used in the present invention. It is included in water soluble vitamins.
  • the water-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification from microorganism culture, enzyme or chemical synthesis.
  • the oil-soluble vitamin may be any compound that can be incorporated into cosmetics, but for example, preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1- ⁇ -tocopherol, d- ⁇ -tocopherol, d- ⁇ - Tocopherol) and derivatives thereof (ascorbic palmitate, ascorbic stearate, ascorbic acid dipalmitine, dl- ⁇ -tocopherol acetate, dl- ⁇ -tocopherol vitamin E, DL-pantothenyl alcohol, nicotinic acid, D-pantothenyl alcohol, pantothenyl ethyl ether and the like) are also included in the oil-soluble vitamins used in the present invention.
  • Oil-soluble vitamins can be obtained by conventional methods such as microbial transformation, purification of microorganism culture, enzyme or chemical synthesis.
  • the polymer peptide may be any compound as long as it can be blended into cosmetics.
  • collagen hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like can be given.
  • Polymeric peptides can be purified and obtained by conventional methods such as purification from microbial cultures, enzymatic methods or chemical synthesis methods, or can be purified and used from natural products such as dermis and pig silk such as pigs and cattle.
  • the polymer polysaccharide may be any compound as long as it can be blended into cosmetics.
  • hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.) may be mentioned.
  • chondroitin sulfate or its salt can be normally purified from a mammal or fish.
  • the sphingolipid may be any compound as long as it can be blended into cosmetics.
  • ceramide, pit spingosine, sphingolipid lipid, and the like are preferable.
  • Sphingo lipids can usually be purified by conventional methods or obtained by chemical synthesis from mammals, fish, shellfish, yeast or plants.
  • the seaweed extract may be any compound as long as it can be blended into cosmetics, and examples thereof include brown algae extract, red algae extract, green algae extract, and the like. Furthermore, calginine, arginic acid and argin purified from these seaweed extracts are preferred. Sodium ginate, potassium arginate and the like can also be included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purification from seaweed by conventional methods.
  • the cosmetics of this invention can be mix
  • Other components that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, Blood circulation accelerators, cooling agents, restriction agents, purified water and the like.
  • Examples of the fat or oil component include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils.
  • the ester fat or oil is, for example, glyceryl tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristin, isopropyl palmitate, ethyl stearate, octyl palmate or isostearic acid isose.
  • hydrocarbon-based oils and fats examples include hydrocarbon-based oils such as squalene, liquid paraffin, ⁇ -olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, and wasselin. .
  • Silicone-based fats and oils for example, polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane, methylcetyloxysiloxane copolymer, dimethylsiloxane, methyl steoxy Siloxane copolymers, alkyl modified silicone oils, amino modified silicone oils and the like.
  • fluorine-based fats and oils examples include perfluoropolyethers.
  • Animal or plant oils for example, avocado oil, almond oil, olive oil, sesame oil, rice bran oil, soybean oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, Sunflower oil, grape seed oil, cottonseed oil, palm oil, counut nut oil, wheat germ oil, rice germ oil, shea butter, moon vinegar oil, marker demy nuts nut, meadow home oil, egg yolk oil, tallow oil, horse oil, mink oil, orange Animal or plant fats and oils such as rape oil, jojoba oil, candeler wax, carnava wax, liquid lanolin, and hardened castor oil.
  • Moisturizing agents include, for example, a water-soluble low molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, a fat-soluble polymer, and the like.
  • fat-soluble polymers examples include polyvinylpyrrolidone-eicosene copolymers, polyvinylpyrrolidone-hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, polymer silicones, and the like.
  • emollient examples include long chain acyl glutamic acid cholesteryl ester, hydroxy stearic acid cholesterol, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like. .
  • surfactant examples include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, and the like.
  • the nonionic surfactant is, for example, self-emulsifying monoglycerate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbitan.
  • Fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE POP (polyoxyethylene polyoxypropylene) copolymer, POE POP alkyl ether, polyether modification Silicone, lauric alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.
  • Anionic surfactants are, for example, fatty acid soaps, ⁇ -acyl sulfonates, alkyl sulfonates, alkylallyl sulfonates, alkylnaphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkylamide sulfates, alkyl phosphates, and POE alkyls.
  • Phosphate, alkylamide phosphate, alkyloylalkyltaurine salt, N-acylamino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate salt, sodium alkyl sulfo acetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphoric acid Ester etc. are mentioned.
  • the cationic surfactant is, for example, alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzyl ammonium chloride, or bromide Heyltrimethylammonium, benzalkonium chloride, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salts of lanolin derivatives, and the like.
  • amphoteric surfactant is, for example, a carboxybetaine type, an amidebetaine type, a sulfobetaine type, a hydroxysulfobetaine type, an amide sulfobetaine type, a phosphobetaine type, an aminocarboxylate type, an imidazoline derivative type, Amphoteric surfactants, such as an amide amine type, etc. are mentioned.
  • Organic and inorganic pigments include, for example, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium film mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, Inorganic pigments such as titanium oxide, aluminum oxide, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, chromium oxide, chromium hydroxide, coloramine, carbon black, and composites thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene, styrene copolymer, Organic pigments such as silk powder, cellulose, CI pigment yellow, CI pigment orange, and composite pigment
  • the organic powder may, for example, be a metal soap such as calcium stearate; Alkyl phosphate metal salts such as zinc sodium cetyl acid, zinc lauryl acid and calcium laurate; Acylamino acid polyvalent metal salts such as N-lauroyl- ⁇ -alanine calcium, N-lauroyl- ⁇ -alanine zinc, and N-lauroylglycine calcium; Amide sulfonic acid polyvalent metal salts, such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-acyl basic amino acids, such as N (epsilon) -lauroyl-L- lysine, N (epsilon) -palmitolysine, N (alpha)-partoylol nitin, N (alpha)-lauroyl arginine, and N (alpha) -cured fat fatty acid acyl arginine; N-acylpolypeptide
  • Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoic acid, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butyl phenyl salicylate, and salicylic acid.
  • Fungicides include, for example, hinokichiol, trichloric acid, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, ginphyllione, Benzalkonium chloride, photosensitizer No. 301, sodium mononitroguicol, undecylenic acid, etc. are mentioned.
  • Antioxidants include, for example, butylhydroxyanisole, propyl gallic acid, erythorbic acid, and the like.
  • pH regulator examples include citric acid, sodium citrate, malic acid, sodium malate, fmaric acid, sodium fmarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, and the like.
  • the alcohol may, for example, be a higher alcohol such as cetyl alcohol.
  • the compounding component which may be added other than this is not limited to this, Moreover, although all said components can be mix
  • Cosmetics of the present invention may take the form of solutions, emulsions, viscous mixtures and the like.
  • Ingredients included in the cosmetic composition of the present invention includes components commonly used in cosmetic compositions in addition to the Schizandra seed extract as an active ingredient, for example, conventional auxiliaries such as stabilizers, solubilizers, vitamins, pigments and flavorings and Carrier.
  • auxiliaries such as stabilizers, solubilizers, vitamins, pigments and flavorings and Carrier.
  • the cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, and includes, for example, emulsion, cream, lotion, pack, foundation, lotion, essence, hair cosmetic, and the like.
  • the cosmetic of the present invention include a flexible lotion, nourishing lotion, nourishing cream, cleansing cream, cleansing foam, cleansing cream, cleansing milk, cleansing lotion, massage cream, cold cream, moisturizing cream, pack, aftershave cream, sunburn prevention cream, Suntan oil, body shampoo, hair shampoo, hair rinse, hand cream, foundation, and the like.
  • the formulation of the present invention is a paste, cream or gel, water carrier, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.
  • a carrier component such as water, water, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component.
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
  • a solvent, solvating or emulsifying agent is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.
  • the carrier component is water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • a liquid diluent such as ethanol or propylene glycol
  • a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide.
  • Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • Schizandra seeds were squeezed using a milking machine by a heat extrusion method (pretreatment at 60-70 ⁇ , temperature: 150-180 ⁇ , pressure: 1-5 kg / cm 2) to obtain Schizandra seed extract.
  • the Schisandra chinensis seed extract of Preparation Example 1 was suspended and lysed in a medium and added to the culture solution of melan-a cells, which are mouse melanocytes, to test the whitening effect at the cellular level.
  • melan-a cells which are melanocytes of mice, are divided into 6-well plates at a concentration of 3 ⁇ 10 4 cells / well and cultured for 48 hours. After attaching, Schisandra chinensis seed extract was treated to a final concentration of 1.25 and 2.5 mg / ml and incubated for 5 days. The cultured cells were washed twice with phosphate buffer (DPBS; Dulbecco's Phosphated Buffered Saline) containing no calcium chloride (CaCl 2 ) or magnesium chloride (MgCl 2 ) and treated with trypsin (Gibco, USA) to separate the cells. The same number of cells were collected per group.
  • DPBS Dulbecco's Phosphated Buffered Saline
  • the cell precipitate was washed with phosphate buffer (DPBS) containing no calcium chloride (CaCl 2 ) or magnesium chloride (MgCl 2 ) and 1 normal concentration with 100 ⁇ l of 10% dimethyl sulfoxide (DMSO). After suspension with sodium hydroxide (N) solution of (N), the resultant was treated for 30 minutes at 60 ° C., and the absorbance was measured at 475 nm.
  • DPBS phosphate buffer
  • CaCl 2 calcium chloride
  • MgCl 2 magnesium chloride
  • DMSO dimethyl sulfoxide
  • the concentration of Schizandra chinensis seed extract was 30.3% when 1.25 mg / ml was added and 54.5% melanin was added when 2.5 mg / ml was added. Was found to be very good.
  • a cream composition a massage cream composition, a lotion composition, a skin lotion composition, an essence composition, a pack composition, and a cleansing foam composition are exemplified as a formulation example of the present invention, but the formulation including the cosmetic composition of the present invention is not limited thereto. no.
  • the oil phase and the water phase were heated and mixed at 75 ° C. in the composition and content (% by weight) shown in Table 1 below, followed by cooling to room temperature.
  • the oil phase and the water phase were heated and mixed at 75 ° C. in the composition and content (% by weight) shown in Table 2 below, and then cooled to room temperature.
  • the oil phase and the water phase were heated, mixed and emulsified at 75 ° C. in the compositions and contents (% by weight) shown in Table 3, and then cooled to room temperature.
  • the aqueous phase and the ethanol phase were prepared and mixed, respectively, and filtered.
  • the aqueous phase and the ethanol phase were produced and mixed, respectively, and filtered.
  • the aqueous phase and the ethanol phase were dispersed and dissolved in the composition and content (% by weight) shown in Table 6, respectively, and then cooled to room temperature.
  • the aqueous phase and the oil phase were dispersed and dissolved in the compositions and contents (% by weight) shown in Table 7, respectively, mixed, and then cooled to room temperature.
  • Subjects should not be mixed with functional cosmetics or drugs other than the test product and avoid excessive physical friction or sun exposure during the test period.
  • the number of subjects was tested by selecting 20 or more subjects according to the guidelines for evaluating the effectiveness of functional cosmetics (2003, 2005), and guidelines for test methods for cosmetic labeling and advertisement (2015).
  • test group significantly improved the degree of pigmentation at the time point after 8 weeks of product use compared to the control group (p ⁇ 0.05).
  • the melanin index was measured using Mexameter MX18 (C + K, Germany). In this test, the pigmentation sites were measured three times at each evaluation time point, and the mean value of melanin index was analyzed.
  • L * is the Luminance parameters (brightness factor)
  • b * is the Chrominance parameters (blue-to-yellow).
  • both the test group and the control group significantly improved the skin brightness (L * value) from 2 weeks after the product use (p ⁇ 0.05, see FIG. 5). .
  • test group significantly improved skin brightness (L * value) compared to the control group.
  • test group significantly improved the skin color (ITA ° value) at the time points 6 and 8 weeks after product use (p ⁇ 0.05).

