WO2001000814A3 - Hetero-associating coiled-coil peptides and screenign method therefor - Google Patents

Hetero-associating coiled-coil peptides and screenign method therefor Download PDF

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Publication number
WO2001000814A3
WO2001000814A3 PCT/EP2000/005922 EP0005922W WO0100814A3 WO 2001000814 A3 WO2001000814 A3 WO 2001000814A3 EP 0005922 W EP0005922 W EP 0005922W WO 0100814 A3 WO0100814 A3 WO 0100814A3
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WO
WIPO (PCT)
Prior art keywords
hetero
peptides
coiled
associating
screenign
Prior art date
Application number
PCT/EP2000/005922
Other languages
French (fr)
Other versions
WO2001000814A2 (en
Inventor
Andreas Plueckthun
Katja Arndt
Kristian Mueller
Joelle Pelletier
Original Assignee
Univ Zuerich
Andreas Plueckthun
Katja Arndt
Kristian Mueller
Joelle Pelletier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich, Andreas Plueckthun, Katja Arndt, Kristian Mueller, Joelle Pelletier filed Critical Univ Zuerich
Priority to CA002377513A priority Critical patent/CA2377513A1/en
Priority to EP00943898A priority patent/EP1194539A2/en
Publication of WO2001000814A2 publication Critical patent/WO2001000814A2/en
Publication of WO2001000814A3 publication Critical patent/WO2001000814A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to methods for the identification of novel hetero-associating coiled-coil peptides and uses of these peptides for hetero-dimerization of fusion proteins. It furthermore relates to vectors, host cells useful for the production of these novel hetero-association peptides and (poly)peptides/proteins comprising these peptides.
PCT/EP2000/005922 1999-06-25 2000-06-26 Hetero-associating coiled-coil peptides and screenign method therefor WO2001000814A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002377513A CA2377513A1 (en) 1999-06-25 2000-06-26 Hetero-associating coiled-coil peptides
EP00943898A EP1194539A2 (en) 1999-06-25 2000-06-26 Hetero-associating coiled-coil peptides and screening method therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34409699A 1999-06-25 1999-06-25
US09/344,096 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000814A2 WO2001000814A2 (en) 2001-01-04
WO2001000814A3 true WO2001000814A3 (en) 2001-03-22

Family

ID=23349034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005922 WO2001000814A2 (en) 1999-06-25 2000-06-26 Hetero-associating coiled-coil peptides and screenign method therefor

Country Status (3)

Country Link
EP (1) EP1194539A2 (en)
CA (1) CA2377513A1 (en)
WO (1) WO2001000814A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696324B2 (en) 1998-11-30 2010-04-13 Perlan Therapeutics, Inc. Humanized antibodies
US9005616B2 (en) 2009-08-31 2015-04-14 Amplimmune, Inc. Methods and compositions for the inhibition of transplant rejection
US9134321B2 (en) 2006-12-27 2015-09-15 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
US9370565B2 (en) 2000-04-28 2016-06-21 The Johns Hopkins University Dendritic cell co-stimulatory molecules

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US7192596B2 (en) * 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
JP2003503067A (en) * 1999-06-26 2003-01-28 オデュッセイ・ファーマシューティカルズ，インコーポレイテッド Optimized in vivo library-to-library selection of protein-protein interactions
ATE557038T1 (en) 2005-06-03 2012-05-15 Ares Trading Sa PREPARATION OF RECOMBINANT IL-18 BINDING PROTEIN
AR060070A1 (en) 2006-03-24 2008-05-21 Merck Patent Gmbh HETERODYMERIC PROTEIN DOMAINS OBTAINED BY ENGINEERING
EP2328919A2 (en) 2008-08-25 2011-06-08 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
FR2948940B1 (en) 2009-08-04 2011-07-22 Servier Lab NOVEL DIHYDROINDOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
EP2552947A4 (en) 2010-03-26 2013-11-13 Dartmouth College Vista regulatory t cell mediator protein, vista binding agents and use thereof
WO2016030888A1 (en) 2014-08-26 2016-03-03 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of autoimmune disorders
AU2011272941B2 (en) 2010-06-30 2014-05-29 Compugen Ltd. C10RF32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
WO2012035518A1 (en) 2010-09-17 2012-03-22 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
BR112013026199A2 (en) 2011-04-15 2017-11-07 Compugen Ltd isolated polypeptide, fusion protein, nucleic acid sequence, expression vector or a virus, recombinant cell, method of producing a soluble ectodomain polypeptide or fusion protein or fragment thereof, pharmaceutical composition, use of a monoclonal antibody or polyclonal or antigen-binding fragment thereof, use of antibody or antigen-binding fragment, use of any of an isolated polypeptide, method of regulating cytokines, induction of t-cell expansion, promotion of cell immunity antigen specific t and promotion of cd4 + and / or cd8 + t cell activation in a subject, method for enhancing an immune response secondary to an antigen in a patient, method of using at least one of: an isolated polypeptide, method for treatment or prevention of an immune system related condition, method for treating or preventing an infectious disease a, method for diagnosing a disease in a subject, method of producing a soluble ectodomain polypeptide tmem25, vsig10, ly6g6f, or fusion protein or fragment thereof, monoclonal or polyclonal antibody or antigen-binding fragment thereof, immunotherapy in a patient and method for combining therapeutic vaccination with an antigen in conjunction with administration of either of a polypeptide
EP2726503B1 (en) 2011-06-30 2019-09-04 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
CA3188124A1 (en) 2012-07-05 2014-01-09 Genentech, Inc. Expression and secretion system
EP2892558B1 (en) 2012-09-07 2019-04-10 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
PT2956476T (en) 2013-02-18 2020-02-21 Vegenics Pty Ltd Ligand binding molecules and uses thereof
US20160146806A1 (en) 2013-05-17 2016-05-26 Amplimmune, Inc. Receptors for b7-h4
ES2920677T3 (en) 2013-12-24 2022-08-08 Janssen Pharmaceutica Nv Anti-VISTA Antibodies and Fragments
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3154585B1 (en) 2014-06-11 2022-02-23 Kathy A. Green Use of vista agonists and antagonists to suppress or enhance humoral immunity
JP2016002009A (en) * 2014-06-13 2016-01-12 国立大学法人名古屋大学 Tagged antibody
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
CN107922497B (en) 2015-06-24 2022-04-12 詹森药业有限公司 anti-VISTA antibodies and fragments
CA2991980A1 (en) 2015-07-13 2017-01-19 Compugen Ltd. Hide1 compositions and methods
TWI756204B (en) 2016-02-12 2022-03-01 比利時商楊森製藥公司 Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
CN118108843A (en) 2016-04-15 2024-05-31 伊穆奈克斯特股份有限公司 Anti-human VISTA antibodies and uses thereof
WO2018027042A1 (en) 2016-08-03 2018-02-08 Bio-Techne Corporation Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy
EP3551667A4 (en) * 2016-12-09 2020-06-17 Seattle Genetics, Inc. Bivalent antibodies masked by coiled coils
WO2019152810A1 (en) 2018-02-02 2019-08-08 Bio-Techne Corporation Compounds that modulate the interaction of vista and vsig3 and methods of making and using
CA3099450A1 (en) * 2018-05-08 2019-11-14 Amgen Inc. Bispecific antibodies with cleavable c-terminal charge-paired tags
EP4332114A1 (en) * 2021-04-30 2024-03-06 Liyang TCR Biotherapeutics Co., Ltd Method for screening alpha beta-tcr heterodimer mutants

