WO2009053654A3 - Prodrogues phosphoesters de la gemcitabine comme agents anticancereux - Google Patents

Prodrogues phosphoesters de la gemcitabine comme agents anticancereux Download PDF

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Publication number
WO2009053654A3
WO2009053654A3 PCT/FR2008/051874 FR2008051874W WO2009053654A3 WO 2009053654 A3 WO2009053654 A3 WO 2009053654A3 FR 2008051874 W FR2008051874 W FR 2008051874W WO 2009053654 A3 WO2009053654 A3 WO 2009053654A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphoester
gemcitabine
prodrugs
anticancer agents
compound
Prior art date
Application number
PCT/FR2008/051874
Other languages
English (en)
Other versions
WO2009053654A2 (fr
Inventor
Christian Perigaud
Suzanne Peyrottes
Charles Dumontet
Original Assignee
Hospices Civils Lyon
Christian Perigaud
Suzanne Peyrottes
Charles Dumontet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospices Civils Lyon, Christian Perigaud, Suzanne Peyrottes, Charles Dumontet filed Critical Hospices Civils Lyon
Publication of WO2009053654A2 publication Critical patent/WO2009053654A2/fr
Publication of WO2009053654A3 publication Critical patent/WO2009053654A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des prodrogues phosphoesters de la gemcitabine, à activité anti-tumorale, de formule (I) dans laquelle n, Y, Z et R1 sont tels que définis à la revendications 1, ainsi que les compositions pharmaceutiques comprenant un tel composé, en combinaison avec au moins un excipient pharmaceutiquement acceptable et l'utilisation d'un tel composé pour la préparation d'un médicament anti¬ tumoral ou anti-cancéreux.
PCT/FR2008/051874 2007-10-17 2008-10-17 Prodrogues phosphoesters de la gemcitabine comme agents anticancereux WO2009053654A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0758386 2007-10-17
FR0758386A FR2922551B1 (fr) 2007-10-17 2007-10-17 Prodrogues phosphoesters de la gemcitabine comme agents anticancereux

Publications (2)

Publication Number Publication Date
WO2009053654A2 WO2009053654A2 (fr) 2009-04-30
WO2009053654A3 true WO2009053654A3 (fr) 2009-08-20

Family

ID=39203136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/051874 WO2009053654A2 (fr) 2007-10-17 2008-10-17 Prodrogues phosphoesters de la gemcitabine comme agents anticancereux

Country Status (2)

Country Link
FR (1) FR2922551B1 (fr)
WO (1) WO2009053654A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2729168A1 (fr) * 2008-07-02 2010-02-04 Idenix Pharmaceuticals, Inc. Composes et compositions pharmaceutiques pour le traitement d'infections virales
CN101525361B (zh) 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
JP2014514295A (ja) * 2011-03-31 2014-06-19 アイディニックス ファーマシューティカルズ インコーポレイテッド ウイルス感染の治療のための化合物および薬学的組成物
CN109956986B (zh) * 2017-12-22 2021-04-27 浙江柏拉阿图医药科技有限公司 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (fr) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Composes chimiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (fr) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Composes chimiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BELTRAN THIERRY ET AL: "Rational design of a new series of pronucleotide", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 13, 9 July 2001 (2001-07-09), pages 1775 - 1777, XP002479283, ISSN: 0960-894X *
JORDHEIM LARS PETTER ET AL: "Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 AUG 2004, vol. 10, no. 16, 15 August 2004 (2004-08-15), pages 5614 - 5621, XP002474644, ISSN: 1078-0432 *
PEYROTTES S ET AL: "SATE Pronucleotide Approaches: An Overview", MINI REVIEWS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 4, no. 4, 1 May 2004 (2004-05-01), pages 395 - 408, XP008088559, ISSN: 1389-5575 *
WU WEIDONG ET AL: "Synthesis and biological activity of a gemcitabine phosphoramidate prodrug.", JOURNAL OF MEDICINAL CHEMISTRY 26 JUL 2007, vol. 50, no. 15, 26 July 2007 (2007-07-26), pages 3743 - 3746, XP002474645, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
FR2922551B1 (fr) 2009-12-25
FR2922551A1 (fr) 2009-04-24
WO2009053654A2 (fr) 2009-04-30

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