WO1999067382A3 - Angiopoietin-like growth factor sequences - Google Patents

Angiopoietin-like growth factor sequences Download PDF

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Publication number
WO1999067382A3
WO1999067382A3 PCT/IL1999/000343 IL9900343W WO9967382A3 WO 1999067382 A3 WO1999067382 A3 WO 1999067382A3 IL 9900343 W IL9900343 W IL 9900343W WO 9967382 A3 WO9967382 A3 WO 9967382A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid sequences
angiopoietin
growth factor
amino acid
factor sequences
Prior art date
Application number
PCT/IL1999/000343
Other languages
French (fr)
Other versions
WO1999067382A2 (en
Inventor
Liat Mintz
Kinneret Savitsky
Original Assignee
Compugen Ltd
Liat Mintz
Kinneret Savitsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12902799A external-priority patent/IL129027A0/en
Priority claimed from IL12937899A external-priority patent/IL129378A0/en
Application filed by Compugen Ltd, Liat Mintz, Kinneret Savitsky filed Critical Compugen Ltd
Priority to AU46436/99A priority Critical patent/AU4643699A/en
Publication of WO1999067382A2 publication Critical patent/WO1999067382A2/en
Publication of WO1999067382A3 publication Critical patent/WO1999067382A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention concerns novel nucleic acid and amino acid sequences, expression vectors, host cells and pharmaceutical compositions comprising same, as well as antibodies directed against said amino acid sequences and methods for detecting the amino acid sequences and the nucleic acid sequences in a sample.
PCT/IL1999/000343 1998-06-24 1999-06-23 Angiopoietin-like growth factor sequences WO1999067382A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46436/99A AU4643699A (en) 1998-06-24 1999-06-23 Angiopoietin-like growth factor sequences

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US9048198P 1998-06-24 1998-06-24
US60/090,481 1998-06-24
US10586998P 1998-10-27 1998-10-27
US60/105,869 1998-10-27
IL12902799A IL129027A0 (en) 1999-03-17 1999-03-17 Novel nucleic acid and amino acid sequence
IL129027 1999-03-17
IL12937899A IL129378A0 (en) 1999-04-09 1999-04-09 Novel nucleic acid and amino acid sequences
IL129378 1999-04-09

Publications (2)

Publication Number Publication Date
WO1999067382A2 WO1999067382A2 (en) 1999-12-29
WO1999067382A3 true WO1999067382A3 (en) 2000-04-27

Family

ID=27452516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000343 WO1999067382A2 (en) 1998-06-24 1999-06-23 Angiopoietin-like growth factor sequences

Country Status (2)

