WO2012134184A8 - 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 - Google Patents

신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 Download PDF

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Publication number
WO2012134184A8
WO2012134184A8 PCT/KR2012/002302 KR2012002302W WO2012134184A8 WO 2012134184 A8 WO2012134184 A8 WO 2012134184A8 KR 2012002302 W KR2012002302 W KR 2012002302W WO 2012134184 A8 WO2012134184 A8 WO 2012134184A8
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WO
WIPO (PCT)
Prior art keywords
chemical formula
novel cephalosporin
cephalosporin derivative
pharmaceutical compositions
prodrug
Prior art date
Application number
PCT/KR2012/002302
Other languages
English (en)
French (fr)
Other versions
WO2012134184A2 (ko
WO2012134184A3 (ko
Inventor
조영락
윤정율
박철순
채상은
이향숙
오규만
허혜진
강대혁
양영재
권현진
박태교
우성호
김용주
Original Assignee
주식회사 레고켐 바이오사이언스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SG2013072962A priority Critical patent/SG193998A1/en
Priority to BR112013025275A priority patent/BR112013025275A2/pt
Priority to PL12765589T priority patent/PL2706062T3/pl
Priority to SI201231355T priority patent/SI2706062T1/sl
Priority to DK12765589.2T priority patent/DK2706062T3/en
Priority to EP12765589.2A priority patent/EP2706062B1/en
Priority to LTEP12765589.2T priority patent/LT2706062T/lt
Priority to MX2013010961A priority patent/MX359435B/es
Priority to AU2012237063A priority patent/AU2012237063B2/en
Priority to ES12765589.2T priority patent/ES2683351T3/es
Priority to CA2831421A priority patent/CA2831421C/en
Priority to EA201391325A priority patent/EA024709B1/ru
Priority to JP2014502466A priority patent/JP6144669B2/ja
Priority to CN201280015502.0A priority patent/CN103547583B/zh
Application filed by 주식회사 레고켐 바이오사이언스 filed Critical 주식회사 레고켐 바이오사이언스
Priority to US13/467,019 priority patent/US8329684B2/en
Publication of WO2012134184A2 publication Critical patent/WO2012134184A2/ko
Priority to US13/691,221 priority patent/US9630977B2/en
Publication of WO2012134184A3 publication Critical patent/WO2012134184A3/ko
Priority to IL228408A priority patent/IL228408A/en
Priority to CU2013000125A priority patent/CU20130125A7/es
Publication of WO2012134184A8 publication Critical patent/WO2012134184A8/ko
Priority to ZA2013/08078A priority patent/ZA201308078B/en
Priority to HRP20181170TT priority patent/HRP20181170T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

본 발명은 명세서 상의 화학식 1로 표시되는 신규한 세파로스포린 유도체에 관한 것이다. 화학식 1에서, X, Y, L, R1, R2 는 발명의 상세한 설명에 정의된 바와 동일하다. 또한, 본 발명은 상기 화학식 1의 신규한 세파로스포린 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염을 유효성분으로 함유하는 항생제용 의약 조성물에 관한 것이다. 본 발명에 따른 신규한 세파로스포린 유도체, 이의 프로드럭, 이의 수화물, 이의 용매화물, 이의 이성질체 및 이의 약제학적으로 허용되는 염은 내성균에 대한 항균 스펙트럼이 넓고, 독성이 낮으며, 특히 그람음성균에 강한 항균효과를 나타내므로, 항생제로 유용하게 사용될 수 있다.
PCT/KR2012/002302 2011-03-30 2012-03-29 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 WO2012134184A2 (ko)

Priority Applications (20)

