WO2007034736A1 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
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- WO2007034736A1 WO2007034736A1 PCT/JP2006/318278 JP2006318278W WO2007034736A1 WO 2007034736 A1 WO2007034736 A1 WO 2007034736A1 JP 2006318278 W JP2006318278 W JP 2006318278W WO 2007034736 A1 WO2007034736 A1 WO 2007034736A1
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- adhesive layer
- mass
- pressure
- sensitive adhesive
- agar
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
Definitions
- the present invention relates to a patch.
- a patch having an adhesive layer containing a high amount of water such as a knitting agent or a sheet-like pack agent
- water-soluble high concentrations of gelatin, polyacrylic acid, polyacrylate, etc. are used for forming the adhesive layer.
- Adhesive bases containing molecules are utilized.
- an adhesive base containing gelatin is suitable because it has a high water content and excellent shape retention and cohesion.
- the adhesive base containing gelatin has a problem that the selection range of substances to be blended is limited because there is a pH range in which the shape retention and cohesion of gelatin are exhibited.
- the pressure-sensitive adhesive layer formed from a pressure-sensitive adhesive base containing gelatin has a problem of dripping when exposed to high temperatures because the melting point of gelatin is low.
- Patent Document 1 Japanese Patent Laid-Open No. 57-42617
- Patent Document 2 JP 2005-176742 A
- a patch having an adhesive layer containing agar is obtained by dissolving agar powder by heating in water, adding a compounding substance, and stirring while heating to obtain an adhesive layer. Release sheet Or it can apply
- Patent Document 2 shows an example of reducing the gel temperature of an agar-containing liquid.
- the gelation temperature (freezing point) of a solution obtained by mixing and dissolving modified agar obtained by mixing cyclocyclodextrin with agar is lower than the gelation temperature of a normal agar-containing solution.
- an object of the present invention is to provide a patch having an adhesive layer that dissolves at a lower temperature at the time of production and does not gel to a lower gelation temperature by a simpler and simpler method. It is to provide.
- the present invention provides a patch comprising a support and a pressure-sensitive adhesive layer disposed on at least one surface of the support.
- Soluble agar and selected from the group consisting of polyacrylamide, polybulal alcohol, polybulurpyrrolidone, sodium alginate, ammonium alginate, carboxymethylcellulose, sodium carboxymethylcellulose, methinorescenellose, arabiya gum, tragacanth gum and xanthan gum
- a patch containing one or more additives and substantially free of gelatin.
- easily soluble agar used in the present invention means agar that dissolves almost 100% at a temperature of 70 ° C.
- Agar composition, molecular weight, The form, jelly strength, sol viscosity, freezing point, pH, water absorption, release property and the like are not particularly limited.
- substantially free of gelatin is an amount that does not affect the jelly strength of the pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive base even if it contains a force that does not contain gelatin. Means that. Here, whether or not it affects the jelly strength of the pressure-sensitive adhesive layer can be determined by the following method.
- the jelly strength of the pressure-sensitive adhesive layer formed from a certain pressure-sensitive adhesive base is increased when the pressure-sensitive adhesive layer contains a certain amount of gelatin. Otherwise, it is determined that there is no effect on the jelly strength of the pressure-sensitive adhesive layer, and a certain amount of gelatin can be regarded as “substantially free of gelatin”. When comparing jelly strength, the difference after taking measurement error into consideration shall be confirmed.
- the patch can contain volatile components and heat-sensitive components.
- one or more additions selected from the group consisting of polyacrylamide, polybutyl alcohol, polybutylpyrrolidone, sodium alginate, ammonium alginate, carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, arabiya gum, tragacanth gum and xanthan gum The agent lowers the freezing point of readily soluble agar by interacting with easily soluble agar. Therefore, the patch can be produced efficiently.
- the reason for the reduction of the freezing point of readily soluble agar is not clear, but it is thought that the additive functions as an anti-gelling agent.
- the freezing point is a temperature at which the sol solution is gelled by cooling.
- the melting point refers to the temperature at which the solidified gel is re-dissolved by heating.
- the additive also has one or more powers selected from the group consisting of polyacrylamide, polybulal alcohol, and polybutylpyrrolidone.
- the pressure-sensitive adhesive layer preferably contains 0.1 to 20% by mass of additives based on the total mass of the pressure-sensitive adhesive layer.
- the pressure-sensitive adhesive layer contains 0.1% by mass or more of the additive, the effect of lowering the freezing point of the pressure-sensitive adhesive base (referred to as a composition forming the pressure-sensitive adhesive layer) can be reliably exhibited. Also included in the adhesive layer Since the additive added is 20% by mass or less, it is possible to prevent the additive from being dissolved or preventing the adhesive base from solidifying!
