WO2005065526A1 - カプセル型医療装置、医療用カプセル筐体とその製造方法 - Google Patents
カプセル型医療装置、医療用カプセル筐体とその製造方法 Download PDFInfo
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- WO2005065526A1 WO2005065526A1 PCT/JP2005/000116 JP2005000116W WO2005065526A1 WO 2005065526 A1 WO2005065526 A1 WO 2005065526A1 JP 2005000116 W JP2005000116 W JP 2005000116W WO 2005065526 A1 WO2005065526 A1 WO 2005065526A1
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- WIPO (PCT)
- Prior art keywords
- capsule
- exterior member
- cover
- opening
- medical
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims description 153
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 238000003466 welding Methods 0.000 claims description 46
- 238000005304 joining Methods 0.000 claims description 37
- 230000002093 peripheral effect Effects 0.000 claims description 33
- 230000005540 biological transmission Effects 0.000 claims description 15
- 229920005989 resin Polymers 0.000 claims description 10
- 239000011347 resin Substances 0.000 claims description 10
- 238000004381 surface treatment Methods 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000009832 plasma treatment Methods 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 3
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- 239000000853 adhesive Substances 0.000 abstract description 12
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- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 238000003384 imaging method Methods 0.000 description 35
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- 229910001882 dioxygen Inorganic materials 0.000 description 3
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- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
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- 229910001923 silver oxide Inorganic materials 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/0011—Manufacturing of endoscope parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00011—Operational features of endoscopes characterised by signal transmission
- A61B1/00016—Operational features of endoscopes characterised by signal transmission using wireless means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00025—Operational features of endoscopes characterised by power management
- A61B1/00027—Operational features of endoscopes characterised by power management characterised by power supply
- A61B1/00032—Operational features of endoscopes characterised by power management characterised by power supply internally powered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S600/00—Surgery
- Y10S600/92—Method of making endoscopes
Definitions
- the present invention relates to a capsule medical device such as a swallowable capsule endoscope that is introduced into a subject and collects information in the subject, and particularly relates to a capsule that maintains high liquid tightness.
- TECHNICAL FIELD The present invention relates to a medical medical device, a medical capsule housing constituting an exterior of a medical force capsule for observing, inspecting or treating a subject, and a method of manufacturing the same.
- capsule endoscopes equipped with an imaging function and a wireless function have appeared.
- This capsule endoscope is used for observation (examination) after swallowed by a subject, the observation period from the subject's living body to spontaneous excretion, and the stomach and small intestine. It moves inside the body (in the body cavity) in accordance with the peristaltic motion, and sequentially captures images using the imaging function.
- image data captured in the body cavity by the capsule endoscope is sequentially transmitted to an external device provided outside the subject by a wireless function such as wireless communication. And stored in a memory provided in the external device.
- a wireless function such as wireless communication
- the subject suffers from inconvenience during the observation period after swallowing the forceps-type endoscope until it is discharged. Action is possible.
- the doctor or nurse can make a diagnosis based on the image data stored in the memory of the external device by displaying the image inside the body cavity on a display device such as a display. .
- This type of capsule endoscope there is a swallowable type as shown in Patent Document 1, for example, in order to execute the above function.
- This capsule-type endoscope uses image data from illumination means such as LEDs, solid-state image sensors such as CCD and CMOS, drive circuits for these illumination means and solid-state image sensors, power supply units including batteries, and solid-state image sensors.
- a function execution unit such as a transmission unit for transmitting to an external device is internally provided.
- a closed capsule-shaped container has been proposed.
- the capsule-shaped container includes a hemispherical transparent cover for illuminating the outside of the container by illuminating means or receiving reflected light from the illuminating light to capture an image of the outside of the container, and a cylinder for accommodating these function executing means.
- the capsule-shaped container is hermetically sealed by joining the transparent cover and the outer case in a liquid-tight manner during manufacture.
- Patent Document 1 Japanese Patent Application Laid-Open No. 2001-91860
- the transparent cover and the outer case are formed of a thin resin member, and the transparent cover and the outer case are attached with an adhesive.
- the connection ensures liquid tightness.
- the capsule endoscope is one in which the subject swallows by mouth and passes through the body cavity of the subject, it is preferable that the safety is ensured in multiple layers.
- irregular portions or burr-like portions may be formed on the outer surface of the forceps by an extra adhesive. In such a case, a complicated process is required to smoothly finish the outer surface of the capsule. Processing had to be done.
- the present invention has been made in view of the above circumstances, and has as its object to provide a capsule medical device capable of ensuring liquid tightness of a container and further enhancing safety. Further, another object of the present invention is to improve the hydrophilicity of the container and improve the light transmittance of the container. Further, the present invention has been made in view of the above circumstances, and provides a medical capsule housing which can easily adhere and fix the first exterior member and the second exterior member, and a method of manufacturing the same. I am aiming.
- a capsule-type medical device has a substantially hemispherical dome-shaped force and a tip force having an open joint end.
