WO2013157320A1 - 湿潤性表面を有するシリコーンハイドロゲルソフトコンタクトレンズ - Google Patents
湿潤性表面を有するシリコーンハイドロゲルソフトコンタクトレンズ Download PDFInfo
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- WO2013157320A1 WO2013157320A1 PCT/JP2013/056613 JP2013056613W WO2013157320A1 WO 2013157320 A1 WO2013157320 A1 WO 2013157320A1 JP 2013056613 W JP2013056613 W JP 2013056613W WO 2013157320 A1 WO2013157320 A1 WO 2013157320A1
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- contact lens
- monomer
- soft contact
- silicone
- silicone hydrogel
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- 0 CC(C(O*CCN(C(C)=O)N)=O)=C Chemical compound CC(C(O*CCN(C(C)=O)N)=O)=C 0.000 description 2
- JBWKIWSBJXDJDT-UHFFFAOYSA-N ClC(c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound ClC(c1ccccc1)(c1ccccc1)c1ccccc1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- MEVXYMFPGMBKNN-UHFFFAOYSA-N OCCOCCOCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound OCCOCCOCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1 MEVXYMFPGMBKNN-UHFFFAOYSA-N 0.000 description 1
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/003—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor characterised by the choice of material
- B29C39/006—Monomers or prepolymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
- C08F220/282—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
- C08F220/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2083/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2011/00—Optical elements, e.g. lenses, prisms
- B29L2011/0016—Lenses
- B29L2011/0041—Contact lenses
Definitions
- the present invention relates to a hydrous soft contact lens having a wettable surface. More specifically, it is obtained by curing a polymerization solution containing at least one silicone monomer having at least one hydroxyl group or polyethylene glycol group in the molecular structure and glycerol mono (meth) acrylate in a double-sided cast mold. Even if the container used for polymerization is a hydrophobic resin material such as polypropylene, it is a post-treatment for improving the surface wettability of the lens-shaped material after polymerization, The present invention relates to a silicone hydrogel having a transparent and wettable surface without containing a high molecular weight hydrophilic polymer for enhancing water wettability.
- the hydrous soft contact lens is generally known to have good wearing feeling due to its soft material, but its oxygen permeability is lower than that of the hard contact lens because of its moisture content. Therefore, recently, a silicone hydrogel containing a silicone monomer or a siloxane macromonomer as one of the lens material components has been developed and commercialized. Moreover, as a manufacturing method of a soft contact lens, since a uniform product can be manufactured in large quantities, the manufacturing method by a cast mold manufacturing method is common.
- Polypropylene is often used as the material of the mold by the cast mold manufacturing method because it is inexpensive and easy to mold.
- the material of polypropylene itself is hydrophobic, and when such a material is used as a mold-type container and a silicone hydrogel is produced, the hydrophobic monomer will be oriented at the part in contact with the polymerization container.
- the lens surface after polymerization becomes highly hydrophobic. If the lens surface is hydrophobic, the lipid component in the tears tends to adhere, causing subjective symptoms such as the lens becoming cloudy or difficult to see while wearing contact lenses, or on the adhered lipid component. Furthermore, there is a possibility that eye diseases may be induced by the attachment of proteins or the like.
- Patent Document 1 a copolymer in which hydroperoxide is formed on the surface of a lens material by exposure to an oxygen atmosphere after low-temperature plasma treatment using an active gas and / or an inert gas is made hydrophilic at a temperature of 100 ° C. or higher.
- a treatment method for improving water wettability and wear resistance by immersing in an aqueous monomer solution and graft polymerizing a hydrophilic monomer on the surface involves many steps up to the production of the copolymer, low-temperature plasma treatment, immersion in a hydrophilic monomer aqueous solution, high-temperature treatment at 100 ° C. or higher, and imparting hydrophilicity to the surface. It is not preferable as a method of conversion.
- Patent Document 2 discloses a silicone hydrogel containing a high molecular weight hydrophilic polymer as an internal wetting agent in a lens material component.
- This method is a method in which a high molecular weight hydrophilic polymer such as polyvinylpyrrolidone is dissolved in a polymerization solution to be a lens component, and then the solution is polymerized to include the high molecular weight hydrophilic polymer in the lens component.
- a hydrophilic surface can be imparted without plasma treatment or graft polymerization of the surface.
- Patent Document 3 discloses a method of manufacturing a contact lens using a mold molded using a resin having a water absorption rate of 0.01 to 0.15% by weight.
- This method is not a polypropylene that has been used as a container material for the conventional cast mold manufacturing method, but a resin having higher water absorption and superior surface water wettability is used as a mold for contact lens production.
- This is a method for producing a contact lens having excellent surface wettability by orienting a hydrophilic monomer in a region close to the mold surface.
- this method is not preferred because the water absorption rate of the resin is high, which causes a problem in shape stability after molding of the mold material, and it is difficult to obtain molding conditions and resin accuracy.
- Patent Document 4 discloses a silicone hydrogel containing 20 to 60% by weight of N-vinyl pyrrolidone in a monomer mixed solution serving as a lens component. This method forms a homopolymer region of polyvinylpyrrolidone in the lens due to the difference in reactivity between N-vinylpyrrolidone having a vinyl group and other lens components having an acryloyl group or a methacryloyl group. As in the invention, a hydrophilic surface is imparted without using a high molecular weight hydrophilic polymer.
- N-vinylpyrrolidone having a different reactivity from the acryloyl group and methacryloyl group becomes a part of the lens in a form close to a homopolymer, and imparts hydrophilicity to the lens surface.
- 20 to 60% by weight of N-vinylpyrrolidone must be used, and the resulting silicone hydrogel has a water content of 50% or more.
- the water content of the lens increases, the amount of water that evaporates from the lens during lens wearing increases, and as a result, the frequency at which the wearer feels dryness increases. Therefore, a lens having a high water content is not preferable because it tends to be uncomfortable due to drying.
- Polyvinyl pyrrolidone exposed on the lens surface is not preferable because it has a slimy feeling and a sticky feeling as a tactile sensation and is difficult to rub after wearing and may be difficult to handle.
- Patent Document 5 discloses a polymer used for contact lens production, obtained from 5 to 95% by weight of at least one silicone-containing monomer and 5 to 80% of at least one hydrophilic monomer.
- glycerol methacrylate is exemplified as the hydrophilic monomer.
- the silicone monomers disclosed in this invention are monomers and macromonomers that do not contain at least one hydroxyl group or polyethylene glycol group in the molecular structure.
- glycerol methacrylate is disclosed as a hydrophilic monomer, this is merely illustrated as a monomer copolymerizable with a silicone monomer and a macromonomer, and materials using glycerol methacrylate are not disclosed in the examples. .
- paragraph [0029] in the specification describes three types of monomers, N, N-dimethylacrylamide, 2-hydroxyethyl methacrylate and N-vinyl-2-pyrrolidone as the most preferable hydrophilic monomers.
- the contact lens obtained from the mixture of the hydrophilic monomer and the silicone monomer is cloudy and is not suitable as a contact lens, or the lens surface exhibits water repellency and is a wettable surface. (Comparative Examples 1 to 5 of the present application).
- Patent Document 6 discloses a soft contact lens obtained from 2,3-dihydroxypropyl methacrylate and organosiloxanyl methacrylate. However, a two-component system of 2,3-dihydroxypropyl methacrylate and a silicone monomer that does not contain a hydroxyl group or a polyethylene glycol group in the molecular structure was unable to obtain a homogeneous monomer mixture (Comparative Examples 8-10). ). In all Examples of Patent Document 6, since glycidyl methacrylate is added, glycidyl methacrylate is considered to be one of essential components. However, this glycidyl methacrylate has strong eye irritation and is a component of contact lenses.