- the pressure-sensitive adhesive layer preferably contains 0.1 to 5.0% by mass of readily soluble agar based on the total mass of the pressure-sensitive adhesive layer. Since the pressure-sensitive adhesive layer contains 0.1% by mass or more of readily soluble agar, it is possible to prevent bleeding. Moreover, since the easily soluble agar contained in the pressure-sensitive adhesive layer is 5.0% by mass or less, the shape retention can be sufficiently maintained.
- BZA is 0.5 or more, the effect of lowering the freezing point of the adhesive base can be surely exhibited.
- BZA 10 or less, it is possible to prevent the additive from being dissolved and the adhesive base from being solidified.
- readily soluble agar is preferably a jelly strength force 50 ⁇ 1000gZcm 2.
- jelly strength (unit: gZcm 2 ) is a surface of a gel prepared by preparing a 1.5% by mass aqueous solution of agar and allowing it to solidify by standing at 20 ° C. for 15 hours. The maximum weight (in grams) that can withstand 20 seconds per square centimeter.
- the jelly strength of the readily soluble agar is 450 gZcm 2 or more, it is possible to prevent the adhesive layer from seeping out and the adhesive paste remaining on the adhesive layer.
- “exudation of the pressure-sensitive adhesive layer” means that the shape retention of the formed pressure-sensitive adhesive layer is reduced, and the pressure-sensitive adhesive layer moves to the support and exudes from the support.
- “Plastic paste remaining on the adhesive layer” means that a part of the adhesive layer remains on the adherend when the patch attached to the adherend is peeled off.
- the jelly strength is lOOOg Zcm 2 or less, it is possible to prevent the cohesive force of the formed adhesive layer from increasing and the adhesive force of the adhesive layer from becoming insufficient.
- FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention.
- FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention.
- a patch 1 includes a support 2, a pressure-sensitive adhesive layer 3 laminated on the support 2, and a release sheet 4 bonded on the pressure-sensitive adhesive layer 3.
- the pressure-sensitive adhesive layer 3 provided in the patch 1 of the present embodiment is formed of a pressure-sensitive adhesive base material containing a readily soluble agar and an additive.
- the adhesive base By using easily soluble agar for the adhesive base, the adhesive base can be dissolved at a temperature of about 70 ° C and a heating time of about 10 to 15 minutes during production. For this reason, the adhesive base can contain a volatile component or a heat-sensitive component. In addition, it has excellent adhesive strength with fewer defects (restriction of pH range, dripping) compared to the patch containing gelatin, and the remaining amount of plaster is reduced. Furthermore, since the temperature of the gelation of the adhesive base is lowered, the desired gelling does not occur without heating the production equipment. Therefore, the patch can be easily manufactured, and cost reduction and efficiency can be reduced during the manufacturing.
- the patch is preferably an aqueous patch.
- Water-based adhesive means an adhesive layer containing moisture. Specific examples include poultices, cooling sheets, knocking agents and the like.
- the readily soluble agar in the present embodiment it is preferable that the agar is almost free of agaropectin which is hardly dissolved even at high temperatures. Agaropectin contains many ionic functional groups and has almost no gelling ability. In order to dissolve normal agar containing agaropectin, heating for at least 10 to 15 minutes in a boiling state is required, and it is unsuitable for containing volatile components and pyrolysis components. In the embodiment of the present invention, it is preferable to use easily soluble agar which can be dissolved at a low temperature!
- jelly strength readily soluble agar used in the present embodiment, 450 ⁇ : LOOOgZcm 2 is laid preferred, preferably from 500 ⁇ 900g / cm 2 force, 600 ⁇ 800g / cm 2 force ⁇ particularly preferred /,! . Easily soluble '14 If the agar jelly strength is 450 gZcm 2 or more, the adhesive layer will bleed out or the adhesive layer It is possible to prevent the remaining plaster. On the other hand, when the jelly strength is lOOOgZcm 2 or less, the cohesive force of the pressure-sensitive adhesive layer 3 increases, and the pressure-sensitive adhesive force of the pressure-sensitive adhesive layer 3 can be prevented from becoming insufficient.
- Examples of commercially available products include “UP-37K” (manufactured by Ina Food Industry Co., Ltd., jelly strength: 700 g / cm 2 ), “UP-26K” (manufactured by Ina Food Industry Co., Ltd., jelly strength: 650 g / cm 2 ), “UP-16KJ (Ina Food Industry Co., Ltd., jelly strength: 600gZcm 2 )", “UZ—5K” (Ina Food Industry Co., Ltd., jelly strength: 420g / cm 2 ), “UM-11K” (Ina For example, Jelly strength: lOOOOg / cm 2 ) manufactured by Food Industry Co., Ltd.