- a bar a torso cover having a hollow cylindrical shape, and having an open joint end; a function execution unit housed inside the torso cover to execute a predetermined function set in advance; Power storage means for accumulating drive power for driving the function execution means.
- the joint end is joined to the joint end of the body cover to form an outer casing that is formed into a capsule shape that can be introduced into the subject and that seals the inside in a liquid-tight manner.
- a capsule medical device according to the invention of claim 2 is characterized in that, in the above invention, the surface of the distal end cover is subjected to a surface treatment.
- the capsule medical device according to the invention of claim 3 is characterized in that, in the above invention, the surface treatment also has a plasma treatment power.
- the capsule medical device according to the invention of claim 4 is characterized in that, in the above invention, the capsule medical device further comprises a joint holding means for holding a joined state between the distal end cover and the trunk cover. I do.
- the joining and holding means is provided at one of joining ends of the tip cover and the trunk cover.
- a projection provided on a joint end provided on the other of the tip cover and the trunk cover, and capable of engaging with the projection. The projection and the groove are engaged with each other to maintain a joint state between the tip cover and the body cover.
- the medical capsule casing according to the invention of claim 6 is characterized in that the first capsule member formed of a resin material and having a cylindrical shape and having an opening at one end, the opening having a predetermined inner diameter.
- a second exterior member formed of a resin material and having a cylindrical shape and having an opening at one end having an opening larger than the outer diameter of the opening of the first exterior member; and the second exterior member.
- a fitting portion between the first exterior member and the second exterior member configured by inserting a predetermined amount of the outer peripheral surface side of the opening of the first exterior member into the inner peripheral surface of the opening. And a heat-welded portion which is closely fixed by heat-welding by an external action.
- the opening side of the first exterior member and the opening side of the second exterior member are inserted and opposed to each other by a predetermined amount.
- the fitting portion between the first exterior member and the second exterior member is heat-welded to form a medical capsule in a tightly fixed state integrally with the first exterior member.
- the method for manufacturing a medical capsule casing according to the invention of claim 14 is characterized in that the ultrasonic welding of the opening of the first exterior member and the opening of the second exterior member is performed by a horn and a die.
- a method for manufacturing a medical capsule housing performed by an ultrasonic welding machine comprising: a hollow hemisphere portion at an end of a first exterior member and a second exterior member; A step was provided on the outer peripheral surface of the hemispherical portion to be arranged on the die, and a step was provided on the outer peripheral surface of the hollow hemispherical portion of the other exterior member for disposing the horn.
- the second exterior member is arranged on the die, for example, by aligning the step of the second exterior member with the die. Further, the horn is aligned with the step of the first exterior member in a state where the first exterior member is inserted and arranged in the second exterior member arranged on the die. Thereafter, by oscillating the horn force ultrasonic vibration, the opening of the first exterior member and the opening of the second exterior member are heat-welded to form a medical capsule in a tightly fixed state integrally. Is done.
- the plasma treatment is performed on the joint surface of the distal end cover and the joint surface of the trunk cover to improve the hydrophilicity of these joint surfaces, and then the joint surface is improved. Since the outer case is sealed and liquid-tightly sealed, the outer case can be formed to seal the inside of the container in a liquid-tight manner. This has the effect of being able to be increased.
- the capsule medical device according to the present invention can improve the hydrophilicity of the distal end cover by performing plasma treatment on the surface of the distal end cover, thereby improving the light transmittance of the container, and thereby achieve good observation. This produces an effect that an image can be obtained.
- a medical capsule housing capable of easily fixing the first exterior member and the second exterior member in close contact with each other, and a method for manufacturing the same.
- FIG. 1 is a side sectional view showing a configuration of a capsule medical device according to a first embodiment of the present invention.
- FIG. 1 is a side sectional view showing a configuration of a capsule medical device according to a first embodiment of the present invention.
- FIG. 2 is a developed top view of the rigid flexible wiring board shown in FIG. 1.
- FIG. 3 is a diagram showing a configuration of a processing apparatus for performing atmospheric pressure plasma processing.
- FIG. 4 is a diagram showing a state of the capsule medical device shown in FIG. 1 at the time of assembly.
- FIG. 5 is a diagram illustrating a capsule endoscope and an external device that constitute the in-vivo information acquiring system.
- FIG. 6 is a diagram illustrating an external device and a terminal device that constitute the in-vivo information acquiring system.
- FIG. 7 is a side sectional view showing a configuration of a capsule medical device according to a second embodiment.
- FIG. 8 is a view for explaining a configuration of an observation-side cover and an opening of a capsule main body for configuring part A shown in FIG. 7.
- FIG. 9 is a view for explaining the positional relationship between the observation side cover and the capsule main body when configuring part A shown in FIG.
- FIG. 10 is a diagram showing a state where a capsule main body is arranged on a die.
- FIG. 11 is a diagram illustrating a state in which an observation side cover is arranged on a capsule body arranged on a die.
- FIG. 12 is a diagram illustrating an ultrasonic welding start state in which a horn is arranged on the observation side cover to start ultrasonic welding.
