WO2014046243A1 - 貼付剤または貼付製剤用の支持体ならびにそれを用いた貼付剤および貼付製剤 - Google Patents
貼付剤または貼付製剤用の支持体ならびにそれを用いた貼付剤および貼付製剤 Download PDFInfo
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- WO2014046243A1 WO2014046243A1 PCT/JP2013/075500 JP2013075500W WO2014046243A1 WO 2014046243 A1 WO2014046243 A1 WO 2014046243A1 JP 2013075500 W JP2013075500 W JP 2013075500W WO 2014046243 A1 WO2014046243 A1 WO 2014046243A1
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- patch
- sensitive adhesive
- pressure
- adhesive layer
- weight
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Definitions
- the present invention relates to a patch and a patch preparation excellent in anchoring properties.
- an adhesive layer is formed on a support laminated with non-woven fabric or woven fabric to improve the anchoring property of the adhesive to the support and prevent the adhesive residue from sticking.
- Patent Document 1 has been proposed.
- this patch does not cause a problem when the pressure-sensitive adhesive layer has a thickness that can sufficiently cover the unevenness of the nonwoven fabric or woven fabric, but the drug-containing pressure-sensitive adhesive layer is made thin in consideration of the drug utilization rate.
- the pressure-sensitive adhesive layer cannot cover the unevenness of the non-woven fabric or woven fabric, and there is a problem that adhesiveness to the skin is lowered, or conversely, adhesive residue on the skin tends to occur.
- Patent Document 2 proposes a technique for improving the anchoring property of the pressure-sensitive adhesive layer to the support by using an isocyanate compound as an undercoat on the support surface.
- the isocyanate compound since the isocyanate compound has a very short pot life, it requires a means such as blocking water and controlling the reaction temperature at a low temperature, which makes the operation extremely complicated.
- isocyanate compounds are highly reactive, depending on the type of pressure-sensitive adhesive or drug, it may cause a cross-linking reaction with the pressure-sensitive adhesive, thereby changing the physical properties of the pressure-sensitive adhesive or causing a decomposition reaction with the drug. Careful attention is required in
- Patent Document 3 a primer composition containing fine particles having an average particle diameter of 100 nm or less is applied to the surface of a support, and an adhesive layer is formed on the primer composition. It has been proposed to improve. However, in this document, the handling property of the primer composition is poor, the dispersibility in the liquid is also problematic, and further improvement is required for the anchoring property of the patch preparation.
- the present invention has been made in order to solve the above problems, and its purpose is to provide anchoring properties to the support of the pressure-sensitive adhesive layer without adversely affecting the adhesive physical properties such as adhesiveness, tackiness and cohesive strength.
- the object is to provide an improved patch or patch preparation.
- a support for a patch or patch preparation includes a base material including a plastic film and an undercoat layer laminated on the base material, and the undercoat layer includes porous inorganic particles having an average particle diameter of 1 ⁇ m to 15 ⁇ m.
- the porous inorganic particles have a pore volume of 0.5 ml / g to 2.5 ml / g.
- the basis weight of the undercoat layer is 0.1 g / m 2 to 10 g / m 2 .
- the porous inorganic particles are porous silica particles.
- the said base material contains a polyolefin resin film.
- the primer layer further contains a binder resin.
- a patch is provided.
- the patch comprises the support and an adhesive layer disposed on one side so as to be adjacent to the undercoat layer.
- a patch preparation is provided. In the patch preparation, the pressure-sensitive adhesive layer further contains a drug in the patch.
- the above problem is solved by providing a primer layer containing porous inorganic particles having a predetermined average particle diameter on the surface of the support on the side where the pressure-sensitive adhesive layer is provided to form irregularities.
- the anchoring property of the pressure-sensitive adhesive layer to the support can be improved.
- FIG. 4 is a schematic cross-sectional view of a support according to another preferred embodiment of the present invention.
- 1 is a schematic cross-sectional view of a patch according to a preferred embodiment of the present invention. It is a schematic sectional drawing of the patch by another preferable embodiment of this invention.
- FIG. 1 is a schematic cross-sectional view of a support according to a preferred embodiment of the present invention.
- the support 10a includes a base material 11 and an undercoat layer 12 laminated thereon (one side).
- the primer layer 12 includes porous inorganic particles having an average particle diameter of 1 ⁇ m to 15 ⁇ m and preferably a pore volume of 0.5 ml / g to 2.5 ml / g.
- FIG. 2 is a schematic cross-sectional view of a support according to another preferred embodiment of the present invention.
- the support 10b includes a base material 11 and undercoat layers 12 and 12 'laminated on both sides thereof.
- the primer layer 12 ′ includes porous inorganic particles having an average particle diameter of 1 ⁇ m to 15 ⁇ m and preferably a pore volume of 0.5 ml / g to 2.5 ml / g.
- Supports 10a and 10b can be suitably used as a support for a patch or patch preparation described below.
- the substrate 11 includes a plastic film.
- the substrate include polyvinyl chloride resin films, polyester resin films such as polyethylene terephthalate, polyolefin resin films such as polyethylene, polypropylene, ethylene / vinyl acetate copolymers, ethylene / vinyl alcohol copolymers, Examples include various plastic films such as polyurethane-based resin films, and laminates in which nonwoven fabrics are laminated on plastic films. It is possible to apply an undercoat containing a solvent, and it is preferable to include a polyolefin-based resin film in terms of excellent flexibility and skin followability, and in particular, ethylene / vinyl alcohol in terms of skin followability. It is more preferable to include a copolymer resin film.
- the thickness of the plastic film is, for example, 1.0 ⁇ m to 80 ⁇ m, preferably 2.0 ⁇ m to 40 ⁇ m, more preferably 2.0 ⁇ m to 30 ⁇ m.
- the present invention it is advantageous to use a support on which the nonwoven fabric is not laminated.
- a support on which the nonwoven fabric is not laminated When a non-woven fabric is laminated, the thickness increases and the bulk becomes high, so that the handleability may be reduced.
- the anchor property of an adhesive layer can be improved by providing the undercoat layer mentioned later, without requiring lamination
- the thickness of the base material 11 can be appropriately set according to the purpose.
- the thickness is, for example, 1.0 ⁇ m to 100 ⁇ m, preferably 2.0 ⁇ m to 60 ⁇ m, more preferably 2.0 ⁇ m to 40 ⁇ m, and still more preferably 2.0 ⁇ m to 30 ⁇ m.
- the primer layer 12, 12 ′ includes porous inorganic particles.
- the undercoat layer preferably further contains a binder resin for attaching the porous inorganic particles to the substrate.