- the blending amount of the easily soluble agar of the present embodiment is preferably 0.1 to 5.0% by mass with respect to the total mass of the pressure-sensitive adhesive layer. 0.2 to 2.5% by mass It is more preferable that Bleeding can be prevented by containing 0.1% by mass or more of readily soluble agar. Further, when the easily soluble agar content is 5.0% by mass or less, the shape retention of the pressure-sensitive adhesive layer 3 can be sufficiently maintained. When the pressure-sensitive adhesive layer is formed from the pressure-sensitive adhesive base, the volatilization of the components does not occur! / In some cases, the blending amount based on the total weight of the pressure-sensitive adhesive layer and the total weight-based adhesive base The amount will be the same.
- the additive is added when preparing the adhesive base containing the readily soluble agar, and lowers the freezing point of the easily soluble agar by interacting with the easily soluble agar.
- a highly polar water-soluble polymer is preferable. Examples include polyacrylamide, polybulal alcohol, polybulurpyrrolidone, polysaccharide sodium alginate, ammonium alginate, carboxymethylcellulose, carboxymethylcellulose sodium, methylcellulose, arabic gum, tragacanth gum, xanthan gum and the like. . As these additional effects, it can also function as a base of the pressure-sensitive adhesive layer 3.
- the compounding amount of the additive is preferably 0.1 to 20% by mass, and more preferably 0.5 to 10% by mass with respect to the total mass of the pressure-sensitive adhesive layer.
- the compounding amount of the additive is preferably 0.1 to 20% by mass, and more preferably 0.5 to 10% by mass with respect to the total mass of the pressure-sensitive adhesive layer.
- the ratio (A: B) of the amount of the easily soluble agar (mass: A) and the additive (mass: B) in the pressure-sensitive adhesive layer 3 is preferably 1: 0.1-1: 50, 0: 5 to 1: 20 force is more preferable, and 1: 0.5 to 1: 10 is more preferable. That is, B / A is preferably 0.5 to 10, more preferably 0.5 to 20, and even more preferably 0.5 to 10.
- BZA is 0.5 or more, the effect of lowering the freezing point of the adhesive base can be surely exhibited.
- BZA is 10 or less, it is possible to prevent the additive from dissolving and preventing the adhesive base from solidifying.
- BZA is preferably 1 to 8.3, more preferably 1 to 1.7.
- the effect of lowering the gelation temperature of the additive is not clear! / ⁇ , but the present inventors presume as follows. Agarose and agaropectin, polysaccharides that are constituents of agar, change to a double helix structure by force cooling that exists in the form of a random coil in the solution state. Turn into.
- the additive in the present embodiment is a highly polar water-soluble polymer. For example, when the agar sol solution is cooled, the additive agent inhibits the formation of a double helix structure by the agar polysaccharide in some way or prevents the construction of a three-dimensional network. It is thought to lower the temperature of the gel.
- the adhesive base disclosed in the present embodiment contains easily soluble agar and additives in specific amounts and proportions, so that the gel temperature of the agar is lowered. Therefore, even when the patch 1 is manufactured, the manufacturing equipment etc. is not kept at 45 ° C or higher, so that it can be efficiently applied without being gelled before the process of applying on the support 2 etc. Patch 1 can be manufactured. In addition, since the dissolution temperature of easily soluble agar is low, volatile components and thermal decomposition components that were difficult with normal agar can be blended into the adhesive base without loss.
- the pressure-sensitive adhesive layer 3 of the patch 1 of the present embodiment may contain other polymer compounds.
- polymer compound examples include gelatin, collagen, pectin, starch, chitin, albumin, casein, polyacrylic acid and / or polyacrylate derivatives, carboxyvinyl polymer, bull pyrrolidone acrylic acid copolymer.
- the adhesive layer 3 of the patch 1 of the present embodiment may contain a medicinal component, a cosmetic component, and a component that can be generally blended in addition to the above-described easily soluble agar and additive. it can.
- the medicinal component is not particularly limited and can be appropriately selected depending on the purpose.
- a volatile component or a pyrolysis component can be used as a medicinal component or a cosmetic component.
- a high temperature above about 90 ° C
- these medicinal or cosmetic ingredients were added at the same time, the loss of these ingredients was significant.
- the above volatile components and pyrolyzable components can be used at the same time because it can be dissolved at a low temperature. Can be easily obtained.
- the production process can be simplified because it can be directly blended into an adhesive base containing agar.
- the volatile component is a component that volatilizes by applying heat (for example, heat during production).
- heat for example, heat during production.