- the present invention has good surface wettability for the lens-shaped material after polymerization, even if it is polypropylene generally used as a mold material for the cast mold manufacturing method without using a special mold resin material. It is an object of the present invention to provide a silicone hydrogel having a wet surface without the need for post-treatment to make it into the surface and without containing a high molecular weight hydrophilic polymer for enhancing the water wettability of the surface.
- the inventor has polymerized a polymerization solution containing at least one silicone monomer having at least one hydroxyl group or polyethylene glycol group in the molecular structure and glycerol mono (meth) acrylate. It was found that the obtained silicone hydrogel can achieve the above object, and the present invention has been completed. According to the method of the present invention, a wettable surface can be easily obtained without using any special post-treatment or a high molecular weight hydrophilic polymer, and even when using a conventionally used polypropylene as a mold material. Can be obtained.
- the present invention is as follows.
- a hydrogel soft contact lens, a silicone hydrogel soft contact lens having a wettable surface without post-treatment to improve the surface water wettability of the lens-shaped material after polymerization is represented by the following general formula (I).
- R 1 , R 2 , R 3 and R 4 are methyl groups, a represents an integer of 1 to 3, n represents 0 or 1, and m represents 0 or 4 to 10. However, when n is 1, m is 0, and when n is 0, m is 4 to 10.
- X in the formula is one selected from substituents represented by the following formulas (Y1) to (Y3). ] (3) It is obtained by polymerizing a polymerization solution containing 30 to 70% by weight of a silicone monomer having at least one hydroxyl group or polyethylene glycol group in the molecular structure and 15 to 60% by weight of glycerol mono (meth) acrylate.
- the silicone hydrogel soft contact lens according to (1) or (2).
- the silicone monomer (c) containing no hydroxyl group or polyethylene glycol group in the molecular structure is tris (trimethylsiloxy) - ⁇ -methacryloxypropylsilane, methacryloyloxyethyl succinate 3- [tris (trimethylsiloxy) silyl]
- Soft contact lens is one or more monomers selected from 2-hydroxyethyl methacrylate, N-vinyl-2-pyrrolidone, and methacrylic acid.
- a method for producing a silicone hydrogel soft contact lens comprising: casting the mixed solution into a double-sided cast mold; and curing the mixed solution in the double-sided cast mold.
- a silicone hydrogel obtained by curing using a double-sided cast mold of a hydrophobic material such as polypropylene has good surface wettability on the lens-shaped material after polymerization. It is possible to provide a silicone hydrogel having a transparent and wettable surface without including a post-treatment for forming a high-molecular weight hydrophilic polymer for enhancing the water wettability of the surface.
- FIG. 1 is a 1 H-NMR spectrum of the compound obtained in Synthesis Example 1.
- FIG. 2 is a MALDI-TOF MS spectrum of the compound obtained in Synthesis Example 1.
- FIG. 3 is an IR spectrum of the compound obtained in Synthesis Example 2.
- the silicone monomer used in the present invention is not particularly limited as long as it has at least one hydroxyl group or polyethylene glycol group in the molecular structure, but those represented by the following general formula (I) are preferable.
- R 1 , R 2 , R 3 and R 4 are methyl groups, a represents an integer of 1 to 3, n represents 0 or 1, and m represents 0 or 4 to 10. However, when n is 1, m is 0, and when n is 0, m is 4 to 10 (value as a repeated average value).
- X in the formula is one selected from substituents represented by the following formulas (Y1) to (Y3). ]
- a silicone monomer having at least one hydroxyl group or polyethylene glycol group in the molecular structure and glycerol mono (meth) acrylate are essential components.
- Glycerol mono (meth) acrylate is a highly hydrophilic monomer having two hydroxyl groups in the molecular structure. Accordingly, in order to obtain a homogeneous monomer mixture, the molecular structure of the silicone monomer as the partner must have a hydrophilic unit such as a hydroxyl group or a polyethylene glycol group.
- Silicone monomers having such a structure are known compounds, such as Japanese Patent Laid-Open Nos. 55-15110, 63-16381, 4-332760, and 2000-191667.
- Japanese Unexamined Patent Publication No. 2001-323024 and US Pat. No. 4,395,496 disclose a contact lens material.
- the materials disclosed in JP-A-55-15110, JP-A-63-163811, JP-A-4-332760, US Pat. No. 4,395,496 and the like are hard contact lenses. Not a silicone hydrogel.
- 2000-191667 and 2001-32024 is a silicone hydrogel, and glycerol mono (meth) acrylate or glycerol mono (meth) acrylate is used as a copolymerizable monomer.
- Other names such as 2,3-dihydroxypropyl (meth) acrylate are exemplified (for example, paragraph number [0029] in JP-A No. 2000-191667 and paragraph number [0034] in JP-A No. 2001-32024).
- these descriptions are merely exemplified as monomers copolymerizable with silicone monomers, and glycerol mono (meth) acrylate and 2,3-dihydroxypropyl (meth) acrylate are not used in the examples.
- the silicone monomer used in the present invention is particularly preferably a monomer having the following A1 to A8 structure.
- polyethylene glycol group refers to a group having an ethylene glycol repeating number (average value) in the range of 4 to 10.
- m is 4 to 10.
- An example of a method for introducing a polyethylene glycol group into the molecular structure of the silicone monomer is as follows.
- tris (trimethylsiloxy) is obtained by hydrosilylation reaction.
- a method of obtaining a desired silicone monomer by reacting a compound having a methacryloyl group at one terminal hydroxyl group (for example, methacryl chloride, 2-isocyanatoethyl methacrylate, 2-methacryloyloxyethoxyethyl isocyanate, etc.).
- a compound having a methacryloyl group at one terminal hydroxyl group for example, methacryl chloride, 2-isocyanatoethyl methacrylate, 2-methacryloyloxyethoxyethyl isocyanate, etc.
- the value of m may have a distribution, and the average value thereof may be about 4 to about 10, or a precursor when the silicone monomer is synthesized.
- the number of glycol repeats is determined by using the number of glycols to be a single repeat number (for example, excluding other numbers (for example, 5 or 7) when n is 6) by column fractionation, etc. It may be made without the distribution of. In order to reduce variations in various physical properties such as mechanical strength and water wettability of the obtained lens, it is preferable that the number of polyethylene glycol repeats has no distribution and has a single unit structure.
- the silicone monomer content is preferably 30 to 70% by weight.
- the lens can be provided with a higher degree of flexibility and flexibility.
- the content of the silicone monomer is more preferably 40 to 70% by weight, and further preferably 40 to 65% by weight.
- silicone monomer refers to gel permeation when the number of silicon atoms in the molecular structure is 4 or less and the molecular weight is less than 1000, or when the number of repeating polyethylene glycol groups is distributed. It means that the number average molecular weight in terms of polystyrene is less than 1000 when measured by chromatography.
- the molecular weight is large, and when a fluorine-containing monomer is used, a fluorine atom exhibits strong water repellency. Tends to be oriented on the mold surface of polypropylene, that is, the lens surface, and the lens surface may exhibit strong water repellency. Therefore, in the present invention, it is preferable that the siloxane macromonomer, the fluorine-containing siloxane macromonomer and the fluorine-containing monomer are not used as raw material components.
