WO2012089101A1 - 一种抗衰老中草药组合物及其制备方法和应用 - Google Patents
一种抗衰老中草药组合物及其制备方法和应用 Download PDFInfo
- Publication number
- WO2012089101A1 WO2012089101A1 PCT/CN2011/084734 CN2011084734W WO2012089101A1 WO 2012089101 A1 WO2012089101 A1 WO 2012089101A1 CN 2011084734 W CN2011084734 W CN 2011084734W WO 2012089101 A1 WO2012089101 A1 WO 2012089101A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- weight
- chinese herbal
- propanediol
- parts
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Definitions
- the invention relates to the field of cosmetics, in particular to a Chinese herbal medicine extract, a preparation thereof and an application thereof, and a Chinese herbal medicine composition having anti-aging, especially anti-photoaging effect, comprising the Chinese herbal medicine extract, and preparation thereof and application in cosmetics.
- UVB UVB
- UVA UVA
- UVA UVA
- the technical problem to be solved by the present invention is to provide a Chinese herbal medicine extract.
- the Chinese herbal medicine extract of the present invention is an aqueous or solvent extract of 10 to 50 parts by weight of snow lotus, 10 to 50 parts by weight of Cistanche, and 20 to 60 parts by weight of Astragalus, wherein the solvent is selected from the group consisting of methanol, ethanol, and isopropanol. , n-butanol, ethylene glycol, 1,2-propanediol, 1, 3-propanediol, 1,3-butanediol, acetone, ethyl acetate or a combination thereof.
- snow lotus refers to the medicinal part of the flower of the plant snow lotus.
- Snow lotus is a herbaceous plant of the genus Chrysanthemum of the genus Chrysanthemum. It mainly includes Saussurea involucrata Kar. et Kir., Saussurea laniceps Hand. -Mazz., S. gnaphaloides (Royle) ) Sch.- ⁇ ., Jellyfish Snow Lotus S. medusa ro'.
- Snow Lotus is mainly produced in Sichuan, Yunnan, Thu, Xinjiang, Gansu, Qinghai, etc., from June to July , when the flowers are open, Plant, remove the soil, dry, cut, and use.
- the Compendium of the Compendium "Snow Lotus, the north of the Ili and Jinchuan, the place of the cold, Ji Xuechun Summer is not scattered, there are grass in the snow, lotus-like, single stem, stylish in the pavilion.”
- Cistanche is a medicinal part of the dried scaly fleshy stem of Cistanche tubulosa or Cistanche tubulosa.
- Cistanche is a dry, scaly fleshy stem of the Cistanche deserticola Y. C. Ma or Cistanche tubulosa (Schrenk) Wight. More than the spring seedlings were not excavated or excavated when they were just released, the inflorescences were removed, cut into sections, and dried.
- Cistanche is mainly distributed in Inner Mongolia, Gansu, Xinjiang, Qinghai and other places.
- Cistanche is contained in "Shen Nong's Herbal Classic". According to the description: Cistanche is sweet, salty, and warm. It has the functions of tonifying kidney yang, benefiting essence blood, and relaxing bowel movements. It treats impotence, infertility, blood stasis, and weak waist and knees. Cold pain, weakness and other symptoms. In the past dynasties, Cicada was used as a royal treasure for the tribute to the courts of the Western Regions. Cistanche is a kidney that nourishes blood and regulates color, can regulate endocrine, promote metabolism and strengthen the body, and has anti-oxidation effect. "Pharmacology”: "Yi marrow, Yue color, Yannian, Dabuyi” "Complete the defeat, face black labor injury.”
- Astragalus also known as Astragalus, is a collective name for plants and Chinese herbal medicines.
- Astragalus membranaceus refers to the medicinal part of the dry root of the plant Mongolian Astragalus or Astragalus membranaceus.
- Astragalus is a leguminous plant Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. j thousand), ⁇ root. In the spring and autumn seasons, the roots and roots are removed and dried. Astragalus membranaceus is produced in North China, Northeast China, Inner Mongolia and Northwest China.
- the Chinese medicinal material Astragalus membranaceus has the effects of tonifying the qi, solidifying the water, reducing the swelling of the water, removing the pus, and stimulating the muscles.
- the medicinal use of Astragalus has been more than 2,000 years old. Modern research, Astragalus saponins, sucrose, polysaccharides, various amino acids, folic acid and Shixi, Ci, copper and other trace elements. It has enhanced immune function, liver protection, diuresis, anti-aging, anti-stress, antihypertensive and broader antibacterial effects. Astragalus replenishing in Yanze noodles can enhance the body's resistance, anti-oxidation and delay aging.
- the effect is comprehensive, and its composition is more suitable for the synergistic effect of traditional Chinese medicine in cosmetics than single Chinese medicine.
