WO2007026221A3 - Procede ameliores d'elaboration de derives d'heteroaryl amide benzocondenses de thienopyridines - Google Patents

Procede ameliores d'elaboration de derives d'heteroaryl amide benzocondenses de thienopyridines Download PDF

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Publication number
WO2007026221A3
WO2007026221A3 PCT/IB2006/002371 IB2006002371W WO2007026221A3 WO 2007026221 A3 WO2007026221 A3 WO 2007026221A3 IB 2006002371 W IB2006002371 W IB 2006002371W WO 2007026221 A3 WO2007026221 A3 WO 2007026221A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
thienopyridines
improved methods
amide derivatives
heteroaryl amide
Prior art date
Application number
PCT/IB2006/002371
Other languages
English (en)
Other versions
WO2007026221A2 (fr
Inventor
Katheryn E Harrison
Sean Timothy Neville
Robert William Scott
John Lloyd Tucker
Original Assignee
Pfizer
Katheryn E Harrison
Sean Timothy Neville
Robert William Scott
John Lloyd Tucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Katheryn E Harrison, Sean Timothy Neville, Robert William Scott, John Lloyd Tucker filed Critical Pfizer
Publication of WO2007026221A2 publication Critical patent/WO2007026221A2/fr
Publication of WO2007026221A3 publication Critical patent/WO2007026221A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

L'invention concerne des procédés d'élaboration de composés représentés par les formules (I) et (XI), ou de sels ou solvates pharmaceutiquement acceptables de ces composés. Les composés représentés par la formule (I) ou (XI) sont utiles comme agents anti-angiogéniques et comme agents destinés à moduler et/ou à inhiber l'activité de protéines kinases, et permettent ainsi de traiter le cancer ou d'autres maladies associées à la prolifération cellulaire impliquant les protéines kinases.
PCT/IB2006/002371 2005-09-02 2006-08-31 Procede ameliores d'elaboration de derives d'heteroaryl amide benzocondenses de thienopyridines WO2007026221A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71399905P 2005-09-02 2005-09-02
US60/713,999 2005-09-02

Publications (2)

Publication Number Publication Date
WO2007026221A2 WO2007026221A2 (fr) 2007-03-08
WO2007026221A3 true WO2007026221A3 (fr) 2007-06-21

Family

ID=37562069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002371 WO2007026221A2 (fr) 2005-09-02 2006-08-31 Procede ameliores d'elaboration de derives d'heteroaryl amide benzocondenses de thienopyridines

Country Status (3)

Country Link
JP (1) JP2007084537A (fr)
AR (1) AR055625A1 (fr)
WO (1) WO2007026221A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719309A (en) * 1984-12-05 1988-01-12 Basf Aktiengesellschaft Preparation of imidazoles
WO1999024440A1 (fr) * 1997-11-11 1999-05-20 Pfizer Products Inc. Derives de thienopyrimidine et thienopyridine utiles comme agents anticancereux
US20040009965A1 (en) * 2002-06-14 2004-01-15 Agouron Pharmaceuticals, Inc. Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719309A (en) * 1984-12-05 1988-01-12 Basf Aktiengesellschaft Preparation of imidazoles
WO1999024440A1 (fr) * 1997-11-11 1999-05-20 Pfizer Products Inc. Derives de thienopyrimidine et thienopyridine utiles comme agents anticancereux
US20040009965A1 (en) * 2002-06-14 2004-01-15 Agouron Pharmaceuticals, Inc. Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. A. RAGAN, J.W. RAGGON, P.D. HILL, B. P. JONES, R.E. MCDERMOTT, M.J. MUNCHHOF, M.A. MARX, J.M. CASAVANT, B.A. COOPER, J.L. DOTY: "Cross-coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine.", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 7, 2003, pages 676 - 683, XP002414438 *

Also Published As

Publication number Publication date
AR055625A1 (es) 2007-08-29
JP2007084537A (ja) 2007-04-05
WO2007026221A2 (fr) 2007-03-08

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