- the macromonomer refers to a polymer having a number average molecular weight of 1000 or more when measured by gel permeation chromatography and calculated in terms of polystyrene. Specific examples include JP-A-2001-311917, Examples thereof include macromonomers described in JP-A Nos. 2001-183502 and 11-502949.
- the fluorine-containing monomer means a monomer having a molecular structure having 1 or more fluorine atoms and a molecular weight of less than 1000.
- Specific examples include 2,2,2-trifluoroethyl methacrylate, 1, Examples thereof include 1,1,3,3,3-hexafluoroisopropyl methacrylate and perfluorooctylethyloxypropylene methacrylate.
- glycerol mono (meth) acrylate is used as the second essential component.
- polypropylene is generally used as a mold material for contact lenses without using any special post-treatment or high molecular weight hydrophilic polymer. Even when used as, a silicone hydrogel having a wettable surface can be easily obtained. It is inferred that having such a specific effect is due to having two hydroxyl groups in the molecular structure of glycerol mono (meth) acrylate.
- the soft contact lens of the present invention exhibits high water repellency (high contact angle) in a dry state, but once the surface is wetted with water, the surface is uniformly covered with a film of water. The state is maintained for a long time.
- the lens surface is uniformly covered with a water film, and the contact angle is measured by the bubble method in water. Shows a low contact angle.
- N- [tris (hydroxymethyl) methyl] acrylamide when used, it does not dissolve with other monomers, and a homogeneous monomer mixture cannot be obtained (see Comparative Example 7 of the present application). Therefore, the use of glycerol mono (meth) acrylate is important in the present invention.
- glycerol mono (meth) acrylate which is an essential component
- structural isomers such as the following formulas (C1) and (C2).
- a mixture of structural isomers may be used, or a mixture consisting of only one of the structures may be used.
- (meth) acrylate means both acrylate and methacrylate.
- the content of glycerol mono (meth) acrylate is preferably 15 to 60% by weight.
- the content of glycerol mono (meth) acrylate 15% by weight or more, there is no need for any special post-treatment or high molecular weight hydrophilic polymer, and the conventionally used polypropylene is used as a template material. Even when it is used, it is possible to easily obtain a silicone hydrogel having a wettable surface, and by making it 60% by weight or less, it is possible to prevent the mechanical strength of the lens from being lowered.
- the content of glycerol mono (meth) acrylate is more preferably 20 to 50% by weight.
- specialty post-treatment refers to a method for improving the wettability of the contact lens surface, such as plasma treatment, graft treatment, base treatment, and acid treatment.
- a wet surface is a surface of the contact lens that is evenly covered with a film of water even after rinsing both surfaces of the contact lens with a cleaning solution for soft contact lenses and rinsing with distilled water or a rinse solution for soft contact lenses. It means that
- the hydrous soft contact lens of the present invention includes a silicone monomer that does not contain a hydroxyl group or polyethylene glycol group in the molecular structure in order to improve oxygen permeability, and a hydrophilic property for adjusting the moisture content.
- a crosslinking monomer for imparting mechanical strength and mechanical strength and durability can be included.
- silicone monomers having no hydroxyl group or polyethylene glycol group in the molecular structure include tris (trimethylsiloxy) - ⁇ -methacryloxypropylsilane, methacryloyloxyethyl succinate 3- [tris (trimethylsiloxy) silyl] propyl, methacryl Amidopropylbis (trimethylsiloxy) methylsilane, O-methacryloxyethoxy-N- [bis (trimethylsiloxy) methylsilyl] propylcarbamate, methacryloxymethylbis (trimethylsiloxy) methylsilane, 3-methacryloxypropylbis (trimethylsiloxy) methylsilane, One kind such as methacryloxymethyltris (trimethylsiloxy) silane, methacryloxypropylbis (trimethylsiloxy) silanol Monomer above mentioned, it can be used in the range of 0 to 20 wt%. By setting the content of these silicone monomers to 20% by weight or less
- hydrophilic monomer for adjusting the water content examples include one or more monomers selected from 2-hydroxyethyl methacrylate, N-vinyl-2-pyrrolidone, methacrylic acid and the like, and in the range of 0 to 50% by weight. Can be used. By setting the content of these hydrophilic monomers to 50% or less, an appropriate water content can be imparted to the lens.
- the content of the hydrophilic monomer is more preferably 0 to 45% by weight, still more preferably 0 to 40% by weight.
- crosslinkable monomer for imparting mechanical strength and durability examples include ethylene glycol di (meth) acrylate, triethylene glycol di (meth) acrylate, tetraethylene glycol di (meth) acrylate, allyl methacrylate, and vinyl methacrylate. , One or more monomers selected from diallyl maleate, triallyl isocyanurate, and the like.
- the content of these crosslinkable monomer components is preferably 0.1 to 1% by weight based on the total amount of the copolymer components.
- the content of the crosslinkable monomer is more preferably 0.2 to 0.8% by weight.
- the water-containing soft contact lens of the present invention has, as a copolymerization component, for example, a polymerizable ultraviolet absorber or the like in order to impart ultraviolet absorbing ability to the obtained soft contact lens or to color it for the purpose of improving visibility.
- a polymerizable dye or the like can be contained.
- the polymerizable ultraviolet absorber examples include 5-chloro-2- [2-hydroxy-5- ( ⁇ -methacryloyloxyethylcarbamoyloxyethyl)] phenyl-2H-benzotriazole, 2- [2-hydroxy -5- ( ⁇ -Methacryloyloxyethylcarbamoyloxyethyl)] phenyl-2H-benzotriazole, 5-chloro-2- [2-hydroxy-4- (p-vinylbenzyloxy-2-hydroxypropyloxy)] phenyl -2H-benzotriazole, 4-methacryloxy-2-hydroxybenzophenone, 2- (2'-hydroxy-5'-methacryloxyethylphenyl) -2H-benzotriazole, and the like.
- polymerizable dye examples include 1,4-bis (4-vinylbenzylamino) anthraquinone, 1-p-hydroxybenzylamino-4-p-vinylbenzylaminoanthraquinone, 1-anilino-4-methacryloylaminoanthraquinone. 1,4-bis [4- (2-methacryloxyethyl) phenylamino] -9,10-anthraquinone and the like.
- the contents of the polymerizable ultraviolet absorber and the polymerizable dye are influenced by the thickness of a lens produced from this material, it is 5% by weight or less, particularly preferably 0.02 to 3% by weight of the copolymer component. It is appropriate that By making the amount used 5% by weight or less, it is possible to prevent the mechanical strength of the obtained contact lens from being lowered, and it is also preferable from the viewpoint of the safety of the contact lens that is in direct contact with the living body.
- a polymerization initiator is added to the mixed solution containing the above monomers and sufficiently stirred to obtain a homogeneous mixed solution of monomers.
- the polymerization initiator used here include peroxides such as lauroyl peroxide, cumene hydroperoxide, and benzoyl peroxide, 2,2′-azobis (2,4-dimethylvaleronitrile), and 2,2′-azobis.
- benzoin methyl ether 1-hydroxycyclohexyl phenyl ketone, 2,2-dimethoxy-2-phenylacetophenone, 2-hydroxy-2-dimethoxy-1- Phenylpropan-1-one, phenylbis (2,4,6-trimethylbenzoyl) phosphine oxide, 2,4,6-trimethylbenzoyl-diphenyl-phosphine oxide, and the like can be used.
- the amount of the polymerization initiator is variously selected depending on the polymerization temperature, the light irradiation wavelength and the irradiation intensity, but is preferably 0.1 to 1% by weight.
