WO2002005844A3 - Proteinkomplex als vehikel für oral verfügbare arzneimittel - Google Patents

Proteinkomplex als vehikel für oral verfügbare arzneimittel Download PDF

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Publication number
WO2002005844A3
WO2002005844A3 PCT/DE2001/002816 DE0102816W WO0205844A3 WO 2002005844 A3 WO2002005844 A3 WO 2002005844A3 DE 0102816 W DE0102816 W DE 0102816W WO 0205844 A3 WO0205844 A3 WO 0205844A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein complex
vehicle
orally administerable
complex serving
medicaments
Prior art date
Application number
PCT/DE2001/002816
Other languages
English (en)
French (fr)
Other versions
WO2002005844A2 (de
WO2002005844A8 (de
Inventor
Hans Bigalke
Juergen Frevert
Original Assignee
Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh
Hans Bigalke
Juergen Frevert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL01364993A priority Critical patent/PL364993A1/xx
Priority to KR1020037000614A priority patent/KR100822006B1/ko
Priority to JP2002511776A priority patent/JP2004503600A/ja
Priority to CA002415712A priority patent/CA2415712A1/en
Priority to BR0112515-0A priority patent/BR0112515A/pt
Priority to DE10192679T priority patent/DE10192679D2/de
Priority to MXPA03000566A priority patent/MXPA03000566A/es
Priority to HU0301644A priority patent/HUP0301644A3/hu
Application filed by Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh, Hans Bigalke, Juergen Frevert filed Critical Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh
Priority to EP01964858A priority patent/EP1303535A2/de
Priority to IL15353901A priority patent/IL153539A0/xx
Priority to AU8568801A priority patent/AU8568801A/xx
Priority to AU2001285688A priority patent/AU2001285688B2/en
Priority to US10/333,477 priority patent/US20040028703A1/en
Publication of WO2002005844A2 publication Critical patent/WO2002005844A2/de
Publication of WO2002005844A8 publication Critical patent/WO2002005844A8/de
Publication of WO2002005844A3 publication Critical patent/WO2002005844A3/de
Priority to NO20030231A priority patent/NO20030231L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft einen Proteinkomplex, umfassend ein oder mehrere Komplexproteine oder Derivate aus Clostridium botulinum Typ A, B, C1, C2, D, E, F oder G und ein ausgewähltes Polypeptid oder niedermolekulares Pharmakon.
PCT/DE2001/002816 2000-07-19 2001-07-19 Proteinkomplex als vehikel für oral verfügbare arzneimittel WO2002005844A2 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP01964858A EP1303535A2 (de) 2000-07-19 2001-07-19 Proteinkomplex als vehikel für oral verfügbare arzneimittel
KR1020037000614A KR100822006B1 (ko) 2000-07-19 2001-07-19 경구적으로 투여가능한 약제의 전파체로서 작용하는단백질 복합체
IL15353901A IL153539A0 (en) 2000-07-19 2001-07-19 Protein complexes and methods for the preparation thereof
BR0112515-0A BR0112515A (pt) 2000-07-19 2001-07-19 Complexo protéico utilizado como veìculo para medicamentos oralmente administráveis
DE10192679T DE10192679D2 (de) 2000-07-19 2001-07-19 Proteinkomplex als Vehikel für oral verfügbare Arzneimittel
MXPA03000566A MXPA03000566A (es) 2000-07-19 2001-07-19 Complejo de proteina que sirve como vehiculo para faramcos que pueden administrarse por via oral.
HU0301644A HUP0301644A3 (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administrable medicaments
PL01364993A PL364993A1 (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administerable medicaments
JP2002511776A JP2004503600A (ja) 2000-07-19 2001-07-19 経口利用可能な医薬品に対するビヒクルとしてのタンパク質複合体
CA002415712A CA2415712A1 (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administerable medicaments
AU8568801A AU8568801A (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administerable medicaments
AU2001285688A AU2001285688B2 (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administerable medicaments
US10/333,477 US20040028703A1 (en) 2000-07-19 2001-07-19 Protein complex serving as a vehicle for orally administerable medicaments
NO20030231A NO20030231L (no) 2000-07-19 2003-01-17 Proteinkompleks som fungerer som en vehikkel for oralt administrerbare medikamenter

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10035156.5 2000-07-19
DE10035155 2000-07-19
DE10035156A DE10035156A1 (de) 2000-07-19 2000-07-19 Proteinkomplex als Vehikel für oral verfügbare Protein-Arzneimittel
DE10035155.7 2000-07-19

Publications (3)

Publication Number Publication Date
WO2002005844A2 WO2002005844A2 (de) 2002-01-24
WO2002005844A8 WO2002005844A8 (de) 2002-02-14
WO2002005844A3 true WO2002005844A3 (de) 2002-06-27

Family

ID=26006444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/002816 WO2002005844A2 (de) 2000-07-19 2001-07-19 Proteinkomplex als vehikel für oral verfügbare arzneimittel

Country Status (18)