Country Link
AU (1) AU4643699A (en)
WO (1) WO1999067382A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
JP2003531811A (en) * 1999-03-08 2003-10-28 ジェネンテック・インコーポレーテッド Promotion or inhibition of angiogenesis and cardiovascularization
ATE380195T1 (en) * 1999-03-08 2007-12-15 Genentech Inc COMPOSITIONS AND METHODS FOR TREATING TUMORS
AU5979300A (en) * 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
ES2291198T3 (en) * 1999-07-20 2008-03-01 Genentech, Inc. COMPOSITIONS AND PROCEDURES FOR THE TREATMENT OF IMMUNOLOGICAL TYPE DISEASES.
AU768034B2 (en) * 1999-12-09 2003-11-27 Sankyo Company Limited Method of testing remedy or preventive for hyperlipemia
WO2001077151A2 (en) * 2000-04-07 2001-10-18 Millennium Pharmaceuticals, Inc. Fdrg proteins and nucleic acid molecules and uses therefor
WO2002101039A1 (en) * 2001-06-08 2002-12-19 Sankyo Company, Limited Method of testing drug for treating or preventing diseases such as hyperlipemia
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JP5105696B2 (en) * 2001-11-16 2012-12-26 ジェネンテック， インコーポレイテッド Angiopoietin-like protein 3 Angptl3-containing composition and method of use thereof
AU2003288918A1 (en) * 2002-10-04 2004-05-04 Van Andel Research Institute Molecular sub-classification of kidney tumors and the discovery of new diagnostic markers
CN101080419B (en) 2004-07-20 2014-07-02 健泰科生物技术公司 Compositions and methods of using angiopoietin-like 4 protein
KR101254815B1 (en) 2004-07-20 2013-09-03 제넨테크, 인크. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
JP5366406B2 (en) 2005-01-07 2013-12-11 レキシコン ファーマシューティカルズ インコーポレーテッド Monoclonal antibody against Angiopoietin-like protein 4 (ANGPTL4)
BRPI0720218A2 (en) 2006-12-08 2013-12-24 Lexicon Pharmaceuticals Inc MONOCLONAL ANTIBODIES AGAINST ANGPTL3
MX2012000707A (en) 2009-07-14 2012-03-21 Scripps Research Inst Mesenchymal stem cell differentiation.
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
JO3564B1 (en) 2013-03-08 2020-07-05 Novartis Ag Peptides and compositions for treatment of joint damage
TW202027794A (en) 2018-10-03 2020-08-01 瑞士商諾華公司 Sustained delivery of angiopoetin-like 3 polypeptides

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000353A1 (en) * 1991-06-20 1993-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
WO1996031598A1 (en) * 1995-04-06 1996-10-10 Regeneron Pharmaceuticals, Inc. Tie-2 ligands, methods of making and uses thereof
WO1997048804A2 (en) * 1996-06-19 1997-12-24 Regeneron Pharmaceuticals, Inc. Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
WO1998005779A1 (en) * 1996-08-02 1998-02-12 Regeneron Pharmaceuticals, Inc. Modified tie-2-receptor ligands
WO1999015654A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie receptor tyrosine kinase ligand homologues
WO1999015653A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie ligand homologues
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000353A1 (en) * 1991-06-20 1993-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sequences characteristic of human gene transcription product
WO1996031598A1 (en) * 1995-04-06 1996-10-10 Regeneron Pharmaceuticals, Inc. Tie-2 ligands, methods of making and uses thereof
WO1997048804A2 (en) * 1996-06-19 1997-12-24 Regeneron Pharmaceuticals, Inc. Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
WO1998005779A1 (en) * 1996-08-02 1998-02-12 Regeneron Pharmaceuticals, Inc. Modified tie-2-receptor ligands
WO1999015654A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie receptor tyrosine kinase ligand homologues
WO1999015653A2 (en) * 1997-09-19 1999-04-01 Genentech, Inc. Tie ligand homologues
WO1999032515A2 (en) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Angiopoietin homolog, dna encoding it, and method of making it

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST 30 E.M.B.L. Databases; 5 August 1993 (1993-08-05), ADAMS M ET AL: "Homo sapiens cDNA clone HIBBA76 5' end similar to Fibrinogen, beta chain", XP002118808 *
DATABASE EMEST29 E.M.B.L. Databases; 28 November 1996 (1996-11-28), MARRA M ET AL: "Mus musculus cDNA clone 479570 5' similar to PIR: JN0596 JN0596 fibrinogen-related protein HFREP-1 precursor", XP002118809 *
DATABASE EMEST4 E.M.B.L. Databases; 24 April 1998 (1998-04-24), MARRA M ET AL: "Mus musculus cDNA clone 1298657 5' similar to TR:Q28763 FIBRINOGEN ALPHA-E SUBUNIT", XP002129381 *
HANAHAN D: "Signaling Vascular Morphogenesis and Maintenance", SCIENCE, vol. 277, 4 July 1997 (1997-07-04), pages 48 - 50, XP002118807 *

Also Published As

Publication number Publication date
AU4643699A (en) 2000-01-10
WO1999067382A2 (en) 1999-12-29

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