- the polymerization can be carried out in the presence or absence of a suitable diluent.
- a suitable diluent may be any that dissolves the monomer components used homogeneously, such as alcohol (eg, ethanol, n-hexanol, octanol, 1,3-propanediol, 1,4-butane). Diol), dipolar aprotic solvents such as dimethyl sulfoxide, and the like.
- a diluent When a diluent is used, the viscosity of the monomer mixture decreases, making it easy to inject into the mold, and effectively removing the heat of polymerization during polymerization. The effect of improving the mechanical strength and reducing the elastic modulus of the lens can be expected.
- the monomer mixture is polymerized after being poured into a contact lens manufacturing mold having a contact lens shape.
- This mold is a mating mold having convex and concave curvatures, and is made of a material such as metal or resin. However, it is preferable that the material has good releasability during polymerization and is excellent in solvent resistance and heat resistance.
- a resin mold is preferable because a mold having a shape necessary for a desired lens design can be easily manufactured. These resin materials are preferably selected from those having low molding shrinkage, good surface transfer from metal, and excellent dimensional accuracy and solvent resistance. Polypropylene is preferred because of its price and availability.
- polypropylene it is not limited only to polypropylene, and for example, polyethylene, polyethylene terephthalate, polymethylpentene, polysulfone, polyphenylene sulfide, cyclic olefin copolymer, ethylene vinyl alcohol copolymer and the like may be used.
- a mold immediately after molding may be used, or a stock that has been stocked for about 10 to 40 hours may be used in order to stabilize the curvature of the mold.
- the pressure on the mold Prior to using the mold, the pressure on the mold is sufficiently reduced to remove substances that affect the reaction such as moisture and oxygen on the mold surface, and after purging with an inert gas such as nitrogen or argon, the monomer mixture is poured into the mold. May be injected.
- an inert gas such as nitrogen or argon
- it may be used after removing oxygen dissolved in the monomer mixture by bubbling the monomer mixture with an inert gas such as nitrogen or argon in advance. You may use without removing dissolved oxygen.
- Examples of the polymerization method include a photopolymerization method in which the photopolymerization initiator is blended and ultraviolet rays or visible rays are irradiated.
- the wavelength of light to be irradiated is appropriately selected depending on the characteristics of the blended photopolymerization initiator. It is possible to use a lamp that emphasizes the 400 to 425 nm region around the 420 nm region, a lamp that emphasizes the 400 to 450 nm region, and the like.
- the value of the light irradiation intensity varies depending on the area of the light receiving portion of the device for measuring the irradiation intensity.
- about 10 to Polymerization is preferably performed in the range of about 1 to 30 minutes with an irradiation intensity of 60 mW / cm 2 .
- the atmosphere at this time may be in the air, but it is also possible to polymerize in an inert gas atmosphere such as nitrogen or argon for the purpose of improving the polymerization rate of the obtained contact lens.
- an inert gas atmosphere such as nitrogen or argon
- a method by thermal polymerization in which the temperature is raised stepwise or continuously in a temperature range of 20 to 120 ° C. and the polymerization is completed in 30 minutes to 24 hours can be applied.
- the environment in the polymerization furnace may be atmospheric pressure conditions, or an atmosphere of an inert gas such as nitrogen or argon, and polymerization may be performed under pressurized conditions.
- the pressure in the furnace is preferably within a pressure range of 0.5 to 3 kgf / cm 2 .
- the mold is subsequently transferred to a polymerization furnace used for thermal polymerization, and then the temperature is raised stepwise or continuously in a temperature range of 20 to 120 ° C.
- the lens-shaped polymer taken out from the mold after polymerization can be removed by extracting unpolymerized monomers and oligomers with a solvent (for example, methanol, ethanol, isopropanol, methanol aqueous solution, ethanol aqueous solution, etc.). Subsequently, the target water-containing soft contact lens can be obtained by immersing it in physiological saline or a storage solution for soft contact lenses.
- a solvent for example, methanol, ethanol, isopropanol, methanol aqueous solution, ethanol aqueous solution, etc.
- the water content of the hydrous soft contact lens of the present invention is preferably 20% or more and less than 50%. If the water content is less than 20%, the lens cannot be provided with an appropriate flexibility, and if it is 50% or more, the moisture evaporation rate from the lens increases, and as a result, it tends to feel a dry feeling during wearing. This is not preferable.
- the water content of the lens is more preferably 20 to 45%.
- Silicone monomer 4Si-6PEG having at least one hydroxyl group or polyethylene glycol group in the molecular structure Silicone monomer 3Si-9PEG obtained in Synthesis Example 1: Silicone monomer 3Si-GMA obtained in Synthesis Example 2: Methacryl Oxy-2-hydroxypropoxypropylbis (trimethylsiloxy) methylsilane
- HEMA 2-hydroxyethyl methacrylate
- NVP N-vinyl-2-pyrrolidone
- MAA Methacrylic acid
- DMAA N, N-dimethylacrylamide
- Synthesis example 1 Synthesis of silicone monomer having only 6 PEG repeats Purchasing commercially available hexaethylene glycol was made to have only 6 repeat PEG moieties by column purification. Next, only one end of hexaethylene glycol was protected with trityl chloride (Scheme 1). The other end of the other end was allylated with allyl chloride (reaction formula 2), and then tris (trimethylsiloxy) silane was added by a hydrosilylation reaction using a platinum catalyst (reaction formula 3). Finally, the trityl group was deprotected to obtain a siloxane compound having only 6 ethylene oxide repeats (formula D1 below).
- the 1 H-NMR spectrum of this compound is shown in FIG. 1, and the MALDI-TOF MS spectrum is shown in FIG. From the 1 H-NMR spectrum, peaks derived from ethylene oxide units (3.6 ppm) and tris (trimethylsiloxy) propylsilane structures (3.4 ppm, 1.6 ppm, 0.4 ppm, 0.1 ppm) were detected. Further, from the MALDI-TOF MS spectrum, an ion [M + Na] + derived from the structure at m / z 641 was detected, and no other unit number (for example, 5 or 7) ions were detected. It was confirmed that the compound had only 6 ethylene oxide repeats.
- the measurement conditions of MALDI-TOF MS are as follows.
- Laser light source N2 laser (wavelength: 337 nm)
- Measurement mode reflector mode, positive ion mode
- Measurement mass range m / z: 20 to 3000 Integration count: 500 times
- Ionizing reagent Sodium trifluoroacetate (THF solution)
- the siloxane compound represented by D1 was reacted with methacryloyl chloride using 1,8-diazabicyclo [5.4.0] -7-undecene as a catalyst in an n-hexane solvent.
- the solution after the reaction was filtered through a glass fiber filter paper, washed with methanol and then with a saturated aqueous sodium chloride solution, purified by column purification, and further distilled off the solvent to obtain a silicone monomer of the following formula D2 (hereinafter, 4Si-6PEG) was obtained.
- Synthesis example 2 Synthesis of silicone monomer having an average number of PEG moiety repeats of 9 [3- (hydroxy (polyethyleneoxy) propyl] having an ethylene oxide repeat number of 1 to 17 and an average of PEG moiety repeat numbers of 9 Heptamethyltrisiloxane was used as the starting material. This compound was reacted with 2-isocyanatoethyl methacrylate in a methylene chloride solvent in the presence of a catalyst (dibutyltin dilaurate).
