WO1999048868A3 - Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase - Google Patents
Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase Download PDFInfo
- Publication number
- WO1999048868A3 WO1999048868A3 PCT/US1999/006468 US9906468W WO9948868A3 WO 1999048868 A3 WO1999048868 A3 WO 1999048868A3 US 9906468 W US9906468 W US 9906468W WO 9948868 A3 WO9948868 A3 WO 9948868A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- protein kinase
- tyrosine protein
- modulating
- modulating tyrosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU33635/99A AU3363599A (en) | 1998-03-26 | 1999-03-26 | Heterocyclic families of compounds for the modulation of tyrosine protein kinase |
CA002325935A CA2325935A1 (fr) | 1998-03-26 | 1999-03-26 | Familles de composes heterocycliques pour la modulation de la tyrosine-proteine kinase |
JP2000537851A JP2002507598A (ja) | 1998-03-26 | 1999-03-26 | チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー |
EP99915018A EP1066257A2 (fr) | 1998-03-26 | 1999-03-26 | Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase |
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7971398P | 1998-03-26 | 1998-03-26 | |
US60/079,713 | 1998-03-26 | ||
US8042298P | 1998-04-02 | 1998-04-02 | |
US60/080,422 | 1998-04-02 | ||
US8179298P | 1998-04-15 | 1998-04-15 | |
US60/081,792 | 1998-04-15 | ||
US8205698P | 1998-04-16 | 1998-04-16 | |
US60/082,056 | 1998-04-16 | ||
US8939798P | 1998-06-15 | 1998-06-15 | |
US60/089,397 | 1998-06-15 | ||
US8952198P | 1998-06-16 | 1998-06-16 | |
US60/089,521 | 1998-06-16 | ||
US9878398P | 1998-09-01 | 1998-09-01 | |
US60/098,783 | 1998-09-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999048868A2 WO1999048868A2 (fr) | 1999-09-30 |
WO1999048868A3 true WO1999048868A3 (fr) | 2000-02-24 |
WO1999048868A9 WO1999048868A9 (fr) | 2000-04-20 |
Family
ID=27568389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/006468 WO1999048868A2 (fr) | 1998-03-26 | 1999-03-26 | Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1066257A2 (fr) |
JP (1) | JP2002507598A (fr) |
AU (1) | AU3363599A (fr) |
CA (1) | CA2325935A1 (fr) |
WO (1) | WO1999048868A2 (fr) |
Families Citing this family (45)
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US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6395734B1 (en) | 1998-05-29 | 2002-05-28 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
TR200101858T2 (tr) | 1998-12-17 | 2001-12-21 | F.Hoffmann-La Roche Ag | JNK protein kinaz inhibitörleri olarak 4-ariloksindoller |
US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
CA2354402A1 (fr) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindoles comme inhibiteurs de proteine kinase |
CN1138773C (zh) | 1998-12-17 | 2004-02-18 | 霍夫曼-拉罗奇有限公司 | 4-链烯基(和炔基)氧吲哚作为细胞周期蛋白-依赖性激酶尤其是cdk2的抑制剂 |
AU3208200A (en) | 1999-01-13 | 2000-08-01 | Research Foundation Of The State University Of New York, The | A novel method for designing protein kinase inhibitors |
ES2367007T3 (es) * | 1999-11-24 | 2011-10-27 | Sugen, Inc. | Derivados de indolinona ionizables y su uso como ligandos de ptk. |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
AU784266B2 (en) * | 1999-12-22 | 2006-03-02 | Sugen, Inc. | Indolinone derivatives for modulation of c-kit tyrosine kinase |
JP2003535038A (ja) * | 1999-12-30 | 2003-11-25 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節および癌化学療法において用いるための3−ヘテロアリーリデニル−2−インドリノン化合物 |
US20020028828A1 (en) | 2000-05-02 | 2002-03-07 | Chung-Chen Wei | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors |
GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
KR20040000507A (ko) * | 2001-05-24 | 2004-01-03 | 야마노우치세이야쿠 가부시키가이샤 | 3-퀴놀린-2(1h)-일리덴인돌린-2-온 유도체 |
GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
US20030119839A1 (en) * | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
WO2003070725A2 (fr) | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Procede de preparation de derives de l'indolinone |
US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
BR0316229A (pt) | 2002-11-13 | 2005-10-04 | Chiron Corp | Métodos de tratamento de câncer e métodos relacionados |
