WO2001040497A3 - Method for obtaining nucleic acids from an environment sample - Google Patents

Method for obtaining nucleic acids from an environment sample Download PDF

Info

Publication number
WO2001040497A3
WO2001040497A3 PCT/FR2000/003311 FR0003311W WO0140497A3 WO 2001040497 A3 WO2001040497 A3 WO 2001040497A3 FR 0003311 W FR0003311 W FR 0003311W WO 0140497 A3 WO0140497 A3 WO 0140497A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
novel
nucleic acid
obtaining
concerns
Prior art date
Application number
PCT/FR2000/003311
Other languages
French (fr)
Other versions
WO2001040497A2 (en
Inventor
Pascale Jeannin
Jean-Luc Pernodet
Michel Guerineau
Pascal Simonet
Sophie Courtois
Carmela Cappellano
Francois Francou
Alain Raynal
Maria Ball
Guennadi Sezonov
Karine Tuphile
Asa Frostegard
Original Assignee
Aventis Pharma Sa
Pascale Jeannin
Jean-Luc Pernodet
Michel Guerineau
Pascal Simonet
Sophie Courtois
Carmela Cappellano
Francois Francou
Alain Raynal
Maria Ball
Guennadi Sezonov
Karine Tuphile
Asa Frostegard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9915032A external-priority patent/FR2801609B1/en
Priority to IL14984600A priority Critical patent/IL149846A0/en
Priority to MXPA02003819A priority patent/MXPA02003819A/en
Priority to US10/148,328 priority patent/US7255989B1/en
Priority to EP00985340A priority patent/EP1268764A2/en
Priority to NZ519883A priority patent/NZ519883A/en
Priority to KR1020027006787A priority patent/KR20020060242A/en
Priority to BR0015993-0A priority patent/BR0015993A/en
Application filed by Aventis Pharma Sa, Pascale Jeannin, Jean-Luc Pernodet, Michel Guerineau, Pascal Simonet, Sophie Courtois, Carmela Cappellano, Francois Francou, Alain Raynal, Maria Ball, Guennadi Sezonov, Karine Tuphile, Asa Frostegard filed Critical Aventis Pharma Sa
Priority to JP2001542561A priority patent/JP2003520578A/en
Priority to CA002393041A priority patent/CA2393041A1/en
Priority to AU21791/01A priority patent/AU781961B2/en
Publication of WO2001040497A2 publication Critical patent/WO2001040497A2/en
Priority to NO20022532A priority patent/NO20022532L/en
Publication of WO2001040497A3 publication Critical patent/WO2001040497A3/en
Priority to AU2005211587A priority patent/AU2005211587A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor

Abstract

The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.
PCT/FR2000/003311 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample WO2001040497A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU21791/01A AU781961B2 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
BR0015993-0A BR0015993A (en) 1999-11-29 2000-11-27 Processes for preparing a collection of nucleic acids, a collection of recombinant vectors and a recombinant vector, detecting a nucleic acid and a polyketide synthase, identifying the production of a compound of interest, selecting a host cell recombinant, for producing a compound of interest and a polyketide synthase and for determining the diversity of nucleic acids contained in a collection, collection of nucleic acids, nucleic acid, vector, vector collection, recombinant host cell, collection of recombinant host cells , compound, polyketide, composition, polyketide synthase, antibody and polyketide synthase detection kit
US10/148,328 US7255989B1 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
EP00985340A EP1268764A2 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample
NZ519883A NZ519883A (en) 1999-11-29 2000-11-27 Extraction of DNA from microorganisms in dry soil samples thereby identifying the diversity of the organisms present
KR1020027006787A KR20020060242A (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
JP2001542561A JP2003520578A (en) 1999-11-29 2000-11-27 Methods for obtaining nucleic acids from environmental samples, resulting nucleic acids, and uses in the synthesis of novel compounds
IL14984600A IL149846A0 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an evironment sample, resulting nucleic acids and use in synthesis of novel compounds
MXPA02003819A MXPA02003819A (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds.
CA002393041A CA2393041A1 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
NO20022532A NO20022532L (en) 1999-11-29 2002-05-28 Process for Preparation of Nucleic Acids from an Environmental Test, The Nucleic Acids Thus Obtained and Their Use in the Synthesis of New Compounds
AU2005211587A AU2005211587A1 (en) 1999-11-29 2005-09-19 Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9915032A FR2801609B1 (en) 1999-11-29 1999-11-29 PROCESS FOR OBTAINING NUCLEIC ACIDS FROM A SAMPLE OF THE ENVIRONMENT, NUCLEIC ACIDS THUS OBTAINED AND THEIR APPLICATION TO THE SYNTHESIS OF NEW COMPOUNDS
FR99/15032 1999-11-29
US20980000P 2000-06-07 2000-06-07
US60/209,800 2000-06-07