- a catalyst dibutyltin dilaurate
- Example 1 10 g (50 wt%) of 4Si-6PEG obtained in Synthesis Example 1, 10 g (50 wt%) of GlyMA, and 0.06 g of EDMA (4Si-6PEG and GlyMA as a crosslinkable monomer) in a brown glass bottle with a capacity of 20 mL 0.12 g of BAPO as a polymerization initiator (0.6% by weight with respect to the total amount of 4Si-6PEG and GlyMA) was weighed and stirred at room temperature for about 16 hours. .
- This monomer mixture was poured into a double-sided cast mold for making contact lenses made of polypropylene, and a cell made by sandwiching polyethylene terephthalate sheets of different thicknesses with a polypropylene plate as a spacer, and a UV curing device (Fusion UV Systems Japan, Inc.) was irradiated for 10 minutes with light having an irradiation intensity of 30 mW / cm 2 in the wavelength region of 395 to 445 nm. Then, it put into the hot-air circulation type dryer previously set to 110 degreeC, and superposition
- a UV curing device Fusion UV Systems Japan, Inc.
- the polymer in the shape of a lens and a flat plate after polymerization is taken out of the mold, immersed in a 50 vol% ethanol aqueous solution for 4 hours, and then rinsed with distilled water and further soft contact lens (trade name: Pure Soak S, manufactured by HOYA Corporation). )
- a soft contact lens and a plate-shaped polymer were obtained using the obtained soft contact lens and the plate-shaped polymer. The results are shown in Table 1.
- the resulting soft contact lens had a high transparency and a wettable surface.
- [Oxygen permeability coefficient] A plate-shaped polymer having a different thickness is punched with a trepan punch ( ⁇ 11 mm) for corneal epithelium, and is measured in an physiological saline solution at 35 ° C. by an electrode method film oxygen permeability measuring instrument manufactured by Tsukubarika Seiki Co., Ltd. The oxygen transmission coefficient was measured. The unit of the oxygen transmission coefficient is (cm 2 / sec) ⁇ (mLO 2 / mL ⁇ mmHg), and the oxygen transmission coefficient in the table is a value obtained by multiplying the original oxygen transmission coefficient by 10 11 .
- the soft contact lens was produced in the same manner as in Example 1 except that the monomer composition was changed to the composition shown in Table 1.
- the resulting soft contact lens had a high transparency and a wettable surface.
- Examples 11-12 The monomer composition of the soft contact lens was changed to the composition shown in Table 1 to obtain a monomer mixture.
- This monomer mixture was injected into a double-sided cast mold for making contact lenses made of polypropylene, and a cell made by sandwiching polyethylene terephthalate sheets of different thicknesses with a polypropylene plate as a spacer, and hot air circulation set at 110 ° C. in advance Polymerization was completed by putting in a dryer and heating for 60 minutes. After the polymerization, the polymer having a lens shape and a flat plate shape is immersed in a 50 vol% ethanol aqueous solution for 4 hours, and then replaced with distilled water or a rinse solution for soft contact lenses (trade name: Pure Soak S manufactured by HOYA). A soft contact lens and a plate-shaped polymer were obtained. Evaluation and measurement were performed using the obtained soft contact lens and the plate-shaped polymer. The results are shown in Table 1. The resulting soft contact lens had a high transparency and a wettable surface.
- Examples 13 to 16 The monomer composition of the soft contact lens was changed to the composition shown in Table 1 to obtain a monomer mixture.
- This monomer mixture was poured into a double-sided cast mold for making contact lenses made of polypropylene, and a cell made by sandwiching polyethylene terephthalate sheets of different thicknesses with a polypropylene plate as a spacer, and a UV curing device (Fusion UV Systems Using a V bulb of Japan Co., Ltd., light having an irradiation intensity of 30 mW / cm 2 in a wavelength region of 395 to 445 nm was irradiated for 5 minutes. Subsequently, the polymerization was completed by placing in a hot-air circulating drier previously set at 110 ° C.
- the polymer having a lens shape and a flat plate shape is immersed in a 50 vol% ethanol aqueous solution for 4 hours, and then replaced with distilled water or a rinse solution for soft contact lenses (trade name: Pure Soak S manufactured by HOYA).
- a soft contact lens and a plate-shaped polymer were obtained. Evaluation and measurement were performed using the obtained soft contact lens and the plate-shaped polymer. The results are shown in Table 1.
- the resulting soft contact lens had a high transparency and a wettable surface.
- Comparative Examples 1 to 5 (system not containing GlyMA as a constituent)
- the monomer composition of the soft contact lens was prepared with the composition shown in Table 2 to obtain a monomer mixture.
- This monomer mixture was injected into a double-sided cast mold for making contact lenses made of polypropylene, and a cell made by sandwiching polyethylene terephthalate sheets of different thicknesses with a polypropylene plate as a spacer, and hot air circulation set at 110 ° C. in advance Polymerization was completed by putting in a dryer and heating for 60 minutes.
- the polymer having a lens shape and a flat plate shape is immersed in a 50 vol% ethanol aqueous solution for 4 hours, and then replaced with distilled water or a rinse solution for soft contact lenses (trade name: Pure Soak S manufactured by HOYA).
- a soft contact lens and a plate-shaped polymer were obtained. Evaluation and measurement were performed using the obtained soft contact lens and the plate-shaped polymer. The results are shown in Table 2.
- the contact lenses of Comparative Examples 1 to 3 showed water repellency after scrubbing and washed, and the contact lens surface was hardly covered with a water film.
- the contact lenses of Comparative Examples 4 and 5 were immersed in a 50 vol% ethanol solution and then replaced with a soft contact lens rinse, the lenses became cloudy and could not be used as contact lenses.
- Comparative Example 6 system using 2-methacryloyloxyethyl acid phosphate as a monomer having two or more hydroxyl groups in the molecular structure
- 2-methacryloyloxyethyl acid phosphate (formula E1 below) as a contact lens component
- a monomer mixture shown in Table 2 was prepared. The monomer mixture was poured into a double-sided cast mold for making a contact lens made of polypropylene, placed in a hot air circulation dryer set at 110 ° C. in advance, and heated for 60 minutes to complete the polymerization.
- the polymer having a lens shape and a flat plate shape is immersed in a 50 vol% ethanol aqueous solution for 4 hours, and then replaced with distilled water or a rinse solution for soft contact lenses (trade name: Pure Soak S manufactured by HOYA).
- a soft contact lens and a plate-shaped polymer were obtained. The results are shown in Table 2.
- the obtained soft contact lens was colored yellow, showed water repellency after scrubbing and washed, and the contact lens surface was hardly covered with a water film.
- Comparative Example 7 (system using N- [tris (hydroxymethyl) methyl] acrylamide as a monomer having two or more hydroxyl groups in the molecular structure)
- the monomer mixture shown in Table 2 was prepared using N- [tris (hydroxymethyl) methyl] acrylamide (formula E2 below) as a contact lens component, but N- [tris (hydroxymethyl) methyl] acrylamide was completely It did not dissolve.
- Comparative Example 8 (when a silicone monomer containing no hydroxyl group or polyethylene glycol group in the molecular structure is used)
- a monomer mixture shown in Table 2 was prepared using 3- [tris (trimethylsiloxy) silyl] propyl methacryloyloxyethyl succinate (formula E3 below) as a component of the contact lens.
- the solution was separated into two layers, A homogeneous monomer mixture with glycerol methacrylate could not be obtained.