- terpenes such as eucalyptus oil, nectar oil, thiamine oil, hearth oil, menthol, camphor, pinene, borneol, limonene, and other herbs such as lavender, peppermint, hearth, gelum, lime, chamomile Essential oils, lower alcohols such as ethyl alcohol and isopropyl alcohol, flavors such as Frederance and flavor, drugs and cosmetics such as amyl nitrite and trimethadione, C8 to C22 such as isostearic acid, octanoic acid and oleic acid C8-C22 fatty alcohols such as fatty acids, oleyl alcohol and lauryl alcohol, lower alkyl esters of C8-C22 fatty acids such as ethyl oleate, isopropyl myristate, but
- C6 to C8 dicarboxylic acid dialky C8-C22 fatty acid monoglyceride examples thereof include liquid excipients composed of reethylene glycolanol ether, polyethylene glycol, propylene glycol, 2- (2 ethoxyethoxy) ethanol, diethylene glycol monomethyl ether, and mixtures thereof.
- the thermally decomposable component is a substance unstable to heat (for example, heat at the time of production).
- non-steroidal anti-inflammatory analgesics with carboxyl groups such as dioctane, fenbinac, indomethacin, ketoprofen, prostaglandins, proteins such as albumin, toxins such as diphtheria toxin, enzymes such as catalase, cyclosporin-8, hirudin , Peptides such as somatostatin and thymopentin, hormones such as estrogen, human growth hormone, pig growth hormone, ushi growth hormone, human calcitonin, salmon calcitonin, carbocalcitonin, and peptide hormones such as insulin, hormone antagonists, acetylcholine, etc.
- Neurotransmitters neurotransmitter antagonists, glycoproteins such as hyaluronic acid, (lipoproteins such as X-lipoprotein, immunoglobulins such as IgG, interferon and interleukin Immunomodulators such as quinine, cellular receptors such as estrogen receptor protein, unfractionated heparin, low molecular heparin, chondroitin 4 sulfate, chondroitin 6-sulfate, and derivatives thereof such as darcosaminodarlicans, Plant extracts such as prostaglandins, ginseng, al-force, and quince, yeasts such as selenium yeast and brewer's yeast, animal proteins such as ovalbumin and gelatin, plant proteins such as dulten, hydrolyzed collagen, hydrolysis Hydrolyzed products of animal or vegetable proteins such as wheat dartene, natural polysaccharides such as hyaluronic acid, lecithin, collagen, placenta extract, ascorbic acid and its esters, reti
- the blending amount is preferably 0.01 to 5.0% by mass with respect to the total mass of the pressure-sensitive adhesive layer. It is better to be. If the mixing ratio power ketoprofen 0.01 mass 0/0 or more, the efficacy of ketoprofen is sufficiently obtained, if 5. than 0 mass%, an excessive amount with respect to efficacy for obtaining such a Rukoto Can be prevented.
- Non-steroidal anti-inflammatory agents such as flurbiprofen, suprofen, loxoprofen, piroxicam, methyl salicylate, glycol salicylate, hydrocortisone, dexamethasone, and the like, which have medicinal effects other than the volatile and thermally decomposable components , Steroidal anti-inflammatory agents such as fluocinoloneacetonide, fludroxycortide, betamethasone valerate, clobetasone acetate, clobetasol propionate, hot pepper such as pepper extract, noranilic acid dirylamide, diphenhydramine hydrochloride, And antihistamines such as chlorfe-lamin maleate.
- Steroidal anti-inflammatory agents such as fluocinoloneacetonide, fludroxycortide, betamethasone valerate, clobetasone acetate, clobetasol propionate, hot pepper such as pepper extract, noranilic acid dirylamide, diphen
- betamethasone valerate for the total weight adhesive layer, 0.1 001-0. It forces preferably 5 mass 0/0, 0.005 to 0. it forces more preferable is a 2 mass 0/0. If the compounding power of betamethasone valerate is 0.001% by mass or more, sufficient medicinal effects can be obtained, and if it is 0.5% by mass or less, side effects can be prevented from increasing.
- water purified water, sterilized water, natural water, or the like can be used.
- Such water acts as a dispersion or dissolution agent for readily soluble agar, water-soluble polymers and other components, and water itself also has the effect of improving the feeling of use during and after use of Patch 1.
- the water content is preferably 45 to 65% by mass, more preferably 30 to 95% by mass with respect to the total mass of the pressure-sensitive adhesive layer.
- polyhydric alcohol examples include glycerin, polyethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, xylitol and the like, and glycerin is particularly preferable.
- the blending amount of the polyhydric alcohol is preferably 10 to 60% by mass, more preferably 20 to 40% by mass with respect to the total mass of the pressure-sensitive adhesive layer. If the blending ratio is 10% by mass or more, it is possible to prevent the workability from being lowered and the cost is high.