- the undercoat layer can be typically formed by applying an undercoat containing porous inorganic particles, a binder resin, and a solvent to a substrate surface, and solidifying and / or curing.
- the average particle diameter of the porous inorganic particles in the undercoat layer 12, 12 ' is 1 ⁇ m to 15 ⁇ m, preferably 1 ⁇ m to 10 ⁇ m, more preferably 1.5 ⁇ m to 9 ⁇ m, and still more preferably 3.2 to 9.0 ⁇ m. If the average particle diameter is less than 1 ⁇ m, the pore volume in the particles becomes small, and there is a problem that the effect of improving the anchoring force becomes insufficient. On the other hand, when the average particle diameter exceeds 15 ⁇ m, there are problems such as the tendency to settle in the undercoat agent and the effect of improving the anchoring force become insufficient.
- the average particle diameter of the porous inorganic particles is a value that is measured without distinguishing the primary particles and the secondary particles by regarding the secondary particles as one particle (volume-converted median diameter). . Further, the shape of the porous inorganic particles may not be a true sphere as long as the average particle diameter of 1 ⁇ m to 15 ⁇ m is satisfied.
- the average particle diameter of the porous inorganic particles in the primer layer can be generally identified with the average particle diameter of the porous inorganic particles in the primer, it is measured by a laser diffraction scattering particle size distribution measurement method.
- the average particle diameter (in volume) of the porous inorganic particles in the primer may be the average particle diameter of the porous inorganic particles in the primer layer.
- the actual measurement of the average particle diameter of the porous inorganic particles in the undercoat layer can be performed as follows using, for example, a three-dimensional measurement X-ray CT apparatus. That is, X-rays are applied to the exposed surface of the primer layer while rotating the sample at an angle of 0 to 180 degrees to obtain transmission image data.
- the particle diameter is measured for any 100 particles that can be observed in an arbitrary region (for example, an area of 5 mm 2 that maintains sufficient resolution) in the three-dimensional stereoscopic image obtained by this, and the average particle diameter is determined from the particle size distribution Is calculated.
- the particle diameter is calculated as a sphere by volume conversion. The said measurement is performed 3 times and let the arithmetic mean median diameter be an average particle diameter.
- the porous inorganic particles preferably have a high surface adsorption activity.
- the pore volume of the porous inorganic particles is preferably 0.5 ml / g to 2.5 ml / g, more preferably 0.7 ml / g to 2.0 ml / g, still more preferably 1.4 ml / g to 1.7 ml / g.
- surface irregularities are small, and the effect of improving the anchoring force may be insufficient.
- particles having a pore volume exceeding 2.5 ml / g are liable to be destroyed, which may make it difficult to maintain the particle shape.
- the pore volume can be measured by a pore distribution measurement method by a nitrogen adsorption method.
- porous inorganic particles examples include porous silica particles, porous alumina particles, and porous titania particles.
- porous silica particles can be preferably used because the particles are not easily broken even in the production process or in the dispersion.
- porous inorganic particle only 1 type may be used and it may be used in combination of 2 or more type.
- the porous silica particles can be roughly classified into dry silica particles and wet silica particles due to the production method.
- Dry silica particles are produced by burning a silane-based gas such as silicon tetrachloride in an oxyhydrogen flame (dry method). Dry silica particles are characterized by a small particle size and a small specific surface area. Generally, particles are loosely attached and exist as aggregated particles or agglomerated particles.
- wet silica particles are obtained by precipitation by a reaction of sodium silicate and mineral acid (wet method).
- Wet silica particles have the advantage that they have higher liquid absorbency than dry silica particles and have a wide range of choice of binder resin described below. In the present invention, wet silica particles are more preferred because the anchoring improvement effect is strongly exhibited when using inorganic particles that are more porous and excellent in liquid absorbency.
- the surface of the porous silica particles may be treated with an organic substance to increase the affinity with a binder resin or a solvent described later. It is desirable that the surface characteristics of the porous silica particles be appropriately selected according to the type of the binder resin.
- porous silica particles only one kind may be used, or two or more kinds may be used in combination.
- Commercially available products can also be used.
- Specific examples of commercially available porous silica particles include trade names “SYLOID72FP”, “SYLOID244FP” (manufactured by WR Grace), trade names “Silicia”, “Syrosphere” (manufactured by Fuji Silysia Chemical), The names “Nipgel”, “Nippil” (manufactured by Tosoh Silica), “Mizukasil” (manufactured by Mizusawa Chemical Industry), “Silkron” (manufactured by SCM), and “Gasil” (manufactured by Crossfield) Can be mentioned.
- any appropriate resin can be used as long as the porous inorganic particles can be adhered to the substrate.
- binder resins can be used.
- binder resins include urethane resins, ethyleneimine resins, aminoethyl resins, polyester resins, and the like. Since various binders containing these binder resins and containing a solvent or a dispersion medium and other additives are commercially available, in the present invention, these commercially available products can also be used.
- the binder include a solvent or a dispersion medium using an aqueous solvent such as water or alcohol and an organic solvent such as benzene or ethyl acetate.
- a resin having no adhesiveness can be used as the binder resin.
- a non-adhesive resin is dissolved in a solvent, porous inorganic particles are dispersed to prepare an undercoat, and after applying the undercoat to the substrate surface, drying and / or light irradiation is performed. Curing is performed.
- resin which does not have this adhesiveness can function as a binder.
- the resin having no adhesiveness those having excellent compatibility with the base material and excellent fixability of the porous inorganic particles can be preferably used. This is because the porous inorganic particles can be satisfactorily fixed to the surface of the base material without causing breakage between the primer layer and the base material.
- a resin that dissolves in a solvent and solidifies by drying is preferable.
- examples of such a resin include a PET resin, an ethylene / vinyl alcohol copolymer resin, and a polyethylene resin.
- the same resin as that used for the base material can be preferably used.
- the same resin as used herein means that when the resin is a polymer, the monomer species are common, preferably the same. Resins having different molecular weights are the same resin as long as the monomer species are common.
- the above primer can be prepared by dispersing or dissolving porous inorganic particles and a binder resin in any appropriate solvent.
- the solvent those having excellent dispersibility of the porous inorganic particles and excellent miscibility with the binder resin can be appropriately selected.
- Specific examples of the solvent include water, methanol, ethanol, 1-propanol, 2-propanol, ethyl acetate, methyl ethyl ketone, toluene and the like.
- a solvent may be used independently and may be used in combination of 2 or more type.