- Comparative Example 9 (when a silicone monomer containing no hydroxyl group or polyethylene glycol group in the molecular structure is used)
- the monomer mixture shown in Table 2 was prepared using tris (trimethylsiloxy- ⁇ -methacryloxypropylsilane (formula E4 below) as a contact lens component, but the solution was separated into two layers and homogeneous with glycerol methacrylate. It was not possible to obtain a simple monomer mixture.
- Comparative Example 10 (when a silicone monomer containing no hydroxyl group or polyethylene glycol group in the molecular structure is used)
- the monomer mixture shown in Table 2 was prepared using tris (trimethylsiloxy) silylpropylvinylcarbamate (formula E5 below) as a component of the contact lens, but the solution was separated into two layers, and a homogeneous monomer with glycerol methacrylate. A liquid mixture could not be obtained.
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Abstract
Description
レンズ表面が疎水性を示すと、涙液中の脂質成分が付着しやすくなり、コンタクトレンズ装用中にレンズがくもる、または見えにくくなるなどの自覚症状が発生したり、付着した脂質成分の上にさらにタンパク質などが付着することにより眼疾患を誘発したりする可能性が生じる。
(1)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーの少なくとも1種以上とグリセロールモノ(メタ)アクリレートとを含む混合液を両面キャストモールドの中で硬化させることによって得られるシリコーンハイドロゲルソフトコンタクトレンズであって、重合後のレンズ形状材料に表面の水濡れ性を良化させるための後処理をしなくても湿潤性表面を有するシリコーンハイドロゲルソフトコンタクトレンズ。
(2)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーが、下記一般式(I)で示される、(1)に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
[式中、R1、R2、R3およびR4はメチル基であって、aは1~3の整数を表し、nは0又は1を表し、mは0又は4~10を表わす。ただし、nが1であるときにはmは0であって、nが0であるときにはmは4~10である。式中のxは下記式(Y1)~(Y3)で表される置換基から選ばれた1つである。]
(3)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーが30~70重量%であり、グリセロールモノ(メタ)アクリレートが15~60重量%を含む重合溶液を重合することにより得られる(1)又は(2)に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(4)(a)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーが30~70重量%、
(b)グリセロールモノ(メタ)アクリレートが15~60重量%、
(c)分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマーが0~20重量%、
(d)親水性モノマーが0~50重量%、
(e)架橋性モノマーが0.1~1重量%
を含む混合液を重合することにより得られる(1)~(3)のいずれか1つに記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(5)分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマー(c)が、トリス(トリメチルシロキシ)-γ-メタクリロキシプロピルシラン、メタクリロイルオキシエチルコハク酸3-[トリス(トリメチルシロキシ)シリル]プロピルから選ばれる1種以上のモノマーである、(4)に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(6)親水性モノマー(d)が2-ヒドロキシエチルメタクリレート、N-ビニル-2-ピロリドン、メタクリル酸から選らばれる1種以上のモノマーである、(4)又は(5)に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(7)両面キャストモールドの材質がポリプロピレンである(1)~(6)のいずれか1つに記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(8)該ソフトコンタクトレンズの含水率が20%以上、50%未満である、(1)~(7)のいずれか1つに記載のシリコーンハイドロゲルソフトコンタクトレンズ。
(9)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーの少なくとも1種以上とグリセロールモノ(メタ)アクリレートとを混合することによって、混合液を調製する工程;
該混合液を両面キャストモールド型にキャストする工程;及び
該混合液を該両面キャストモールド型中で硬化させる工程
を含む、シリコーンハイドロゲルソフトコンタクトレンズの製造方法。
(10)重合後のレンズ形状材料に表面の水濡れ性を良化させるための後処理をしない、(9)に記載の製造方法。
[式中、R1、R2、R3およびR4はメチル基であって、aは1~3の整数を表し、nは0又は1を表し、mは0又は4~10を表わす。ただし、nが1であるときにはmは0であって、nが0であるときにはmは4~10(繰り返し平均値としての値)である。式中のxは下記式(Y1)~(Y3)で表される置換基から選ばれた1つである。]
式A3~A8においては、mは4~10である。シリコーンモノマーの分子構造中にポリエチレングリコール基を導入する方法の一例としては以下が挙げられる。すなわち、テトラエチレングリコール、ペンタエチレングリコール、ヘキサエチレングリコール、ヘプタエチレングリコール、オクタエチレングリコール、ノナエチレングリコール、デカエチレングリコールなどのエチレングリコールの片末端をアリル化した後、ヒドロシリル化反応によりトリス(トリメチルシロキシ)シリル基、やメチルビス(トリメチルシロキシ)シリル基と反応させる。次に、片末端の水酸基にメタクリロイル基を有する化合物(例えば、メタクリルクロライド、2-イソシアナトエチルメタクリレート、2-メタクリロイルオキシエトキシエチルイソシアネートなど)を反応させて目的のシリコーンモノマーを得る方法である。このとき、ポリエチレングリコールの繰り返し単位が4以上のグリコールを単品で入手することは困難であるので、複数の繰り返し数を有するグリコールが混在しているのが一般的である。本発明に用いるA3~A8のモノマーについては、mの値が分布を有しその平均値が約4~約10であるものであっても良いし、シリコーンモノマーの合成を行う際に、前駆体となるグリコール類をカラム分取などにより単一繰り返し数(例えば、nが6のときにその他の数(例えば5や7)は含まない)にした上で合成に用いることで、グリコールの繰り返し数の分布がないものにしても良い。得られるレンズの機械的強度や水濡れ性をはじめとする種々の物性値のばらつきを少なくするためには、ポリエチレングリコールの繰り返し数は分布がなく、単一ユニット構造である方が好ましい。
本明細書において「平均値」とは、シリコーンモノマー構造中のポリエチレングリコール基の繰り返し数が分布を有している場合に適用され、出発原料となる前駆体あるいは最終構造物を1H-NMR分析し、エチレンオキサイドユニットのピーク積分強度比を用いて算出した繰り返し数のことをいう。
