WO2002098390A3 - Administration d'aerosols contenant de petites particules via une voie d'inhalation - Google Patents

Administration d'aerosols contenant de petites particules via une voie d'inhalation Download PDF

Info

Publication number
WO2002098390A3
WO2002098390A3 PCT/US2002/018608 US0218608W WO02098390A3 WO 2002098390 A3 WO2002098390 A3 WO 2002098390A3 US 0218608 W US0218608 W US 0218608W WO 02098390 A3 WO02098390 A3 WO 02098390A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
particles
small particles
containing small
aerodynamic diameter
Prior art date
Application number
PCT/US2002/018608
Other languages
English (en)
Other versions
WO2002098390A2 (fr
Inventor
Craig C Hodges
Peter M Lloyd
Daniel Mufson
Daniel D Rogers
Martin J Wensley
Original Assignee
Alexza Molecular Delivery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Molecular Delivery Corp filed Critical Alexza Molecular Delivery Corp
Priority to EP02742015A priority Critical patent/EP1392263A2/fr
Priority to CA002447210A priority patent/CA2447210C/fr
Priority to JP2003501430A priority patent/JP2004532881A/ja
Publication of WO2002098390A2 publication Critical patent/WO2002098390A2/fr
Publication of WO2002098390A3 publication Critical patent/WO2002098390A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A61M11/044—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical with electrodes immersed in the liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1075—Preparation of respiratory gases or vapours by influencing the temperature
    • A61M16/109—Preparation of respiratory gases or vapours by influencing the temperature the humidifying liquid or the beneficial agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/16—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating or cooling the material to be sprayed
    • B05B7/1686—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas incorporating means for heating or cooling the material to be sprayed involving vaporisation of the material to be sprayed or of an atomising-fluid-generating product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nozzles (AREA)
  • Organic Insulating Materials (AREA)
  • Dental Preparations (AREA)

Abstract

L'invention concerne l'administration par inhalation d'aérosols contenant de petites particules. Plus particulièrement, l'invention concerne l'administration d'aérosols, dans le cadre d'une inhalothérapie, renfermant des médicaments, les particules de ces aérosols présentant un diamètre aérodynamique moyen en masse inférieur à 1 ν. Selon un aspect de composition, l'aérosol renfermant un médicament comprend des particules dont le diamètre aérodynamique moyen en masse est compris entre 10 nm et 1 ν. De préférence, ces particules présentent un diamètre aérodynamique moyen en masse compris entre 10 et 900 nm. Plus préférablement, ces particules présentent un diamètre aérodynamique moyen compris entre 10 et 800 nm, 10 et 700 nm, 10 et 600 nm, 10 et 500 nm, 10 et 400 nm, 10 et 300 nm, 10 et 200nm, et 10 et 100 nm.
PCT/US2002/018608 2001-06-05 2002-05-13 Administration d'aerosols contenant de petites particules via une voie d'inhalation WO2002098390A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02742015A EP1392263A2 (fr) 2001-06-05 2002-05-13 Administration d'aerosols contenant de petites particules via une voie d'inhalation
CA002447210A CA2447210C (fr) 2001-06-05 2002-05-13 Administration d'aerosols contenant de petites particules via une voie d'inhalation
JP2003501430A JP2004532881A (ja) 2001-06-05 2002-05-13 吸入経路を介す微粒子含有エアロゾルの送出

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US29622501P 2001-06-05 2001-06-05
US60/296,225 2001-06-05
US10/057,198 US20030051728A1 (en) 2001-06-05 2001-10-26 Method and device for delivering a physiologically active compound
US10/057,198 2001-10-26
US10/057,197 US7766013B2 (en) 2001-06-05 2001-10-26 Aerosol generating method and device
US10/057,197 2001-10-26

Publications (2)

Publication Number Publication Date
WO2002098390A2 WO2002098390A2 (fr) 2002-12-12
WO2002098390A3 true WO2002098390A3 (fr) 2003-02-20

Family

ID=27369190

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2002/015363 WO2002098496A1 (fr) 2001-06-05 2002-05-13 Dispositif formant un generateur d'aerosol destine a etre utilise en inhalotherapie
PCT/US2002/015425 WO2002098389A1 (fr) 2001-06-05 2002-05-13 Procede de formation d'un aerosol pour administration par voie inhalee
PCT/US2002/018608 WO2002098390A2 (fr) 2001-06-05 2002-05-13 Administration d'aerosols contenant de petites particules via une voie d'inhalation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2002/015363 WO2002098496A1 (fr) 2001-06-05 2002-05-13 Dispositif formant un generateur d'aerosol destine a etre utilise en inhalotherapie
PCT/US2002/015425 WO2002098389A1 (fr) 2001-06-05 2002-05-13 Procede de formation d'un aerosol pour administration par voie inhalee

Country Status (17)

Country Link
US (15) US20030051728A1 (fr)
EP (3) EP1392381B9 (fr)
JP (4) JP2004532881A (fr)
CN (2) CN100496458C (fr)
AT (2) ATE503516T1 (fr)
AU (4) AU2002311926B2 (fr)
CA (4) CA2447210C (fr)
CZ (2) CZ20033223A3 (fr)
DE (2) DE60236430D1 (fr)
ES (1) ES2343678T3 (fr)
HK (2) HK1068293A1 (fr)
HU (2) HUP0401948A3 (fr)
IL (2) IL158955A0 (fr)
MX (2) MXPA03011269A (fr)
NZ (2) NZ529298A (fr)
PL (2) PL374048A1 (fr)
WO (3) WO2002098496A1 (fr)