- the amount of the porous inorganic particles in the undercoat is preferably 0.1 to 200 parts by weight, more preferably 1 to 200 parts by weight, and still more preferably 20 parts by weight with respect to 100 parts by weight of the binder resin. ⁇ 180 parts by weight. If the amount of the porous inorganic particles is less than 0.1 parts by weight, the porous inorganic particles are likely to be embedded in the binder resin, and there may be cases where sufficient unevenness cannot be imparted to the support surface. If it exceeds 200 parts by weight, it may be difficult to uniformly disperse the porous inorganic particles in the primer.
- the solid content concentration of the primer can be set to any appropriate value from the viewpoint of workability and the like.
- the basis weight (weight per unit area) of the undercoat layer 12, 12 ′ can be appropriately set according to the type, use, purpose, etc. of the base material or the pressure-sensitive adhesive layer.
- the basis weight is preferably 0.1 g / m 2 to 10 g / m 2 , more preferably 0.1 g / m 2 to 8 g / m 2 , and still more preferably 0.2 g / m 2 to 5 g / m 2 . .
- the basis weight can be adjusted to a desired value by appropriately setting the solid content concentration, the coating amount, etc. of the primer.
- the undercoat contains a water-dispersed binder resin, it is possible to select a coating amount that provides a uniform coating film (ie, undercoat layer) according to the average particle diameter of the porous inorganic particles. preferable.
- FIG. 3 is a schematic cross-sectional view of a patch according to a preferred embodiment of the present invention.
- the patch 100a includes the support 10a and the pressure-sensitive adhesive layer 20 disposed so as to be adjacent to the undercoat layer 12 on one surface of the support 10a.
- FIG. 4 is a schematic cross-sectional view of a patch according to another preferred embodiment of the present invention.
- the patch 100b includes the support 10b and a pressure-sensitive adhesive layer 20 disposed on one side of the support 10b so as to be adjacent to the undercoat layer 12. According to the patch 100b using the support 10b having the undercoat layer 12 ′, the appearance at the time of application is excellent, and the effect of increasing the strength of the support 10b and preventing wrinkles and the like can be obtained. . Practically, a release liner is provided on the surface of the adhesive layer 20 of the patch 100a or 100b (not shown).
- the pressure-sensitive adhesive layer 20 includes a pressure-sensitive adhesive.
- a pressure-sensitive adhesive any appropriate pressure-sensitive adhesive can be used depending on the base material, the type of the primer, the purpose and the like.
- acrylic adhesives, natural rubber adhesives, synthetic rubber adhesives, silicone adhesives and the like can be mentioned. These pressure-sensitive adhesives may be used alone or in combination of two or more.
- any pressure-sensitive adhesive can be used, but a synthetic rubber pressure-sensitive adhesive and / or an acrylic pressure-sensitive adhesive is preferably used.
- the acrylic pressure-sensitive adhesive is particularly advantageous because the anchoring force improving effect is exhibited without being affected by the functional group contained.
- the above-mentioned acrylic pressure-sensitive adhesive means a pressure-sensitive composition containing an acrylic polymer as a pressure-sensitive adhesive polymer at room temperature and, if necessary, a tackifier added.
- the acrylic polymer is, for example, a polymer obtained by polymerizing a monomer component containing an acrylic monomer such as (meth) acrylic acid alkyl ester or (meth) acrylic acid as a main component.
- the main component means a monomer contained in an amount of 50% by weight or more based on the total weight of all monomers constituting the polymer.
- the above-mentioned natural or synthetic rubber-based pressure-sensitive adhesive is composed of natural rubber, polyisoprene, styrene-isoprene-styrene block copolymer (SIS), styrene-butadiene-styrene block copolymer (SBS), an elastomer such as polyisobutylene, rosin It means an adhesive composition containing a tackifier such as a terpene, terpene, or petroleum as required. The tackifier is usually blended in an amount of 10 to 50% by weight based on the total weight of the adhesive.
- the above silicone-based pressure-sensitive adhesive means a pressure-sensitive adhesive composition in which a tackifier such as silicone resin is blended with silicone rubber as necessary.
- the tackifier is usually blended in an amount of 10 to 50% by weight based on the total weight of the adhesive.
- a hydrophobic pressure-sensitive adhesive layer is preferable, and a non-water-containing pressure-sensitive adhesive layer is more preferable.
- the non-water-containing pressure-sensitive adhesive layer mentioned here is not necessarily limited to one that does not contain water completely, that is, one that does not contain water substantially, that is, some moisture derived from air humidity, skin, etc. Those containing are included.
- the slight amount of moisture referred to here is preferably 5% by weight or less, more preferably 2% by weight or less, and most preferably 1% by weight or less as the moisture content of the laminate of the support and the pressure-sensitive adhesive layer.
- the moisture content of the laminate of the support and the pressure-sensitive adhesive layer is measured by Karl Fischer coulometric titration, and the water contained in the laminate of the support and the pressure-sensitive adhesive layer from which the release liner has been peeled is present. It means the weight ratio (weight percentage of water with respect to the total weight of the laminate of the support and the pressure-sensitive adhesive layer), and is specifically as follows. That is, a specimen having a release liner, if present, is punched out to a predetermined size in an environment controlled at a temperature of 23 ⁇ 2 ° C. and a relative humidity of 40 ⁇ 5% RH to produce a test piece. Thereafter, the release liner, if present, is removed from the test piece and placed in a moisture vaporizer.
- the test piece is heated at 140 ° C. in the moisture vaporizer, and the moisture generated thereby is introduced into the titration flask using nitrogen as a carrier, and the moisture content (% by weight) of the sample is measured by the Karl Fischer coulometric titration method. .
- the pressure-sensitive adhesive layer 20 can contain any appropriate additive as required.
- the additive include softeners such as esters of monobasic acids or polybasic acids and branched alcohols and / or esters of unsaturated fatty acids or branched acids and tetrahydric alcohols, isocyanate-based, epoxy-based, Examples thereof include crosslinkers such as metal ions, and organic liquid components such as fatty acid alkyl esters and fatty acid triglycerides. These additives can be used alone or in combination of two or more. The content of these additives in the pressure-sensitive adhesive layer can be appropriately set depending on the purpose and the like.
- the content of the pressure-sensitive adhesive in the pressure-sensitive adhesive layer 20 is preferably 30% by weight to 100% by weight, more preferably 40% by weight to 100% by weight, based on the total weight of the pressure-sensitive adhesive layer. When the amount of the pressure-sensitive adhesive is less than 30% by weight, the internal cohesive force of the pressure-sensitive adhesive layer may be reduced.
- the thickness of the pressure-sensitive adhesive layer 20 is preferably 10 to 300 ⁇ m, more preferably 15 to 200 ⁇ m, and most preferably 20 to 100 ⁇ m from the viewpoint of skin adhesiveness.
- the release liner is not particularly limited. Specific examples of the release liner include glassine paper, polyethylene, polypropylene, polyester, polyethylene terephthalate, polystyrene, aluminum film, foamed polyethylene film, foamed polypropylene film, and the like, or a laminate of those selected from these, and further processed with silicone. And those that have been embossed.
- a polyester (particularly, polyethylene terephthalate) resin release liner is preferable in terms of barrier properties, cost, and ease of material selection.
- a surface peeling treatment may be applied to the pressure-sensitive adhesive layer side surface of the release liner.
- the release liner preferably has a uniform thickness in consideration of ease of processing and processing accuracy.
- the thickness of the release liner is preferably 25 ⁇ m to 200 ⁇ m, more preferably 50 ⁇ m to 150 ⁇ m, from the viewpoint of ease of manufacture of the patch, cost of the release liner, portability of the patch, operability, and the like.
- the adhesive layer further contains a drug.
- the drug is not particularly limited. Preferably, it is a drug that can be administered to mammals such as humans through its skin, that is, a drug that can be absorbed transdermally.
- drugs include general anesthetics, hypnotics / sedatives, antiepileptics, antipyretic analgesics, antipruritics, neuropsychiatric drugs, central nervous system drugs, anti-dementia drugs, local anesthetics, skeleton Muscle relaxant, autonomic drug, antispasmodic, antiparkinsonian, antihistamine, cardiotonic, arrhythmic, diuretic, antihypertensive, vasoconstrictor, coronary vasodilator, peripheral vasodilator, arteriosclerosis Drugs, cardiovascular drugs, respiratory stimulants, antitussive expectorants, hormonal drugs, topical suppurative drugs, analgesic / antipruritic / astringent / anti-inflammatory drugs, parasitic skin disease drugs, hemostatic drugs, gout treatment drugs , Diabetes drugs, antineoplastic drugs, antibiotics, chemotherapeutic drugs, narcotics, smoking cessation aids.
- the drug can be present in the adhesive layer in an amount sufficient to produce a desired result in the treatment of a disease, condition or disorder, eg, a desired therapeutic result (ie, an effective amount).
- effective amount of drug is meant, for example, an amount of drug that is non-toxic but sufficient to produce a selected effect over a specified period of time. Such an amount can be readily determined by one skilled in the art.
- the content of the drug in the pressure-sensitive adhesive layer is not particularly limited as long as it satisfies the effect of the drug for percutaneous absorption and does not impair the adhesive properties of the pressure-sensitive adhesive.
- the content of the drug is preferably 0.1% to 60% by weight, more preferably 0.5% to 40% by weight, based on the total weight of the pressure-sensitive adhesive layer. If the drug content is less than 0.1% by weight, the therapeutic effect may not be sufficient. If the content of the drug is more than 60% by weight, the content of the pressure-sensitive adhesive and other additives constituting the pressure-sensitive adhesive layer may be low, and sufficient skin adhesion may not be obtained. There may be disadvantages.
- the patch or patch preparation of the present invention can be produced by any appropriate method.
- the following method is mentioned.
- any appropriate surface treatment such as corona treatment may be applied to the surface of the substrate in advance.
- the application means is not particularly limited, and any appropriate means such as a kiss coater, a gravure coater, a bar coater, or a spray coater can be applied.
- a release liner is prepared, an adhesive layer is laminated on one side of the release liner, and a support is laminated on the adhesive layer to obtain a laminated sheet.
- a pressure-sensitive adhesive layer is laminated on the undercoat layer surface of the support, and a release liner is laminated on the pressure-sensitive adhesive layer to obtain a laminated sheet.
- the method for laminating the support and the pressure-sensitive adhesive layer is not particularly limited. Specific examples include application, adhesion, fusion, and welding.
- a method is used in which a composition for forming a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive, an organic solvent, and optionally a drug is prepared, applied to a release liner or support, and then the organic solvent is dried and removed.
- the obtained laminated sheet is cut into a predetermined shape to obtain a patch or patch preparation.
- the patch or patch preparation can be packaged in any suitable packaging container.
- a resin film, a metal foil, and a bag made of a laminated film thereof are usually used.
- ⁇ Measurement of average particle diameter The average particle size in the undercoat was measured in terms of volume using a laser diffraction particle size distribution analyzer (manufactured by Shimadzu Corporation).
- ⁇ Measurement of pore volume The pore volume was measured by a nitrogen adsorption method using a pore distribution measuring device by a gas adsorption method.
- Example 1 (1) In a reaction vessel equipped with a cooling pipe, a nitrogen gas introduction pipe, a thermometer, a dropping funnel and a stirrer, 43 parts by weight of 2-ethylhexyl acrylate as a monomer, 43 parts by weight of butyl acrylate, 14 parts by weight of diacetone acrylamide And stirred in ethyl acetate.
- a polymerization initiator 2,2′-azobisisobutyronitrile was added in an amount of 0.2 parts by weight based on the above monomers. The content is controlled to be kept at 40 ° C.
- the acrylic polymer solution (A) is diluted with ethyl acetate to form a pressure-sensitive adhesive layer-containing composition containing an acrylic pressure-sensitive adhesive, and this is a release liner (so that the thickness after drying is 40 ⁇ m)
- a pressure-sensitive adhesive layer was formed by applying and drying on a polyester film having a surface subjected to a release treatment.
- EVOH resin ethylene / vinyl alcohol copolymer resin
- silica particles trade name “SYLOID72FP”, manufactured by WR Grace Co., Ltd.
- the obtained primer is coated on one side of a base material (EVOH film having a thickness of 20 ⁇ m (product name “EF-E”, manufactured by Kuraray Co., Ltd.)) with a weight per unit area of a coating film (undercoat layer) of 0.6 g / m.
- the base coat layer was formed by coating and drying so as to be 2 , thereby obtaining a support.
- the pressure-sensitive adhesive layer was transferred to the surface of the undercoat layer of the obtained support to obtain patch 1.
- Example 3 In the composition for forming the pressure-sensitive adhesive layer containing the acrylic pressure-sensitive adhesive used in Example 1, 10 silica particles (trade name “SYLOID72FP”, manufactured by WR Grace Co., Ltd.) are used with respect to 90 parts by weight of the solid content.
- the composition for pressure-sensitive adhesive layer formation containing silica particles was obtained by adding and mixing parts by weight.