Publications (2)

Publication Number Publication Date
WO2001040497A2 WO2001040497A2 (en) 2001-06-07
WO2001040497A3 true WO2001040497A3 (en) 2002-10-17

Family

ID=26235170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003311 WO2001040497A2 (en) 1999-11-29 2000-11-27 Method for obtaining nucleic acids from an environment sample

Country Status (9)

Country Link
EP (1) EP1268764A2 (en)
JP (1) JP2003520578A (en)
KR (1) KR20020060242A (en)
AU (2) AU781961B2 (en)
BR (1) BR0015993A (en)
CA (1) CA2393041A1 (en)
IL (1) IL149846A0 (en)
NO (1) NO20022532L (en)
WO (1) WO2001040497A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7749366B2 (en) 2002-08-20 2010-07-06 B.R.A.I.N. Biotechnology Research And Information Network Ag Isolation and cloning of DNA from uncultivated organisms

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010047029A1 (en) * 2000-04-26 2001-11-29 Handelsman Jo E. Triaryl cation antibiotics from environmental DNA
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
FR2834997B1 (en) * 2002-01-21 2004-03-19 Evialis METHOD FOR DETECTION OF OCHRATOXIN A OR CITRININ PRODUCING FUNGI
EP1386966A1 (en) * 2002-07-24 2004-02-04 Libragen Method for the expression of unknown environmental DNA into adapted host cells
EP1905833B1 (en) 2002-10-08 2015-08-12 Aventis Pharma S.A. Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences coding these polypeptides and their uses
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122099A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
WO2005073377A1 (en) * 2004-01-28 2005-08-11 Toudai Tlo, Ltd. Method of collecting dna from environmental sample
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP2458619B1 (en) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
WO2005121336A1 (en) * 2004-06-08 2005-12-22 Toagosei Co., Ltd. Method of purifying environmental dna and method of efficiently screening protein-encoding gene from environmental dna
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
AU2006272776B2 (en) 2005-07-21 2012-01-19 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
AU2007353877B2 (en) 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
JP5680304B2 (en) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド Rapid forensic DNA analysis
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
US9175353B2 (en) 2008-11-14 2015-11-03 Gen-Probe Incorporated Compositions, kits and methods for detection of campylobacter nucleic acid
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionization probe assemblies
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
ES2628739T3 (en) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Multiple displacement amplification
EP2325312A1 (en) * 2009-11-19 2011-05-25 Qiagen GmbH Method for selective enrichment and isolation of microbial and optional additionally of viral nucleic acids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900677A (en) * 1986-09-26 1990-02-13 E. I. Du Pont De Nemours And Company Process for rapid isolation of high molecular weight DNA
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways
WO1999020799A2 (en) * 1997-10-23 1999-04-29 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
WO1999067374A1 (en) * 1998-06-23 1999-12-29 Biosearch Italia S.P.A. Methods for transferring the capability to produce a natural product into a suitable production host

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900677A (en) * 1986-09-26 1990-02-13 E. I. Du Pont De Nemours And Company Process for rapid isolation of high molecular weight DNA
WO1996034112A1 (en) * 1995-04-24 1996-10-31 Chromaxome Corp. Methods for generating and screening novel metabolic pathways
WO1999020799A2 (en) * 1997-10-23 1999-04-29 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
WO1999067374A1 (en) * 1998-06-23 1999-12-29 Biosearch Italia S.P.A. Methods for transferring the capability to produce a natural product into a suitable production host