- FIG. 13 is a diagram for explaining an example of an ultrasonic welding operation according to the third embodiment of the present invention. Explanation of symbols
- Solid-state imaging device Imaging lens a, 42b Lens focus adjustment mechanism a Fixed frame b Movable frame
- FIG. 1 is a side sectional view showing a configuration of a capsule medical device according to a first embodiment of the present invention.
- FIG. 2 is an expanded top view of the rigid flexible wiring board shown in FIG.
- a capsule endoscope a capsule endoscope in which a force such as a mouth of a subject, which is a subject, is introduced into a body cavity to photograph a test site in the body cavity will be described. .
- the capsule endoscope 1 includes a sealed container 2 which is an outer casing formed in a capsule shape, and a function execution for executing a predetermined function set in advance.
- Illuminating means 3 for emitting illumination light for illuminating the body cavity to be inspected at the site to be examined, and imaging means 4 for receiving the reflected light of the illumination light and imaging the site to be inspected as the function execution means.
- Control means 5 for controlling driving and signal processing of the illuminating means 3 and the imaging means 4; power storage means 6 for storing driving power for driving the function execution means; and image data obtained by the imaging means 4.
- Wireless transmission means 7 for wirelessly transmitting the outside of the subject.
- the sealed container 2 is of a size that can be swallowed by a person, and is formed by elastically fitting a substantially hemispherical tip cover 21 and a cylindrical body cover 22.
- the tip cover 21 has a substantially hemispherical dome shape, and the rear side of the dome is opened in a circular shape.
- the tip cover 21 is formed of a transparent member having transparency or translucency, for example, a cycloolefin polymer or polycarbonate which is preferable for securing optical performance and strength, and receives illumination light from the illumination means 3.
- the light can be transmitted to the outside of the sealed container 2 and the reflected light from the subject due to the illumination light can be transmitted to the inside.
- the trunk cover 22 is a member that is located behind the front cover 21 and covers the function executing unit.
- the body cover 22 is formed integrally with a cylindrical body 23 and a substantially hemispherical dome-shaped rear end 26, and the front side of the body 23 is open in a circular shape.
- the body cover 22 is made of polysulfone or the like, which is preferable for ensuring strength, and accommodates the illumination means 3, the imaging means 4, and the control means 5 in the body 23, and the wireless transmission means 7 at the rear end. 2 housed in 6.
- a cylindrical joining end 24 is provided along the edge of the opening end.
- a cylindrical joining end 25 is provided in the opening of the body 23 along the edge of the opening end.
- the joining ends 24 and 25 are overlapped inside and outside the closed container 2 and are in contact with each other.
- the joining end 24 of the front cover 21 is inside the closed container 2
- the outer surface forms a joining surface 24 a
- the joining end 25 of the body cover 22 is outside the closed container 2.
- the inner surface thereof forms a joining surface 25a
- the outer diameter of the joining surface 24a and the inner diameter of the joining surface 25a are formed substantially coincident with each other.
- the joining ends 24 and 25 are straight, for example, with a draft angle of 0 ° during molding, and are formed to have substantially the same inner and outer diameters to facilitate mutual joining. .
- the joining surface 24a has an endless projection 24b over the entire periphery thereof, and the joining surface 25a has an endless groove 25b over the entire periphery thereof.
- the projection 24b and the groove 25b are engaged with each other with the joining surfaces 24a and 25a overlapping.
- the projection 24b and the groove 25b constitute a joining and holding means for holding the joined state between the distal end cover 21 and the body cover 22 by engaging with each other.
- the lighting means 3 includes a disc-shaped lighting board 30 provided with a through hole 30a in the center, and a front face of the lighting board 30 (a front cover in FIG. 1). 21), four light-emitting diodes 31 such as white LEDs, for example, and a circuit for driving the light-emitting elements 31 on the rear surface (in FIG. 1, the imaging substrate 40 side) as shown in FIG.
- the illumination light from the illuminant 31 is radiated to the outside via the front cover 21.
- the imaging means 4 includes an imaging substrate 40 formed in a disk shape, and a CCD, CMOS, or the like provided on the front surface of the imaging substrate 40 (in FIG. 1, the illumination substrate 30 side).
- the solid-state imaging device 41 includes an imaging lens 42 that forms an image of a subject on the solid-state imaging device 41.
- the imaging lens 42 is provided on the front surface of the solid-state imaging device 41 (in FIG. 1, on the side of the illumination board 30), and includes a first lens 42a provided on the fixed frame 43a located on the subject side and a solid-state imaging device. It is composed of a second lens 42b provided on the movable frame 43b and located on the 41 side.
- the fixed frame 43a and the movable frame 43b constitute a focus adjustment mechanism 43 for moving the second lens 42b along the optical axis.
- the fixed frame 43a extends through the through hole 30a of the lighting board 30, and the optical axis of the imaging lens 42 faces the front of the lighting board 30.
- the imaging unit 4 can image the range illuminated by the illumination light of the illumination unit 3.