- Examples of the polyvalent metal salt include hydroxyaluminum hydroxide, hydroxyaluminum gel, hydrous aluminum silicate, kaolin, aluminum acetate, aluminum lactate, aluminum stearate, calcium chloride, magnesium chloride, and chloride.
- Examples thereof include aluminum, dihydroxyaluminum acetate, magnesium aluminate metasilicate, and magnesium aluminate. Of these, dihydroxyaluminum aminoacetate, synthetic aluminum silicate and magnesium aluminate metasilicate are particularly preferred.
- the blending amount of the polyvalent metal salt is preferably 0.01 to 1 mass%, more preferably 0.02 to 0.5 mass%, based on the total mass of the pressure-sensitive adhesive layer. If the blending ratio is 0.01% by mass or more, the reaction can be sufficiently advanced and the gel strength can be made sufficient. On the other hand, if it is 1% by mass or less, the reaction rate at the time of production is too fast to prevent gelation from becoming uneven and workability to deteriorate, or to prevent the adhesive layer from having insufficient adhesiveness. Can
- surfactant examples include anionic surfactants such as sodium dioctylsulfosuccinate, alkyl sulfate salts, 2-ethylhexylalkylsulfate sodium salt, and sodium sodium dodecylbenzenesulfonate; Cationic surfactants such as decyltrimethylammonium chloride, octadecyldimethylbenzylammonium chloride, polyoxyethylene dodecyl monomethylammonium chloride; polyoxyethylene stearyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene tridecyl ether Polyoxyethylene monostearate, such as polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenol ether, polyethylene glycol monostearate: Sorbitan monostearate, sorbitan monopaluminate, sorbitan sesquioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene
- polyethylene glycol monostearate polyoxyethylene hydrogenated castor oil, monooleic acid, and polyoxyethylene sorbitan are preferred.
- the blending amount of the surfactant is preferably 0.01 to 5% by mass with respect to the total mass of the pressure-sensitive adhesive layer. More preferably, the content is 0.1 to 2% by mass. If the blending ratio is 0.01% by mass or more, bleeding can be prevented, and if it is 5% by mass or less, shape retention can be easily maintained.
- the adhesive base of this embodiment includes, as necessary, skin-beautifying ingredients, moisturizing ingredients, antioxidants, crosslinking agents, preservatives, tackifiers, solubilizers, dyes, fragrances, and UV absorbers. It is also possible to add an inorganic filler and a pH adjuster.
- herbal medicinal components such as button pi, katsong, chatayak, touki, senkiyu, chiyouji, semblish, sojutsu, chimpi, spruce, keihi, ollen, ovabata, yewyo, etc., bentonite, montmorillonite, sabonite And mud components such as hectorite.
- Examples of the moisturizing component include an acylated kefiran aqueous solution, malt extract, and glycols. These can be used alone or in combination of two or more
- Antioxidants include ascorbic acid, propyl gallate, butylhydroxyl-sol, dibutylhydroxytoluene, nordihydroayaretic acid, tocopherol, tocopherol acetate, natural vitamin E, sodium nitrite, nitrite Examples include sodium hydride.
- cross-linking agent examples include poorly water-soluble aluminum compounds, polyfunctional epoxy compounds, amino resins, phenol resins, epoxy resins, alkyd resins, unsaturated polyester, and other thermosetting resins, isocyanate compounds, Examples thereof include block isocyanate compounds, organic crosslinking agents, and inorganic crosslinking agents such as metals or metal compounds. These can be used alone or in combination of two or more. A combination of the above can be used.
- Examples of the preservative include ethyl paraoxybenzoate, propyl noxybenzoate, butyl parabenzoate, sorbic acid, and dehydroacetic acid.
- tackifier examples include casein, pullulan, dextran, sodium alginate, soluble starch, carboxy starch, dextrin, carboxymethyl cellulose, canoleoxy methinoresenorelose sodium, methinoresenorelose, ethinoresenorelose.
- Hydroxy shetilt cellulose polybutyl alcohol, polyethylene oxide, polyacrylamide, polyacrylic acid, polybulur pyrrolidone, carboxybule polymer, polybutyl ether, polymaleic acid copolymer, methoxyethylene maleic anhydride copolymer, isobutyl Tylene maleic anhydride copolymer, polyethyleneimine, polybulol alcohol partial saponified product, hydroxypropyl methylcellulose, xanthan gum, N-bulucetamide, etc. It is below.
- solubilizers include decyl sebacate, N-methyl-2-pyrrolidone, methyl salicylate, glycol salicylate, triacetin, oleyl alcohol, benzyl alcohol, isopropyl myristate, diisopropyl adipate, crotamiton, and hatsu. Power oil, camellia oil, castor oil, olive oil and the like.