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CLERC SYLVIE ET AL: "Efficiency of the transfer of a pSAM2-derivative plasmid between two strains of Streptomyces lividans in conditions ranging from agar slants to non-sterile soil microcosms.", FEMS MICROBIOLOGY ECOLOGY, vol. 21, no. 3, 1996, pages 157 - 165, XP000946441, ISSN: 0168-6496 *
FROSTEGARD ASA ET AL: "Quantification of bias related to the extraction of DNA directly from soils.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 65, no. 12, December 1999 (1999-12-01), pages 5409 - 5420, XP002148458, ISSN: 0099-2240 *
FROSTEGARD, ASA ET AL: "Quantification of bias related to the extraction of DNA directly from soils", APPL. ENVIRON. MICROBIOL. (1999), 65(12), 5409-5420, XP002166435 *
MAIDAK BONNIE L ET AL: "A new version of the RDP (Ribosomal Database Project).", NUCLEIC ACIDS RESEARCH, vol. 27, no. 1, 1 January 1999 (1999-01-01), pages 171 - 173, XP002166433, ISSN: 0305-1048 *
MILLER DN. ET AL.: "Evaluation and optimization of DNA extraction and purification procedures for soil and sediment samples.", APPL ENVIRON MICROBIOL 1999 NOV;65(11):4715-24, XP002148457 *
PAGET ERIC ET AL: "The fate of recombinant plant DNA in soil.", EUROPEAN JOURNAL OF SOIL BIOLOGY, vol. 34, no. 2, April 1998 (1998-04-01), pages 81 - 88, XP000946574, ISSN: 1164-5563 *
PICARD C ET AL: "DETECTION AND ENUMERATION OF BACTERIA IN SOIL BY DIRECT DNA EXTRACTION AND POLYMERASE CHAIN REACTION", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 58, no. 9, 1992, pages 2717 - 2722, XP000946427, ISSN: 0099-2240 *
RAYNAL A. ET AL.: "Structure of the chromosomal insertion site for pSAM2: Functional analysis in Escherichia coli.", MOLECULAR MICROBIOLOGY, vol. 28, no. 2, April 1998 (1998-04-01), pages 333 - 342, XP002166432, ISSN: 0950-382X *
SEOW KAH-TONG ET AL: "A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms.", JOURNAL OF BACTERIOLOGY, vol. 179, no. 23, December 1997 (1997-12-01), pages 7360 - 7368, XP002148456, ISSN: 0021-9193 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7749366B2 (en) 2002-08-20 2010-07-06 B.R.A.I.N. Biotechnology Research And Information Network Ag Isolation and cloning of DNA from uncultivated organisms

Also Published As

Publication number Publication date
NO20022532D0 (en) 2002-05-28
BR0015993A (en) 2002-08-06
IL149846A0 (en) 2002-11-10
EP1268764A2 (en) 2003-01-02
NO20022532L (en) 2002-06-26
AU2179101A (en) 2001-06-12
WO2001040497A2 (en) 2001-06-07
JP2003520578A (en) 2003-07-08
CA2393041A1 (en) 2001-06-07
AU781961B2 (en) 2005-06-23
AU2005211587A1 (en) 2005-10-13
KR20020060242A (en) 2002-07-16

Similar Documents

Publication Publication Date Title
WO2001040497A3 (en) Method for obtaining nucleic acids from an environment sample
WO1998050554A3 (en) Enterococcus faecalis polynucleotides and polypeptides
WO1997033909A3 (en) Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer
WO2002042418A3 (en) 3-hydroxypropionic acid and other organic compounds
WO2004029220A3 (en) Synthetic genes
WO2001029222A3 (en) Polypeptides having phospholipase b activity and nucleic acids encoding same
WO2003089598A3 (en) Polypeptides having xyloglucanase activity and nucleic acids encoding same
WO2003020894A3 (en) Insulin related transcription factor and uses thereof
AU8127494A (en) Chimeric proteins comprising borrelia polypeptides: uses therefor
WO2002062999A8 (en) Proteins and nucleic acids encoding same
WO2002008277A3 (en) Nucleic acids, vectors, host cells, polypeptides, and uses thereof
WO1999067382A3 (en) Angiopoietin-like growth factor sequences
WO1999043830A3 (en) Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity
WO2002059315A3 (en) Human nucleic acids and polypeptides and methods of use thereof
WO2002046409A3 (en) Proteins and nucleic acids encoding same
WO2003089602A3 (en) Toll-like receptor 11 and toll-like receptor 12
WO2005001099A8 (en) Protein expression system
WO2000028043A3 (en) Polypeptides having lactonohydrolase activity and nucleic acids encoding same
WO2000004041A3 (en) Methods and molecules relating to cd39-like polypeptides
WO2002090500A3 (en) Novel human proteins, polynucleotides encoding them and methods of using the same
WO2000068376A8 (en) Novel chimpanzee erythropoietin (chepo) polypeptides and nucleic acids encoding the same
WO2002046408A3 (en) Human proteins, polynucleotides encoding them and methods of using the same
WO2001062918A3 (en) Secretory polypeptides and corresponding polynucleotides
WO2002077009A3 (en) Polypeptides having gamma-glutamyl transpeptidase activity and nucleic acids encoding same
WO2001081546A3 (en) CeSERT GENES, PROTEINS, AND MODULATORY COMPOUNDS

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/003819

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2002/00458/DE

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2002/03532

Country of ref document: ZA

Ref document number: 200203532

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 21791/01

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2000985340

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 149846

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 1020027006787

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2001 542561

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2393041

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 519883

Country of ref document: NZ

WWP Wipo information: published in national office

Ref document number: 1020027006787

Country of ref document: KR

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000985340

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 519883

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 519883

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 21791/01

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 2000985340

Country of ref document: EP