- the front and rear surfaces of the imaging substrate 40 in FIG. 1, the switch substrate 62 side) are solid-state.
- a chip component 44 constituting a circuit for driving the solid-state imaging device 41 is provided so as to surround the imaging device 41.
- the control means 5 has a DSP (Digital Signal Processor) 51, and the DSP 51 is provided in a mode surrounded by a chip component 52 on the rear surface of the imaging substrate 40.
- the DSP 51 controls the driving of the capsule endoscope 1 and controls the driving of the solid-state imaging device 41, the output signal processing, and the driving of the illumination means 3.
- the chip component 44 on the rear surface of the imaging board 40 is a semiconductor device having a function of mixing two signals, a video signal and a clock signal, output from the DSP 51 into one signal when transmitting the two signals from the wireless transmission means 7. It is a member.
- the power storage means 6 includes a button-type dry battery 61 such as a silver oxide battery, a switch substrate 62 formed in a disk shape, a lead switch 63a, and a bias magnet 63b.
- a switch section 63 and a power supply section 64 are provided on the front surface of the switch board 62 (in FIG. 1, the imaging board 40 side).
- a plurality of button type dry batteries 61 for example, three in this embodiment, are arranged in series with the negative electrode cap side facing the rear side.
- the number of the batteries 61 is not limited to a silver oxide battery, but may be a rechargeable battery, a power generation battery, or the like.
- a contact 65 formed of a panel is provided on the rear surface of the switch substrate 62.
- the contact 65 comes into contact with the positive electrode can of the button-type battery 61, and the button-type battery 61 is connected to the panel.
- the biasing force is applied to the rear side (in FIG. 1, the power supply board 66 side).
- the power supply unit 64 includes a power supply board 66 formed in a disk shape, and a DCZDC converter 64a provided on a rear surface of the power supply board 66 (the rear end 26 side in FIG. 1).
- the DCZDC converter 64a controls the voltage obtained by the button-type dry battery 61 by, for example, increasing the voltage in order to always obtain a constant voltage required for the system.
- a contact is provided on the front surface of the power supply board 66 (in FIG. 1, on the side of the switch board 62) to be in contact with the negative electrode cap of the button type dry battery 61.
- the power storage means 6 has a plurality of button-type dry batteries 61 connected in series between a switch board 62 and a power supply board 66 to enable power supply to each function execution means.
- the wireless transmission means 7 includes a transmission substrate 71 formed in a disc shape and a rear surface of the transmission substrate 71 (see FIG. 1, an oscillation circuit 72 provided on the rear end 26 side), an antenna substrate 73, and an antenna 74 provided on the rear surface of the antenna substrate 73 (the rear end 26 side in FIG. 1). As shown in FIG. 2, the antenna 74 is formed in a substantially spiral pattern on the rear surface of the antenna substrate 73.
- the wireless transmission means 7 extracts a signal having a constant frequency, amplitude, and waveform mixed by the chip component 44 (semiconductor member) by the oscillation circuit 72, and extracts the extracted signal from the antenna 74 by a capsule-type endoscope. Transmit outside mirror 1.
- the transmitting board 71 and the antenna board 73 are electrically connected by solder to form an integrated transmitting unit.
- the illumination board 30, the imaging board 40, the switch board 62, the power supply board 66, and the transmission board 71 also have a rigid board power. As shown in FIG. 2, these rigid boards are provided so as to sandwich a series of flexible boards 80, respectively, to constitute a rigid-flex wiring board 8. That is, the rigid boards are arranged at predetermined intervals in the order of the illumination board 30, the imaging board 40, the switch board 62, the power supply board 66, and the transmission board 71 via the flexible board 80, and are electrically connected to each other. Have been.
- the rigid flexible wiring board 8 is accommodated in the closed container 2 in a state where the flexible board 80 is bent.
- the bonding ends 24 and 25 are formed.
- an atmospheric pressure plasma treatment is performed to improve the bonding property.
- polysulfone or the like forming the body cover 22 is not a material having good adhesiveness to the adhesive. Therefore, in this embodiment, the atmospheric pressure plasma processing is performed on the bonding surfaces 24a and 25a of the bonding ends 24 and 25, and the atmospheric pressure plasma processing is also performed on the surface of the tip cover to improve the hydrophilicity. Plan.
- FIG. 3 is a diagram showing a configuration of a processing apparatus for performing atmospheric pressure plasma processing.
- an atmospheric pressure plasma processing apparatus 90 includes gas cylinders 91 and 92 filled with argon gas and oxygen gas, a gas mixing control section 93 for mixing these gases and controlling the mixing amount, and a plasma Reactor 94, high-frequency power supply 95, and plasma jet for jetting plasma And a transport device 97 such as a conveyor for transporting the to-be-processed tip cover 21 and body cover 22, a gas transport path 98, and a valve 99 provided on the transport path 98. Have been.