Country Link
US (1) US20040028703A1 (de)
EP (1) EP1303535A2 (de)
JP (1) JP2004503600A (de)
KR (1) KR100822006B1 (de)
CN (1) CN100497379C (de)
AU (2) AU2001285688B2 (de)
BR (1) BR0112515A (de)
CA (1) CA2415712A1 (de)
CU (1) CU23381A3 (de)
CZ (1) CZ2003169A3 (de)
DE (2) DE10035156A1 (de)
HU (1) HUP0301644A3 (de)
IL (1) IL153539A0 (de)
MX (1) MXPA03000566A (de)
NO (1) NO20030231L (de)
PL (1) PL364993A1 (de)
RU (1) RU2002134755A (de)
WO (1) WO2002005844A2 (de)

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US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
JP2003009897A (ja) * 2001-07-03 2003-01-14 Keiji Oguma ボツリヌス毒素の分離・精製法
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20040086532A1 (en) * 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
JP2007070225A (ja) * 2003-07-25 2007-03-22 Yukako Fujinaga クロストリジウム属菌由来成分を含む医薬製剤
DE102004035606A1 (de) * 2004-07-22 2006-03-30 Biotecon Therapeutics Gmbh Carrier für Arzneimittel zur Gewinnung der oralen Bioverfügbarkeit
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
JP2009081997A (ja) * 2007-09-27 2009-04-23 Chemo Sero Therapeut Res Inst ボツリヌス毒素成分ｈａを核酸の細胞内導入キャリアーとして利用する方法
WO2009131435A1 (en) * 2008-04-23 2009-10-29 Erasmus University Medical Center Rotterdam Linker containing bungarotoxin and a binding peptide
CA2745657C (en) 2008-12-04 2022-06-21 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
WO2011075500A2 (en) * 2009-12-18 2011-06-23 Allergan, Inc. Stabilization of therapeutic agents to facilitate administration
KR101134146B1 (ko) * 2010-05-31 2012-04-19 메덱스젠 주식회사 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법
US9393291B2 (en) 2012-04-12 2016-07-19 Botulinum Toxin Research Associates, Inc. Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US11123411B2 (en) * 2016-12-08 2021-09-21 Gary E. Borodic Method of treating macular degeneration using botulinum toxin-based pharmaceuticals
US11096993B2 (en) 2016-12-08 2021-08-24 Gary E. Borodic Method of treating macular degeneration using botulinum toxin-based pharmaceuticals
US20210121542A1 (en) * 2019-10-28 2021-04-29 Prime Bio, Inc. Composition for delivery of protein therapeutics through oral, sublingual and buccal route

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WO1995032738A1 (en) * 1994-05-31 1995-12-07 Allergan, Inc. Modification of clostridial toxins for use as transport proteins
US5696077A (en) * 1992-06-23 1997-12-09 Associated Synapse Biologics Pharmaceutical composition containing botulinum B complex
DE19735105A1 (de) * 1997-08-13 1999-03-04 Univ Albert Ludwigs Freiburg Transportsystem zur Einbringung von Proteinen in Zielzellen mit Hilfe eines Fusionsproteins, Nucleinsäurekonstrukte kodierend für die Komponenten des Transportsystems und Arzneimittel, die Komponenten des Transportsystems umfassen
WO1999017806A1 (en) * 1997-10-08 1999-04-15 The Speywood Laboratory Limited Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

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WO1995032738A1 (en) * 1994-05-31 1995-12-07 Allergan, Inc. Modification of clostridial toxins for use as transport proteins
DE19735105A1 (de) * 1997-08-13 1999-03-04 Univ Albert Ludwigs Freiburg Transportsystem zur Einbringung von Proteinen in Zielzellen mit Hilfe eines Fusionsproteins, Nucleinsäurekonstrukte kodierend für die Komponenten des Transportsystems und Arzneimittel, die Komponenten des Transportsystems umfassen
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Also Published As

Publication number Publication date
CU23381A3 (es) 2009-06-25
HUP0301644A3 (en) 2010-01-28
CN100497379C (zh) 2009-06-10
CZ2003169A3 (cs) 2004-02-18
NO20030231L (no) 2003-03-18
AU2001285688B2 (en) 2005-09-08
KR100822006B1 (ko) 2008-04-15
RU2002134755A (ru) 2004-07-10
DE10192679D2 (de) 2003-06-18
KR20030045013A (ko) 2003-06-09
IL153539A0 (en) 2003-07-06
CN1443196A (zh) 2003-09-17
DE10035156A1 (de) 2002-02-07
PL364993A1 (en) 2004-12-27
WO2002005844A2 (de) 2002-01-24
WO2002005844A8 (de) 2002-02-14
MXPA03000566A (es) 2004-12-13
US20040028703A1 (en) 2004-02-12
BR0112515A (pt) 2003-07-01
CA2415712A1 (en) 2003-01-10
HUP0301644A2 (hu) 2003-08-28
AU8568801A (en) 2002-01-30
EP1303535A2 (de) 2003-04-23
JP2004503600A (ja) 2004-02-05
NO20030231D0 (no) 2003-01-17

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