Application Number Priority Date Filing Date Title
EA201391325A EA024709B1 (ru) 2011-03-30 2012-03-29 Производные цефалоспорина и их фармацевтические композиции
PL12765589T PL2706062T3 (pl) 2011-03-30 2012-03-29 Nowa pochodna cefalosporyny i zawierająca ją kompozycja farmaceutyczna
SI201231355T SI2706062T1 (sl) 2011-03-30 2012-03-29 Novi derivat cefalosporina in njegov farmacevtski sestavek
DK12765589.2T DK2706062T3 (en) 2011-03-30 2012-03-29 Hitherto unknown cephalosporine derivative and pharmaceutical composition thereof
EP12765589.2A EP2706062B1 (en) 2011-03-30 2012-03-29 Novel cephalosporin derivative and pharmaceutical composition thereof
LTEP12765589.2T LT2706062T (lt) 2011-03-30 2012-03-29 Naujas cefalosporino darinys ir jo farmacinė kompozicija
BR112013025275A BR112013025275A2 (pt) 2011-03-30 2012-03-29 derivados de cefalosporina e suas composições farmacêuticas
AU2012237063A AU2012237063B2 (en) 2011-03-30 2012-03-29 Novel cephalosporin derivative and medical composition containing same
ES12765589.2T ES2683351T3 (es) 2011-03-30 2012-03-29 Nuevo derivado de cefalosporina y composición farmacéutica del mismo
CA2831421A CA2831421C (en) 2011-03-30 2012-03-29 Novel cephalosporin derivatives and pharmaceutical compositions thereof
MX2013010961A MX359435B (es) 2011-03-30 2012-03-29 Derivados novedosos de cefalosporinas y composiciones farmaceuticas de estos.
SG2013072962A SG193998A1 (en) 2011-03-30 2012-03-29 Novel cephalosporin derivatives and pharmaceutical compositions thereof
CN201280015502.0A CN103547583B (zh) 2011-03-30 2012-03-29 头孢菌素衍生物及其药物组合物
JP2014502466A JP6144669B2 (ja) 2011-03-30 2012-03-29 新規セファロスポリン誘導体およびその医薬組成物
US13/467,019 US8329684B2 (en) 2011-03-30 2012-05-08 Cephalosporin derivatives and pharmaceutical compositions thereof
US13/691,221 US9630977B2 (en) 2011-03-30 2012-11-30 Cephalosporin derivatives and pharmaceutical compositions thereof
IL228408A IL228408A (en) 2011-03-30 2013-09-12 History as phalosporin and their medicinal products
CU2013000125A CU20130125A7 (es) 2011-03-30 2013-09-27 Derivados novedosos de cefalosporinas y composiciones farmacéuticas de estos
ZA2013/08078A ZA201308078B (en) 2011-03-30 2013-10-30 Novel cephalosporin derivative and medical composition containing same
HRP20181170TT HRP20181170T1 (hr) 2011-03-30 2018-07-24 Novi derivat cefalosporina i njegov farmaceutski pripravak

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110028603A KR101719556B1 (ko) 2011-03-30 2011-03-30 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
KR10-2011-0028603 2011-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/467,019 Continuation US8329684B2 (en) 2011-03-30 2012-05-08 Cephalosporin derivatives and pharmaceutical compositions thereof

Publications (3)

Publication Number Publication Date
WO2012134184A2 WO2012134184A2 (ko) 2012-10-04
WO2012134184A3 WO2012134184A3 (ko) 2013-03-07
WO2012134184A8 true WO2012134184A8 (ko) 2013-10-24

Family

ID=46932135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/002302 WO2012134184A2 (ko) 2011-03-30 2012-03-29 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물

Country Status (27)