- pigments examples include Red No. 2 (Amaranth), Red No. 3 (Ellis Mouth Shin), and Red No. 102.
- fragrance examples include, for example, heart force oil, keihi oil, timber oil, wikiyo oil, castor oil, turpentine oil, eucalyptus oil, orange oil, lavender oil, lemon oil, rose oil, lemongrass oil, Examples include plant extracts such as rosemary and sage.
- Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid ester, paradimethylamino amyl amyl amylate, salicylic acid ester, menthyl anthralate, umbelliferone, esculin, benzyl quinoate, synoxate, guazulene, urocanic acid, 2- (2-hydroxy-1-5-methylphenyl) benzotriazole, 4-methoxybenzopheno , 2-hydroxy-4-methoxybenzophenone, dioxybenzone, octabenzone, dihydroxydimethoxybenzophenone, thrisobenzone, benzoresorcinol, octyl dimethylparaaminobenzoate, ethylhexylparamethoxycynamate, and butylmethoxybenzoy Lumethane etc. are mentioned.
- Examples of the inorganic filler include, for example, calcium carbonate, magnesium carbonate, silicate (eg, aluminum silicate, magnesium silicate), kaic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, Examples include acid titanium.
- pH adjusters include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, glycolic acid, malic acid, citrate, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, calcium hydroxide, methylamine , Ethylamine, Propylamine, Dimethylamine, Jetylamine, Dipropylamine, Trimethylamine, Triethylamine, Tripropylamine, Monomethanolamine, Monoethanolamine, Monopropanolamine, Dimethanolamine, Diethanolamine, Dipropanolamine Amine, trimethanolamine, triethanolamine, tripropanolamine, citrate buffer, glycine buffer, acetate buffer and other buffers.
- the pH of the pressure-sensitive adhesive layer 3 of the patch 1 of this embodiment is a force that can be arbitrarily set within the range without reducing the jelly strength of the agar. Particularly at the time of production, the agar is preferable because it is easily decomposed at a pH of 3 or less. Absent. Further, pH 5 to 7 is preferred, and pH 5 to 7 is more preferred.
- a stretchable or non-stretchable support that is not limited as long as it can support the pressure-sensitive adhesive layer 3 can be used.
- synthetic fibers or natural fibers such as polyurethane, polyester, polypropylene, polyvinyl acetate, polyvinyl chloride, polyethylene, polyethylene terephthalate, aluminum sheet, nylon, talyl, cotton, rayon, acetate, or the like.
- a woven fabric or a nonwoven fabric fiber sheet made of polyester, polyethylene, or polyethylene terephthalate is more preferable. Even if such a fiber sheet is thick, it has flexibility and easily follows the skin. , Skin irritation is low. Furthermore, it is possible to obtain a patch having an appropriate self-supporting property by using such a fiber sheet.
- the pressure-sensitive adhesive layer 3 of the patch 1 of the present embodiment is provided with a release sheet 4 on the surface in contact with the skin opposite to the support 2.
- the release sheet 4 include films such as polyesters such as polyethylene terephthalate, polychlorinated burs, polysalt vinylidene, and laminated films of fine paper and polyolefin.
- These release sheets 4 are preferably those having a silicone treatment on the surface in contact with the pressure-sensitive adhesive layer 3. By using the silicone treatment, the release sheet 4 can be easily peeled off from the pressure-sensitive adhesive layer 3 at the time of use.
- the shape of the patch 1 of this embodiment is not limited to a normal rectangle or a shape having rounded four corners, but may be a circle, an ellipse, or the like. May be. Furthermore, the shape of the patch 1 may be appropriately designed according to the body part where the patch 1 is used. For example, it is cut into a face shape so that it can be applied to the face, and the eyes, nose, mouth, chin, etc. are appropriately cut into appropriate shapes.
- the temperature of the gel cake of the solution containing the readily soluble agar is lowered by the addition of the additive. Therefore, the sol state can be maintained for the time required for coating on the support 2 or the like without specially maintaining the temperature of the container or apparatus to be used, so that the production is easy.
- each component such as readily soluble agar, additives, and medicinal components is added to purified water at 65 to 75 ° C and stirred until the readily soluble agar is dissolved.
- the prepared adhesive base is applied onto the support 2 to form a coating film, and the release sheet 4 is laminated on the coating film. Store for several days and crosslink to form adhesive layer 3. After the pressure-sensitive adhesive layer 3 is formed, the patch 1 of this embodiment is obtained by cutting into a predetermined shape.
- the prepared adhesive base may be applied onto the release sheet 4 to form the adhesive layer 3, and then the support 2 may be bonded together.
