WO2007026221A3 - Improved methods for preparing benzofused heteroaryl amide derivatives of thienopyridines - Google Patents

Improved methods for preparing benzofused heteroaryl amide derivatives of thienopyridines Download PDF

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Publication number
WO2007026221A3
WO2007026221A3 PCT/IB2006/002371 IB2006002371W WO2007026221A3 WO 2007026221 A3 WO2007026221 A3 WO 2007026221A3 IB 2006002371 W IB2006002371 W IB 2006002371W WO 2007026221 A3 WO2007026221 A3 WO 2007026221A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
thienopyridines
improved methods
amide derivatives
heteroaryl amide
Prior art date
Application number
PCT/IB2006/002371
Other languages
French (fr)
Other versions
WO2007026221A2 (en
Inventor
Katheryn E Harrison
Sean Timothy Neville
Robert William Scott
John Lloyd Tucker
Original Assignee
Pfizer
Katheryn E Harrison
Sean Timothy Neville
Robert William Scott
John Lloyd Tucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Katheryn E Harrison, Sean Timothy Neville, Robert William Scott, John Lloyd Tucker filed Critical Pfizer
Publication of WO2007026221A2 publication Critical patent/WO2007026221A2/en
Publication of WO2007026221A3 publication Critical patent/WO2007026221A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

The invention relates to methods for preparing compounds of formulae (I) and (XI): or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) and (XI) Fare useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.
PCT/IB2006/002371 2005-09-02 2006-08-31 Improved methods for preparing benzofused heteroaryl amide derivatives of thienopyridines WO2007026221A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71399905P 2005-09-02 2005-09-02
US60/713,999 2005-09-02

Publications (2)

Publication Number Publication Date
WO2007026221A2 WO2007026221A2 (en) 2007-03-08
WO2007026221A3 true WO2007026221A3 (en) 2007-06-21

Family

ID=37562069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002371 WO2007026221A2 (en) 2005-09-02 2006-08-31 Improved methods for preparing benzofused heteroaryl amide derivatives of thienopyridines

Country Status (3)

Country Link
JP (1) JP2007084537A (en)
AR (1) AR055625A1 (en)
WO (1) WO2007026221A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719309A (en) * 1984-12-05 1988-01-12 Basf Aktiengesellschaft Preparation of imidazoles
WO1999024440A1 (en) * 1997-11-11 1999-05-20 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
US20040009965A1 (en) * 2002-06-14 2004-01-15 Agouron Pharmaceuticals, Inc. Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719309A (en) * 1984-12-05 1988-01-12 Basf Aktiengesellschaft Preparation of imidazoles
WO1999024440A1 (en) * 1997-11-11 1999-05-20 Pfizer Products Inc. Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
US20040009965A1 (en) * 2002-06-14 2004-01-15 Agouron Pharmaceuticals, Inc. Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. A. RAGAN, J.W. RAGGON, P.D. HILL, B. P. JONES, R.E. MCDERMOTT, M.J. MUNCHHOF, M.A. MARX, J.M. CASAVANT, B.A. COOPER, J.L. DOTY: "Cross-coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine.", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 7, 2003, pages 676 - 683, XP002414438 *

Also Published As

Publication number Publication date
AR055625A1 (en) 2007-08-29
JP2007084537A (en) 2007-04-05
WO2007026221A2 (en) 2007-03-08

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