Country Link
US (2) US8329684B2 (ko)
EP (1) EP2706062B1 (ko)
JP (1) JP6144669B2 (ko)
KR (1) KR101719556B1 (ko)
CN (1) CN103547583B (ko)
AU (1) AU2012237063B2 (ko)
BR (1) BR112013025275A2 (ko)
CA (1) CA2831421C (ko)
CL (1) CL2013002820A1 (ko)
CO (1) CO6821935A2 (ko)
CR (1) CR20130501A (ko)
CU (1) CU20130125A7 (ko)
DK (1) DK2706062T3 (ko)
DO (1) DOP2013000214A (ko)
EA (1) EA024709B1 (ko)
ES (1) ES2683351T3 (ko)
HR (1) HRP20181170T1 (ko)
HU (1) HUE039086T2 (ko)
IL (1) IL228408A (ko)
LT (1) LT2706062T (ko)
MX (1) MX359435B (ko)
PL (1) PL2706062T3 (ko)
PT (1) PT2706062T (ko)
SG (1) SG193998A1 (ko)
SI (1) SI2706062T1 (ko)
WO (1) WO2012134184A2 (ko)
ZA (1) ZA201308078B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
MX2017003518A (es) 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Estimuladores de guanilato ciclasa soluble (sgc).
US10059680B2 (en) * 2014-12-18 2018-08-28 Merck Sharp & Dohme Corp. Thiadiazolyl-oximinoacetic acid derivative compounds
US20160176897A1 (en) * 2014-12-23 2016-06-23 Merck Sharp & Dohme Corp. 7-aminocephem derivative compounds
WO2017096472A1 (en) 2015-12-10 2017-06-15 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use
EP3526225A1 (en) * 2016-10-14 2019-08-21 Universidade do Porto Hydroxycinnamic derivatives, methods and uses thereof
KR20180093307A (ko) * 2017-02-13 2018-08-22 주식회사 레고켐 바이오사이언스 4, 5-디아미노 치환 피리미딘 유도체의 제조방법 및 이를 제조하기 위한 신규한 화합물
WO2019145784A2 (en) * 2018-01-26 2019-08-01 Legochem Biosciences, Inc. Combination therapies for multi-drug resistant pathogens
CN109762791B (zh) * 2018-11-19 2021-02-09 厦门联合安金生物工程有限公司 包含BPI-Fc嵌合基因的重组腺病毒及其用途
CN111471058A (zh) * 2019-01-23 2020-07-31 中国医学科学院药物研究所 用于制备头孢吡普类似物的方法
CA3147354A1 (en) * 2019-09-06 2021-03-11 Rosemarie Riedl Siderophore cephalosporin conjugates and uses thereof
CN111635377A (zh) * 2020-06-30 2020-09-08 南京红杉生物科技有限公司 噻二唑类化合物及其合成方法
KR20220152157A (ko) * 2021-05-07 2022-11-15 한국생명공학연구원 신규 사이드로포어 화합물 및 이를 이용한 금속 나노입자 복합체

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Also Published As

Publication number Publication date
MX2013010961A (es) 2014-03-27
KR101719556B1 (ko) 2017-03-24
CU20130125A7 (es) 2014-03-26
IL228408A0 (en) 2013-12-31
EA201391325A1 (ru) 2014-04-30
CO6821935A2 (es) 2013-12-31
PT2706062T (pt) 2018-09-28
CN103547583A (zh) 2014-01-29
JP2014510750A (ja) 2014-05-01
HRP20181170T1 (hr) 2018-11-02
ZA201308078B (en) 2019-01-30
EA024709B1 (ru) 2016-10-31
SG193998A1 (en) 2013-11-29
BR112013025275A2 (pt) 2016-12-13
ES2683351T3 (es) 2018-09-26
PL2706062T3 (pl) 2018-11-30
WO2012134184A2 (ko) 2012-10-04
CL2013002820A1 (es) 2014-04-11
MX359435B (es) 2018-09-28
CR20130501A (es) 2014-05-13
EP2706062B1 (en) 2018-05-09
CA2831421C (en) 2019-06-04
WO2012134184A3 (ko) 2013-03-07
KR20120110625A (ko) 2012-10-10
AU2012237063B2 (en) 2017-03-16
IL228408A (en) 2017-01-31
CN103547583B (zh) 2016-11-16
JP6144669B2 (ja) 2017-06-07
LT2706062T (lt) 2018-10-25
DK2706062T3 (en) 2018-08-06
HUE039086T2 (hu) 2018-12-28
SI2706062T1 (sl) 2018-11-30
US8329684B2 (en) 2012-12-11
AU2012237063A1 (en) 2013-10-17
US20130178455A1 (en) 2013-07-11
DOP2013000214A (es) 2013-12-15
EP2706062A2 (en) 2014-03-12
US20120264727A1 (en) 2012-10-18
CA2831421A1 (en) 2012-10-04
EP2706062A4 (en) 2015-01-21
US9630977B2 (en) 2017-04-25

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