- a patch C3 was obtained in the same manner as in Example 1 except that the pressure-sensitive adhesive layer was formed using the composition and that the primer was prepared without adding the silica particles.
- a primer was prepared by adding silica particles (trade name “Aerosil 200”, manufactured by Nippon Aerosil Co., Ltd.) at a blending ratio of 5 parts by weight with respect to 100 parts by weight of EVOH resin, and A patch C4 was obtained in the same manner as in Example 1 except that the basis weight was 0.3 g / m 2 .
- each patch was applied to a SUS plate covered with Celgard (manufactured by Hoechst) and then peeled off at a rate of 100 mm / min in a 180 degree direction by a Tensilon tensile tester.
- the failure mode was evaluated according to the following criteria. The results are shown in Table 1. [Evaluation criteria] ⁇ : Throwing was not destroyed ⁇ : Throwing was partially destroyed ⁇ : Throwing was broken
- patches 1 to 10 and patch C2 shows that the anchoring force is improved by providing an undercoat layer containing silica particles on the contact surface of the support with the adhesive layer. Further, when the patches 1 to 10 and the patch C1 are compared, it can be seen that silica particles having an average particle diameter of 1 ⁇ m to 15 ⁇ m exhibit the anchoring force improving effect. Comparing patches 1 to 7 and patches 8 to 10, it can be seen that silica particles having a pore volume of 0.5 ml / g or more exhibit an excellent anchoring force improving effect. Also, patches C3 to C5 had insufficient anchoring power.
- Example 11 10 parts by weight of isopropyl myristate as an organic liquid component is added to 90 parts by weight of the solid content of a commercially available acrylic adhesive (trade name “Duro-Tak87-9301”, manufactured by National Starch and Chemical Co., Ltd.) did. These were stirred in an ethyl acetate solution to obtain a composition for forming an adhesive layer.
- a commercially available acrylic adhesive trade name “Duro-Tak87-9301”, manufactured by National Starch and Chemical Co., Ltd.
- the resulting pressure-sensitive adhesive layer-forming composition was applied and dried on a release liner (polyester film having a surface subjected to a release treatment) so that the thickness after drying was 40 ⁇ m to form a pressure-sensitive adhesive layer Except for this, patch 11 was obtained in the same manner as in Example 3.
- Example 12 To a pressure-sensitive adhesive containing, as a pressure-sensitive adhesive, an acrylic copolymer obtained by copolymerizing 72 parts by weight of acrylic 2-ethylhexyl ester, 25 parts by weight of N-vinyl-2-pyrrolidone, and 3 parts by weight of acrylic acid, As an organic liquid component, 35 parts by weight of fatty acid triglyceride (trade name “Coconard RK”, manufactured by Kao Corporation) and 0.26 part by weight of a crosslinking agent were added to 64.74 parts by weight of the solid content. These were stirred in an ethyl acetate solution to obtain a composition for forming an adhesive layer.
- an acrylic copolymer obtained by copolymerizing 72 parts by weight of acrylic 2-ethylhexyl ester, 25 parts by weight of N-vinyl-2-pyrrolidone, and 3 parts by weight of acrylic acid.
- As an organic liquid component 35 parts by weight of fatty acid triglyceride (trade name “Co
- the resulting pressure-sensitive adhesive layer-forming composition was applied and dried on a release liner (polyester film with a release treatment on the surface) so that the thickness after drying was 60 ⁇ m to form a pressure-sensitive adhesive layer Except for this, patch 12 was obtained in the same manner as in Example 3.
- Example 13 (1) 20 parts by weight of polyisobutylene (manufactured by BASF, viscosity average molecular weight 4 million), 20 parts by weight of polyisobutylene (manufactured by BASF, viscosity average molecular weight 55,000), and polybutene (kinematic viscosity: 60 parts by weight of 4000 mm 2 / s (100 ° C.) was mixed in toluene to obtain a rubber-based pressure-sensitive adhesive.
- polyisobutylene manufactured by BASF, viscosity average molecular weight 4 million
- polyisobutylene manufactured by BASF, viscosity average molecular weight 55,000
- polybutene kinematic viscosity: 60 parts by weight of 4000 mm 2 / s (100 ° C.
- the breaking mode was evaluated in the same manner as the patches 1 to 10 and C1 to C5. As a result, the patch 13 did not throw and break, but the patch C6 did throw and break. From this, it can be seen that according to the support provided with the primer layer containing silica particles, the anchoring force improving effect is exhibited even in the pressure-sensitive adhesive layer containing polyisobutylene.
- Example 14 Mix 95 parts by weight of a commercially available silicone adhesive (trade name “BIO-PSA7-4202”, manufactured by Dow Corning) and 5 parts by weight of silicone oil (trade name “Q7-9120”, manufactured by Dow Corning). Thus, a composition for forming an adhesive layer was obtained.
- a commercially available silicone adhesive trade name “BIO-PSA7-4202”, manufactured by Dow Corning
- silicone oil trade name “Q7-9120”, manufactured by Dow Corning
- the resulting pressure-sensitive adhesive layer-forming composition was applied and dried on a release liner (polyester film having a surface subjected to a release treatment) so that the thickness after drying was 50 ⁇ m to form a pressure-sensitive adhesive layer Except for this, patch 14 was obtained in the same manner as in Example 3.
- Example 15 In a reaction vessel equipped with a cooling pipe, a nitrogen gas introduction pipe, a thermometer, a dropping funnel and a stirrer, 55 parts by weight of 2-ethylhexyl acrylate, 5 parts by weight of N-hydroxyethylacrylamide, N-vinyl-2-pyrrolidone 40 parts by weight and 233.3 parts by weight of ethyl acetate as a solvent were added, and the mixture was stirred for 1 hour while performing nitrogen gas bubbling (100 mL / min) at room temperature.
- composition for forming an adhesive layer obtained in (2) was applied and dried on a release liner (polyester film having a surface subjected to a release treatment) so that the thickness after drying was 40 ⁇ m, A patch preparation 15 was obtained in the same manner as in Example 1 except that the pressure-sensitive adhesive layer was formed.
- Example 16 to 23 Patch preparations 16 to 23 were obtained in the same manner as in Example 15 except that different types of silica particles were used.
- the pressure-sensitive adhesive layers of Examples 1 to 23 were substantially free of water.
- a patch preparation C9 was obtained in the same manner as in Example 15 except that the primer was prepared without adding silica particles.
- the patch preparations 15 to 23 having the primer layer containing porous silica particles having a predetermined average particle diameter had improved anchoring force compared to the patch preparations C8 to C9.