Families Citing this family (231)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962904B1 (en) * 1998-03-13 2005-11-08 Connective Tissue Imagineering Elastin peptide analogs and uses thereof
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
WO2002094242A1 (fr) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Administration de rizatriptan ou de zolmitriptan par voie d'inhalation
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
EP1392262A1 (fr) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Administration d'esters medicamenteux par inhalation
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
JP4357842B2 (ja) * 2001-05-24 2009-11-04 アレックザ ファーマシューティカルズ， インコーポレイテッド 所定の吸入ルートによるアルプラゾラム、エスタゾラム、ミダゾラムまたはトリアゾラムの送出
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
GB2381450B (en) * 2001-10-31 2006-05-31 Gw Pharma Ltd Compositions for administration of natural or synthetic cannabinoids by vaporisation
WO2003041693A1 (fr) * 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Administration de diazepam a travers une voie pulmonaire
CA2467833A1 (fr) * 2001-11-19 2003-09-04 Becton, Dickinson And Company Compositions pharmaceutiques sous forme particulaire
AU2002363947A1 (en) * 2001-11-21 2003-07-24 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
GB2384184B (en) * 2002-01-10 2005-01-12 Aea Technology Plc Cannabis aerosol
WO2003094900A1 (fr) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Distribution de medicament a base d'amines par voie d'inhalation
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
JP2006514633A (ja) * 2002-11-26 2006-05-11 アレックザ ファーマシューティカルズ， インコーポレイテッド 吸入によって送達される抗精神病薬を用いた頭痛の治療
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
DK1567164T3 (da) * 2002-11-26 2009-05-18 Alexza Pharmaceuticals Inc Anvendelse af loxapin til fremstilling af et lægemiddel til behandling af smerte
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1596824A4 (fr) * 2003-02-04 2011-11-23 Chrysalis Tech Inc Formulations d'aerosols et distribution par aerosols de buspirone, buprenorphine, triazolam, cyclobenzaprine et zolpidem
WO2005082369A1 (fr) * 2003-02-28 2005-09-09 Delex Therapeutics Inc. Systeme d'administration d'un opioide
MXPA05009179A (es) * 2003-02-28 2006-03-08 Delex Therapeutics Inc Sistema para suministro de opioides.
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
US7648981B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
CN100381083C (zh) 2003-04-29 2008-04-16 韩力 一种非可燃性电子喷雾香烟
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
EP1625336B9 (fr) * 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Utilisation d'une couche de combustible solide, procédé pour fabriquer une telle couche et unité de chauffage correspondante
US20050042177A1 (en) * 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
US20050037506A1 (en) * 2003-08-04 2005-02-17 Alexza Molecular Delivery Corporation Methods of determining film thicknesses for an aerosol delivery article
EP1656171B9 (fr) * 2003-08-04 2010-10-20 Alexza Pharmaceuticals, Inc. Substrats pour dispositif d'administration de medicaments et procedes de preparation
US7252050B2 (en) * 2003-09-04 2007-08-07 Maury Dean Cole Substance inhalation system
WO2005037949A2 (fr) * 2003-10-07 2005-04-28 Chrysalis Technologies Incorporated Formulations d'aerosol et administration par aerosol de butalbital, lorazepam, ipratropium, baclofene, morphine et scopolamine
DE10356925B4 (de) * 2003-12-05 2006-05-11 Lts Lohmann Therapie-Systeme Ag Inhalator für basische pharmazeutische Wirkstoffe sowie Verfahren für dessen Herstellung
CN2719043Y (zh) 2004-04-14 2005-08-24 韩力 雾化电子烟
US7402777B2 (en) * 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
SI1750788T1 (sl) 2004-06-03 2014-05-30 Alexza Pharmaceuticals, Inc. Naprave za več odmerkov kondenzacijskega aerosola in postopki tvorjenja kondenzacijskih aerosolov
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
US8628796B2 (en) * 2004-12-09 2014-01-14 Insys Therapeutics, Inc. Room-temperature stable dronabinol formulations
FR2880279A1 (fr) * 2005-01-05 2006-07-07 Cvb Sarl Sarl Dispositif de diffusion multi-odeurs
AU2006216696B2 (en) * 2005-02-23 2011-08-18 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
US7213347B2 (en) * 2005-05-03 2007-05-08 Eastman Kodak Company Metering material to promote rapid vaporization
KR101348594B1 (ko) * 2005-05-18 2014-01-07 노바르티스 아게 기관지 치료를 위한 밸브, 장치 및 방법
EP1733753A1 (fr) * 2005-06-14 2006-12-20 RIZK, Nelly Kamel Appareil pour l'application d'une composition
CA2578626C (fr) 2005-06-27 2011-07-19 Biovail Laboratories International S.R.L. Formulations a liberation modifiee d'un sel de bupropion
US20090107495A1 (en) * 2005-07-21 2009-04-30 National Institute For Materials Science Device for inhalation of medicine
CN101262901B (zh) * 2005-08-23 2012-02-01 亚罗擎公司 自密封t形接头和带阀的t形接头
US7900625B2 (en) * 2005-08-26 2011-03-08 North Carolina State University Inhaler system for targeted maximum drug-aerosol delivery
CA2622200A1 (fr) * 2005-09-13 2007-03-22 Elan Pharma International, Limited Formulations nanoparticulaires de tadalafil
FR2891435B1 (fr) * 2005-09-23 2007-11-09 Bull Sa Sa Systeme de maintien en position d'un assemblage a trois parties assurant un effort de compression predetermine sur la partie intermediaire
WO2007079118A1 (fr) * 2005-12-29 2007-07-12 Molex Incorporated Ensemble de connexion pour un element chauffant comportant des bornes fixees par insertion en force
US8357114B2 (en) * 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8865743B2 (en) * 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
US20070286818A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
WO2007145868A1 (fr) * 2006-06-07 2007-12-21 Wyeth Traitement d'une fibrose cystique par des antibiotiques via un médicament aérosol
WO2007141668A2 (fr) 2006-06-09 2007-12-13 Philip Morris Products S.A. Générateur d'aérosol capillaire indirectement chauffé
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
WO2008019146A2 (fr) * 2006-08-04 2008-02-14 Insys Therapeutics Inc. Formulations aqueuses de dronabinol
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
US20100105724A1 (en) * 2006-12-07 2010-04-29 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
WO2008080170A1 (fr) * 2006-12-22 2008-07-03 Alexza Pharmaceuticals, Inc. Compositions aérosol de médicament mixte
US7513781B2 (en) 2006-12-27 2009-04-07 Molex Incorporated Heating element connector assembly with insert molded strips
EP1964564A1 (fr) * 2007-04-19 2008-09-03 LAB International SRL Gestion efficace de la douleur
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US20090181080A1 (en) * 2007-08-06 2009-07-16 Insys Therapeutics Inc. Oral cannabinnoid liquid formulations and methods of treatment
KR101606944B1 (ko) * 2007-08-07 2016-03-28 아셀알엑스 파마슈티컬스 인코퍼레이티드 경구 경점막 투여형을 사용한 시술시 진정과 무통을 위한 조성물 및 방법
WO2009049159A1 (fr) 2007-10-10 2009-04-16 Parion Sciences, Inc. Administration d'osmolytes par canule nasale
DK2230934T3 (da) 2007-12-14 2012-11-26 Aerodesigns Inc Afgivelse af aerosoliserbare næringsmiddelprodukter
MX2010009765A (es) 2008-03-06 2013-07-12 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
ES2419204T3 (es) * 2008-05-27 2013-08-19 The University Of Melbourne Métodos para tratar a mamíferos con disfunciones de la trompa de Eustaquio
US20100065052A1 (en) * 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
US7834295B2 (en) * 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
EP2350118B1 (fr) * 2008-09-19 2016-03-30 Nektar Therapeutics Polymères à base de glucide pour administration de médicaments et leurs conjugués
WO2010033220A2 (fr) * 2008-09-19 2010-03-25 Nektar Therapeutics Peptides thérapeutiques modifiés, procédés pour les préparer et les utiliser
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
WO2010065547A1 (fr) * 2008-12-01 2010-06-10 Map Pharmaceuticals, Inc. Procédés et dispositif d’administration par inhalation
WO2010074753A1 (fr) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs
WO2010107761A1 (fr) 2009-03-18 2010-09-23 Acelrx Pharmaceuticals, Inc. Dispositifs de stockage et de distribution améliorés pour l'administration de formes posologiques transmucosales orales
US20100300433A1 (en) * 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
CN201445686U (zh) * 2009-06-19 2010-05-05 李文博 高频感应雾化装置
US8488952B2 (en) * 2009-06-22 2013-07-16 Magic-Flight General Manufacturing, Inc. Aromatic vaporizer
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US9149588B2 (en) * 2009-07-17 2015-10-06 Nektar Therapeutics Systems and methods for driving sealed nebulizers
WO2011014562A1 (fr) 2009-07-28 2011-02-03 North Carolina State University Procédés et dispositifs pour injection ciblée de microsphères
NZ599202A (en) 2009-10-13 2014-05-30 Philip Morris Prod Air freshening device
US20110091544A1 (en) * 2009-10-16 2011-04-21 Acelrx Pharmaceuticals, Inc. Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
WO2011094450A1 (fr) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Petites molecules contenant du bore
US9078985B2 (en) 2010-03-08 2015-07-14 Stc.Unm Dry powder nebulizer
CN102009012B (zh) * 2010-03-31 2012-10-24 范维林 带温度控制的液态雾化气溶胶发生装置
US11247003B2 (en) 2010-08-23 2022-02-15 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
EA033311B1 (ru) 2010-09-07 2019-09-30 Анакор Фармасьютикалс, Инк. Производные бензоксаборола в качестве антибактериальных средств
PL2654864T3 (pl) 2010-12-22 2021-07-12 Syqe Medical Ltd. System dostarczania leku
US8945605B2 (en) * 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
JP5717218B2 (ja) * 2011-08-19 2015-05-13 日本たばこ産業株式会社 エアロゾル吸引器
KR102309513B1 (ko) 2011-09-06 2021-10-05 니코벤처스 트레이딩 리미티드 가열식 흡연가능 재료
US9282772B2 (en) 2012-01-31 2016-03-15 Altria Client Services Llc Electronic vaping device
HUE033664T2 (en) * 2012-03-09 2017-12-28 Vectura Gmbh Mixing channel for inhalation device and inhalation device
AU2013234834A1 (en) * 2012-03-19 2014-11-06 Joseph Fisher Virtual respiratory gas delivery systems and circuits
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
CN104955508A (zh) * 2012-11-28 2015-09-30 艾尼科提恩科技公司 用于化合物递送的方法和设备
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
BR112015017176A2 (pt) * 2013-01-18 2017-07-11 Tonix Pharmaceuticals Inc isômero isometepteno
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
WO2014140765A1 (fr) 2013-03-15 2014-09-18 Trudell Medical International Circuit de ventilateur, adaptateur utilisé dans le circuit de ventilateur et leurs procédés d'utilisation
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
GB2515992A (en) 2013-03-22 2015-01-14 British American Tobacco Co Heating smokeable material
CN105263345A (zh) 2013-05-06 2016-01-20 派克斯实验公司 用于气溶胶装置的烟碱盐调配物及其方法
EP4268640A3 (fr) 2013-05-22 2023-12-06 Njoy, Inc. Compositions, dispositifs, et procédés pour administration d'aérosols de nicotine
CN104274426A (zh) 2013-07-03 2015-01-14 陆克塞纳医药公司 昂丹司琼细粉、昂丹司琼气溶胶组合物及其用途
WO2016004409A1 (fr) * 2014-07-03 2016-01-07 Luxena Pharmaceuticals, Inc. Nouvelles préparations d'aérosol de l'ondansétron et leurs utilisations
US10010692B2 (en) * 2013-07-08 2018-07-03 Virginia Commonwealth University Systems, devices, and methods for changing therapeutic aerosol size and improving efficiency of ventilation and aerosol drug delivery