- the Chinese herbal medicine extract of the present invention is 30 parts by weight of snow lotus, 20 parts by weight of Cistanche, 50 parts by weight of water or a solvent extract of xanthine, and the solvent is selected from the group consisting of methanol, ethanol, isopropanol, n-butanol, Ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, acetone, ethyl acetate or a combination thereof.
- the extraction is selected from the group consisting of boiling, refluxing, dipping, percolating, or a combination thereof.
- the above extract may be in a form selected from the group consisting of a solution, a powder, an ointment, a film or a cream.
- the present invention also provides a Chinese herbal medicine composition having an anti-photoaging effect, the composition comprising the above extract.
- the Chinese herbal medicine extract and the Chinese herbal medicine composition of the present invention can be directly used for preventing skin aging, especially photoaging, and can also be added to cosmetics as an efficacy additive.
- the Chinese herbal medicine extract and the Chinese herbal medicine composition of the invention have anti-aging effect, especially anti-photoaging effect, help the skin to resist oxidation, promote the proliferation of dermal fibroblasts, especially help the skin to resist UVB and UVA ultraviolet radiation, protect the skin, reduce damage, It prevents skin photoaging and is non-irritating to the skin.
- the cosmetic may be a cosmetic cream, an eye cream, a facial mask, a facial cleanser, a toner or a serum.
- the invention also provides a preparation method of the above Chinese herbal medicine extract, the method comprising:
- the solvent is selected from the group consisting of decyl alcohol, ethanol, and isopropyl alcohol.
- the doubling amount refers to the ratio of the volume of the solvent to the total weight of the medicinal material, wherein the unit of the solvent volume is ml, and the unit of the total weight of the medicinal material is g; Shen
- the alcohol precipitation supernatant recovers the solvent.
- the alcohol precipitate can be formulated into various dosage forms such as solutions, powders, ointments, films or creams.
- the alcohol precipitation is selected from the group consisting of decyl alcohol, ethanol, isopropanol, n-butanol, ethylene glycol, 1 > 2- An alcohol of propylene glycol, 1,3-propanediol, 1, 3-butanediol or a combination thereof.
- the extract of the present invention can be added with water to prepare a composition containing a crude drug amount of 50 to 1000 mg/ml.
- Free radicals are a class of chemical substances that are active and highly oxidizing. Ultraviolet light UVA/UVB irradiation produces a large amount of free radicals, causing damage to the body and accelerating aging.
- the in vitro antioxidant activity of the extracts in the examples was determined by DPPH radical scavenging method.
- the extracts in the examples were diluted to two concentrations of 1% and 0.5% (v/v), respectively, with distilled water. Then, 2 ml of the extract of the example, a concentration of 50 ( ⁇ mol/L of DPPH ethanol solution 0.5 ml and 1.5 ml of water were added to the same test tube, shaken, and allowed to stand. After 30 min, the absorbance (OD) was measured at 517 nm. And the corresponding mixture was used as a blank control.
- the clearance rate of DPPH of the example extract was calculated according to the following formula:
- the prepared cell suspension (prepared to a concentration of 5*10 3 /ml) was inoculated into a 96-well plate, and after the cells were attached, 20 ul of the corresponding concentration of the Chinese herbal medicine of the example was added to each well except the blank control group. Extract, set 4 concentration groups, 6 holes in each group, incubate in incubator (37 ° C, 5% C0 2 ) for 24 h, then add 20 ul of MTT solution, continue in the incubator (37 ° C, 5 Incubate for 4 h in %C0 2 ). After removing the microplate, carefully remove the culture solution from each well, add DMSO, and mix well. The optical density (570 nm) was measured by enzyme-linked immunosorbent assay, and the relative proliferation rate of the sample group was obtained by comparison with the control group.
- UVB medium-wave ultraviolet
- UVA long-wave ultraviolet
- UVA/UVB irradiation causes damage to fibroblasts, causing damage to the skin and causing photoaging.
- UV-irradiation experiment was used to examine the photoaging effect of the herbal extract of the examples against UV-induced cell protection.
- the irradiated Fb cells were used as a model group, and the Fb cells co-cultured with the sample extract (0.15 mg/ml) and DMEM were irradiated with UVA/UVB as the drug-added group. 24 hours after the ultraviolet treatment, the enzyme was labeled with CCK-8. The absorbance (OD value) of each well was measured, and the cell proliferation rate was the percentage of the OD value of each treatment group to the negative control group, and each test face was repeated three times.
- Extract A of Example 1 the extract of Example 2, and the extract of Example 3 (:, Extract D of Example 4 can all reduce the damage of fibroblasts by UV irradiation, so that the cell proliferation rate is basically the same.