- the mass flows 93a and 93b in the gas mixing / control section 93 adjust the mixing flow rate of the argon gas and the oxygen gas at a predetermined mixing ratio. And oxygen gas are mixed in a mixer 93c and sent out to a reactor 94.
- the mixed gas is ionized by a high-frequency voltage from the high-frequency power supply 95 to generate plasma.
- the generated plasma is converted into a jet stream from the plasma jet 96 and is transferred by the transfer device 97 to the outer surface 21a of the tip cover 21 and the joining surfaces 24a, 25a of the tip cover 21 and the lunar cover 22. Then, the surface is treated as shown in Fig. 4.
- the front cover 21 is placed on the transport device 97 with the outer surface facing upward, and the monthly cover 22 with the opening facing upward.
- the portion to be subjected to the plasma processing also includes the protrusion 24b and the groove 25b.
- the front end cover 21 and the body cover 22 that have been subjected to the plasma processing are joined together, the gaps between the illumination board 30, the imaging board 40, and the switch board 62, and the power supply board 66
- the rigid flexible wiring board 8 is mounted on the front cover 21 with the sealing resin 82 filled in the gaps between the transmission board 71 and the antenna board 73.
- the front cover 21 is attached to a holding table (not shown) so as to cover the outer surface 21a of the front cover 21.
- a sealing resin 82 for filling the gap between the outer surface and the inner surface of the sealed container 2 is applied to the outer surface of each component of the function executing means except the antenna substrate 73.
- an adhesive is applied to the joint surface 24a of the joint end 24 of the front cover 21. Then, the joining end 25 of the body cover 22 is overlapped with and joined to the joining end 24 of the tip cover 21, and the projection 24b as the joint holding means and the groove 25b are engaged. As a result, the adhesive infiltrates between the joint surfaces 24a, 25a having improved adhesiveness. Finally, while maintaining the joint state of the projection 24b and the groove 25b, Then, the joint surfaces 24a and 25a are relatively rotated.
- the adhesive that has infiltrated between the joining surfaces 24a and 25a reaches between the projections 24b and the grooves 25b that engage with each other, and the front cover 21 and the monthly cover 22 are joined in a state where liquid tightness is secured. Is done.
- the outer surface of the distal end cover and the joint surface between the distal end cover and the body cover constituting the closed container are subjected to the surface treatment with the plasma, so that many fine irregularities are formed on the surface.
- external moisture e.g., moisture in the subject
- the imaging means can obtain a good observation image.
- the surface area is increased by a large number of fine irregularities formed on the joint surface between the front cover and the body cover, and a large amount of adhesive is uniformly adhered to the joint surface to make contact. It is possible to form an outer case that seals the inside of the container in a liquid-tight manner by improving the adhesion and preventing the interface from peeling off, thereby ensuring the liquid-tightness of the container and further improving the safety.
- a projection and a groove are provided on the joint surface, and the projection and the groove are engaged with each other at the time of assembling, so that the joint state between the distal end cover and the body cover is maintained. Therefore, safety can be further enhanced in a state where the liquid tightness of the container is further secured.
- the present invention is not limited to this, and the surface treatment of the cover can be performed using an active gas other than plasma, for example, ozone or ultraviolet light, and furthermore, a chemical treatment using a chemical is possible.
- an active gas other than plasma for example, ozone or ultraviolet light
- a chemical treatment using a chemical is possible.
- FIGS. 5 to 12 relate to a second embodiment of the present invention
- FIG. 5 is a diagram illustrating a capsule endoscope and an external device constituting a capsule endoscope apparatus (hereinafter, “in-subject information acquisition system”).
- Fig. 6 is a diagram illustrating an external device and a terminal device constituting an in-vivo information acquisition system
- Fig. 7 is a diagram illustrating a configuration of a capsule medical device according to a second embodiment.
- FIG. 8 is a cross-sectional view
- FIG. Fig. 9 is a diagram illustrating the positional relationship between the observation side cover and the capsule body when configuring part A shown in Fig. 7, and Fig. 10 shows a state where the capsule body is arranged on the die.
- Fig. 10 shows a state where the capsule body is arranged on the die.
- FIG. 11 is a diagram illustrating the state in which the observation side cover is arranged on the capsule body placed on the die
- Fig. 12 is the ultrasonic welding start in which the horn is arranged on the observation side cover to start ultrasonic welding. It is a figure explaining a state.
- the medical capsule will be described as a capsule endoscope.
- the in-vivo information acquiring system 11 mainly includes a capsule endoscope 12, which is a capsule medical device according to the present invention, and an external device 13. .
- the capsule endoscope 12 is introduced into a body cavity by, for example, a subject (hereinafter, also referred to as a “subject”) 14 swallowing.
- the capsule endoscope 12 introduced into the body cavity of the subject acquires the subject information such as image information in the body cavity.
- the subject information acquired by the capsule endoscope 12 is transmitted to the external device 13 by wireless.
- the external device 13 is arranged outside the body of the subject 14.
- the external device 13 has, for example, a box shape, and a liquid crystal monitor 13a for displaying an image and an operation unit 13b for giving operation instructions and the like are provided on the front of the box unit.