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Patent Citations (1)

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WO1998034120A1 (en) * 1997-01-31 1998-08-06 Universite De Montreal Protein fragment complementation assays to detect biomolecular interactions

Non-Patent Citations (8)

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ARNDT KATJA M ET AL: "A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble.", JOURNAL OF MOLECULAR BIOLOGY, vol. 295, no. 3, 21 January 2000 (2000-01-21), pages 627 - 639, XP002156489, ISSN: 0022-2836 *
HODGES R S: "DE NOVO DESIGN OF ALPHA-HELICAL PROTEINS: BASIC RESEARCH TO MEDICALAPPLICATIONS", BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE,XX,XX, vol. 74, no. 2, 1996, pages 133 - 154, XP000605834, ISSN: 0829-8211 *
JOHN MATTHIAS ET AL: "Two pairs of oppositely charged amino acids from Jun and Fos confer heterodimerization to GCN4 leucine zipper.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 23, 1994, pages 16247 - 16253, XP002156486, ISSN: 0021-9258 *
O'SHEA E K ET AL: "MECHANISM OF SPECIFICITY IN THE FOS-JUN ONCOPROTEIN HETERODIMER", CELL, vol. 68, no. 4, 1992, pages 699 - 708, XP002156487, ISSN: 0092-8674 *
O'SHEA E K ET AL: "PEPTIDE 'VELCRO*': DESIGN OF A HETERODIMERIC COILED COIL", CURRENT BIOLOGY,GB,CURRENT SCIENCE,, vol. 3, no. 10, 1993, pages 658 - 667, XP000653001, ISSN: 0960-9822 *
PELLETIER, J.N. ET AL.: "An in vivo library-versus-library selection of optimized protein-protein interactions.", NATURE BIOTECHNOLOGY, vol. 17, July 1999 (1999-07-01), pages 683 - 90, XP002156488 *
YU Y ET AL: "INVESTIGATION OF ELECTROSTATIC INTERACTIONS IN TWO-STRANDED COILED-COILS THROUGH RESIDUE SHUFFLING", BIOPHYSICAL CHEMISTRY,AMSTERDAM,NL, vol. 59, 16 April 1996 (1996-04-16), pages 299 - 314, XP000971324 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696324B2 (en) 1998-11-30 2010-04-13 Perlan Therapeutics, Inc. Humanized antibodies
US8586712B2 (en) 1998-11-30 2013-11-19 Perlan Therapeutics, Inc. Humanized antibodies
US9370565B2 (en) 2000-04-28 2016-06-21 The Johns Hopkins University Dendritic cell co-stimulatory molecules
US9134321B2 (en) 2006-12-27 2015-09-15 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
US9005616B2 (en) 2009-08-31 2015-04-14 Amplimmune, Inc. Methods and compositions for the inhibition of transplant rejection
US9011853B2 (en) 2009-08-31 2015-04-21 Amplimmune, Inc. B7-H4 fusion proteins and methods of use thereof

Also Published As

Publication number Publication date
EP1194539A2 (en) 2002-04-10
WO2001000814A2 (en) 2001-01-04
CA2377513A1 (en) 2001-01-04

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