JP6397493B2 (ja) 2013-07-11 2018-09-26 アレックザ ファーマシューティカルズ， インコーポレイテッド メタ−サリチル酸とのニコチン塩
US11116914B2 (en) 2014-11-09 2021-09-14 Sipnose Ltd. Device and method for aerosolized delivering of substance to a natural orifice of the body
US11471618B2 (en) 2014-11-09 2022-10-18 Sipnose Ltd. Adjustable dosing delivery and multi sectioned drug compartment
US11992604B2 (en) 2014-11-09 2024-05-28 Sipnose Ltd. Devices and methods for delivering a substance to a body cavity
DE202013105715U1 (de) 2013-08-22 2014-02-19 Sipnose Ltd. Vorrichtung zur Abgabe einer vorbestimmten Menge einer Substanz an eine natürliche Öffnung des Körpers
US11278682B2 (en) 2014-11-09 2022-03-22 Sipnose Ltd. Device and method for aerosolized delivery of substance to a natural orifice of the body
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
US10039321B2 (en) 2013-11-12 2018-08-07 Vmr Products Llc Vaporizer
US10980273B2 (en) 2013-11-12 2021-04-20 VMR Products, LLC Vaporizer, charger and methods of use
EP3068244A4 (fr) 2013-11-15 2017-07-05 VMR Products, LLC Vaporisateur ayant une gaine de revêtement
CA3144602A1 (en) 2013-12-05 2015-06-11 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
WO2015089105A1 (fr) 2013-12-09 2015-06-18 Respira Therapeutics, Inc. Formulations en poudre d'inhibiteur pde5 et procédés y associés
EP3082816B1 (fr) 2013-12-20 2019-03-20 Indivior UK Limited Compositions de naloxone intranasales et leurs procédés de préparation et d'utilisation
CN104740737A (zh) * 2013-12-26 2015-07-01 北京谊安医疗***股份有限公司 麻醉机及用于麻醉机的吸收回路的加热装置
AU2014381786B2 (en) * 2014-02-10 2019-02-21 Philip Morris Products S.A. An aerosol-generating system having a fluid-permeable heater assembly
US10821240B2 (en) 2014-02-11 2020-11-03 Vapor Cartridge Technology Llc Methods and drug delivery devices using cannabis
US9220294B2 (en) 2014-02-11 2015-12-29 Timothy McCullough Methods and devices using cannabis vapors
US9380813B2 (en) 2014-02-11 2016-07-05 Timothy McCullough Drug delivery system and method
USD788697S1 (en) 2014-03-04 2017-06-06 VMR Products, LLC Battery portion for a vaporizer
USD763502S1 (en) 2014-03-04 2016-08-09 Vmr Products Llc Cartomizer for a vaporizer
USD749505S1 (en) 2014-03-07 2016-02-16 VMR Products, LLC Charger for a vaporizer
USD752278S1 (en) 2014-03-07 2016-03-22 VMR Products, LLC Battery portion of a vaporizer
USD752280S1 (en) 2014-03-07 2016-03-22 VMR Products, LLC Cartomizer for a vaporizer
TWI589308B (zh) * 2014-03-25 2017-07-01 林信湧 一種用於治療帕金森氏症之吸入式醫藥組成物及其備製方法
USD804090S1 (en) 2014-04-08 2017-11-28 VMR Products, LLC Vaporizer with indicators
USD750320S1 (en) 2014-08-05 2016-02-23 VMR Products, LLC Vaporizer
KR101667177B1 (ko) 2014-05-21 2016-10-24 필립모리스 프로덕츠 에스.에이. 다중 물질 서셉터를 갖는 에어로졸 발생 물품
TWI661782B (zh) 2014-05-21 2019-06-11 瑞士商菲利浦莫里斯製品股份有限公司 電熱式氣溶膠產生系統、電熱式氣溶膠產生裝置及產生氣溶膠之方法
TWI669072B (zh) 2014-05-21 2019-08-21 瑞士商菲利浦莫里斯製品股份有限公司 電熱式霧劑產生系統及用於此系統中之匣筒
GB201410562D0 (en) 2014-06-13 2014-07-30 Nicoventures Holdings Ltd Aerosol provision system
CA3111682A1 (fr) 2014-06-26 2015-12-30 Island Breeze Systems Ca, Llc Produits associes a un aerosol doseur, et procedes d'utilisation
EP3939639A1 (fr) 2014-06-30 2022-01-19 Syqe Medical Ltd. Cartouche de dosage de médicaments pour dispositif inhalateur
CN106573123B (zh) 2014-06-30 2021-08-31 Syqe医药有限公司 用于活性剂的肺部递送的方法、装置及***
AU2015283590B2 (en) 2014-06-30 2020-04-16 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
CN106604755B (zh) 2014-06-30 2020-08-11 Syqe医药有限公司 流量调节的吸入器装置
US11298477B2 (en) 2014-06-30 2022-04-12 Syqe Medical Ltd. Methods, devices and systems for pulmonary delivery of active agents
EP3160553B1 (fr) 2014-06-30 2021-10-20 Syqe Medical Ltd. Dispositif utilisables en vue de la vaporisation et de l'inhalation de substances isolées
CN104122179B (zh) * 2014-08-05 2017-03-22 云南中烟工业有限责任公司 一种评价电子烟烟雾量的方法
IL251279B2 (en) 2014-10-15 2024-04-01 Altria Client Services Llc Electronic inhaler and components thereof
SG11201704797TA (en) 2014-12-23 2017-07-28 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
GB201423317D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Apparatus for heating smokable material
GB201423312D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Heating device for apparatus for heating smokable material and method of manufacture
GB201423318D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Cartridge for use with apparatus for heating smokable material
CN107438373A (zh) * 2015-02-02 2017-12-05 无畏品牌责任有限公司 个人电子蒸发器
WO2016138505A1 (fr) * 2015-02-27 2016-09-01 Ebbu, LLC Compositions comprenant des combinaisons de cannabinoïdes purifiés, ayant au moins un flavonoïde, terpène ou minéral
WO2017100369A1 (fr) * 2015-12-07 2017-06-15 Ebbu, LLC Compositions de cannabinoïdes et de terpènes imprimables
CN114522307A (zh) 2015-03-11 2022-05-24 艾利斯达医药品公司 气道中的防静电材料用于热气溶胶凝结方法的用途
GB201511358D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US10994084B2 (en) 2015-06-30 2021-05-04 Maury D. Cole Substance inhalation system and method
US9943388B2 (en) 2015-06-30 2018-04-17 Maury D. Cole Substance inhalation system and method
KR20180052566A (ko) 2015-07-02 2018-05-18 키비타스 테라퓨틱스, 인코포레이티드. 폐 전달용 트립탄 분말
US20170038184A1 (en) * 2015-08-06 2017-02-09 Charles E. Ankner Formulation delivery system
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170055574A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Cartridge for use with apparatus for heating smokable material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119050A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
US20170119051A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
AU2017204945B2 (en) * 2016-01-06 2022-11-10 Syqe Medical Ltd. Low dose therapeutic treatment
CN114712642A (zh) * 2016-01-11 2022-07-08 Syqe医药有限公司 个人用蒸发装置
US11027086B2 (en) * 2016-02-07 2021-06-08 The Government Of The United States As Represented By The Secretary Of The Army Oro-nasal inhalation plethysmography mask exposure system
WO2017153827A1 (fr) * 2016-03-07 2017-09-14 Wallbrooke Investments Ltd. Appareil de chauffage par induction et procédé associé
US10244795B2 (en) * 2016-03-31 2019-04-02 Altria Client Services Llc Vaporizing assembly comprising sheet heating element and liquid delivery device for an aerosol generating system
EP3436117B1 (fr) * 2016-03-31 2021-09-22 Philip Morris Products S.A. Ensemble de vaporisation comprenant un élément chauffant en feuille
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
EP3452152A4 (fr) * 2016-05-03 2020-01-01 Pneuma Respiratory, Inc. Méthodes permettant de générer et d'administrer des gouttelettes au système pulmonaire à l'aide d'un dispositif d'administration de gouttelettes
KR102468749B1 (ko) 2016-06-29 2022-11-17 니코벤처스 트레이딩 리미티드 흡연가능 물질을 가열하기 위한 장치
WO2018044953A1 (fr) 2016-08-29 2018-03-08 Ebbu, LLC Compositions hydrosolubles comprenant des cannabinoïdes purifiés
US10736359B2 (en) 2016-12-02 2020-08-11 VMR Products, LLC Cartridge-based vaporizers
EP4272827A3 (fr) 2016-12-09 2024-01-24 Alexza Pharmaceuticals, Inc. Procédé de traitement de l'épilepsie
US10149843B1 (en) 2017-02-07 2018-12-11 Gneus Lifescineces Inc. Pharmaceutical compositions and methods of using the same
US10413505B1 (en) 2017-02-07 2019-09-17 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US10231961B1 (en) 2017-02-07 2019-03-19 Genus Lifesciences Inc. Pharmaceutical compositions and methods of using the same
US20200129504A1 (en) 2017-03-13 2020-04-30 Beyondspring Pharmaceuticals, Inc. Compositions of plinabulin and use thereof
EP3634552A4 (fr) 2017-05-19 2021-03-03 Pneuma Respiratory, Inc. Dispositif d'administration de poudre sèche et procédés d'utilisation
TWI760513B (zh) 2017-06-30 2022-04-11 瑞士商菲利浦莫里斯製品股份有限公司 具有有效電力控制的感應加熱系統之氣溶膠產生裝置與氣溶膠產生系統
US10292436B2 (en) 2017-07-10 2019-05-21 Arc Innovations, Inc. Electronic smoking systems, devices, and methods
UA127273C2 (uk) 2017-09-15 2023-07-05 Брітіш Амерікан Тобакко (Інвестментс) Лімітед Пристрій для нагрівання курильного матеріалу, курильний матеріал, система для нагрівання вказаного матеріалу, що містить вказаний пристрій, спосіб нагрівання вказаного матеріалу і теплоізолятор для використання у вказаному пристрої
US10506830B2 (en) 2017-09-22 2019-12-17 Altria Client Services Llc Air flow design for an e-vaping cartridge, method of making the e-vaping cartridge, and e-vaping device including the cartridge
EP4111951A1 (fr) * 2017-10-02 2023-01-04 Lightlab Imaging, Inc. Sondes intravasculaires de collecte de données et ensembles correspondants
CN111526914A (zh) 2017-10-04 2020-08-11 精呼吸股份有限公司 电子呼吸致动式直线型液滴输送装置及其使用方法
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CN111479604B (zh) 2017-11-08 2022-12-30 精呼吸股份有限公司 具有小体积安瓿的电动呼吸致动直列液滴输送装置及使用方法
US20210046259A1 (en) * 2018-02-02 2021-02-18 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
EP3793655A4 (fr) * 2018-05-17 2022-04-06 Sipnose Ltd Dispositif et procédé d'administration par aérosol d'une substance dans un orifice naturel du corps
US11260195B2 (en) 2018-09-20 2022-03-01 General Electric Company Systems and methods for an inductively heated anesthetic vaporizer
WO2020097052A1 (fr) 2018-11-05 2020-05-14 Juul Labs, Inc. Cartouches pour dispositifs de vaporisation
EP3876763B1 (fr) 2018-11-05 2022-12-28 Juul Labs, Inc. Une cartouche pour un dispositif de vaporisation
WO2020127225A1 (fr) 2018-12-17 2020-06-25 Philip Morris Products S.A. 3- (1,2,3,6-tétrahydropyridin-2-yl) pyridine glutarate ou un solvate pharmaceutiquement acceptable de celui-ci
WO2020143864A1 (fr) * 2019-01-07 2020-07-16 Nuuvera Deutschland GmbH Dispositif de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire
CN114555078A (zh) 2019-02-22 2022-05-27 Gh研究爱尔兰有限公司 用于治疗抑郁症的5-甲氧基-n,n-二甲基色胺(5-meo-dmt)
CN109876252A (zh) * 2019-04-04 2019-06-14 林晓霞 一种固定式小儿内科用雾化吸入装置
KR20220008824A (ko) 2019-04-17 2022-01-21 컴퍼스 패쓰파인더 리미티드 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법
MX2022003189A (es) * 2019-09-16 2022-06-08 Vapor Cartridge Tech Llc Sistema de administración de fármacos con sustratos apilables.
EP3868364A1 (fr) 2020-02-24 2021-08-25 GH Research Limited Aérosol comrpenant 5-methoxy-n,n-dimethyltryptamine
US11666553B2 (en) 2020-02-25 2023-06-06 North Cell Pharmceticals Inc. Method of reducing anxiety in non-human mammals by increasing brain serotonin levels
CN116940351A (zh) * 2021-01-15 2023-10-24 阿奎斯蒂弗医疗股份有限公司 前药组合物和治疗方法
KR20240037245A (ko) 2021-06-22 2024-03-21 뉴마 레스퍼러토리 인코포레이티드 푸시 이젝션에 의한 액적 전달 장치
RU209490U1 (ru) * 2021-07-05 2022-03-16 Общество с ограниченной ответственностью "ИнертГаз Медикал" Универсальный ингаляционный аппарат для проведения терапии инертными газами с функцией подогрева газовой смеси
EP4159192A1 (fr) 2021-09-30 2023-04-05 Biomind Labs Inc Spray nasal à base de diméthyltriptamine pour le traitement personnalisé des troubles neurologiques et psychiatriques
CN114028595B (zh) * 2021-10-28 2023-09-19 武汉生物制品研究所有限责任公司 一种新型冠状病毒气溶胶暴露***消毒及评价方法
CN113876748A (zh) * 2021-11-22 2022-01-04 兆科药业（广州）有限公司 一种用于治疗肺动脉高压的曲前列尼尔气溶胶吸入剂的雾化方法
WO2023186829A1 (fr) 2022-03-27 2023-10-05 GH Research Ireland Limited 5-méthoxy-n, n-diméthyltryptamine pour le traitement d'un retrait ou d'un détachement social/émotionnel

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735217A (en) * 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
WO1994009842A1 (fr) * 1992-10-28 1994-05-11 Rosen Charles A Procede et dispositifs permettant l'inhalation de medicaments
US5388574A (en) * 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
WO1996031198A1 (fr) * 1995-04-07 1996-10-10 Edward Mendell Co., Inc. Excipient pour insufflation, a liberation progressive, destine a des medicaments

Family Cites Families (551)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1864980A (en) * 1932-06-28 Vapobizeb
US3080624A (en) * 1963-03-12 weber iii
US1803334A (en) * 1931-05-05 Ootthujp lehmann
US2243669A (en) * 1941-05-27 Electrical vaporizer
US1239634A (en) 1916-07-25 1917-09-11 Frank J Stuart Medical appliance.
US1535486A (en) * 1922-08-28 1925-04-28 James W Lundy Electric-lamp bulb
US2086140A (en) 1933-09-08 1937-07-06 Silten Ernst Automatic temperature regulated narcosis apparatus
US2084299A (en) 1934-12-15 1937-06-15 Arthur G Borden Medicament holder for nasal inhalers
US2230754A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
US2230753A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
GB502761A (en) 1938-01-29 1939-03-24 Christopher Engelbreth Improvements in and relating to hand inhalation apparatus
US2309846A (en) * 1941-03-06 1943-02-02 Holm Einar Marius Inhaler
FR921852A (fr) 1945-12-06 1947-05-21 Diffuseur de produits volatils
US2469656A (en) * 1946-04-19 1949-05-10 Peter H Lienert Vaporizer
US2714649A (en) 1952-11-25 1955-08-02 Lyle H Critzer Vaporizer
US2761055A (en) 1953-06-10 1956-08-28 Malcome Van Ike Lamp-heated vaporizer
US2741812A (en) * 1954-02-15 1956-04-17 Tellier Andre Perfume dispenser
US2902484A (en) 1954-04-27 1959-09-01 Rhone Poulenc Sa Phenthiazine derivatives and processes for their preparation
US2887106A (en) * 1956-09-27 1959-05-19 Robinson Joseph Combined vaporizer and cover for medicament jar
US2898649A (en) 1956-11-19 1959-08-11 Elaine T Cassidy Perfume diffuser
US3371085A (en) 1959-12-10 1968-02-27 Hoffmann La Roche 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US3043977A (en) 1960-03-30 1962-07-10 Puritron Corp Device and method for producing negative ions
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB903866A (en) 1961-05-09 1962-08-22 Dausse Lab Therapeutic preparations containing 7-substituted theophylline derivatives
NL135583C (fr) * 1961-10-10
US3299185A (en) 1962-09-27 1967-01-17 Ube Nitto Kasei Co Dyeable polyolefin fibers containing a binary copolymer of styrene and acrylonitrile
US3169095A (en) * 1962-10-30 1965-02-09 Rexall Drug Chemical Self-propelling powder-dispensing compositions
NL289785A (fr) 1962-11-29
GB1063512A (en) * 1962-11-30 1967-03-30 Benger Lab Ltd Aerosols
US3282729A (en) 1963-02-27 1966-11-01 Union Carbide Corp Barrier coated thermoplastic olefin polymer substrates
US3200819A (en) 1963-04-17 1965-08-17 Herbert A Gilbert Smokeless non-tobacco cigarette
NL298071A (fr) 1963-06-04
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US3909463A (en) 1968-11-29 1975-09-30 Allied Chem Grafted block copolymers of synthetic rubbers and polyolefins
US3987052A (en) 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US4008723A (en) 1970-03-23 1977-02-22 Imperial Chemical Industries Limited Smoking mixture
US3863347A (en) * 1970-04-13 1975-02-04 Philip Michael Banner Navigation device
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
US3831606A (en) 1971-02-19 1974-08-27 Alza Corp Auto inhaler
US3749547A (en) 1971-09-09 1973-07-31 Airco Inc Flashlamp with improved combustible foil
US3847650A (en) 1971-09-09 1974-11-12 Airco Inc Flashlamp with improved combustion foil and method of making same
US4166087A (en) 1971-11-22 1979-08-28 Cline-Buckner, Inc. Automatic intermittent vapor dispenser
US3701782A (en) 1972-02-10 1972-10-31 Upjohn Co 1-carbolower alkoxy - 6 - phenyl-4h-s-triazolo(1,4)benzodiazepine compounds
US3763347A (en) 1972-04-13 1973-10-02 Ncr Co Vaporous lamp
IE37524B1 (en) 1972-04-20 1977-08-17 Gallaher Ltd Synthetic smoking product
US3864326A (en) 1972-05-22 1975-02-04 Robert S Babington Spraying devices, in particular nebulizing devices
USRE30285E (en) 1972-05-22 1980-05-27 Spraying devices, in particular nebulizing devices
GB1366041A (en) 1972-07-21 1974-09-11 Kodama Bros Co Ltd Device for volatilizing insecticides and the like
US3773995A (en) 1972-10-27 1973-11-20 Westinghouse Electric Corp Motor advanced spring charging pawl and ratchet mechanism with spring assist
US3949743A (en) * 1973-03-19 1976-04-13 Schick Incorporated Medicated vapor production method and apparatus
US3930796A (en) * 1973-09-13 1976-01-06 Universal Oil Products Company Catalytic fume control device
US3982095A (en) 1973-10-04 1976-09-21 Searle Cardio-Pulmonary Systems Inc. Respiratory humidifier
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3894040A (en) 1974-09-16 1975-07-08 American Home Prod 2,5,6,7-Tetrahydro-3H-imidazo(1,2-D)(1,4)benzodiazepine-5,6-dicarboxylic acid esters
US4045156A (en) 1974-12-23 1977-08-30 Gte Sylvania Incorporated Photoflash lamp
US4020379A (en) * 1975-10-02 1977-04-26 Eg&G, Inc. Bulb-shaped flashtube with metal envelope
US4104210A (en) 1975-12-17 1978-08-01 Monsanto Company Thermoplastic compositions of high unsaturation diene rubber and polyolefin resin
US4121583A (en) 1976-07-13 1978-10-24 Wen Yuan Chen Method and apparatus for alleviating asthma attacks
US4286604A (en) 1976-10-05 1981-09-01 Gallaher Limited Smoking materials
US4079742A (en) 1976-10-20 1978-03-21 Philip Morris Incorporated Process for the manufacture of synthetic smoking materials
US4160765A (en) 1976-11-17 1979-07-10 Smithkline Corporation Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4141369A (en) 1977-01-24 1979-02-27 Burruss Robert P Noncombustion system for the utilization of tobacco and other smoking materials
US4184099A (en) * 1977-04-27 1980-01-15 International Flavors & Fragrances Inc. Composition for slow release of volatile ingredients at _high temperature; and article comprising same
DE2752384A1 (de) 1977-08-29 1979-03-15 Simes Pharmazeutisches praeparat auf der basis beklemmungsloesender mittel und hemmstoffe der beta-adrenergischen rezeptoren
SE7812207L (sv) 1977-12-01 1979-06-02 Welsh Nat School Med Apparat, forfarande och framstellda produkter for anvendning vid administration av antihistaminer
US4183912A (en) * 1978-01-16 1980-01-15 American Home Products Corporation Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine
JPS54120065A (en) 1978-02-24 1979-09-18 Osaka Takeshi Stick for blind person
US4198200A (en) 1978-05-18 1980-04-15 Lord Corporation Damage-preventive coatings
US4284089A (en) 1978-10-02 1981-08-18 Ray Jon P Simulated smoking device
US4276243A (en) * 1978-12-08 1981-06-30 Western Electric Company, Inc. Vapor delivery control system and method
US4280629A (en) 1979-01-08 1981-07-28 Anchor Brush Company, Inc. Container for nail polish or the like
US4219031A (en) 1979-03-05 1980-08-26 Philip Morris Incorporated Smoking product having core of fibrillar carbonized matter
US4229931A (en) 1979-03-05 1980-10-28 Deere & Company Hydraulic height sensing system with cylinder by-pass
IL59407A (en) 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
US4654370A (en) 1979-03-12 1987-03-31 Abbott Laboratories Glyceryl valproates
US4251525A (en) 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4340072A (en) 1979-11-16 1982-07-20 Imperial Group Limited Smokeable device
ATE3774T1 (de) 1980-05-02 1983-06-15 Schering Corporation Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung.
US4391285A (en) 1980-05-09 1983-07-05 Philip Morris, Incorporated Smoking article
US4347855A (en) 1980-07-23 1982-09-07 Philip Morris Incorporated Method of making smoking articles
US4303083A (en) 1980-10-10 1981-12-01 Burruss Jr Robert P Device for evaporation and inhalation of volatile compounds and medications
US4376767A (en) 1981-01-02 1983-03-15 Merck & Co., Inc. Pyridylmethyl esters of selected bio-affecting carboxylic acids
US4346059A (en) 1981-03-03 1982-08-24 Donald Spector Aroma-generating lamp structure
DE3116951C2 (de) * 1981-04-29 1984-12-20 Drägerwerk AG, 2400 Lübeck Vorrichtung zur Beimischung flüssiger Narkosemittel in das dem Patienten zuzuführende Atemgas
JPS5876038A (ja) 1981-10-28 1983-05-09 高森　正之 殺虫剤や芳香剤の蒸発装置
GB2122903B (en) 1982-06-22 1986-11-05 Masayuki Takamori Vaporizers for vaporisable substances and support media for substances usable therewith
DE3224849A1 (de) 1982-07-02 1984-01-05 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Dampfinhaliergeraet
US4556539A (en) 1982-08-27 1985-12-03 Donald Spector Disc-playing aroma generator
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
DE3390229C2 (de) 1982-09-30 1987-10-01 Dainippon Jochugiku Kk Thermischer Verdampfungsapparat f}r Chemikalien
US4474191A (en) 1982-09-30 1984-10-02 Steiner Pierre G Tar-free smoking devices
US4753758A (en) 1983-05-19 1988-06-28 Intertech Resources Inc. Respiratory humidifier
US4523589A (en) 1983-06-29 1985-06-18 Krauser Robert S Method and apparatus for treating ailments
US5038769A (en) 1983-06-29 1991-08-13 Krauser Robert S Method and apparatus for treating ailments
DE3326089A1 (de) 1983-07-20 1985-02-07 Gödecke AG, 1000 Berlin Zur inhalation bestimmte darreichungsform von calcium-antagonisten
AU591451B2 (en) 1983-08-01 1989-12-07 Mclean Hospital Corporation, The Gamma amino butyric acid esters
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
ATE44470T1 (de) 1983-11-08 1989-07-15 Bunnell Life Systems Inc Befeuchter, insbesondere fuer atmungshilfesysteme.
FI68988C (fi) * 1984-01-04 1985-12-10 Rauma Repola Oy Flissikt vars siktkorg delats i tvao korgsektorer
GB8405190D0 (en) 1984-02-28 1984-04-04 British Petroleum Co Plc Thermoplastic elastomer composition
US4627963A (en) 1984-02-29 1986-12-09 Lad Technology, Inc. Heat activated dispenser and method of dispensing a vapor therefrom
US4683231A (en) 1984-03-02 1987-07-28 Research Foundation For Mental Hygiene, Inc. Method of preventing withdrawal symptoms associated with the cessation or reduction of tobacco smoking
DE3414640A1 (de) * 1984-04-18 1985-10-24 W. Schlafhorst & Co, 4050 Mönchengladbach Rotations-schaftmaschine
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4647428A (en) * 1984-06-04 1987-03-03 Gyulay Joseph M Air freshener method
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
US5042509A (en) 1984-09-14 1991-08-27 R. J. Reynolds Tobacco Company Method for making aerosol generating cartridge
US4854331A (en) 1984-09-14 1989-08-08 R. J. Reynolds Tobacco Company Smoking article
US4793365A (en) 1984-09-14 1988-12-27 R. J. Reynolds Tobacco Company Smoking article
US5020548A (en) 1985-08-26 1991-06-04 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US5067499A (en) 1984-09-14 1991-11-26 R. J. Reynolds Tobacco Company Smoking article
US4647433A (en) * 1984-10-01 1987-03-03 Donald Spector Long-life aroma-generating capsule
CN1018607B (zh) 1984-12-21 1992-10-14 美国耳·杰·瑞诺兹烟草公司 吸烟制品
GB8501015D0 (en) 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US4928714A (en) 1985-04-15 1990-05-29 R. J. Reynolds Tobacco Company Smoking article with embedded substrate
US5119834A (en) 1985-04-15 1992-06-09 R. J. Reynolds Tobacco Company Smoking article with improved substrate
DE3686025T2 (de) 1985-05-22 1993-01-07 Liposome Technology Inc Verfahren und system zum einatmen von liposomen.
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US4800903A (en) 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US4722334A (en) * 1985-07-16 1988-02-02 Transpirator Technologies, Inc. Method and apparatus for pulmonary and cardiovascular conditioning of racehorses and competition animals
US4989619A (en) 1985-08-26 1991-02-05 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US5105831A (en) 1985-10-23 1992-04-21 R. J. Reynolds Tobacco Company Smoking article with conductive aerosol chamber
US4756318A (en) 1985-10-28 1988-07-12 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US5033483A (en) 1985-10-28 1991-07-23 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US5060666A (en) 1985-10-28 1991-10-29 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US4793366A (en) 1985-11-12 1988-12-27 Hill Ira D Nicotine dispensing device and methods of making the same
JPS62204756A (ja) * 1986-03-04 1987-09-09 大研医工株式会社 薬剤揮散方法および装置
DE3767615D1 (de) 1986-03-10 1991-02-28 Kurt Burghart Pharmazeutikum sowie verfahren zu seiner herstellung.
US4708151A (en) 1986-03-14 1987-11-24 R. J. Reynolds Tobacco Company Pipe with replaceable cartridge
US4765347A (en) 1986-05-09 1988-08-23 R. J. Reynolds Tobacco Company Aerosol flavor delivery system
US4771795A (en) 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4917120A (en) 1986-05-21 1990-04-17 Advanced Tobacco Products, Inc. Nicotine impact modification
US4774971A (en) 1986-06-03 1988-10-04 Vieten Michael J Cigarette substitute
US4801411A (en) 1986-06-05 1989-01-31 Southwest Research Institute Method and apparatus for producing monosize ceramic particles
US4858630A (en) 1986-12-08 1989-08-22 R. J. Reynolds Tobacco Company Smoking article with improved aerosol forming substrate
IL84516A0 (en) 1986-12-12 1988-04-29 Reynolds Tobacco Co R Smoking articles comprising impact modifying agents
US4734560A (en) 1987-01-20 1988-03-29 Medical Enterprises, Ltd. Vaporizing unit
US4819665A (en) 1987-01-23 1989-04-11 R. J. Reynolds Tobacco Company Aerosol delivery article
US4924883A (en) 1987-03-06 1990-05-15 R. J. Reynolds Tobacco Company Smoking article
US4968885A (en) 1987-03-06 1990-11-06 Extrel Corporation Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors
HU201685B (en) 1987-04-23 1990-12-28 Chinoin Gyogyszer Es Vegyeszet For producing pharmaceutical compositions for inhalation and compositions for scenting air containing volatile active component in cyclodextrine inclusion, and air-scenting composition
US4889850A (en) 1987-05-11 1989-12-26 Thornfeldt Carl R Treatment of colic and teething
US5017575A (en) 1987-06-09 1991-05-21 Golwyn Daniel H Treatment of immunologically based disorders, specifically Crohn's disease
GB8713645D0 (en) 1987-06-11 1987-07-15 Imp Tobacco Ltd Smoking device
US5019122A (en) 1987-08-21 1991-05-28 R. J. Reynolds Tobacco Company Smoking article with an enclosed heat conductive capsule containing an aerosol forming substance
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US5072726A (en) 1987-10-09 1991-12-17 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vaporizer for inhalation anesthetics during high-frequency jet ventilation and associated method
US4911157A (en) * 1988-01-07 1990-03-27 Pegasus Research Corporation Self-regulating, heated nebulizer system
US4906417A (en) 1988-02-08 1990-03-06 Associated Mills Inc. Humidifier
JPH01221313A (ja) 1988-02-29 1989-09-04 Hayashi Teruaki 昇華放出薬剤組成物とその放出システム
US4853517A (en) 1988-03-28 1989-08-01 John G. Bowen Vaporizing unit
DE3815221C2 (de) * 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5137034A (en) 1988-05-16 1992-08-11 R. J. Reynolds Tobacco Company Smoking article with improved means for delivering flavorants
US4881556A (en) 1988-06-06 1989-11-21 R. J. Reynolds Tobacco Company Low CO smoking article
US5264433A (en) 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
CH678151A5 (en) 1988-07-13 1991-08-15 Heinz Hermann Weick Self-medication nasal dispenser
US5345951A (en) 1988-07-22 1994-09-13 Philip Morris Incorporated Smoking article
US4852561A (en) 1988-07-27 1989-08-01 Sperry C R Inhalation device
EP0358114A3 (fr) 1988-09-08 1990-11-14 R.J. Reynolds Tobacco Company Appareil électrique pour administrer des aérosols
US4947875A (en) 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Flavor delivery articles utilizing electrical energy
US4922901A (en) * 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
US4947874A (en) 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Smoking articles utilizing electrical energy
US4950664A (en) 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
USRE36744E (en) 1988-09-16 2000-06-20 Ribogene, Inc. Nasal administration of benzodiazepine hypnotics
US4963289A (en) 1988-09-19 1990-10-16 The United States Of America As Represented By The United States Department Of Energy Method for producing monodisperse aerosols
US4917830A (en) 1988-09-19 1990-04-17 The United States Of America As Represented By The United States Department Of Energy Monodisperse aerosol generator
US5511726A (en) 1988-09-23 1996-04-30 Battelle Memorial Institute Nebulizer device
HU200105B (en) 1988-10-04 1990-04-28 Ferenc Inkovics Electrically actuated inhaler of uniform medicine feeding
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US4917119A (en) 1988-11-30 1990-04-17 R. J. Reynolds Tobacco Company Drug delivery article
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US4959380A (en) 1988-12-19 1990-09-25 Wilson Jordan E Method of treating people to stop smoking and composition
US4881541A (en) 1988-12-21 1989-11-21 The Regents Of The University Of California Vaporizer for an anesthetic having a vapor pressure about one atmosphere
GB8900267D0 (en) 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US4892109A (en) * 1989-03-08 1990-01-09 Brown & Williamson Tobacco Corporation Simulated smoking article
DE3908161A1 (de) 1989-03-13 1990-09-27 Bat Cigarettenfab Gmbh Rauchbarer artikel
AU643435B2 (en) 1989-04-28 1993-11-18 Riker Laboratories, Inc. Dry powder inhalation device
GB8909891D0 (en) 1989-04-28 1989-06-14 Riker Laboratories Inc Device
HUT60631A (en) 1989-05-05 1992-10-28 North Sydney Area Health Serv Process for producing pharmaceutical compositions suitable for increasing fertility
US4941483A (en) 1989-09-18 1990-07-17 R. J. Reynolds Tobacco Company Aerosol delivery article
US6048857A (en) 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6313176B1 (en) 1989-10-17 2001-11-06 Everett J. Ellinwood, Jr. Dosing method of administering deprenyl via intraoral administration or inhalation administration
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5224498A (en) 1989-12-01 1993-07-06 Philip Morris Incorporated Electrically-powered heating element
US5093894A (en) * 1989-12-01 1992-03-03 Philip Morris Incorporated Electrically-powered linear heating element
US5060671A (en) 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
US5269327A (en) 1989-12-01 1993-12-14 Philip Morris Incorporated Electrical smoking article
US5144962A (en) 1989-12-01 1992-09-08 Philip Morris Incorporated Flavor-delivery article
US5408574A (en) * 1989-12-01 1995-04-18 Philip Morris Incorporated Flat ceramic heater having discrete heating zones
CA2070823C (fr) 1989-12-05 1999-01-12 William H. Ii Frey Agents neurologiques devant etre administres au cerveau par voie nasale
US5109180A (en) * 1989-12-14 1992-04-28 Phillips Petroleum Company Apparatus providing a shatter-resistant electric lamp
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
GB9000042D0 (en) * 1990-01-03 1990-03-07 Ralph John F Decorative wall covering applied to steel radiators
GB2239807A (en) * 1990-01-09 1991-07-17 Boc Group Plc Anaesthetic vaporiser
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
US5156170A (en) 1990-02-27 1992-10-20 R. J. Reynolds Tobacco Company Cigarette
US5099861A (en) 1990-02-27 1992-03-31 R. J. Reynolds Tobacco Company Aerosol delivery article
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5366770A (en) 1990-04-17 1994-11-22 Xingwu Wang Aerosol-plasma deposition of films for electronic cells
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5192548A (en) 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
PT97888B (pt) 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
SE9002052D0 (sv) 1990-06-08 1990-06-08 Pharmacia Ab Smoking composition
US5167242A (en) 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
US5455043A (en) 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5126123A (en) 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
DE69110785T3 (de) * 1990-08-02 2002-05-23 Boc Group Plc Narkosemittelverdampfer.
US5060667A (en) 1990-08-16 1991-10-29 Brown & Williamson Tobacco Corporation Smoking article
US5292499A (en) 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5166202A (en) 1990-09-19 1992-11-24 Trustees Of The University Of Pennsylvania Method for the treatment of panic disorder
NO904226D0 (no) 1990-09-28 1990-09-28 Forsvarets Forsknings Fukteanordning.
US5175152A (en) 1990-09-28 1992-12-29 Singh Nikhilesh N Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form
US5095921A (en) * 1990-11-19 1992-03-17 Philip Morris Incorporated Flavor generating article
US5179966A (en) * 1990-11-19 1993-01-19 Philip Morris Incorporated Flavor generating article
HU219778B (hu) 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5519019A (en) 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
FR2671487B1 (fr) 1991-01-14 1993-03-19 Oreal Utilisation d'un facteur de croissance dans une composition amincissante.
ATE179605T1 (de) * 1991-02-09 1999-05-15 B S D Bio Science Dev Snc Di O Antireaktive antiasthmatische wirkung von acetylsalicylsäure durch inhalation
US5469750A (en) 1991-03-05 1995-11-28 Aradigm Corporation Method and apparatus for sensing flow in two directions and automatic calibration thereof
WO1994016757A2 (fr) 1991-03-05 1994-08-04 Miris Medical Corporation Appareil de liberation minutee d'une dose de medicament en aerosol
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5226411A (en) 1991-03-07 1993-07-13 Walter Levine Aerosol nebulizer heater
US5249586A (en) 1991-03-11 1993-10-05 Philip Morris Incorporated Electrical smoking
US5479948A (en) * 1993-08-10 1996-01-02 Philip Morris Incorporated Electrical smoking article having continuous tobacco flavor web and flavor cassette therefor
US5505214A (en) * 1991-03-11 1996-04-09 Philip Morris Incorporated Electrical smoking article and method for making same
US5186164A (en) * 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5605897A (en) 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
US5817656A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5627178A (en) 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5938117A (en) 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
GB9109021D0 (en) 1991-04-26 1991-06-12 Boc Group Plc Dosing pump
GB9109442D0 (en) * 1991-05-01 1991-06-26 Volex Group Plc Apparatus for emitting a chemical agent
US5261424A (en) 1991-05-31 1993-11-16 Philip Morris Incorporated Control device for flavor-generating article
US5160664A (en) * 1991-05-31 1992-11-03 Msp Corporation High output monodisperse aerosol generator
US5149538A (en) 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5177071A (en) 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
CA2069687A1 (fr) 1991-06-28 1992-12-29 Chandra Kumar Banerjee Article de fumeur avec source electrochimique de chaleur
US5285798A (en) 1991-06-28 1994-02-15 R. J. Reynolds Tobacco Company Tobacco smoking article with electrochemical heat source
CN1103609C (zh) * 1991-08-07 2003-03-26 伊万·菲利普·吉勒·佩森蒂 吸入装置
US5184133A (en) * 1991-11-26 1993-02-02 Texas Instruments Incorporated ISAR imaging radar system
US5457100A (en) 1991-12-02 1995-10-10 Daniel; David G. Method for treatment of recurrent paroxysmal neuropsychiatric
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
GB9200047D0 (en) 1992-01-03 1992-02-26 Univ Alberta Nicotine-containing nasal spray
US5229120A (en) 1992-02-05 1993-07-20 Devincent James F Treatment for ***e abuse
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
DK64592D0 (da) 1992-05-14 1992-05-14 Carlbiotech Ltd As Peptider til terapeutisk behandling
US5584701A (en) 1992-05-13 1996-12-17 University Of Florida Research Foundation, Incorporated Self regulating lung for simulated medical procedures
US5391081A (en) 1992-05-13 1995-02-21 University Of Florida Research Foundation, Incorporated Method and apparatus for simulating neuromuscular stimulation during medical surgery
US5525329A (en) 1992-05-21 1996-06-11 The Johns Hopkins University Inhibition of phosphodiesterase in olfactory mucosa
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5622944A (en) 1992-06-12 1997-04-22 Affymax Technologies N.V. Testosterone prodrugs for improved drug delivery
US5626871A (en) 1992-06-12 1997-05-06 Teijin Limited Preparation for intratracheobronchial administration
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5322075A (en) * 1992-09-10 1994-06-21 Philip Morris Incorporated Heater for an electric flavor-generating article
US5613505A (en) * 1992-09-11 1997-03-25 Philip Morris Incorporated Inductive heating systems for smoking articles
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
US6098620A (en) 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5970973A (en) 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5915378A (en) 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5694919A (en) 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5372148A (en) 1993-02-24 1994-12-13 Philip Morris Incorporated Method and apparatus for controlling the supply of energy to a heating load in a smoking article
US5468936A (en) 1993-03-23 1995-11-21 Philip Morris Incorporated Heater having a multiple-layer ceramic substrate and method of fabrication
GB9310412D0 (en) 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
CN1082365A (zh) 1993-05-25 1994-02-23 潘昆年 营养保健香烟
AU7227494A (en) 1993-06-03 1995-01-03 Barthold Von Schrader Inhalator
US5666977A (en) 1993-06-10 1997-09-16 Philip Morris Incorporated Electrical smoking article using liquid tobacco flavor medium delivery system
US5894841A (en) * 1993-06-29 1999-04-20 Ponwell Enterprises Limited Dispenser
DE4328243C1 (de) 1993-08-19 1995-03-09 Sven Mielordt Rauch- oder Inhalationsvorrichtung
US5456247A (en) 1993-08-26 1995-10-10 Iowa State University Research Foundation, Inc. Method for delivering drugs soluble in a vaporization vehicle
US5462740A (en) 1993-09-17 1995-10-31 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
US5400969A (en) * 1993-09-20 1995-03-28 Keene; Christopher M. Liquid vaporizer and diffuser
SE9303574D0 (sv) 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
FI98270C (fi) * 1993-11-29 1997-05-26 Instrumentarium Oy Menetelmä ja sovitelma anesteetin höyrystämisen yhteydessä
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
US5543434A (en) 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
US5522008A (en) 1994-03-16 1996-05-28 Bernard; Costello J. Device for heating and vaporizing a vaporizable module
US5451408A (en) 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
CZ286796A3 (en) 1994-03-30 1997-03-12 Procter & Gamble Foamy cosmetic preparation having the form of a rod for moistening and cleaning skin
US6102036A (en) 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
JP3911290B2 (ja) 1994-05-13 2007-05-09 アラダイム コーポレーション エアゾールを含む麻酔用処方
US5457101A (en) 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
WO1996000069A1 (fr) 1994-06-23 1996-01-04 The Procter & Gamble Company Traitement du besoin de nicotine et/ou des symptomes de manque du fumeur au moyen d'une composition solide ou semi-solide contenant de la nicotine et de la cafeine ou de la xanthine, notamment pour administration par voie nasale
MA23588A1 (fr) 1994-06-23 1995-12-31 Procter & Gamble Traitement du besoin en nicotine et/ou du syndrome de manque lie au tabagisme
MA23587A1 (fr) 1994-06-23 1995-12-31 Procter & Gamble Traitement du besoin en nicotine et/ou du syndrome de manque lie au tabagisme
CA2152684A1 (fr) 1994-07-01 1996-01-02 Richard Anthony Henry Administration de midazolam sous forme d'aerosol
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
WO1996006087A1 (fr) 1994-08-22 1996-02-29 Smithkline Beecham Corporation Composes bicycliques
US5456677A (en) 1994-08-22 1995-10-10 Spector; John E. Method for oral spray administration of caffeine
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5537507A (en) 1994-09-28 1996-07-16 Advanced Ceramics Corporation Coated flash evaporator heater
WO1996010663A1 (fr) 1994-09-30 1996-04-11 M & J Fibretech A/S Installation et procede de production par voie seche d'un produit en forme de bande
EP0785788B1 (fr) 1994-10-14 2001-12-12 GLAXO WELLCOME S.p.A. Utilisation d'antagonistes du recepteur cck-b pour le traitement de troubles du sommeil
AU709572B2 (en) 1994-10-28 1999-09-02 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5767117A (en) * 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
US5540959A (en) 1995-02-21 1996-07-30 Howard J. Greenwald Process for preparing a coated substrate
US5747001A (en) 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
ATE274341T1 (de) 1995-02-24 2004-09-15 Elan Pharma Int Ltd Nanopartikel-dispersionen enthaltende aerosole
DE19507410C2 (de) 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Herstellung von Aerosolen
US5565148A (en) 1995-03-16 1996-10-15 Minnesota Mining And Manufacturing Company Device for selectively providing a multiplicity of aromas
CA2216443A1 (fr) 1995-03-31 1996-10-03 Aradigm Corporation Administration intrapulmonaire d'un medicament hematopoietique
US6014970A (en) 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
ES2179192T3 (es) 1995-04-14 2003-01-16 Smithkline Beecham Corp Inhibidor dosificador para albuterol.
PL180901B1 (pl) 1995-04-14 2001-04-30 Glaxo Wellcome Inc Inhalator z dozymetrem
US6149892A (en) 1995-04-14 2000-11-21 Glaxowellcome, Inc. Metered dose inhaler for beclomethasone dipropionate
US5725756A (en) 1995-04-18 1998-03-10 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts with supercritical reaction media
US5690809A (en) 1995-04-18 1997-11-25 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts by pretreatment of hydrocarbon feed to reduce peroxides and oxygen impurities
US5776928A (en) 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
FR2733594B1 (fr) * 1995-04-28 1997-06-06 France Etat Dispositif pour le prelevement de substances gazeuses, de liquides, d'aerosols ou meme de matieres pulverulents, en vue de leur analyse in situ
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
DE19519056A1 (de) 1995-05-24 1997-01-16 Klinge Co Chem Pharm Fab Verwendung von Antidepressiva zur Behandlung von Asthma und/oder Atemwegserkrankungen mittels inhalatorischer Applikation
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
GB9512708D0 (en) 1995-06-22 1995-08-23 Reckitt & Colman Inc Improvements in or relating to organic compounds
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5591409A (en) * 1995-08-15 1997-01-07 Watkins; Carl J. Providing aromas
SE9503141D0 (sv) 1995-09-12 1995-09-12 Siemens Elema Ab Narkosapparat
US5649554A (en) 1995-10-16 1997-07-22 Philip Morris Incorporated Electrical lighter with a rotatable tobacco supply
US6013050A (en) 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
AU7669496A (en) 1995-11-03 1997-05-22 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
US6017963A (en) 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
US5564442A (en) 1995-11-22 1996-10-15 Angus Collingwood MacDonald Battery powered nicotine vaporizer
US6041777A (en) * 1995-12-01 2000-03-28 Alliance Pharmaceutical Corp. Methods and apparatus for closed-circuit ventilation therapy
ATE263546T1 (de) 1995-12-14 2004-04-15 Taisho Pharmaceutical Co Ltd Aerosolzubereitung
SE9504580L (sv) 1995-12-21 1997-06-22 Siemens Elema Ab Förfarande vid förgasning av en narkosvätska och en förgasare
AU1335397A (en) 1995-12-21 1997-07-17 Eli Lilly And Company Method for treating dermatitis
WO1997027804A1 (fr) 1996-02-05 1997-08-07 Aradigm Corporation Imagerie de ventilation au moyen d'un generateur d'aerosol a fines particules
US5829436A (en) 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
DE19606107C1 (de) * 1996-02-19 1997-02-13 Martin Umwelt & Energietech Feuerungsrost, insbesondere für Müllverbrennungsanlagen
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
GB9604329D0 (en) 1996-02-29 1996-05-01 Ici Plc Electrostatic spraying
JP3986086B2 (ja) 1996-03-01 2007-10-03 ザ ユニバーシティ オブ カンザス 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法
US5833891A (en) 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
WO1997033581A1 (fr) 1996-03-13 1997-09-18 Yale University Traitements pour cesser de fumer impliquant l'utilisation de naltrexone et de composes associes
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
US5944012A (en) 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
GB9606677D0 (en) 1996-03-29 1996-06-05 Glaxo Wellcome Inc Process and device
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
GB2312848B (en) 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
EP0896525B1 (fr) 1996-04-29 2003-08-27 Dura Pharmaceuticals, Inc. Methode d'inhalation de poudre seche
US5743251A (en) * 1996-05-15 1998-04-28 Philip Morris Incorporated Aerosol and a method and apparatus for generating an aerosol
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5929093A (en) 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
KR100267462B1 (ko) 1996-06-17 2000-10-16 미즈노 마사루 향미생성물품 및 향미생성기구
JP3325028B2 (ja) * 1996-06-17 2002-09-17 日本たばこ産業株式会社 香味生成物品
US6089857A (en) 1996-06-21 2000-07-18 Japan Tobacco, Inc. Heater for generating flavor and flavor generation appliance
GB9613015D0 (en) 1996-06-21 1996-08-28 Reckitt & Colman Inc Device
AU3400797A (en) 1996-06-27 1998-01-14 Merck & Co., Inc. A method for treating meniere's disease
JP2001508027A (ja) 1996-07-11 2001-06-19 ファーマーク、ニーダーランド、ベスローテン、フェンノートシャップ 基本薬剤の酸付加塩を含有する医薬組成物
US6004516A (en) 1996-08-06 1999-12-21 Illinois Institute Of Technology Apparatus for generating odor upon electronic signal demand
US6325475B1 (en) 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
WO1998014180A1 (fr) 1996-10-03 1998-04-09 Dmitri Kirpotin Microparticules hydrophiles et leurs procedes de preparation
US5934289A (en) 1996-10-22 1999-08-10 Philip Morris Incorporated Electronic smoking system
US6694975B2 (en) * 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US5878752A (en) 1996-11-25 1999-03-09 Philip Morris Incorporated Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses
US5744469A (en) 1996-11-26 1998-04-28 Eli Lilly And Company Method for treating dermatitis
CA2222830C (fr) * 1996-12-02 2004-03-30 Fisher & Paykel Limited Appareil de traitement d'apnee obstructive du sommeil
CA2628857C (fr) 1996-12-30 2011-09-13 Batelle Memorial Institute Preparation et methode de traitement de neoplasmes par inhalation
PT954282E (pt) 1997-01-16 2005-06-30 Massachusetts Inst Technology Preparacao de particulas para inalacao
WO1998034595A1 (fr) 1997-02-05 1998-08-13 Jago Research Ag Formulations medicales pour aerosols
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6051257A (en) 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US5829435A (en) 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US5837713A (en) 1997-02-26 1998-11-17 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids
HU219329B (en) 1997-04-21 2001-03-28 Radelkis Elektroanalitikai Mue Ph-electrode based on glass material
US5769621A (en) * 1997-05-23 1998-06-23 The Regents Of The University Of California Laser ablation based fuel ignition
US5907075A (en) 1997-06-11 1999-05-25 The University Of Kansas Solid acid supercritical alkylation reactions using carbon dioxide and/or other co-solvents
US5906811A (en) 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
US5928520A (en) 1997-07-16 1999-07-27 Abanaki Corporation Method and apparatus for extracting ground water contaiminants
KR100289448B1 (ko) 1997-07-23 2001-05-02 미즈노 마사루 향미발생장치
HUP9701284A3 (en) 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US5874841A (en) * 1997-07-28 1999-02-23 Philips Electronics North America Corporation Sample-and-hold circuit for a switched-mode power supply
US6090212A (en) * 1997-08-15 2000-07-18 Micro C Technologies, Inc. Substrate platform for a semiconductor substrate during rapid high temperature processing and method of supporting a substrate
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US6250301B1 (en) * 1997-08-28 2001-06-26 Hortal Harm B.V. Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix
CN1176075A (zh) 1997-08-29 1998-03-18 宋国合 不燃烧***无毒香烟制品及其制备方法
US6138683A (en) 1997-09-19 2000-10-31 Thione International, Inc. Smokeless tobacco products containing antioxidants
EP1019021B2 (fr) 1997-09-29 2012-12-26 Novartis AG Preparations stabilisees pour aerosols-doseurs
US6390453B1 (en) * 1997-10-22 2002-05-21 Microfab Technologies, Inc. Method and apparatus for delivery of fragrances and vapors to the nose
US6403597B1 (en) * 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
ES2172945T3 (es) 1997-11-12 2002-10-01 Bayer Ag Imidazotriazinonas sustituidas en 2 con fenilo como inhibidores de fosfodiesterasas.
HUP0100277A3 (en) 1998-01-27 2002-03-28 American Cyanamid Company Madi 2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as metalloproteinase inhibitors, process for their preparation and pharmaceutical compositions containing them
US6044777A (en) 1998-02-09 2000-04-04 Walsh; Michael J. Composite metal safe and method of making
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US5996589A (en) * 1998-03-03 1999-12-07 Brown & Williamson Tobacco Corporation Aerosol-delivery smoking article
US6544542B1 (en) 1998-03-05 2003-04-08 Nippon Shinyaku Co., Ltd. Fat emulsions for inhalational administration
CA2322193C (fr) 1998-03-05 2006-10-24 Batelle Memorial Institute Systeme et methode de dosage pulmonaire
US6228875B1 (en) 1998-04-14 2001-05-08 The General Hospital Corporation Methods for treating neuropsychiatric disorders
WO1999055362A1 (fr) * 1998-04-29 1999-11-04 Genentech, Inc. Formulations de igf-i sechees par pulverisation
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6060212A (en) * 1998-06-11 2000-05-09 Clariant Finance (Bvi) Limited 193 nm positive-working photoresist composition
AU4680699A (en) 1998-06-12 1999-12-30 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
US6095153A (en) 1998-06-19 2000-08-01 Kessler; Stephen B. Vaporization of volatile materials
TWI223598B (en) 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
WO2000000215A1 (fr) 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Systemes administration de particules et procedes d'utilisation
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
US6090403A (en) 1998-08-17 2000-07-18 Lectec Corporation Inhalation therapy decongestant with foraminous carrier
CA2346029A1 (fr) 1998-10-02 2000-04-13 Anthony R. Imondi Chimiotherapie par inhalation pour la prevention et le traitement des tumeurs metastatiques du poumon
US6234167B1 (en) * 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6509005B1 (en) * 1998-10-27 2003-01-21 Virginia Commonwealth University Δ9 Tetrahydrocannabinol (Δ9 THC) solution metered dose inhaler
US6255334B1 (en) 1998-10-30 2001-07-03 Pfizer Inc 5HT 1 receptor agonists and metoclopramide for the treatment of migraine
ATE353630T1 (de) 1998-11-12 2007-03-15 Transave Inc Inhalationssystem
DE19854007C2 (de) 1998-11-12 2001-05-17 Reemtsma H F & Ph System zur Bereitstellung eines inhalierbaren Aerosols
DE19854012C2 (de) 1998-11-12 2001-05-10 Reemtsma H F & Ph System zur Bereitstellung eines inhalierbaren Aerosols
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
EP1283036B2 (fr) 1998-11-13 2020-01-01 Jagotec AG Poudre sèche pour inhalation
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
MXPA01004914A (es) 1998-11-16 2003-03-10 Aradigm Corp Metodo para fabricar membrana porosa con estructura porosa unica para el suministro aerosolizado de medicamentos.
US6113795A (en) 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
JP3506618B2 (ja) 1998-11-18 2004-03-15 ウシオ電機株式会社 黄色光放射用白熱電球
IL143576A0 (en) 1998-12-11 2002-04-21 Pharmachemie Bv Pharmaceutical preparation for inhalation of an opioid
IL142816A0 (en) 1998-12-24 2002-03-10 Du Pont Pharm Co SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
DK1031347T3 (da) 1999-01-27 2002-07-08 Idea Ag Transnasal transport/immunisering med meget tilpasselige bærere
AR022423A1 (es) 1999-01-27 2002-09-04 American Cyanamid Co Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
US6376550B1 (en) * 1999-02-09 2002-04-23 Asta Medica Ag Pharmaceutical compositions containing tramadol for migraine
AU2879100A (en) 1999-02-12 2000-08-29 Miles A. Libbey Iii Formulation and system for intra-oral delivery of pharmaceutical agents
US6591839B2 (en) 1999-02-17 2003-07-15 Dieter Meyer Filter material for reducing harmful substances in tobacco smoke
US6053176A (en) * 1999-02-23 2000-04-25 Philip Morris Incorporated Heater and method for efficiently generating an aerosol from an indexing substrate
AU3393600A (en) 1999-03-05 2000-09-21 Battelle Memorial Institute Method for safely and effectively administering a drug by inhalation
JP2002543092A (ja) 1999-04-27 2002-12-17 イーライ・リリー・アンド・カンパニー 肺投与用インスリン結晶
ATE258439T1 (de) 1999-04-30 2004-02-15 Univ Michigan Verwendung von benzodiazepinen zur behandlung von apoptose-induzierten autoimmunerkrankungen
AU4979700A (en) 1999-05-03 2000-11-17 Battelle Memorial Institute Compositions for aerosolization and inhalation
US6428769B1 (en) 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
US6309986B1 (en) 1999-05-07 2001-10-30 S. C. Johnson & Son, Inc. Mat for dispensing volatile materials
CN1240373C (zh) 1999-05-27 2006-02-08 阿库斯菲尔公司 多孔药物基质及其制造方法
AU767486B2 (en) 1999-06-11 2003-11-13 Aradigm Corporation Method for producing an aerosol
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
CA2378913C (fr) 1999-07-16 2010-02-23 Aradigm Corporation Systeme permettant d'arreter de fumer
EP1210121A2 (fr) 1999-08-24 2002-06-05 Cellgate Inc. Compositions et procedes ameliorant la diffusion de medicaments a travers et dans des tissus epitheliaux
WO2001017568A2 (fr) 1999-09-07 2001-03-15 Conjuchem, Inc. Diffusion pulmonaire permettant la bioconjugaison
CA2382442C (fr) 1999-09-15 2009-07-07 Aradigm Corporation Structures de pores permettant une aerosolisation a pression reduite
DE60026155T2 (de) * 1999-09-30 2006-08-10 Neurogen Corp., Branford Einige alkylendiamin-substituierte heterocyclen
SI1224174T1 (en) 1999-10-15 2003-12-31 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
DK1223915T3 (da) 1999-10-29 2006-03-06 Nektar Therapeutics Törpulverpræparater med forbedret dispersivitet
AU1261501A (en) 1999-12-06 2001-06-18 Stanley L. Gore Compositions and methods for intranasal delivery of active agents to the brain
DE19961300A1 (de) 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
DE10001035A1 (de) * 2000-01-13 2001-07-26 Bayer Ag Wirkstoffchip mit integriertem Heizelement
EP1941868A3 (fr) 2000-02-28 2011-06-29 PharmaKodex Limited Améliorations portant sur ou en relation avec l'administration orale de médicaments
BR0109685B1 (pt) * 2000-03-23 2013-07-23 sistema de fumo elÉtrico e mÉtodo para fabricaÇço de cigarro para sistema de fumo elÉtrico
US6632047B2 (en) 2000-04-14 2003-10-14 Board Of Regents, The University Of Texas System Heater element for use in an in situ thermal desorption soil remediation system
JP2001299916A (ja) 2000-04-18 2001-10-30 Kao Corp マスク型吸入器
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
WO2001093846A2 (fr) 2000-05-23 2001-12-13 The Trustees Of Columbia University In The City Of New York Procede de traitement des troubles respiratoires associes a une lesion de la fibre elastique pulmonaire
AU2001225663A1 (en) 2000-06-15 2001-12-24 Respiratorius Ab A composition comprising a combination of receptor agonists and antagonists
GB0015981D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
FR2812545B1 (fr) 2000-08-03 2003-03-28 Air Liquide Sante Int Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US20020117175A1 (en) 2000-10-27 2002-08-29 Kottayil S. George Thermal vaporizing device for drug delivery
US20030121906A1 (en) 2000-11-29 2003-07-03 Abbott Richard C. Resistive heaters and uses thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6681998B2 (en) * 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6701921B2 (en) * 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6443152B1 (en) 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
FI20010115A0 (fi) 2001-01-18 2001-01-18 Orion Corp Menetelmä nanopartikkelien valmistamiseksi
US6680668B2 (en) 2001-01-19 2004-01-20 Vishay Intertechnology, Inc. Fast heat rise resistor using resistive foil
EP1383376A4 (fr) 2001-03-19 2006-03-08 Praecis Pharm Inc Formulations pharmaceutiques a liberation prolongee
US20030004142A1 (en) * 2001-04-18 2003-01-02 Prior Christopher P. Use of NSAIDs for prevention and treatment of cellular abnormalities of the lung or bronchial pathway
US20030023638A1 (en) * 2001-05-02 2003-01-30 Weight Christopher F. Method and apparatus for processing content
US20030032638A1 (en) * 2001-05-24 2003-02-13 Kim John J. Delivery of benzodiazepines through an inhalation route
US20030131843A1 (en) 2001-11-21 2003-07-17 Lu Amy T. Open-celled substrates for drug delivery
US7645442B2 (en) * 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
EP1392262A1 (fr) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Administration d'esters medicamenteux par inhalation
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20080038363A1 (en) * 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030118512A1 (en) 2001-10-30 2003-06-26 Shen William W. Volatilization of a drug from an inclusion complex
US7585493B2 (en) * 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
DE60231611D1 (de) 2001-05-24 2009-04-30 Alexza Pharmaceuticals Inc Verabreichung von opioiden durch inhalation
WO2002094242A1 (fr) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Administration de rizatriptan ou de zolmitriptan par voie d'inhalation
US20030138508A1 (en) 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
JP4357842B2 (ja) * 2001-05-24 2009-11-04 アレックザ ファーマシューティカルズ， インコーポレイテッド 所定の吸入ルートによるアルプラゾラム、エスタゾラム、ミダゾラムまたはトリアゾラムの送出
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
JP4680498B2 (ja) * 2001-07-31 2011-05-11 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 蒸発した液体を発生するための方法及び装置
US6568390B2 (en) * 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6648950B2 (en) 2001-10-15 2003-11-18 Hewlett-Packard Development Company, L.P. Electro-thermal odor-releasing inks and methods for releasing odors from the same
US6779520B2 (en) 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
GB0126150D0 (en) 2001-10-31 2002-01-02 Gw Pharma Ltd A device method and resistive element for vaporising a substance
WO2003041693A1 (fr) * 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Administration de diazepam a travers une voie pulmonaire
AU2002363947A1 (en) 2001-11-21 2003-07-24 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US6681769B2 (en) * 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US20030106551A1 (en) 2001-12-06 2003-06-12 Sprinkel F. Murphy Resistive heater formed inside a fluid passage of a fluid vaporizing device
CN1176075C (zh) 2001-12-07 2004-11-17 北京燕山石油化工公司研究院 吡咯衍生物的制备方法
US6701922B2 (en) * 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US6772756B2 (en) 2002-02-09 2004-08-10 Advanced Inhalation Revolutions Inc. Method and system for vaporization of a substance
US6961515B2 (en) 2002-02-15 2005-11-01 Dekko Technologies, Inc. PTC heater with flexible printed circuit board
US6728478B2 (en) * 2002-02-21 2004-04-27 Dekko Heating Technologies, Inc. Heated chemical delivery system
WO2003094900A1 (fr) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Distribution de medicament a base d'amines par voie d'inhalation
US20060193788A1 (en) 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US7074806B2 (en) * 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
KR20050009738A (ko) * 2002-06-06 2005-01-25 에스.씨. 존슨 앤드 선, 인코포레이티드 국부화된 표면 휘발 장치
EP1539284B1 (fr) * 2002-09-06 2020-01-29 Philip Morris Products S.a.s. Generateur aerosols et procede de generation d'aerosols
US6772757B2 (en) 2002-10-25 2004-08-10 Chrysalis Technologies Incorporated Concentric controlled temperature profile fluid vaporizing device
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
DK1567164T3 (da) 2002-11-26 2009-05-18 Alexza Pharmaceuticals Inc Anvendelse af loxapin til fremstilling af et lægemiddel til behandling af smerte
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
JP2006514633A (ja) 2002-11-26 2006-05-11 アレックザ ファーマシューティカルズ， インコーポレイテッド 吸入によって送達される抗精神病薬を用いた頭痛の治療
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625336B9 (fr) 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Utilisation d'une couche de combustible solide, procédé pour fabriquer une telle couche et unité de chauffage correspondante
US20050037506A1 (en) * 2003-08-04 2005-02-17 Alexza Molecular Delivery Corporation Methods of determining film thicknesses for an aerosol delivery article
EP1656171B9 (fr) * 2003-08-04 2010-10-20 Alexza Pharmaceuticals, Inc. Substrats pour dispositif d'administration de medicaments et procedes de preparation
CA2551127A1 (fr) 2003-12-15 2005-07-07 Alexza Pharmaceuticals, Inc. Traitement de douleur aigue par inhalation en aerosol de medicaments
US20050131739A1 (en) 2003-12-16 2005-06-16 Alexza Molecular Delivery Corporation Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time
US7402777B2 (en) 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20060032496A1 (en) * 2004-08-12 2006-02-16 Alexza Molecular Delivery Corporation Inhalation actuated percussive ignition system
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
WO2006022714A1 (fr) * 2004-08-12 2006-03-02 Alexza Pharmaceuticals, Inc. Dispositif de distribution de drogue par aérosol intégrant des conditionnements thermiques actionnés par percussion
US20060120962A1 (en) 2004-10-12 2006-06-08 Rabinowitz Joshua D Cardiac safe, rapid medication delivery
WO2007079118A1 (fr) 2005-12-29 2007-07-12 Molex Incorporated Ensemble de connexion pour un element chauffant comportant des bornes fixees par insertion en force
WO2008080170A1 (fr) 2006-12-22 2008-07-03 Alexza Pharmaceuticals, Inc. Compositions aérosol de médicament mixte
US7513781B2 (en) 2006-12-27 2009-04-07 Molex Incorporated Heating element connector assembly with insert molded strips
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US20080306285A1 (en) 2007-04-27 2008-12-11 Alexza Pharmaceuticals, Inc. Heat-Labile Prodrugs
US20090180968A1 (en) 2008-01-11 2009-07-16 Alexza Pharmaceuticals, Inc. Metal Coordination Complexes Of Volatile Drugs
US20100068155A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Reactant Formulations and Methods for Controlled Heating
US20100065052A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
US7834295B2 (en) 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
US20100300433A1 (en) 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
US20100181387A1 (en) 2009-12-01 2010-07-22 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
JP6397493B2 (ja) 2013-07-11 2018-09-26 アレックザ ファーマシューティカルズ， インコーポレイテッド メタ−サリチル酸とのニコチン塩