- the external device 13 includes an antenna unit 15 for receiving subject information wirelessly transmitted from the capsule endoscope 12.
- the antenna unit 15 is provided with a plurality of antennas 16, 16,.
- the antenna unit 15 is provided, for example, on a jacket 17 worn by the subject 14.
- the external device 13 is equipped with a recording medium 18 such as a compact flash (registered trademark) memory as a portable object information recording means.
- a recording medium 18 such as a compact flash (registered trademark) memory
- the subject information transmitted from the capsule endoscope 12, received by the external device 13, and recorded on the recording medium 18 is taken into a terminal device 19 such as a personal computer.
- the shape of the antenna unit 15 is not limited to the illustrated shape. Further, in this embodiment, the antenna unit 15 is provided on the jacket 17 worn by the subject 14, but may be directly attached to the body surface of the subject 14 instead of being provided on the jacket 17. Further, the external device 13 is detachably attached to a belt worn by the subject 14 with a hook or the like. Also, when the remaining battery level is low in the external device 13, It is also possible to provide an LED for displaying a remaining battery level warning for notifying that the power supply is off, or to provide only a power switch instead of providing the operation section 13b.
- the external device 13 is mounted on a cradle 19a also serving as a charger, or is electrically connected to the terminal device 19 via a USB cable or the like (not shown).
- a cradle 19a also serving as a charger, or is electrically connected to the terminal device 19 via a USB cable or the like (not shown).
- object information such as images stored in the external device 13 can be taken.
- the input 'operation devices such as the keyboard 19c and the mouse 19d.
- Images and the like captured in the terminal device 19 can be displayed on the monitor 19e by operating the keyboard 19c and the mouse 19d.
- an observation optical unit As shown in FIG. 7, in the capsule endoscope 12 of the present embodiment, an observation optical unit, an illumination unit, peripheral circuit components, and a power supply unit, which will be described later, are a medical capsule housing (hereinafter abbreviated as a capsule). It is arranged inside 110.
- a capsule a medical capsule housing
- the capsule 110 includes an observation-side cover 111 as a first exterior member and a capsule body 112 as a second exterior member.
- the observation-side cover 111 and the capsule body 112 are cylindrical and have an opening at one end, and the other end is formed, for example, as a hollow hemisphere.
- a boundary surface formed by the cover-side opening end 11la of the observation-side cover 111 and the body-side opening end 112a of the capsule body 112 is integrally and water-tightly fixed by the heat welding portion 113.
- the observation-side cover 111 and the capsule body 112 are thermoplastic resin members formed of a colorless and transparent polycarbonate having a predetermined light transmittance and biocompatibility. Being done.
- an objective optical system 114 for forming an optical image incident through the observation side cover 111 is provided.
- the objective optical system 114 is constituted by an optical lens (not shown) arranged on an objective lens 115 and a lens frame 116.
- a CCD imager 117 is arranged as an image pickup device.
- a plurality (for example, four) of white LEDs 118, which are illumination optical systems, are arranged on the same plane.
- the signal processing circuit 119 includes a circuit for driving the white LED 118 to emit light, a circuit for driving the CCD imager 117, a circuit for performing processing for generating an image signal output from the CCD imager 117 into an image signal, and the like.
- the communication processing circuit 120 performs processing for transmitting the image signal generated by the signal processing circuit 119 to the external device 13 as an electric wave.
- An antenna 122 is arranged on the rear end side of the button-type battery 121, that is, inside the hollow hemisphere portion of the capsule body 112.
- the communication processing circuit 120 is electrically connected to the antenna 122. As a result, the signal processed by the communication processing circuit 120 is transmitted to the external device 13 via the antenna 122.
- a tubular member 123 is arranged inside the capsule 110. Inside the tubular member 123, a CCD imager 117, a signal processing circuit 119, a communication processing circuit 120, and a button-type battery 121 are arranged. Reference numerals 124a and 124b denote filling portions described later.
- the configuration of the boundary surface serving as a heat-welded portion constituted by the opening end of the observation-side cover 111 and the opening end of the capsule body 112 will be specifically described. Will be explained.
- a cover-side opening end 11 la that forms an end of the opening of the observation-side cover 111 has an inner peripheral surface side that forms a cover-side opening that has a predetermined inner diameter.
- the projection 131 is formed!
- a ridge 13 la formed by a sharp edge is provided at the tip of the inner peripheral side projection 131 over the entire circumference.
- an outer peripheral surface side convex portion 141 forming the main body side opening is formed at the main body side opening end portion 112a forming the end of the opening of the capsule main body 112.
- the diameter of the main body side opening formed by the outer peripheral side projection 141 is larger than the outer diameter of the inner peripheral side projection 131 forming the cover side opening by a predetermined dimension. That is, the outer-surface-side convex portion 141 of the capsule main body 112 is fitted and arranged with the inner-peripheral surface-side convex portion 131 of the observation-side cover 111.
- the outer peripheral surface side convex portion 141 and the inner peripheral surface of the capsule main body 112 are continuously connected to each other by an inclined surface portion 141a.
- the relationship between the inclined surface portion 141a and the ridgeline portion 131a is such that when the observation-side cover 111 and the capsule body 112 are in close contact with each other, the inclined surface portion 14la On the other hand, the ridge 131a interferes by a predetermined amount t as shown by a broken line. Therefore, when the capsule body 112 is fitted and arranged on the observation side cover 111, the ridge 131a and the inclined surface 141a come into contact with each other.
- the capsule 110 when the capsule body 112 is fitted and arranged on the observation side cover 111 to form the capsule 110, the capsule 110 is located on the closed space side forming the inner peripheral surface side of the capsule 110. In this state, a contact portion is formed in which the ridge portion 13 la and the inclined surface portion 14 la are in contact with each other.
- the interference between the end surface 132 of the outer periphery of the cover of the observation side cover 111 and the end surface 142 of the outer periphery of the main body, which is the tip of the capsule body 112 corresponds to the interference portion.
- Gap t is formed. Note that this interfering portion becomes a portion to be melted in an ultrasonic welding step described later.
- step 125 in FIG. 7 On the outer peripheral surfaces of the observation side cover 111 and the capsule body 112, at the time of ultrasonic welding, a horn and a die constituting an ultrasonic welding machine described later are respectively arranged (step 125 in FIG. 7). Is formed.
- the formation position of the step portion 125 formed on the observation side cover 111 and the capsule main body 112 is on the outer periphery of the hemisphere. Further, the step portion 125 is formed with an annular flat portion 125a perpendicular to an axis connecting the center of the hollow hemisphere portion of the observation side cover 111 and the center of the hollow hemisphere portion of the capsule body 112.
- the ultrasonic welding step of joining the observation side cover 111 and the capsule body 112 will be described.
- a tubular member on which a CCD imager 117, a signal processing circuit 119, a communication processing circuit 120, a button-type battery 121, and an antenna 122 are arranged beforehand in the inner surface of the capsule body 112 before the ultrasonic welding step. 123 are assembled.
- a capsule body 112 on which a tubular member 123 and the like are assembled is arranged on a die 151 constituting an ultrasonic welding machine.
- the step 125 formed on the capsule body 112 is arranged at a predetermined position on the die 151.
- the capsule body 112 is placed on the die 151.
- the observation-side cover 111 is arranged to face the capsule body 112 placed on the die 151. Then, the observation-side cover 111 is moved to the capsule body 112 side as shown by the arrow in the figure, and the outer peripheral side projection 131 is The peripheral surface is fitted and arranged on the inner peripheral surface of the outer peripheral surface side convex portion 141. Thereafter, as shown in FIG. 9, the ridge 13la of the observation side cover 111 is fitted to the inclined surface 14la of the capsule body 112. Abut. As a result, a predetermined gap t is formed between the outer peripheral end face 132 of the cover and the outer peripheral end face 142 of the main body.
- a horn 152 constituting the ultrasonic welding machine 150 is placed in contact with a step 125 formed on the observation side cover 111. This completes the setting before processing. Thereafter, ultrasonic welding by the ultrasonic welding machine 150 is started. In other words, the horn 152 applies minute ultrasonic vibration to the observation side cover 111, and also applies a pressing force as indicated by an arrow to the observation side cover 111.
- the molten metal is melted by the amount of the interfering portion. Touch Then, the contact surface is melted by ultrasonic heating. Thereafter, the application of ultrasonic vibration is stopped and cooling is performed. Then, the portion melted by the ultrasonic heating is solidified to form a capsule 110 having a heat-welded portion 113 for fixing the observation-side cover 111 and the capsule body 112 in a watertight manner and physically as shown in FIG. Is done.
- the horn 152 is removed from the step portion 125 of the observation side cover 111, and the capsule 110 in which the observation side cover 111 and the capsule 112 are integrated is taken out from the die 151 and stored in, for example, a storage box.
- the capsule body 112 on which the new tubular member 123 and the like are assembled is placed on the die 151 of the ultrasonic welding machine 150, and the next welding operation is performed.
- filling portions 124a and 124b are provided by filling, for example, an adhesive into a step portion 125 formed on the observation side cover 111 and the capsule body 112 of the welded capsule 110 stored in the storage box. .
- the capsule endoscope 12 shown in FIG. 7 is configured.
- the inner peripheral surface side convex portion 131 is provided on the observation side cover 111 and the outer peripheral surface side convex portion 141 is provided on the capsule body 112.
- the outer peripheral surface side convex portion may be provided, and the inner peripheral surface side convex portion may be provided on the capsule body 112.
- observation side cover 111 is set in a state where the observation side cover 111 is fitted to the capsule body 112 in advance.
- the capsule body 112 may be arranged on the die 151!
- a welded portion is provided only at the boundary surface between the observation side cover and the capsule body.
- water-tight integral fixing can be performed.