- Patch preparations 15 to 20 resulted in cohesive failure, and the exact anchoring force could not be measured, but the actual anchoring force was even greater than the measured value.
- the patch or patch preparation of the present invention can be suitably used for protecting wounds on the skin surface and transdermal administration of drugs.
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Abstract
Description
好ましい実施形態においては、上記多孔質無機粒子の細孔容積が0.5ml/g~2.5ml/gである。
好ましい実施形態においては、上記下塗り剤層の目付量が、0.1g/m2~10g/m2である。
好ましい実施形態においては、上記多孔質無機粒子が、多孔質シリカ粒子である。
好ましい実施形態においては、上記基材が、ポリオレフィン系樹脂フィルムを含む。
好ましい実施形態においては、上記下塗り剤層が、バインダー樹脂をさらに含む。
本発明の別の局面によれば、貼付剤が提供される。該貼付剤は、上記支持体と、その片面に該下塗り剤層と隣接するように配置された粘着剤層とを備える。
本発明のさらに別の局面によれば、貼付製剤が提供される。該貼付製剤は、上記貼付剤において、粘着剤層がさらに薬物を含んでなる。
図1は、本発明の好ましい実施形態による支持体の概略断面図である。支持体10aは、基材11とその上(片面)に積層された下塗り剤層12とを備える。下塗り剤層12は、平均粒子径が1μm~15μmであり、好ましくは細孔容積が0.5ml/g~2.5ml/gである多孔質無機粒子を含む。
基材11は、プラスチックフィルムを含む。基材の具体例としては、ポリ塩化ビニル系樹脂フィルム、ポリエチレンテレフタレートなどのポリエステル系樹脂フィルム、ポリエチレン、ポリプロピレン、エチレン/酢酸ビニル共重合体、エチレン/ビニルアルコール共重合体などのポリオレフィン系樹脂フィルム、ポリウレタン系樹脂フィルムなどの各種プラスチックフィルム、および、プラスチックフィルムへ不織布を積層した積層体が挙げられる。溶媒を含む下塗り剤を塗布することが可能であり、また、柔軟性および皮膚追従性に優れる点で、ポリオレフィン系樹脂フィルムを含むことが好ましく、なかでも、皮膚追従性の点でエチレン/ビニルアルコール共重合樹脂フィルムを含むことがより好ましい。
下塗り剤層12、12’は、多孔質無機粒子を含む。該下塗り剤層は、多孔質無機粒子を基材に付着させるためのバインダー樹脂をさらに含むことが好ましい。該下塗り剤層は、代表的には、多孔質無機粒子とバインダー樹脂と溶媒とを含む下塗り剤を基材表面に塗布し、固化および/または硬化させることによって形成され得る。
図3は、本発明の好ましい実施形態による貼付剤の概略断面図である。貼付剤100aは、上記支持体10aと、該支持体10aの片面に下塗り剤層12と隣接するように配置された粘着剤層20とを備える。また、図4は、本発明の別の好ましい実施形態による貼付剤の概略断面図である。貼付剤100bは、上記支持体10bと、該支持体10bの片面に下塗り剤層12と隣接するように配置された粘着剤層20とを備える。下塗り剤層12’を備える支持体10bを用いた貼付剤100bによれば、貼付時の外観が優れるとともに、支持体10bの強度を増大させ、シワの発生等を防止するという効果が得られ得る。実用的には、貼付剤100aまたは100bの粘着剤層20表面には、剥離ライナーが設けられている(図示せず)。
支持体10aおよび10bとしては、上記A項に記載の支持体が用いられる。
粘着剤層20は、粘着剤を含む。該粘着剤としては、基材、下塗り剤の種類、目的などに応じて、任意の適切な粘着剤を用いることができる。例えば、アクリル系粘着剤、天然ゴム系粘着剤、合成ゴム系粘着剤、シリコーン系粘着剤等が挙げられる。これらの粘着剤は、単独で用いてもよく、2種以上を併用してもよい。本発明ではいずれの粘着剤も使用可能であるが、好ましくは合成ゴム系粘着剤および/またはアクリル系粘着剤が用いられる。アクリル系粘着剤によれば、含有する官能基に影響を受けることなく投錨力向上効果が発揮されることから、アクリル系粘着剤が特に有利である。
上記剥離ライナーは、特に限定されない。剥離ライナーの具体例としては、グラシン紙、ポリエチレン、ポリプロピレン、ポリエステル、ポリエチレンテレフタレート、ポリスチレン、アルミフィルム、発泡ポリエチレンフィルム又は発泡ポリプロピレンフィルムなど、もしくはこれらから選ばれたものの積層物、さらにこれらにシリコーン加工したものや、エンボス加工を施したものなどが挙げられる。バリアー性、価格、材料の選択容易性の点からポリエステル(特に、ポリエチレンテレフタレート)樹脂製剥離ライナーが好ましい。剥離ライナーを粘着剤層からさらに容易に剥離可能とするために、剥離ライナーの粘着剤層側表面に表面剥離処理を施してもよい。
本発明の貼付製剤は、上記貼付剤において、粘着剤層がさらに薬物を含むものである。該薬物は特に限定されない。好ましくは、ヒトなどの哺乳動物にその皮膚を通して投与し得る薬物、すなわち経皮吸収可能な薬物である。そのような薬物の具体例としては、全身性麻酔薬、催眠・鎮静薬、抗癲癇薬、解熱鎮痛消炎薬、鎮暈薬、精神神経用薬、中枢神経薬、抗痴呆薬、局所麻酔薬、骨格筋弛緩薬、自律神経用薬、鎮痙薬、抗パーキンソン薬、抗ヒスタミン薬、強心薬、不整脈用薬、利尿薬、血圧降下薬、血管収縮薬、冠血管拡張薬、末梢血管拡張薬、動脈硬化用薬、循環器用薬、呼吸促進薬、鎮咳去痰薬、ホルモン薬、化膿性疾患用外用薬、鎮痛・鎮痒・収斂・消炎用薬、寄生性皮膚疾患用薬、止血用薬、痛風治療用薬、糖尿病用薬、抗悪性腫瘍用薬、抗生物質、化学療法薬、麻薬、禁煙補助薬が挙げられる。
本発明の貼付剤または貼付製剤は、任意の適切な方法により製造することができる。例えば、以下の方法が挙げられる。まず、基材の片面または両面に下塗り剤を薄層状に塗布後、溶媒を乾燥、除去し、必要に応じて紫外線硬化させて支持体を得る。ここで、基材と下塗り剤層との密着性向上の観点から、予め基材表面にコロナ処理などの任意の適切な表面処理を施しておいてもよい。塗布手段は特に限定されず、キスコータ、グラビアコータ、バーコータ、スプレーコータなどの任意の適切な手段を適用することができる。次いで、剥離ライナーを用意し、剥離ライナーの片面に粘着剤層を積層し、該粘着剤層上に支持体を積層して積層シートを得る。あるいは、支持体の下塗り剤層面に粘着剤層を積層し、該粘着剤層上に剥離ライナーを積層して積層シートを得る。支持体と粘着剤層の積層の手法は、特に限定されない。具体例としては、塗布、接着、融着、溶着などが挙げられる。好ましくは、粘着剤、有機溶媒、任意に薬物などを含む粘着剤層形成用の組成物を調製し、これを剥離ライナーまたは支持体上に塗布した後、有機溶媒を乾燥、除去させる方法が採用される。得られた積層シートを所定の形状に切断し、貼付剤または貼付製剤を得る。所望により、貼付剤または貼付製剤を、任意の適切な包装容器で包装することができる。包装容器としては、樹脂フィルム、金属箔およびそれらの積層フィルムで作成された袋などが通常用いられる。