- the recovery was more than 80%, and the effect of Extract D of Example 4 was the best.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2823422A CA2823422C (en) | 2010-12-31 | 2011-12-27 | Anti-aging chinese herbal medicine composition, preparation method and use thereof |
AU2011352576A AU2011352576B2 (en) | 2010-12-31 | 2011-12-27 | Anti-aging traditional Chinese medicinal herbal composition and preparation method and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010621920.7A CN102552420B (zh) | 2010-12-31 | 2010-12-31 | 一种抗衰老中草药组合物及其制备方法和应用 |
CN201010621920.7 | 2010-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012089101A1 true WO2012089101A1 (zh) | 2012-07-05 |
Family
ID=46382308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2011/084734 WO2012089101A1 (zh) | 2010-12-31 | 2011-12-27 | 一种抗衰老中草药组合物及其制备方法和应用 |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN102552420B (zh) |
AU (1) | AU2011352576B2 (zh) |
CA (1) | CA2823422C (zh) |
WO (1) | WO2012089101A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111374936A (zh) * | 2020-04-02 | 2020-07-07 | 安赛搏(重庆)生物技术有限公司 | 多元液体体系制备雪莲细胞提取物的方法及其用途 |
CN111374915A (zh) * | 2018-12-29 | 2020-07-07 | 上海洵都医疗科技有限公司 | 一种抗衰老组合物及其制备方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103893029A (zh) * | 2012-12-25 | 2014-07-02 | 南京恒青楼宇设备有限公司青岛分公司 | 一种藏药面膜 |
CN105687059A (zh) * | 2016-04-05 | 2016-06-22 | 余云丰 | 一种用于抗衰老的化妆品组合物及其配制方法、应用 |
CN107998033B (zh) * | 2017-12-28 | 2020-06-30 | 珠海伊斯佳科技股份有限公司 | 一种具有抗衰老功能的组合物及在化妆品中应用 |
CN108670911A (zh) * | 2018-08-21 | 2018-10-19 | 王志强 | 一种美白祛斑的纯中药面膜 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1096684A (zh) * | 1993-06-16 | 1994-12-28 | 姜伟栋 | 枸杞雪莲口服液 |
CN1795916A (zh) * | 2004-12-22 | 2006-07-05 | 那顺布赫 | 祛除中老年斑延年益寿药物及其制备方法 |
CN1965797A (zh) * | 2006-11-20 | 2007-05-23 | 马春芳 | 植物祛斑洗面粉及其配制方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1054284C (zh) * | 1993-03-25 | 2000-07-12 | 中国科学院新疆化学研究所 | 护肤天然原料——新疆雪莲醇提物 |
CN1276233A (zh) * | 1999-06-02 | 2000-12-13 | 林世海 | 青春永驻灵及其制作方法 |
KR20080069297A (ko) * | 2007-01-23 | 2008-07-28 | 김우원 | 한방 초콜렛의 제조방법 |
KR20080094459A (ko) * | 2007-04-20 | 2008-10-23 | 주식회사 엘지생활건강 | 항산화 활성을 갖는 화장료 조성물 |
KR101051362B1 (ko) * | 2007-08-31 | 2011-07-22 | (주)콤비메드 | 생약재 발효산물을 포함하는 아토피성 피부염 치료 및/또는예방용 조성물 |
KR101652244B1 (ko) * | 2008-12-10 | 2016-08-30 | (주)아모레퍼시픽 | 여드름 피부 개선용 화장료 조성물 |
-
2010
- 2010-12-31 CN CN201010621920.7A patent/CN102552420B/zh active Active
-
2011
- 2011-12-27 CA CA2823422A patent/CA2823422C/en not_active Expired - Fee Related
- 2011-12-27 WO PCT/CN2011/084734 patent/WO2012089101A1/zh active Application Filing
- 2011-12-27 AU AU2011352576A patent/AU2011352576B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1096684A (zh) * | 1993-06-16 | 1994-12-28 | 姜伟栋 | 枸杞雪莲口服液 |
CN1795916A (zh) * | 2004-12-22 | 2006-07-05 | 那顺布赫 | 祛除中老年斑延年益寿药物及其制备方法 |
CN1965797A (zh) * | 2006-11-20 | 2007-05-23 | 马春芳 | 植物祛斑洗面粉及其配制方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111374915A (zh) * | 2018-12-29 | 2020-07-07 | 上海洵都医疗科技有限公司 | 一种抗衰老组合物及其制备方法 |
CN111374936A (zh) * | 2020-04-02 | 2020-07-07 | 安赛搏(重庆)生物技术有限公司 | 多元液体体系制备雪莲细胞提取物的方法及其用途 |
Also Published As
Publication number | Publication date |
---|---|
CN102552420B (zh) | 2014-06-04 |
CA2823422C (en) | 2019-01-29 |
CA2823422A1 (en) | 2012-07-05 |
CN102552420A (zh) | 2012-07-11 |
AU2011352576B2 (en) | 2017-02-02 |
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