MX2012001420A - Derivados de pirrolo[1,2-b]piridazina como inhibidores de cinasa janus. - Google Patents
Derivados de pirrolo[1,2-b]piridazina como inhibidores de cinasa janus.Info
- Publication number
- MX2012001420A MX2012001420A MX2012001420A MX2012001420A MX2012001420A MX 2012001420 A MX2012001420 A MX 2012001420A MX 2012001420 A MX2012001420 A MX 2012001420A MX 2012001420 A MX2012001420 A MX 2012001420A MX 2012001420 A MX2012001420 A MX 2012001420A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- pyrrolo
- kinase inhibitors
- janus kinase
- pyridazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención proporciona compuestos de la fórmula I (ver fórmula (I)) o una sal de los mismos como se describe en la presente. La invención también proporciona composiciones farmacéuticas que comprenden el compuesto de la fórmula I, procedimientos para preparar los compuestos de la fórmula I, intermediarios útiles para preparar compuestos de la fórmula I y métodos terapéuticos para suprimir una respuesta inmune o tratar cáncer o una malignidad hematológica usando los compuestos de la fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23049009P | 2009-07-31 | 2009-07-31 | |
PCT/US2010/043987 WO2011014817A1 (en) | 2009-07-31 | 2010-07-30 | Pyrrolo [1, 2-b] pyridazine derivatives as janus kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012001420A true MX2012001420A (es) | 2012-03-26 |
Family
ID=42670611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012001420A MX2012001420A (es) | 2009-07-31 | 2010-07-30 | Derivados de pirrolo[1,2-b]piridazina como inhibidores de cinasa janus. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20120149691A1 (es) |
EP (1) | EP2459562A1 (es) |
JP (1) | JP2013501003A (es) |
KR (1) | KR20120085738A (es) |
CN (1) | CN102596959A (es) |
AR (1) | AR077346A1 (es) |
AU (1) | AU2010278730A1 (es) |
BR (1) | BR112012002110A2 (es) |
CA (1) | CA2769209A1 (es) |
IL (1) | IL217798A0 (es) |
MX (1) | MX2012001420A (es) |
RU (1) | RU2012107101A (es) |
TW (1) | TW201107330A (es) |
WO (1) | WO2011014817A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
CN106074548A (zh) | 2010-09-23 | 2016-11-09 | 艾伯维巴哈马有限公司 | 氮杂金刚烷衍生物的一水合物 |
WO2012125886A1 (en) * | 2011-03-17 | 2012-09-20 | Bristol-Myers Squibb Company | Pyrrolopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
AR085436A1 (es) | 2011-03-17 | 2013-10-02 | Bristol Myers Squibb Co | Derivados de pirrolopiridazina inhibidores de jak3, composiciones farmaceuticas que los contienen y su uso para tratar enfermedades inflamatorias y autoinmunes |
US8987268B2 (en) | 2011-03-17 | 2015-03-24 | Bristol-Myers Squibb Company | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
WO2012172043A1 (en) | 2011-06-15 | 2012-12-20 | Laboratoire Biodim | Purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections |
US9428511B2 (en) * | 2012-09-06 | 2016-08-30 | Bristol-Myers Squibb Company | Imidazopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
JP6223452B2 (ja) | 2012-09-07 | 2017-11-01 | ノバルティス アーゲー | インドールカルボキサミド誘導体およびその使用 |
EP2924026A1 (en) * | 2014-03-28 | 2015-09-30 | Novartis Tiergesundheit AG | Aminosulfonylmethylcyclohexanes as JAK inhibitors |
PL233595B1 (pl) | 2017-05-12 | 2019-11-29 | Celon Pharma Spolka Akcyjna | Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK |
CN109232575B (zh) * | 2017-07-10 | 2022-01-25 | 中国科学院上海药物研究所 | 吡咯[1,2-b]哒嗪类化合物或其可药用盐及它们的用途 |
TWI721483B (zh) * | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
US10851102B2 (en) | 2019-01-23 | 2020-12-01 | Theravance Biopharma R&D Ip, Llc | Imidazole and triazole containing bicyclic compounds as JAK inhibitors |
JP2022545364A (ja) * | 2019-08-13 | 2022-10-27 | ブリストル-マイヤーズ スクイブ カンパニー | Irak4阻害剤として有用な二環ヘテロアリール化合物 |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
WO2022109492A1 (en) * | 2020-11-23 | 2022-05-27 | Gossamer Bioservices, Inc. | Pyrrolopyridazine compounds as kinase inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US6900208B2 (en) * | 2002-03-28 | 2005-05-31 | Bristol Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
US7030112B2 (en) * | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
CN101312977B (zh) * | 2005-09-22 | 2012-06-13 | 布里斯托尔-迈尔斯.斯奎布公司 | 用作激酶调节剂的稠合杂环化合物 |
US7531539B2 (en) * | 2006-08-09 | 2009-05-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
JP2010508315A (ja) * | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 抗炎症剤としてのヘテロ環式化合物 |
JP5394404B2 (ja) * | 2008-02-06 | 2014-01-22 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用な置換イミダゾピリダジン類 |
KR20110050654A (ko) | 2008-08-01 | 2011-05-16 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | Jak3 억제제로서의 피페리딘 유도체 |
-
2010
- 2010-07-30 KR KR1020127005361A patent/KR20120085738A/ko not_active Application Discontinuation
- 2010-07-30 MX MX2012001420A patent/MX2012001420A/es not_active Application Discontinuation
- 2010-07-30 TW TW099125508A patent/TW201107330A/zh unknown
- 2010-07-30 WO PCT/US2010/043987 patent/WO2011014817A1/en active Application Filing
- 2010-07-30 EP EP10739455A patent/EP2459562A1/en not_active Withdrawn
- 2010-07-30 BR BR112012002110A patent/BR112012002110A2/pt not_active IP Right Cessation
- 2010-07-30 RU RU2012107101/04A patent/RU2012107101A/ru unknown
- 2010-07-30 AR ARP100102784A patent/AR077346A1/es unknown
- 2010-07-30 JP JP2012523103A patent/JP2013501003A/ja not_active Withdrawn
- 2010-07-30 AU AU2010278730A patent/AU2010278730A1/en not_active Abandoned
- 2010-07-30 CA CA2769209A patent/CA2769209A1/en not_active Abandoned
- 2010-07-30 US US13/387,569 patent/US20120149691A1/en not_active Abandoned
- 2010-07-30 CN CN2010800450215A patent/CN102596959A/zh active Pending
-
2012
- 2012-01-29 IL IL217798A patent/IL217798A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2769209A1 (en) | 2011-02-03 |
IL217798A0 (en) | 2012-03-29 |
BR112012002110A2 (pt) | 2018-04-10 |
US20120149691A1 (en) | 2012-06-14 |
EP2459562A1 (en) | 2012-06-06 |
WO2011014817A1 (en) | 2011-02-03 |
RU2012107101A (ru) | 2013-09-10 |
AR077346A1 (es) | 2011-08-17 |
TW201107330A (en) | 2011-03-01 |
KR20120085738A (ko) | 2012-08-01 |
CN102596959A (zh) | 2012-07-18 |
JP2013501003A (ja) | 2013-01-10 |
AU2010278730A1 (en) | 2012-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |