WO2005070113A3 - 9n-substituted 6-11 bicyclic erythromycin derivatives - Google Patents

9n-substituted 6-11 bicyclic erythromycin derivatives Download PDF

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Publication number
WO2005070113A3
WO2005070113A3 PCT/US2005/000643 US2005000643W WO2005070113A3 WO 2005070113 A3 WO2005070113 A3 WO 2005070113A3 US 2005000643 W US2005000643 W US 2005000643W WO 2005070113 A3 WO2005070113 A3 WO 2005070113A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
compounds
substituted
erythromycin derivatives
iii
Prior art date
Application number
PCT/US2005/000643
Other languages
French (fr)
Other versions
WO2005070113A2 (en
Inventor
Yao-Ling Qiu
Deqiang Niu
Zhe Wang
Ly Tam Phan
Original Assignee
Enanta Pharm Inc
Yao-Ling Qiu
Deqiang Niu
Zhe Wang
Ly Tam Phan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc, Yao-Ling Qiu, Deqiang Niu, Zhe Wang, Ly Tam Phan filed Critical Enanta Pharm Inc
Publication of WO2005070113A2 publication Critical patent/WO2005070113A2/en
Publication of WO2005070113A3 publication Critical patent/WO2005070113A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Abstract

The present invention discloses compounds of formula (I), (II), (III), or (IV), or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: formulas (I), (II), (III), (IV), which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
PCT/US2005/000643 2004-01-09 2005-01-07 9n-substituted 6-11 bicyclic erythromycin derivatives WO2005070113A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53522604P 2004-01-09 2004-01-09
US60/535,226 2004-01-09
US55230704P 2004-03-11 2004-03-11
US60/552,307 2004-03-11

Publications (2)

Publication Number Publication Date
WO2005070113A2 WO2005070113A2 (en) 2005-08-04
WO2005070113A3 true WO2005070113A3 (en) 2005-11-03

Family

ID=34811304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/000643 WO2005070113A2 (en) 2004-01-09 2005-01-07 9n-substituted 6-11 bicyclic erythromycin derivatives

Country Status (2)

Country Link
US (1) US7265094B2 (en)
WO (1) WO2005070113A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7384922B2 (en) 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7589067B2 (en) * 2005-10-12 2009-09-15 Enanta Pharmaceuticals, Inc. 6, 11-bridged tricyclic macrolides
EP2023721A2 (en) * 2006-06-05 2009-02-18 Auspex Pharmaceuticals Inc. Preparation and utility of substituted erythromycin analogs
ES2691252T3 (en) * 2007-09-17 2018-11-26 Enanta Pharmaceuticals, Inc. Biaryl macrolides with bridge in 6.11
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
WO2009064953A1 (en) * 2007-11-15 2009-05-22 Enanta Pharmaceuticals, Inc. Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
US11420995B2 (en) 2017-03-03 2022-08-23 Synovo Gmbh Anti-infective and anti-inflammatory compounds

Citations (1)

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US6645941B1 (en) * 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives

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US7064110B2 (en) 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US6753318B1 (en) 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US6878691B2 (en) 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
NZ536402A (en) 2002-05-13 2006-08-31 Enanta Pharm Inc 6,11 bicyclic erythromycin derivatives
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7022679B2 (en) 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
US7273853B2 (en) 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645941B1 (en) * 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives

Also Published As

Publication number Publication date
US7265094B2 (en) 2007-09-04
WO2005070113A2 (en) 2005-08-04
US20050171033A1 (en) 2005-08-04

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