下塗り剤中の平均粒子径を、レーザー回折式粒子径分布測定装置(島津製作所社製)を用いて、体積換算にて測定した。
≪細孔容積の測定≫
細孔容積は、ガス吸着法による細孔分布測定装置を使用して、窒素吸着法によって測定した。
(1)冷却管、窒素ガス導入管、温度計、滴下漏斗および攪拌機を備えた反応容器に、モノマーとしてのアクリル酸2-エチルヘキシル43重量部、アクリル酸ブチル43重量部、ダイアセトンアクリルアミド14重量部を投入し、酢酸エチル中にて撹拌した。重合開始剤として2,2’-アゾビスイソブチロニトリルを上記モノマーに対して0.2重量部加えた。撹拌速度の調整、外浴温度の調整、希釈溶媒としての酢酸エチルの滴下などにて、内容物の温度を40℃に保つよう制御し、窒素ガス流中で90分間重合を行い、次いで、60℃で6時間保持し、さらに80℃にて18時間保持した。当該溶液重合により、アクリル系共重合体(A)の溶液を得た。
(2)アクリル系重合体溶液(A)を酢酸エチルにて希釈してアクリル系粘着剤を含む粘着剤層形成用の組成物とし、これを乾燥後の厚みが40μmとなるように剥離ライナー(表面に剥離処理を施したポリエステルフィルム)上に塗布および乾燥して、粘着剤層を形成した。
異なる種類のシリカ粒子を用いたこと以外は実施例1と同様にして、貼付剤2~10を得た。
異なる種類のシリカ粒子を用いたこと以外は実施例1と同様にして、貼付剤C1を得た。
シリカ粒子を添加せずに下塗り剤を調製したこと以外は実施例1と同様にして、貼付剤C2を得た。
実施例1で用いたアクリル系粘着剤を含む粘着剤層形成用の組成物に、その固形分90重量部に対してシリカ粒子(商品名「SYLOID72FP」、W.R.グレース社製)を10重量部添加および混合して、シリカ粒子を含む粘着剤層形成用の組成物を得た。該組成物を用いて粘着剤層を形成したこと、および、シリカ粒子を添加せずに下塗り剤を調製したこと以外は実施例1と同様にして、貼付剤C3を得た。
シリカ粒子(商品名「アエロジル200」、日本アエロジル(株)社製)をEVOH樹脂100重量部に対して5重量部の配合比で添加して下塗り剤を調製したこと、および、下塗り剤層の目付量を0.3g/m2としたこと以外は実施例1と同様にして、貼付剤C4を得た。
シリカ粒子の代わりに塩化ナトリウム(和光純薬工業社製)(入手後、粒子径を調整)を用いたこと、および、下塗り剤層の目付量を0.3g/m2としたこと以外は実施例1と同様にして、貼付剤C5を得た。
[評価基準]
○:投錨破壊しなかった
△:一部投錨破壊した
×:投錨破壊した
市販のアクリル系粘着剤(商品名「Duro-Tak87―9301」、ナショナルスターチ・アンド・ケミカル社製)に、その固形分90重量部に対して、有機液状成分としてミリスチン酸イソプロピルを10重量部添加した。これらを酢酸エチル溶液中にて撹拌して、粘着剤層形成用の組成物を得た。
アクリル2-エチルヘキシルエステル72重量部と、N-ビニル-2-ピロリドン25重量部と、アクリル酸3重量部とを共重合してなるアクリル系共重合体を粘着性ポリマーとして含む粘着剤に、その固形分64.74重量部に対して、有機液状成分として脂肪酸トリグリセリド(商品名「ココナードRK」、花王社製)35重量部、架橋剤0.26重量部を添加した。これらを酢酸エチル溶液中にて撹拌して、粘着剤層形成用の組成物を得た。
(1)ポリイソブチレン(BASF社製、粘度平均分子量400万)20重量部、ポリイソブチレン(BASF社製、粘度平均分子量5.5万)20重量部、および、タッキファイヤーとしてポリブデン(動粘性率:4000mm2/s(100℃))60重量部をトルエン中にて混合し、ゴム系粘着剤を得た。
(2)上記ゴム系粘着剤に、その固形分82.5重量部に対して、オクチルドデカノール10重量部、および、ポリビニルピロリドン(商品名「INF-10」、ISP社製)7.5重量部を添加した。これらをトルエン溶液中にて撹拌して、粘着剤層形成用の組成物を得た。
(3)(2)で得られた粘着剤層形成用の組成物を乾燥後の厚みが100μmとなるように剥離ライナー(表面に剥離処理を施したポリエステルフィルム)上に塗布および乾燥して、粘着剤層を形成したこと以外は実施例3と同様にして、貼付剤13を得た。
シリカ粒子を添加せずに下塗り剤を調製したこと以外は実施例13と同様にして、貼付剤C6を得た。
市販のシリコーン系粘着剤(商品名「BIO-PSA7-4202」、ダウコーニング社製)95重量部と、シリコーンオイル(商品名「Q7-9120」、ダウコーニング社製)5重量部とを混合して、粘着剤層形成用の組成物とした。
シリカ粒子を添加せずに下塗り剤を調製したこと以外は実施例14と同様にして、貼付剤C7を得た。
(1)冷却管、窒素ガス導入管、温度計、滴下漏斗および攪拌機を備えた反応容器に、アクリル酸2-エチルヘキシル55重量部、N-ヒドロキシエチルアクリルアミド5重量部、N-ビニル-2-ピロリドン40重量部、および溶媒として酢酸エチル233.3重量部を入れ、室温において窒素ガスバブリング(100mL/分)を行いながら1時間攪拌した。その後、反応容器の内容物を加熱し、60℃に達した時点で、重合開始剤として2,2’-アゾビスイソブチロニトリル0.2重量部を加えた。内容物の温度を60℃に保つよう制御し、窒素ガス流中で6時間重合を行い、次いで76℃で15時間保持した。当該溶液重合により、アクリル系共重合体(B)の溶液を得た。
(2)アクリル系共重合体溶液(B)に、該共重合体溶液の固形分50重量部に対して、有機液状成分としてミリスチン酸イソプロピルを45重量部添加した。さらに、薬物としてリドカインを5重量部添加した。これらを酢酸エチル溶液中にて撹拌して、粘着剤層形成用の組成物を得た。
(3)(2)で得られた粘着剤層形成用の組成物を乾燥後の厚みが40μmとなるように剥離ライナー(表面に剥離処理を施したポリエステルフィルム)上に塗布および乾燥して、粘着剤層を形成したこと以外は実施例1と同様にして、貼付製剤15を得た。
異なる種類のシリカ粒子を用いたこと以外は実施例15と同様にして、貼付製剤16~23を得た。なお、上記実施例1~23の粘着剤層は実質的に水を含まないものであった。
異なる種類のシリカ粒子を用いたこと以外は実施例15と同様にして、貼付製剤C8を得た。
シリカ粒子を添加せずに下塗り剤を調製したこと以外は実施例15と同様にして、貼付製剤C9を得た。
<投錨力試験>
12×50mmに裁断した貼付製剤をサンプルとした。サンプルの支持体面を両面テープで25×100mmのSUS板に固定し、剥離ライナーを剥離した後、粘着剤層面にセルガード(ヘキスト社製)(サンプル貼付面とは異なる面に両面テープで剥離紙が貼付されている)を、荷重2000gのローラを用いて貼付した。次いで、23℃、50%R.H.の条件下で、テンシロン引張試験機によって、180度方向に100mm/分の速度で剥離紙を剥離し、その際の負荷応力を測定した。