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Abstract

La présente invention concerne une composition cosmétique permettant d'améliorer le blanchiment de la peau, plus particulièrement, une composition cosmétique permettant d'améliorer le blanchiment de la peau qui réduit au minimum les effets secondaires tels que l'irritation de la peau, etc., et présente un excellent effet de blanchiment de la peau par le fait qu'elle comprend un extrait de graines de Schisandra chinensis.
PCT/KR2016/008042 2015-07-23 2016-07-22 Composition cosmétique permettant d'améliorer le blanchissement de la peau contenant un extrait de graines de schisandra chinensis WO2017014597A1 (fr)

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KR20150104392 2015-07-23
KR10-2015-0104392 2015-07-23
KR1020160093457A KR101896609B1 (ko) 2015-07-23 2016-07-22 오미자 종자 추출물을 포함하는 피부 미백 개선용 화장품 조성물
KR10-2016-0093457 2016-07-22

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10995299B2 (en) 2014-07-23 2021-05-04 Becton, Dickinson And Company Self-lubricating polymer composition
US11613719B2 (en) 2018-09-24 2023-03-28 Becton, Dickinson And Company Self-lubricating medical articles

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US10995299B2 (en) 2014-07-23 2021-05-04 Becton, Dickinson And Company Self-lubricating polymer composition
US10995298B2 (en) 2014-07-23 2021-05-04 Becton, Dickinson And Company Self-lubricating polymer composition
US11613719B2 (en) 2018-09-24 2023-03-28 Becton, Dickinson And Company Self-lubricating medical articles

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