AU2003284572A1 (en) * | 2002-11-22 | 2004-06-18 | Yamanouchi Pharmaceutical Co., Ltd. | 2-oxoindoline derivatives |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
BRPI0507891A (pt) | 2004-02-20 | 2007-07-24 | Chiron Corp | modulação dos processos inflamatório e metastático |
GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
SG154451A1 (en) | 2005-05-23 | 2009-08-28 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1- yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts |
EP1978961B1 (fr) | 2006-01-06 | 2016-03-16 | Sunovion Pharmaceuticals Inc. | Inhibiteurs de recaptage de monoamine a base de tetralone |
EP1976513B1 (fr) | 2006-01-06 | 2016-08-24 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines inhibiteurs du recaptage des monoamines |
DK2816024T3 (en) | 2006-03-31 | 2017-10-30 | Sunovion Pharmaceuticals Inc | CHIRALE AMINER |
US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
EP1918277B1 (fr) * | 2006-11-01 | 2015-06-10 | Industrial Technology Research Institute | Composés d'azulène |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
AU2008206039A1 (en) | 2007-01-18 | 2008-07-24 | Sepracor Inc. | Inhibitors of D-amino acid oxidase |
WO2008138184A1 (fr) * | 2007-05-14 | 2008-11-20 | Shanghai Hengrui Pharmaceutical Co.Ltd. | Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases |
MX2009012685A (es) | 2007-05-31 | 2009-12-14 | Sepracor Inc | Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. |
AR068063A1 (es) | 2007-08-27 | 2009-11-04 | Basf Plant Science Gmbh | Co mpuestos de pirazol para controlar plagas de invertebrados |
JP2011505341A (ja) * | 2007-11-21 | 2011-02-24 | デコード ジェネティクス イーエイチエフ | 炎症性、心血管およびcns障害を治療するビアリールpde4抑制剤 |
CN102223798A (zh) | 2008-09-24 | 2011-10-19 | 巴斯夫欧洲公司 | 用于防治无脊椎动物害虫的吡唑化合物 |
CN102224149B (zh) | 2008-09-24 | 2014-09-10 | 巴斯夫欧洲公司 | 防治无脊椎动物害虫的吡唑化合物 |
US8710056B2 (en) | 2009-07-06 | 2014-04-29 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
EP2451804B1 (fr) | 2009-07-06 | 2014-04-30 | Basf Se | Composés pyridazine destinés à la lutte contre les nuisibles invertébrés |
CN102469785A (zh) | 2009-07-24 | 2012-05-23 | 巴斯夫欧洲公司 | 防治无脊椎动物害虫的吡啶衍生物 |
US8569331B2 (en) | 2010-11-01 | 2013-10-29 | Arqule, Inc. | Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991013055A2 (fr) * | 1990-02-28 | 1991-09-05 | Farmitalia Carlo Erba S.R.L. | Nouveaux derives d'aryl- et heteroarylethenylene, et leur procede de preparation |
WO1992007830A2 (fr) * | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Antagonistes de peptide aux oxindoles |
WO1992020642A1 (fr) * | 1991-05-10 | 1992-11-26 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryle et heteroaryle bis monocycliques et/ou bicycliques qui inhibent la tyrosine kinase d'un recepteur du egf et/ou du pdgf |
WO1994014808A1 (fr) * | 1992-12-23 | 1994-07-07 | Farmitalia Carlo Erba Srl | Derives vinylene-azaindoliques et leur procede de preparation |
WO1995024190A2 (fr) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant |
WO1996000226A1 (fr) * | 1994-06-24 | 1996-01-04 | Pharmacia S.P.A. | Composes azaindolylidene substitues et leur procede de preparation |
WO1996016964A1 (fr) * | 1994-11-28 | 1996-06-06 | Pharmacia & Upjohn S.P.A | Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparation |
WO1996040116A1 (fr) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Composes d'indolinone pour le traitement de maladies |
WO1998007695A1 (fr) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Banques combinatoires d'indolinone, produits et procedes associes pour traiter des maladies |
WO1998045708A1 (fr) * | 1997-04-08 | 1998-10-15 | Sugen, Inc. | Etude et traitement des maladies liees a des fonctions cellulaires specifiques de proteines tyrosines kinases receptrices |
WO1998050356A1 (fr) * | 1997-05-07 | 1998-11-12 | Sugen, Inc. | Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase |
WO1998056376A1 (fr) * | 1997-06-13 | 1998-12-17 | Sugen, Inc. | Nouveaux composes heteroaryle pour la modulation de la transduction de signaux cellulaires associee aux enzymes proteine tyrosine |