10 支持体
11 基材
12、12’ 下塗り剤層
20 粘着剤層
Claims (8)
- プラスチックフィルムを含む基材と、該基材上に積層された下塗り剤層とを備える貼付剤または貼付製剤用の支持体であって、
該下塗り層が、平均粒子径が1μm~15μmである多孔質無機粒子を含む、支持体。 - 前記多孔質無機粒子の細孔容積が、0.5ml/g~2.5ml/gである、請求項1に記載の支持体。
- 前記下塗り剤層の目付量が、0.1g/m2~10g/m2である、請求項1に記載の支持体。
- 前記多孔質無機粒子が、多孔質シリカ粒子である、請求項1に記載の支持体。
- 前記基材が、ポリオレフィン系樹脂フィルムを含む、請求項1に記載の支持体。
- 前記下塗り剤層が、バインダー樹脂をさらに含む、請求項1に記載の支持体。
- 請求項1に記載の支持体と、該支持体の片面に該下塗り剤層と隣接するように配置された粘着剤層とを備える貼付剤。
- 請求項7に記載の貼付剤において、粘着剤層がさらに薬物を含んでなる、貼付製剤。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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ES13840058T ES2777208T3 (es) | 2012-09-21 | 2013-09-20 | Cuerpo de soporte para parche transdérmico o preparación transdérmica, y parche transdérmico y preparación transdérmica que usan el mismo |
US14/427,208 US9622985B2 (en) | 2012-09-21 | 2013-09-20 | Support body for transdermal patch or transdermal preparation, and transdermal patch and transdermal preparation using same |
KR1020157006620A KR102071744B1 (ko) | 2012-09-21 | 2013-09-20 | 부착제 또는 부착 제제용 지지체 및 그것을 사용한 부착제 및 부착 제제 |
EP13840058.5A EP2898879B1 (en) | 2012-09-21 | 2013-09-20 | Support body for transdermal patch or transdermal preparation, and transdermal patch and transdermal preparation using same |
CN201380049046.6A CN104661657B (zh) | 2012-09-21 | 2013-09-20 | 贴附剂或贴附制剂用的支承体以及使用该支承体的贴附剂和贴附制剂 |
CA2883123A CA2883123C (en) | 2012-09-21 | 2013-09-20 | Support body for transdermal patch or transdermal preparation, and transdermal patch and transdermal preparation using same |
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JP2012-208538 | 2012-09-21 | ||
JP2012208538 | 2012-09-21 |
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PCT/JP2013/075500 WO2014046243A1 (ja) | 2012-09-21 | 2013-09-20 | 貼付剤または貼付製剤用の支持体ならびにそれを用いた貼付剤および貼付製剤 |
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US (1) | US9622985B2 (ja) |
EP (1) | EP2898879B1 (ja) |
JP (1) | JP6176846B2 (ja) |
KR (1) | KR102071744B1 (ja) |
CN (1) | CN104661657B (ja) |
CA (1) | CA2883123C (ja) |
ES (1) | ES2777208T3 (ja) |
WO (1) | WO2014046243A1 (ja) |
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US10010511B2 (en) * | 2016-05-25 | 2018-07-03 | Prosolus, Inc. | Transdermal drug delivery system |
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KR101978377B1 (ko) * | 2017-06-27 | 2019-05-15 | 동의대학교 산학협력단 | 치아 미백용 스티커 |
JP7490399B2 (ja) * | 2020-03-13 | 2024-05-27 | 日東電工株式会社 | 再剥離粘着テープ |
WO2022167953A1 (en) * | 2021-02-02 | 2022-08-11 | 3M Innovative Properties Company | Primer layer for flexographic plate mounting tape |
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KR102071744B1 (ko) | 2020-01-30 |
JP2014076990A (ja) | 2014-05-01 |
EP2898879A1 (en) | 2015-07-29 |
US20150238436A1 (en) | 2015-08-27 |
US9622985B2 (en) | 2017-04-18 |
CA2883123A1 (en) | 2014-03-27 |
EP2898879A4 (en) | 2016-05-18 |
CA2883123C (en) | 2020-06-02 |
JP6176846B2 (ja) | 2017-08-09 |
KR20150058208A (ko) | 2015-05-28 |
EP2898879B1 (en) | 2020-02-12 |
ES2777208T3 (es) | 2020-08-04 |
CN104661657A (zh) | 2015-05-27 |
CN104661657B (zh) | 2017-12-05 |
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