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735217A (en) * 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
WO1994009842A1 (fr) * 1992-10-28 1994-05-11 Rosen Charles A Procede et dispositifs permettant l'inhalation de medicaments
US5388574A (en) * 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
WO1996031198A1 (fr) * 1995-04-07 1996-10-10 Edward Mendell Co., Inc. Excipient pour insufflation, a liberation progressive, destine a des medicaments

Also Published As

Publication number Publication date
CN1304067C (zh) 2007-03-14
US20110240013A1 (en) 2011-10-06
US20030035776A1 (en) 2003-02-20
CZ20033249A3 (cs) 2004-05-12
AU2007207865B2 (en) 2010-06-03
US20090229600A1 (en) 2009-09-17
CA2447081A1 (fr) 2002-12-12
EP1392242B1 (fr) 2010-05-19
US9439907B2 (en) 2016-09-13
HK1068293A1 (en) 2005-04-29
EP1392381B1 (fr) 2011-03-30
JP4510438B2 (ja) 2010-07-21
US20030051728A1 (en) 2003-03-20
US20140060532A1 (en) 2014-03-06
PL374048A1 (en) 2005-09-19
HUP0401008A2 (en) 2004-08-30
CN1512900A (zh) 2004-07-14
WO2002098389A1 (fr) 2002-12-12
US20030015197A1 (en) 2003-01-23
US8955512B2 (en) 2015-02-17
HUP0401948A2 (hu) 2005-01-28
US20130276779A1 (en) 2013-10-24
CN1514719A (zh) 2004-07-21
AU2007231750A1 (en) 2007-11-29
DE60239604D1 (de) 2011-05-12
NZ529296A (en) 2008-07-31
IL158954A0 (en) 2004-05-12
JP2004529724A (ja) 2004-09-30
EP1392263A2 (fr) 2004-03-03
US20030015196A1 (en) 2003-01-23
US7942147B2 (en) 2011-05-17
DE60236430D1 (en) 2010-07-01
US11065400B2 (en) 2021-07-20
JP2004532881A (ja) 2004-10-28
US20040096402A1 (en) 2004-05-20
EP1392381A1 (fr) 2004-03-03
CZ20033223A3 (cs) 2004-07-14
IL158955A0 (en) 2004-05-12
US20110240022A1 (en) 2011-10-06
US9308208B2 (en) 2016-04-12
US6682716B2 (en) 2004-01-27
CA2447354C (fr) 2008-12-02
AU2002311923B2 (en) 2007-05-17
AU2007207865A1 (en) 2007-09-06
MXPA03011268A (es) 2004-03-18
ATE503516T1 (de) 2011-04-15
WO2002098389A8 (fr) 2006-10-12
US8074644B2 (en) 2011-12-13
HK1068268A1 (en) 2005-04-29
NZ529298A (en) 2008-03-28
JP2010057950A (ja) 2010-03-18
US7537009B2 (en) 2009-05-26
AU2007231750B2 (en) 2010-06-24
EP1392381B9 (fr) 2011-09-14
AU2002311926B2 (en) 2007-12-06
CA2447354A1 (fr) 2002-12-12
US20030062042A1 (en) 2003-04-03
CA2646756A1 (fr) 2002-12-12
US7766013B2 (en) 2010-08-03
ES2343678T3 (es) 2010-08-06
JP2005503846A (ja) 2005-02-10
US20170281884A1 (en) 2017-10-05
US20140066618A1 (en) 2014-03-06
WO2002098496A1 (fr) 2002-12-12
WO2002098390A2 (fr) 2002-12-12
MXPA03011269A (es) 2004-03-18
CA2447081C (fr) 2010-02-23
US20150157635A1 (en) 2015-06-11
US9687487B2 (en) 2017-06-27
EP1392242A1 (fr) 2004-03-03
CN100496458C (zh) 2009-06-10
ATE468105T1 (de) 2010-06-15
CA2447210A1 (fr) 2002-12-12
US20100294268A1 (en) 2010-11-25
PL373836A1 (en) 2005-09-19
JP4912566B2 (ja) 2012-04-11
CA2646756C (fr) 2010-10-26
CA2447210C (fr) 2007-09-11
HUP0401948A3 (en) 2008-04-28

Similar Documents

Publication Publication Date Title
WO2002098390A3 (fr) Administration d'aerosols contenant de petites particules via une voie d'inhalation
WO2002094244A3 (fr) Administration de benzodiazepines via une voie pulmonaire
CA2447521A1 (fr) Administration d'antihistaminiques par inhalation
WO2002094218A3 (fr) Administration par voie pulmonaire d'alprazolam, d'estazolam, de midazolam ou de triazolam
WO2004060433A3 (fr) Dispositifs d'administration
AU2001293899A1 (en) Ihnalation particles incorporating a combination of two or more active ingredients
WO2003024396A3 (fr) Formulations de medicament en poudre seche
AU2002366203A1 (en) Medicament dispensing system
AU2003217950A1 (en) Agglomerated particles for aerosol drug delivery
TNSN04148A1 (en) Aerosol formulations for pulmonary administration of medicaments to produce a systemic effect
AU2002363947A1 (en) Delivery of caffeine through an inhalation route
AUPR894201A0 (en) Respiratory delivery for gene therapy and lentiviral delivery particle
WO2006108556A3 (fr) Composition pharmaceutique sous forme d'aerosol
WO2002043702A3 (fr) Compositions pharmaceutiques pour inhalation
NZ334149A (en) Pharmaceutical aerosol composition containing an active material, a propellant containing a hydrofluoroalkane and a cosolvent and a low volatility component
WO2002047668A3 (fr) Nouvelles compositions medicamenteuses a base d'anticholinergiques et de ciclesonide
CA2461517A1 (fr) Preparations de nicotine comprenant du cacao, et utilisation
AU2001293900A1 (en) Combination particles for the treatment of asthma
EP1315672A4 (fr) Composition de vecteur d'administration et procede pour l'administration d'antigenes et d'autres medicaments
WO2003059331A3 (fr) Compositions medicinales en aerosol contenant un excipient d'amide et/ou d'ester
WO2002015880A8 (fr) Procede de production et d'utilisation de mannitol en poudre et compositions renfermant du mannitol
WO2000027430A3 (fr) Composition d'une substance pharmaceutiquement active et dispositif de distribution
CA2333154A1 (fr) Preconcentres de microemulsion contenant un antagoniste de la substance p a base de piperidine
WO2002060533A3 (fr) Compositions medicamenteuses a faibles effets secondaires
WO2002094219A3 (fr) Administration par voie pulmonaire de medicaments contre les troubles de l'erection

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2002315076

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 529297

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2003501430

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2447210

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002742015

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002742015

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642