本発明のコンタクトレンズにおいて、シリコーンモノマーの含有量は、30~70重量%であることが好ましい。シリコーンモノマーの含有量を30重量%以上とすることで、この材料から調製されるコンタクトレンズに十分な酸素透過性を付与することが可能となり、70重量%以下とすることで素材に適度な含水率を付与することが出来、さらに柔軟性に富んだレンズを得ることが出来る。シリコーンモノマーの含有量は、より好ましくは40~70重量%であり、40~65重量%であることがさらに好ましい。本発明においてシリコーンモノマーとは、分子構造中のケイ素原子の数が4以下であって分子量が1000未満のものであるか、ポリエチレングリコール基の繰り返し数に分布がある場合には、ゲルパーミエーションションクロマトグラフィーによる測定で、ポリスチレン換算で数平均分子量を算出したときに1000未満であるもののことをいう。
以下の実施例で用いられている化学物質の名称と略語を示す。
4Si-6PEG:合成例1で得られたシリコーンモノマー
3Si-9PEG:合成例2で得られたシリコーンモノマー
3Si-GMA:メタクリルオキシ-2-ヒドロキシプロポキシプロピルビス(トリメチルシロキシ)メチルシラン
GlyMA:グリセロールモノメタクリレート
MTS:メタクリロイルオキシエチルコハク酸3-[トリス(トリメチルシロキシ)シリル]プロピル
TRIS:トリス(トリメチルシロキシ)-γ-メタクリロキシプロピルシラン
TRIS-VC:トリス(トリメチルシロキシ)シリルプロピルビニルカルバメート
HEMA:2-ヒドロキシエチルメタクリレート
NVP:N-ビニル-2-ピロリドン
MAA:メタクリル酸
DMAA:N,N-ジメチルアクリルアミド
EDMA:エチレングリコールジメタクリレート
DAM:ジアリルマレエート
VMA:ビニルメタクリレート
P-1M:2-メタクリロイルオキシエチルアシッドホスフェート
TRIS-AA:N-[トリス(ヒドロキシメチル)メチル]アクリルアミド
AIBM:2,2’-アゾビス(イソブチロニトリル)
BAPO:フェニルビス(2,4,6-トリメチルベンゾイル)ホスフィンオキサイド
PEG部分の繰り返し数が6のみであるシリコーンモノマーの合成
市販のヘキサエチレングリコールを購入し、カラム精製によりPEG部分の繰り返し数が6のもののみとした。次に、ヘキサエチレングリコールの片末端のみをトリチルクロリドを用いて保護した(反応式1)。もう一方の片末端はアリルクロライドを用いてアリル化した後(反応式2)、白金触媒を用いたヒドロシリル化反応によりトリス(トリメチルシロキシ)シランを付与した(反応式3)。最後に、トリチル基を脱保護することでエチレンオキサイドの繰り返し数が6のみであるシロキサン化合物(下記式D1)を得た。
観測周波数:1H;600MHz
測定溶媒:CDCl3
測定温度:室温
化学シフト基準:測定溶媒(1H:7.25ppm)
レーザー光源:N2レーザー(波長:337nm)
測定モード:リフレクターモード、ポジティブイオンモード
測定質量範囲(m/z):20~3000
積算回数:500回
イオン化試薬:トリフルオロ酢酸ナトリウム(THF溶液)
合成例2
PEG部分の繰り返し数の平均値が9であるシリコーンモノマーの合成
エチレンオキサイドの繰り返し数が1~17であって、PEG部分の繰り返し数の平均値が9である3-[ヒドロキシ(ポリエチレンオキシ)プロピル]ヘプタメチルトリシロキサンを出発原料に用いた。この化合物を触媒(ジブチルスズジラウレート)の存在下で、2-イソシアナトエチルメタクリレートと塩化メチレン溶媒中で反応させた。反応はIRスペクトルにおけるイソシアネートの吸収帯が消失するまで行い、反応終了後濾過および溶媒を留去することで下記式D3のシリコーンモノマー(以下、3Si-9PEG)を得た。この化合物のIRスペクトルを図3に示す。また、ゲルパーミエーションクロマトグラフィーにより分子量測定を行った結果、数平均分子量は907(ポリスチレン換算)であった。
カラム:Shodex KF-402.5HQ 2本
溶離液:THF
流 量:0.3mL/min
検出器:RI
カラム温度:40℃
容量20mLの褐色のガラス瓶に合成例1で得られた4Si-6PEGを10g(50重量%)、GlyMAを10g(50重量%)、架橋性モノマーとしてEDMAを0.06g(4Si-6PEGとGlyMAの合計量に対して0.3重量%)、重合開始剤としてBAPOを0.12g(4Si-6PEGとGlyMAの合計量に対して0.6重量%)を計り取り、室温で約16時間撹拌した。このモノマー混合液をポリプロピレン製のコンタクトレンズ作製用の両面キャストモールド型、および厚さの異なるポリエチレンテレフタレートシートをスペーサーとしてポリプロピレン板で挟むことにより作製したセルに注入し、UV硬化装置(フュージョンUVシステムズ・ジャパン(株))のVバルブを用いて、395~445nmの波長域の照射強度が30mW/cm2の光を10分間照射した。引き続き、あらかじめ110℃に設定した熱風循環式乾燥機に入れ、60分加熱することで重合を完結させた。
重合前のモノマー混合液の一部を透明なガラス瓶に入れ、目視で以下の評価基準に従い評価した。
評価基準
○:モノマー混合液は溶解し均質である
×:モノマー混合液は白濁するか二層に分離し溶解しない
ソフトコンタクトレンズの透明性を、目視で以下の評価基準に従い評価した。
評価基準
○:レンズは透明である
×:レンズは白濁あるいは黄色に着色している
ソフトコンタクトレンズの両面をソフトコンタクトレンズ用洗浄液(HOYA(株)社製 商品名:ピュアクリーナーS)でこすり洗いし、その後、蒸留水で十分にすすいだ。すすぎ後のソフトコンタクトレンズをピンセットでつまみ、コンタクトレンズ表面の水濡れ性を目視で以下の評価基準に従い評価した。
評価基準
○:レンズの表面は一様に水の膜で覆われている
×:レンズ表面は撥水性を示し、水の膜で覆われている部分はほとんどない
23℃で平衡膨潤に達したソフトコンタクトレンズの含水状態の重量(Ww)、および真空乾燥機で70℃、4時間以上乾燥させた乾燥状態の重量(Wd)を測定し、次式により含水率を算出した。
含水率(%)=(Ww-Wd)/Ww×100
厚さの異なる平板形状の重合物を角膜上皮用トレパン・パンチ(φ11mm)で打ち抜き、ツクバリカセイキ(株)社製の電極法フィルム酸素透過率測定器により、35℃の生理食塩液中にて酸素透過係数を測定した。なお、酸素透過係数の単位は(cm2/sec)・(mLO2/mL×mmHg)であり、表中の酸素透過係数は、本来の酸素透過係数に1011を乗じた値である。
ソフトコンタクトレンズ表面の水濡れ性を接触角測定により評価した。ソフトコンタクトレンズ表面の水分を拭き取った後、保持台にレンズを貼り付け、蒸留水を用いた液滴法により接触角を測定した。測定には協和界面科学(株)社製の接触角計を用い、液滴の大きさはシリンジで約1.5mmとした。
また、ソフトコンタクトレンズを保持台に貼り付け、その保持台ごと25℃の蒸留水中に浸漬し、シリンジを用いて約1.7μLの気泡をソフトコンタクトレンズ表面に付着させ、蒸留水中におけるソフトコンタクトレンズと気泡とのなす角を測定した。いずれの測定方法においても、値が小さい方が水濡れ性に優れることを表す。
ソフトコンタクトレンズのモノマー組成を表1に示す組成に変更した以外は、実施例1と同様の方法で作製した。得られたソフトコンタクトレンズは、高い透明性と湿潤性表面を有するものであった。
ソフトコンタクトレンズのモノマー組成を表1に示す組成に変更しモノマー混合液を得た。このモノマー混合液をポリプロピレン製のコンタクトレンズ作製用の両面キャストモールド型、および厚さの異なるポリエチレンテレフタレートシートをスペーサーとしてポリプロピレン板で挟むことにより作製したセルに注入し、あらかじめ110℃に設定した熱風循環式乾燥機に入れ60分加熱することで重合を完結させた。
重合後のレンズ形状および平板形状の重合物を50vol%エタノール水溶液に4時間浸漬した後、蒸留水、さらにはソフトコンタクトレンズ用すすぎ液(HOYA(株)社製 商品名:ピュアソークS)で置換しソフトコンタクトレンズおよび平板形状重合物を得た。得られたソフトコンタクトレンズおよび平板形状重合物を用いて評価および測定を行った。結果を表1に示す。得られたソフトコンタクトレンズは、高い透明性と湿潤性表面を有するものであった。
ソフトコンタクトレンズのモノマー組成を表1に示す組成に変更しモノマー混合液を得た。このモノマー混合液をポリプロピレン製のコンタクトレンズ作製用の両面キャストモールド型、および厚さの異なるポリエチレンテレフタレートシートをスペーサーとしてポリプロピレン板で挟むことにより作製したセルに注入し、UV硬化装置(フュージョンUVシステムズ・ジャパン(株))のVバルブを用いて、395~445nmの波長域の照射強度が30mW/cm2の光を5分間照射した。引き続き、あらかじめ110℃に設定した熱風循環式乾燥機に入れ30分加熱することで重合を完結させた。