-
1999
- 1999-03-26 AU AU33635/99A patent/AU3363599A/en not_active Abandoned
- 1999-03-26 EP EP99915018A patent/EP1066257A2/fr not_active Withdrawn
- 1999-03-26 CA CA002325935A patent/CA2325935A1/fr not_active Abandoned
- 1999-03-26 JP JP2000537851A patent/JP2002507598A/ja not_active Withdrawn
- 1999-03-26 WO PCT/US1999/006468 patent/WO1999048868A2/fr active Search and Examination
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1991013055A2 (fr) * | 1990-02-28 | 1991-09-05 | Farmitalia Carlo Erba S.R.L. | Nouveaux derives d'aryl- et heteroarylethenylene, et leur procede de preparation |
WO1992007830A2 (fr) * | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Antagonistes de peptide aux oxindoles |
WO1992020642A1 (fr) * | 1991-05-10 | 1992-11-26 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryle et heteroaryle bis monocycliques et/ou bicycliques qui inhibent la tyrosine kinase d'un recepteur du egf et/ou du pdgf |
WO1994014808A1 (fr) * | 1992-12-23 | 1994-07-07 | Farmitalia Carlo Erba Srl | Derives vinylene-azaindoliques et leur procede de preparation |
WO1995024190A2 (fr) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant |
WO1996000226A1 (fr) * | 1994-06-24 | 1996-01-04 | Pharmacia S.P.A. | Composes azaindolylidene substitues et leur procede de preparation |
WO1996016964A1 (fr) * | 1994-11-28 | 1996-06-06 | Pharmacia & Upjohn S.P.A | Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparation |
WO1996040116A1 (fr) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Composes d'indolinone pour le traitement de maladies |
WO1998007695A1 (fr) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Banques combinatoires d'indolinone, produits et procedes associes pour traiter des maladies |
WO1998045708A1 (fr) * | 1997-04-08 | 1998-10-15 | Sugen, Inc. | Etude et traitement des maladies liees a des fonctions cellulaires specifiques de proteines tyrosines kinases receptrices |
WO1998050356A1 (fr) * | 1997-05-07 | 1998-11-12 | Sugen, Inc. | Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase |
WO1998056376A1 (fr) * | 1997-06-13 | 1998-12-17 | Sugen, Inc. | Nouveaux composes heteroaryle pour la modulation de la transduction de signaux cellulaires associee aux enzymes proteine tyrosine |
Non-Patent Citations (6)
Title |
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GAZIT,A. ET AL.: "Tyrphostins. 2. Heterocyclic and alpha-Substituted Benzylidenmalonitirle Tyrphostins as Poitent Inhibitors of EGRF Receptor and ErbB2/neu Tyrosine Kinases", J.MED.CHEM., vol. 34, no. 6, June 1991 (1991-06-01), WASHINGTON, pages 1896 - 1907, XP000472938 * |
LEVITZKI A ET AL: "TYROSINE KINASE INHIBITION: AN APPROACH TO DRUG DEVELOPMENT", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 267, March 1995 (1995-03-01), pages 1782-1788, XP002048355, ISSN: 0036-8075 * |
MOHAMMADI M ET AL: "STRUCTURES OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR IN COMPLEX WITH INHIBITORS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 276, no. 5314, pages 955-960, XP002065235, ISSN: 0036-8075 * |
SPADA A P ET AL: "SMALL MOLECULE INHIBITORS OF TYROSINE KINASE ACTIVITY", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 5, no. 8, 1 January 1995 (1995-01-01), pages 805 - 817, XP000567587, ISSN: 1354-3776 * |
SUN,LO. ET AL.: "Synthesis and Biological Evaluation of 3-Substituted Indolin-2-ones : A novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particualr Receptor Tyrosine Kinases", J.MED.CHEM., vol. 41, no. 14, 2 July 1998 (1998-07-02), WASHINGTON, pages 2588 - 2603, XP002122185 * |
TRAXLER,P.M.: "Protein tyrosine kinase inhibitors in cancer treatment", EXP.OPIN.THER.PATENTS, vol. 7, no. 6, 1997, LONDON, pages 571 - 588, XP002122590 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999048868A2 (fr) | 1999-09-30 |
WO1999048868A9 (fr) | 2000-04-20 |
AU3363599A (en) | 1999-10-18 |
JP2002507598A (ja) | 2002-03-12 |
CA2325935A1 (fr) | 1999-09-30 |
EP1066257A2 (fr) | 2001-01-10 |
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