- the adhesive base having a specific composition containing the readily soluble agar and the additive in a specific ratio and amount shown in the present embodiment has a reduced gelation temperature, and the support 2 or the like at the time of manufacture. Gely wrinkle does not occur until it is applied. As a result, gelling at an undesired time during the production of the adhesive base and the patch 1 can be prevented without heating the production equipment.
- the obtained patch 1 is excellent in water retention, shape retention, and adhesive strength, and the adhesive layer exudation and the adhesive paste remaining in the adhesive layer are sufficiently reduced.
- UP-37K as a readily soluble agar (trade name, manufactured by Ina Food Industry Co., Ltd., jelly strength: 700 gZ cm 2 ) 0.5 part by mass, 0.5 part by mass of synthetic aluminum silicate, polyethylene monostearate as a surfactant 0.5 parts by mass of glycol and 3.0 parts by mass of polybulal alcohol were added to 70 to 80 ° C. warm water and stirred while keeping the temperature at 70 ° C. to dissolve the raw materials. Next, the entire amount of the solution was transferred to a cooled mixer, followed by 0.5 parts by mass of magnesium aluminate metasilicate, 0.3 parts by weight of sodium edetate, 1.0 part by weight of L-menthol, polyatariate.
- Example 1 Example 2 Example 3 Example 4 Example 5 Easily soluble agar (700 gZcm 2 ) 0.5 0. 3 1. 0 3. 0 5. 0 Partially neutralized polyacrylic acid 5. 0 4.0 3. 0 3. 5 3. 0 Polyacrylic acid 2. 0 3. 0 2. 0 1.0 Polyvinyl alcohol 3. 0 2. 5 4. 0 5. 0 5. 0 Glycerin 30. 0 30. 0 25. 0 20. 0 20. 0 Polyethylene glycol 5.0
- the obtained adhesive base was applied onto a polyester support so that the coating amount was 1000 (g / cm 2), and a release sheet was bonded to the adhesive base (thickness: about 140 mm). m) was formed, and then cut into 14 cm ⁇ 10 cm to obtain a patch.
- an adhesive base was prepared in the same manner as in Example 1 except that the component composition shown in Table 1 was used.
- the readily soluble agar solution during production was transferred to a cooled mixer, the gelation state of the agar was observed, but no gelling was observed. Obtained viscosity A patch was obtained in the same manner as in Example 1 using the base. Further, the obtained patch was evaluated in the same manner as in Example 1. The results are shown in Table 2.
- the component composition does not contain polybulal alcohol as an additive, and these mixed liquids were stirred at 70 ° C to prepare an adhesive base.
- a patch was obtained in the same manner as in Example 1.
- gelation of agar was observed when the readily soluble agar solution during production was transferred to a cooled mixer.
- a patch having a pressure-sensitive adhesive layer that is dissolved at a lower temperature at the time of manufacture and does not gel to a lower V and gelation temperature by a simpler and simpler technique.
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007536467A JP4990150B2 (ja) | 2005-09-20 | 2006-09-14 | 貼付剤 |
US11/992,250 US20100217170A1 (en) | 2005-09-20 | 2006-09-14 | Adhesive Skin Patch |
EP06797990A EP1938809A4 (en) | 2005-09-20 | 2006-09-14 | ADHESIVE SKIN PATCH |
KR1020087006438A KR101411673B1 (ko) | 2005-09-20 | 2006-09-14 | 첩부제 |
CN2006800319260A CN101252923B (zh) | 2005-09-20 | 2006-09-14 | 贴剂 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2005-272590 | 2005-09-20 | ||
JP2005272590 | 2005-09-20 |
Publications (1)
Publication Number | Publication Date |
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WO2007034736A1 true WO2007034736A1 (ja) | 2007-03-29 |
Family
ID=37888781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2006/318278 WO2007034736A1 (ja) | 2005-09-20 | 2006-09-14 | 貼付剤 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100217170A1 (ja) |
