WO2009008508A1 - スルフォスチン、及びスルフォスチン関連化合物を有効成分とした抗腫瘍剤 - Google Patents

スルフォスチン、及びスルフォスチン関連化合物を有効成分とした抗腫瘍剤 Download PDF

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Publication number
WO2009008508A1
WO2009008508A1 PCT/JP2008/062599 JP2008062599W WO2009008508A1 WO 2009008508 A1 WO2009008508 A1 WO 2009008508A1 JP 2008062599 W JP2008062599 W JP 2008062599W WO 2009008508 A1 WO2009008508 A1 WO 2009008508A1
Authority
WO
WIPO (PCT)
Prior art keywords
sulfostin
antitumor agent
active ingredient
related compound
general formula
Prior art date
Application number
PCT/JP2008/062599
Other languages
English (en)
French (fr)
Inventor
Tetsuo Akiyama
Toru Masuda
Masatoshi Abe
Original Assignee
Microbial Chemistry Research Foundation
Nippon Kayaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Nippon Kayaku Kabushiki Kaisha filed Critical Microbial Chemistry Research Foundation
Priority to EP08778114A priority Critical patent/EP2174930A4/en
Publication of WO2009008508A1 publication Critical patent/WO2009008508A1/ja
Priority to US12/685,241 priority patent/US20100179324A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

　本発明は、体内での腫瘍細胞の増殖を特異的かつ効果的に阻害することができ、副作用が少なく、安全性の高い、優れた抗腫瘍剤、及び、前記抗腫瘍剤を含む医薬組成物を提供することを目的とする。即ち、本発明は、下記一般式（Ｉ）で表されるスルフォスチン関連化合物、その薬理学上許容され得る塩、及びその水和物の少なくともいずれかを有効成分とすることを特徴とする抗腫瘍剤、並びに、前記抗腫瘍剤を含む医薬組成物に関する。 ただし、前記一般式（Ｉ）中、ｎは１～３の整数を表す。
PCT/JP2008/062599 2007-07-11 2008-07-11 スルフォスチン、及びスルフォスチン関連化合物を有効成分とした抗腫瘍剤 WO2009008508A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08778114A EP2174930A4 (en) 2007-07-11 2008-07-11 SULFOSTIN AND SULPHOSTINE-RELATED COMPOUNDS CONTAINING AN ACTIVE ANTITUM-MEANS
US12/685,241 US20100179324A1 (en) 2007-07-11 2010-01-11 Anti-tumor agent comprising sulphostin or sulphostin-related compound as the active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007182594A JP5148941B2 (ja) 2007-07-11 2007-07-11 スルフォスチン、及びスルフォスチン関連化合物を有効成分とした抗腫瘍剤
JP2007-182594 2007-07-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/685,241 Continuation US20100179324A1 (en) 2007-07-11 2010-01-11 Anti-tumor agent comprising sulphostin or sulphostin-related compound as the active ingredient

Publications (1)

Publication Number Publication Date
WO2009008508A1 true WO2009008508A1 (ja) 2009-01-15

Family

ID=40228678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/062599 WO2009008508A1 (ja) 2007-07-11 2008-07-11 スルフォスチン、及びスルフォスチン関連化合物を有効成分とした抗腫瘍剤

Country Status (4)

Country Link
US (1) US20100179324A1 (ja)
EP (1) EP2174930A4 (ja)
JP (1) JP5148941B2 (ja)
WO (1) WO2009008508A1 (ja)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08143569A (ja) 1994-11-14 1996-06-04 Banyu Pharmaceut Co Ltd 抗腫瘍物質ｂｅ−４３４７２類
JPH08239379A (ja) 1995-03-03 1996-09-17 Kirin Brewery Co Ltd 新規物質ｋｒ２８２７誘導体、その製造法および使用
JPH09249647A (ja) 1996-03-14 1997-09-22 Taiho Yakuhin Kogyo Kk Ｉｔ−１４３物質、及びその用途
JPH1121263A (ja) 1997-07-01 1999-01-26 Banyu Pharmaceut Co Ltd 抗腫瘍性物質ｂｅ−４５９８５類
JP2000327689A (ja) * 1999-05-17 2000-11-28 Microbial Chem Res Found スルフォスチン類縁体、並びにスルフォスチン及びその類縁体の製造方法
WO2002055088A1 (fr) * 2001-01-16 2002-07-18 Nippon Kayaku Kabushiki Kaisha Remedes destines au traitement de la suppression de la moelle osseuse et de maladies infectieuses et agents permettant d'augmenter la concentration leucocytaire du sang
JP2004043429A (ja) * 2002-02-25 2004-02-12 Eisai Co Ltd 新規キサンチン誘導体およびｄｐｐｉｖ阻害剤
JP2005523248A (ja) * 2001-12-26 2005-08-04 ギルフォード、ファーマスーティカルズ ジペプチジルペプチダーゼｉｖの阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025719A1 (fr) * 1997-11-18 1999-05-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Substance physiologiquement active, la sulphostine, procede de fabrication et utilisation
US20030130199A1 (en) * 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
WO2003051895A1 (fr) * 2001-12-17 2003-06-26 Nippon Kayaku Kabushiki Kaisha Procedes de preparation de sulfostine et d'analogues ou d'intermediaires de celle-ci
DE60304911D1 (de) * 2002-02-25 2006-06-08 Eisai Co Ltd Xanthin-Derivate als DPP-IV-Inhibitoren

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08143569A (ja) 1994-11-14 1996-06-04 Banyu Pharmaceut Co Ltd 抗腫瘍物質ｂｅ−４３４７２類
JPH08239379A (ja) 1995-03-03 1996-09-17 Kirin Brewery Co Ltd 新規物質ｋｒ２８２７誘導体、その製造法および使用
JPH09249647A (ja) 1996-03-14 1997-09-22 Taiho Yakuhin Kogyo Kk Ｉｔ−１４３物質、及びその用途
JPH1121263A (ja) 1997-07-01 1999-01-26 Banyu Pharmaceut Co Ltd 抗腫瘍性物質ｂｅ−４５９８５類
JP2000327689A (ja) * 1999-05-17 2000-11-28 Microbial Chem Res Found スルフォスチン類縁体、並びにスルフォスチン及びその類縁体の製造方法
WO2002055088A1 (fr) * 2001-01-16 2002-07-18 Nippon Kayaku Kabushiki Kaisha Remedes destines au traitement de la suppression de la moelle osseuse et de maladies infectieuses et agents permettant d'augmenter la concentration leucocytaire du sang
JP2005523248A (ja) * 2001-12-26 2005-08-04 ギルフォード、ファーマスーティカルズ ジペプチジルペプチダーゼｉｖの阻害剤
JP2004043429A (ja) * 2002-02-25 2004-02-12 Eisai Co Ltd 新規キサンチン誘導体およびｄｐｐｉｖ阻害剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ADAMS S. ET AL.: "PH-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism", CANCER RESEARCH, vol. 64, 2004, pages 5471 - 5480, XP002525260 *
CANCER RESEARCH, vol. 64, 2004, pages 5471 - 5480
MOL. CANCER THER., vol. 4, 2005, pages 351

Also Published As

Publication number Publication date
JP2009019006A (ja) 2009-01-29
EP2174930A4 (en) 2011-07-13
US20100179324A1 (en) 2010-07-15
JP5148941B2 (ja) 2013-02-20
EP2174930A1 (en) 2010-04-14

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