WO2012138254A3 - Dérivés de 4,4'-diphénylamines possédant une activité pharmacologique et médicaments sur leur base - Google Patents

Dérivés de 4,4'-diphénylamines possédant une activité pharmacologique et médicaments sur leur base Download PDF

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Publication number
WO2012138254A3
WO2012138254A3 PCT/RU2012/000238 RU2012000238W WO2012138254A3 WO 2012138254 A3 WO2012138254 A3 WO 2012138254A3 RU 2012000238 W RU2012000238 W RU 2012000238W WO 2012138254 A3 WO2012138254 A3 WO 2012138254A3
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WO
WIPO (PCT)
Prior art keywords
pharmacologically active
drugs based
biphenylamide
derivatives
neurodegenerative diseases
Prior art date
Application number
PCT/RU2012/000238
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English (en)
Russian (ru)
Other versions
WO2012138254A2 (fr
Inventor
Максим Эдуардович ЗАПОЛЬСКИЙ
Николай Серафимович ЗЕФИРОВ
Владимир Александрович ПАЛЮЛИН
Мстислав Игоревич ЛАВРОВ
Алексей Сергеевич МОРОЗОВ
Вера Леонидовна ЛАПТЕВА
Original Assignee
Zapolsky Maxim Eduardovich
Zefirov Nikolay Serafimovich
Palyulin Vladimir Alexandrovich
Lavrov Mstislav Igorevich
Morozov Alexey Sergeevich
Lapteva Vera Leonidovna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zapolsky Maxim Eduardovich, Zefirov Nikolay Serafimovich, Palyulin Vladimir Alexandrovich, Lavrov Mstislav Igorevich, Morozov Alexey Sergeevich, Lapteva Vera Leonidovna filed Critical Zapolsky Maxim Eduardovich
Publication of WO2012138254A2 publication Critical patent/WO2012138254A2/fr
Publication of WO2012138254A3 publication Critical patent/WO2012138254A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne de nouveaux dérivés de 4,4'-diphénylamines possédant une activité pharmacologique et pouvant être utilisés pour traiter la maladie d'Alzheimer, la maladie de Parkinson et d'autres pathologies neurodégénératives. La présente invention concerne également les médicaments comprenant les substances en question. L'invention propose des dérivés de 4,4'-diphénylamines possédant une activité pharmacologique correspondant aux formules générales 1 dans lesquelles: HY représente ici et plus bas un acide pharmaceutiquement acceptable; R1, R1' peuvent être identiques ou différents et chacun représente indépendamment Н, alkyle C1-C6, alcoxy C1-C10, halogène, un groupe nitro, un groupe amino, nitrile, acyle, aryle; R3, R3', R4, R4', R5, R5', R6, R6' et peuvent être identiques ou différents, et chacun représente indépendamment Н, alkyle C1-C6, alcoxy C1-C10; R2 est représenté conjointement par les formules générales (1.1а), (1.2а), (1.3а), (1.4а), (1.5а). L'invention porte aussi sur des médicaments pour traiter les troubles cognitifs, y compris les troubles de l'attention ou de la mémoire quelle que soit leur genèse; pour traiter les troubles de comportement liés aux troubles cognitifs; pour traiter les troubles déficitaires en cas de troubles psychiques fonctionnels; pour traiter le syndrome dit « Attention Deficit Hyperactivity Disorder (ADHD) »; pour traiter les manifestations d'hypersomnie et de narcolepsie; pour traiter les troubles d'humeur; pour améliorer la mémoire et l'attention et pour faciliter l'apprentissage chez les personnes en bonne santé pendant les périodes d'un effort plus important; pour la prévention des effets nocifs des interventions chirurgicales sur le SNC pendant lors du sommeil artificiel ou pendant les interventions neurochirurgicales. Cette invention permet d'élargir la gamme de médicaments pouvant s'utiliser en tant que nouveaux modulateurs allostériques efficaces des récepteurs AMPA.
PCT/RU2012/000238 2011-04-06 2012-04-02 Dérivés de 4,4'-diphénylamines possédant une activité pharmacologique et médicaments sur leur base WO2012138254A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011113045 2011-04-06
RU2011113045/15A RU2456266C1 (ru) 2011-04-06 2011-04-06 Производные 4,4'-бифениламидов, обладающие фармакологической активностью, и лекарственные средства на их основе

Publications (2)

Publication Number Publication Date
WO2012138254A2 WO2012138254A2 (fr) 2012-10-11
WO2012138254A3 true WO2012138254A3 (fr) 2012-12-13

Family

ID=46847377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2012/000238 WO2012138254A2 (fr) 2011-04-06 2012-04-02 Dérivés de 4,4'-diphénylamines possédant une activité pharmacologique et médicaments sur leur base

Country Status (2)

Country Link
RU (1) RU2456266C1 (fr)
WO (1) WO2012138254A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110173A2 (fr) * 2004-10-05 2006-10-19 Smithkline Beecham Corporation Nouveaux composes
WO2007031791A1 (fr) * 2005-09-16 2007-03-22 Arrow Therapeutics Limited Dérivés de biphényle et leur utilisation dans le traitement de l'hépatite c
WO2010137351A1 (fr) * 2009-05-29 2010-12-02 Raqualia Pharma Inc. Dérivés de carboxamide substitués par aryle comme inhibiteurs des canaux calciques ou sodiques
RU2009126653A (ru) * 2009-07-14 2011-01-20 Учреждение Российской Академии наук Институт физиологически активных веществ РАН (ИФАВ РАН) (RU) Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110173A2 (fr) * 2004-10-05 2006-10-19 Smithkline Beecham Corporation Nouveaux composes
WO2007031791A1 (fr) * 2005-09-16 2007-03-22 Arrow Therapeutics Limited Dérivés de biphényle et leur utilisation dans le traitement de l'hépatite c
WO2010137351A1 (fr) * 2009-05-29 2010-12-02 Raqualia Pharma Inc. Dérivés de carboxamide substitués par aryle comme inhibiteurs des canaux calciques ou sodiques
RU2009126653A (ru) * 2009-07-14 2011-01-20 Учреждение Российской Академии наук Институт физиологически активных веществ РАН (ИФАВ РАН) (RU) Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n,n'-замещенных 3,7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения

Also Published As

Publication number Publication date
RU2456266C1 (ru) 2012-07-20
WO2012138254A2 (fr) 2012-10-11

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