- a welded portion is formed only on the boundary surface, so that a watertight structure with little variation and requiring no post-processing can be obtained by easy process control.
- observation-side cover and the capsule body are formed of the same resin member, it is possible to prevent a problem of heat welding due to a knock of the member and to obtain a reliable heat welding effect.
- a ridge portion is provided at the tip of the inner peripheral surface side convex portion of the observation side cover, and an inclined surface portion that continuously connects the outer peripheral surface side convex portion of the capsule main body and the inner peripheral surface of the capsule main body is provided. Since the ridges are formed so as to interfere with each other by a predetermined amount, when ultrasonic heat is generated by ultrasonic vibration, melting starts from the inner surface of the capsule where the ridges and the inclined surface come into contact with each other, and watertightness in the capsule is achieved. Can reliably be ensured. By welding and fixing the outer peripheral surface side convex portion to the tip end surface, the watertightness can be further improved and the welding force can be greatly improved.
- an ultrasonic welding machine is formed at each step.
- ultrasonic welding can be performed by applying a uniform pressing force to the boundary surface between the observation side cover and the capsule body, and the die constituting the ultrasonic welding machine is provided.
- the portion where the horn abuts the surface of the observation side cover and the surface of the capsule body can be prevented from being carelessly damaged.
- the medical capsule is described as a capsule endoscope for acquiring subject information such as image information, but the medical capsule is limited to the capsule endoscope.
- the medical capsule is not equipped with ultrasonic transducer, temperature sensor, pressure sensor It may be equipped with various sensors such as a sensor and a pH sensor.
- FIG. 13 is a diagram illustrating an example of an ultrasonic welding operation according to the third embodiment of the present invention. As shown in the figure, in the present embodiment, an ultrasonic welding machine 150 is provided in a vacuum furnace 160, and the ultrasonic welding operation is performed in a vacuum environment.
- the capsule member 112 is disposed on the die 151 of the ultrasonic welding machine 150, and the tubular member 123 and the like are assembled.
- evacuation is performed, and then, welding is performed.
- the capsule medical device that is useful in the present invention is useful for a medical observation device that is introduced into a human body and observes a test site, and in particular, ensures liquid tightness of a container. Therefore, it is suitable for further enhancing safety and improving the hydrophilicity of the container, and improving the light transmittance of the container.
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- Engineering & Computer Science (AREA)
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- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Manufacturing & Machinery (AREA)
- Computer Networks & Wireless Communication (AREA)
- Endoscopes (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05703382.1A EP1702555B1 (en) | 2004-01-07 | 2005-01-07 | Capsule type medical device, medical capsule enclosure and production method therefor |
US11/483,050 US7931584B2 (en) | 2004-01-07 | 2006-07-07 | Medical capsule housing formed by thermal welding |
US13/080,999 US8709329B2 (en) | 2004-01-07 | 2011-04-06 | Medical capsule housing formed by thermal welding |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004-002424 | 2004-01-07 | ||
JP2004002424A JP2005192820A (ja) | 2004-01-07 | 2004-01-07 | カプセル型医療装置 |
JP2004075066A JP3850416B2 (ja) | 2004-03-16 | 2004-03-16 | 医療用カプセル筐体とその製造方法 |
JP2004-075066 | 2004-03-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US11/483,050 Continuation US7931584B2 (en) | 2004-01-07 | 2006-07-07 | Medical capsule housing formed by thermal welding |
Publications (1)
Publication Number | Publication Date |
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WO2005065526A1 true WO2005065526A1 (ja) | 2005-07-21 |
Family
ID=34752088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2005/000116 WO2005065526A1 (ja) | 2004-01-07 | 2005-01-07 | カプセル型医療装置、医療用カプセル筐体とその製造方法 |
Country Status (3)
Country | Link |
---|---|
US (2) | US7931584B2 (ja) |
EP (1) | EP1702555B1 (ja) |
WO (1) | WO2005065526A1 (ja) |
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2006
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8709329B2 (en) | 2004-01-07 | 2014-04-29 | Olympus Corporation | Medical capsule housing formed by thermal welding |
US20080255410A1 (en) * | 2005-12-19 | 2008-10-16 | Koji Okuzumi | Capsule endoscope and manufacturing method thereof |
WO2012073634A1 (ja) * | 2010-11-29 | 2012-06-07 | オリンパスメディカルシステムズ株式会社 | カプセル型医療装置及びその製造方法 |
JP7403008B2 (ja) | 2020-06-01 | 2023-12-21 | アンコン メディカル テクノロジーズ (シャンハイ) カンパニー リミテッド | 医療用カプセル |
Also Published As
Publication number | Publication date |
---|---|
US20060252986A1 (en) | 2006-11-09 |
US20110180197A1 (en) | 2011-07-28 |
EP1702555A4 (en) | 2009-05-13 |
EP1702555B1 (en) | 2016-12-07 |
EP1702555A1 (en) | 2006-09-20 |
US7931584B2 (en) | 2011-04-26 |
US8709329B2 (en) | 2014-04-29 |
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