WO2009075277A1 - ４－アミノピリミジン誘導体および該化合物を含有する医薬組成物 - Google Patents

４－アミノピリミジン誘導体および該化合物を含有する医薬組成物 Download PDF

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WO2009075277A1
WO2009075277A1 PCT/JP2008/072367 JP2008072367W WO2009075277A1 WO 2009075277 A1 WO2009075277 A1 WO 2009075277A1 JP 2008072367 W JP2008072367 W JP 2008072367W WO 2009075277 A1 WO2009075277 A1 WO 2009075277A1
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compound
composition containing
medicinal composition
group
aminopyrimidine derivative
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PCT/JP2008/072367
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English (en)
French (fr)
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Hideyasu Fujiwara
Takako Iso
Kumiko Fujita
Takanobu Masuda
Naoki Higuchi
Miwa Hirai
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Genecare Research Institute Co., Ltd.
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Publication of WO2009075277A1 publication Critical patent/WO2009075277A1/ja

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/42—One nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

　下記一般式（Ｉ） 〔式（Ｉ）中、Ｒ１は、ハロゲン原子または他の基を表し；またはＲ１は下記式（ＩＩ） （式（ＩＩ）中、Ｒ５は、ハロゲン原子を置換基に有していてもよいＣ６－１０アリール基または他の基を表す）を表し； 　式（Ｉ）中、Ｒ２またはＲ３のいずれか一方が水素原子であり、他方が－（ＣＨ2）nＲ4（式中、ｎは０、１、２または３を表し；Ｒ４は水素原子、ヒドロキシ基または他の基を表し； または、Ｒ２とＲ３とは、隣接する窒素原子と一緒になって置換基を有していてもよい４～８員ヘテロ環式基を形成していてもよい。〕で表される化合物もしくはその薬学的に許容される塩、またはその水和物もしくは溶媒和物。
PCT/JP2008/072367 2007-12-11 2008-12-10 ４－アミノピリミジン誘導体および該化合物を含有する医薬組成物 WO2009075277A1 (ja)

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JP2007-319253 2007-12-11
JP2007319253A JP2011032169A (ja) 2007-12-11 2007-12-11 ４−アミノピリミジン誘導体および該化合物を含有する医薬組成物

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CN102713692A (zh) * 2010-02-24 2012-10-03 东丽株式会社 侧光型背光源用白色反射膜和使用该白色反射膜的背光源

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504365A (ja) * 2012-12-28 2016-02-12 アメリカ合衆国 Ｕｓｐ１／ｕａｆ１デユビキチナーゼ複合体阻害剤及びその使用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019065A1 (en) * 1995-11-20 1997-05-29 Celltech Therapeutics Limited Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
WO2001060816A1 (en) * 2000-02-17 2001-08-23 Amgen Inc. Kinase inhibitors
WO2002022604A1 (en) * 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2003045941A1 (en) * 2001-11-21 2003-06-05 Celltech R & D Limited Pyridine and pyrimidine derivatives
WO2005040133A1 (en) * 2003-10-23 2005-05-06 Pharmacia Corporation Pyrimidine compounds for the treatment of inflammation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019065A1 (en) * 1995-11-20 1997-05-29 Celltech Therapeutics Limited Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
WO2001060816A1 (en) * 2000-02-17 2001-08-23 Amgen Inc. Kinase inhibitors
WO2002022604A1 (en) * 2000-09-15 2002-03-21 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2003045941A1 (en) * 2001-11-21 2003-06-05 Celltech R & D Limited Pyridine and pyrimidine derivatives
WO2005040133A1 (en) * 2003-10-23 2005-05-06 Pharmacia Corporation Pyrimidine compounds for the treatment of inflammation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GIBSON,R.E. ET AL.: "Enzyme inhibitors. Inhibition of brain choline acetyltransferase by derivatives of 4-styrylpyrimidine", JOURNAL OF MEDICINAL CHEMISTRY, vol. 17, no. 12, 1974, pages 1290 - 3 *
MA,Y. ET AL.: "Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 6, no. 3, 2004, pages 426 - 430 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102713692A (zh) * 2010-02-24 2012-10-03 东丽株式会社 侧光型背光源用白色反射膜和使用该白色反射膜的背光源
CN102713692B (zh) * 2010-02-24 2014-12-10 东丽株式会社 侧光型背光源用白色反射膜和使用该白色反射膜的背光源
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

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