重合後のレンズ形状および平板形状の重合物を50vol%エタノール水溶液に4時間浸漬した後、蒸留水、さらにはソフトコンタクトレンズ用すすぎ液(HOYA(株)社製 商品名:ピュアソークS)で置換しソフトコンタクトレンズおよび平板形状重合物を得た。得られたソフトコンタクトレンズおよび平板形状重合物を用いて評価および測定を行った。結果を表1に示す。得られたソフトコンタクトレンズは、高い透明性と湿潤性表面を有するものであった。
ソフトコンタクトレンズのモノマー組成を表2に示す組成で調製しモノマー混合液を得た。このモノマー混合液をポリプロピレン製のコンタクトレンズ作製用の両面キャストモールド型、および厚さの異なるポリエチレンテレフタレートシートをスペーサーとしてポリプロピレン板で挟むことにより作製したセルに注入し、あらかじめ110℃に設定した熱風循環式乾燥機に入れ60分加熱することで重合を完結させた。重合後のレンズ形状および平板形状の重合物を50vol%エタノール水溶液に4時間浸漬した後、蒸留水、さらにはソフトコンタクトレンズ用すすぎ液(HOYA(株)社製 商品名:ピュアソークS)で置換しソフトコンタクトレンズおよび平板形状重合物を得た。得られたソフトコンタクトレンズおよび平板形状重合物を用いて評価および測定を行った。結果を表2に示す。比較例1~3のコンタクトレンズは、こすり洗い洗浄後において撥水性を示し、コンタクトレンズ表面が水の膜で覆われている部分はほとんどなかった。次に、比較例4および5のコンタクトレンズは、50vol%エタノール溶液に浸漬した後、ソフトコンタクトレンズ用すすぎ液で置換したところレンズは白濁しコンタクトレンズとして使用できるものではなかった。
コンタクトレンズの成分として2-メタクリロイルオキシエチルアシッドフォスフェート(下記式E1)を用いて、表2に示すモノマー混合液を調製した。このモノマー混合液をポリプロピレン製のコンタクトレンズ作製用の両面キャストモールド型に注入し、あらかじめ110℃に設定した熱風循環式乾燥機に入れ60分加熱することで重合を完結させた。重合後のレンズ形状および平板形状の重合物を50vol%エタノール水溶液に4時間浸漬した後、蒸留水、さらにはソフトコンタクトレンズ用すすぎ液(HOYA(株)社製 商品名:ピュアソークS)で置換しソフトコンタクトレンズおよび平板形状重合物を得た。結果を表2に示す。得られたソフトコンタクトレンズは黄色に着色し、しかもこすり洗い洗浄後において撥水性を示し、コンタクトレンズ表面が水の膜で覆われている部分はほとんどなかった。
コンタクトレンズの成分としてN-[トリス(ヒドロキシメチル)メチル]アクリルアミド(下記式E2)を用いて、表2に示すモノマー混合液を調製したが、N-[トリス(ヒドロキシメチル)メチル]アクリルアミドが全く溶解しなかった。
比較例8(分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマーを用いた場合)
コンタクトレンズの成分として、メタクリロイルオキシエチルコハク酸3-[トリス(トリメチルシロキシ)シリル]プロピル(下記式E3)を用いて、表2に示すモノマー混合液を調製したが、溶液は二層分離し、グリセロールメタクリレートとの均質なモノマー混合液を得ることは出来なかった。
コンタクトレンズの成分として、トリス(トリメチルシロキシ-γ-メタクリロキシプロピルシラン(下記式E4)を用いて、表2に示すモノマー混合液を調製したが、溶液は二層分離し、グリセロールメタクリレートとの均質なモノマー混合液を得ることは出来なかった。
比較例10(分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマーを用いた場合)
コンタクトレンズの成分として、 トリス(トリメチルシロキシ)シリルプロピルビニルカルバメート(下記式E5)を用いて、表2に示すモノマー混合液を調製したが、溶液は二層分離し、グリセロールメタクリレートとの均質なモノマー混合液を得ることは出来なかった。
Claims (10)
- 分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーの少なくとも1種以上とグリセロールモノ(メタ)アクリレートとを含む混合液を両面キャストモールドの中で硬化させることによって得られるシリコーンハイドロゲルソフトコンタクトレンズであって、重合後のレンズ形状材料に表面の水濡れ性を良化させるための後処理をしなくても湿潤性表面を有するシリコーンハイドロゲルソフトコンタクトレンズ。
- 分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーが30~70重量%であり、グリセロールモノ(メタ)アクリレートが15~60重量%を含む重合溶液を重合することにより得られる請求項1又は2に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
- (a)分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーが30~70重量%、
(b)グリセロールモノ(メタ)アクリレートが15~60重量%、
(c)分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマーが0~20重量%、
(d)親水性モノマーが0~50重量%、
(e)架橋性モノマーが0.1~1重量%
を含む混合液を重合することにより得られる請求項1~3のいずれか1項に記載のシリコーンハイドロゲルソフトコンタクトレンズ。 - 分子構造中に水酸基またはポリエチレングリコール基を含まないシリコーンモノマー(c)が、トリス(トリメチルシロキシ)-γ-メタクリロキシプロピルシラン、メタクリロイルオキシエチルコハク酸3-[トリス(トリメチルシロキシ)シリル]プロピルから選ばれる1種以上のモノマーである、請求項4に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
- 親水性モノマー(d)が2-ヒドロキシエチルメタクリレート、N-ビニル-2-ピロリドン、メタクリル酸から選らばれる1種以上のモノマーである、請求項4又は5に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
- 両面キャストモールドの材質がポリプロピレンである請求項1~6のいずれか1項に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
- 該ソフトコンタクトレンズの含水率が20%以上、50%未満である、請求項1~7のいずれか1項に記載のシリコーンハイドロゲルソフトコンタクトレンズ。
- 分子構造中に少なくとも1つの水酸基またはポリエチレングリコール基を有するシリコーンモノマーの少なくとも1種以上とグリセロールモノ(メタ)アクリレートとを混合することによって、混合液を調製する工程;
該混合液を両面キャストモールド型にキャストする工程;及び
該混合液を該両面キャストモールド型中で硬化させる工程
を含む、シリコーンハイドロゲルソフトコンタクトレンズの製造方法。 - 重合後のレンズ形状材料に表面の水濡れ性を良化させるための後処理をしない、請求項9に記載の製造方法。
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Also Published As
Publication number | Publication date |
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SG11201402563RA (en) | 2014-09-26 |
US20140362339A1 (en) | 2014-12-11 |
KR101918645B1 (ko) | 2018-11-15 |
JP2013222141A (ja) | 2013-10-28 |
EP2840431A4 (en) | 2016-01-06 |
JP5927014B2 (ja) | 2016-05-25 |
CN103959140A (zh) | 2014-07-30 |
EP2840431B1 (en) | 2016-09-07 |
CN103959140B (zh) | 2016-05-04 |
EP2840431A1 (en) | 2015-02-25 |
US10241234B2 (en) | 2019-03-26 |
KR20140146050A (ko) | 2014-12-24 |
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