EP (1) | EP1938809A4 (ja) |
JP (1) | JP4990150B2 (ja) |
KR (1) | KR101411673B1 (ja) |
CN (1) | CN101252923B (ja) |
TW (1) | TWI428152B (ja) |
WO (1) | WO2007034736A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009120365A2 (en) * | 2008-03-27 | 2009-10-01 | Agigma, Inc. | Methods and compositions for the delivery of agents |
JP2013018745A (ja) * | 2011-07-12 | 2013-01-31 | Teikoku Seiyaku Co Ltd | 外用貼付剤 |
WO2016104644A1 (ja) * | 2014-12-26 | 2016-06-30 | 花王株式会社 | 含水ゲル組成物 |
JP2020180098A (ja) * | 2019-04-26 | 2020-11-05 | 凸版印刷株式会社 | 肌貼付用フィルム、および、転写シート |
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CN101361784B (zh) * | 2008-09-01 | 2012-02-15 | 北京世纪博康医药科技有限公司 | 一种含有褐藻多糖硫酸酯和葛根的组合物和其应用 |
KR100949716B1 (ko) * | 2009-09-03 | 2010-03-29 | 주식회사 더멋진 바이오텍 | 케퍼란을 함유하는 피부보호 및 개선용 기능성 화장료 조성물 |
US8387443B2 (en) * | 2009-09-11 | 2013-03-05 | The Board Of Trustees Of The University Of Illinois | Microcantilever with reduced second harmonic while in contact with a surface and nano scale infrared spectrometer |
RU2582454C2 (ru) | 2010-06-09 | 2016-04-27 | Као Корпорейшн | Парогенерирующее устройство обогрева |
DE102010032586B4 (de) * | 2010-07-28 | 2024-06-06 | Beiersdorf Aktiengesellschaft | Hautauflage mit optimierter Wirkstofffreisetzung |
TWI500508B (zh) | 2010-07-29 | 2015-09-21 | Hisamitsu Pharmaceutical Co | 貼布材料用支撐薄膜及貼布材料 |
ES2529662T3 (es) * | 2010-07-29 | 2015-02-24 | Hisamitsu Pharmaceutical Co., Inc. | Parche adhesivo médico |
EP2671573B1 (en) * | 2011-02-02 | 2017-06-28 | Nitto Denko Corporation | Patch and patch preparation |
CN104066578B (zh) | 2012-01-27 | 2015-11-25 | 久光制药株式会社 | 带材料用支承膜和带材料 |
JP7170232B2 (ja) * | 2018-05-17 | 2022-11-14 | パナソニックIpマネジメント株式会社 | 生体貼付用膜及び生体貼付用膜を貼り付ける美容方法 |
US11642288B2 (en) | 2020-02-07 | 2023-05-09 | Kao Corporation | Skin external composition |
KR102296502B1 (ko) * | 2021-01-25 | 2021-09-02 | 주식회사 아진피앤피 | 농작물용 포장원지의 제조방법 및 이를 이용한 농작물용 포장지 |
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- 2006-09-14 JP JP2007536467A patent/JP4990150B2/ja active Active
- 2006-09-14 KR KR1020087006438A patent/KR101411673B1/ko active IP Right Grant
- 2006-09-14 EP EP06797990A patent/EP1938809A4/en not_active Withdrawn
- 2006-09-14 CN CN2006800319260A patent/CN101252923B/zh active Active
- 2006-09-14 WO PCT/JP2006/318278 patent/WO2007034736A1/ja active Application Filing
- 2006-09-19 TW TW095134644A patent/TWI428152B/zh active
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009120365A2 (en) * | 2008-03-27 | 2009-10-01 | Agigma, Inc. | Methods and compositions for the delivery of agents |
WO2009120365A3 (en) * | 2008-03-27 | 2010-01-28 | Agigma, Inc. | Methods and compositions for the delivery of agents |
US9233080B2 (en) | 2008-03-27 | 2016-01-12 | Agigma, Inc. | Compositions and methods for the delivery of agents |
US9949921B2 (en) | 2008-03-27 | 2018-04-24 | Agigma, Inc. | Compositions and methods for the delivery of agents |
JP2013018745A (ja) * | 2011-07-12 | 2013-01-31 | Teikoku Seiyaku Co Ltd | 外用貼付剤 |
WO2016104644A1 (ja) * | 2014-12-26 | 2016-06-30 | 花王株式会社 | 含水ゲル組成物 |
JP2016124870A (ja) * | 2014-12-26 | 2016-07-11 | 花王株式会社 | 含水ゲル組成物 |
US10660829B2 (en) | 2014-12-26 | 2020-05-26 | Kao Corporation | Hydrogel composition |
JP2020180098A (ja) * | 2019-04-26 | 2020-11-05 | 凸版印刷株式会社 | 肌貼付用フィルム、および、転写シート |
Also Published As
Publication number | Publication date |
---|---|
EP1938809A1 (en) | 2008-07-02 |
CN101252923B (zh) | 2010-11-03 |
JPWO2007034736A1 (ja) | 2009-03-19 |
JP4990150B2 (ja) | 2012-08-01 |
CN101252923A (zh) | 2008-08-27 |
TWI428152B (zh) | 2014-03-01 |
KR101411673B1 (ko) | 2014-06-25 |
TW200803923A (en) | 2008-01-16 |
US20100217170A1 (en) | 2010-08-26 |
EP1938809A4 (en) | 2012-05-16 |
KR20080044882A (ko) | 2008-05-21 |
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