WO1997012961B1 - Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5 - Google Patents
Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5Info
- Publication number
- WO1997012961B1 WO1997012961B1 PCT/US1996/015167 US9615167W WO9712961B1 WO 1997012961 B1 WO1997012961 B1 WO 1997012961B1 US 9615167 W US9615167 W US 9615167W WO 9712961 B1 WO9712961 B1 WO 9712961B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- iccs
- matrix
- cells
- laminin
- human
- Prior art date
Links
- 108010028309 kalinin Proteins 0.000 title claims abstract 11
- 230000001058 adult Effects 0.000 title claims abstract 6
- 210000004153 Islets of Langerhans Anatomy 0.000 title claims abstract 5
- 210000004027 cells Anatomy 0.000 claims abstract 13
- 239000011159 matrix material Substances 0.000 claims abstract 11
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract 10
- 102000004877 Insulin Human genes 0.000 claims abstract 5
- 108090001061 Insulin Proteins 0.000 claims abstract 5
- 210000002744 Extracellular Matrix Anatomy 0.000 claims abstract 3
- 206010005003 Bladder cancer Diseases 0.000 claims abstract 2
- 241000700159 Rattus Species 0.000 claims abstract 2
- 201000001531 bladder carcinoma Diseases 0.000 claims abstract 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 3
- 239000001963 growth media Substances 0.000 claims 3
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 210000000301 Hemidesmosomes Anatomy 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 102100011560 LAMA3 Human genes 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- YTOPFCCWCSOHFV-UHFFFAOYSA-N Tridemorph Chemical compound CCCCCCCCCCCCCN1CC(C)OC(C)C1 YTOPFCCWCSOHFV-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002919 epithelial cells Anatomy 0.000 claims 1
- 230000002349 favourable Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 230000002480 immunoprotection Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 108091008117 polyclonal antibodies Proteins 0.000 claims 1
- 230000001737 promoting Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Abstract
L'invention concerne un procédé qui permet d'augmenter le nombre des cellules adultes des îlots de Langerhans du pancreas, aux fins de transplantation, et consiste à mettre en contact ces cellules avec une matrice extracellulaire de laminine 5. Après trois passages en culture, le nombre des cellules est multiplié par 1500 suite au contact avec la matrice déposée provenant de cellules d'un carcinome de vessie de rat de type 804G. On observe également une augmentation du nombre des cellules des îlots au contact d'une matrice soluble de type 804G. Les nouvelles cellules des îlots de Langerhans du pancreas ainsi obtenues contiennent de l'insuline et réagissent à l'épreuve de tolérance au glucose.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9514294A JPH11513253A (ja) | 1995-10-06 | 1996-09-23 | 成体膵島細胞のラミニン5による成長 |
EP96935891A EP0859830B1 (fr) | 1995-10-06 | 1996-09-23 | Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5 |
AT96935891T ATE255631T1 (de) | 1995-10-06 | 1996-09-23 | Wachstum von adulten langenhans-zellen des pankreas mit laminin-5 |
AU73672/96A AU706581B2 (en) | 1995-10-06 | 1996-09-23 | Growth of adult pancreatic islet cells |
DE69630972T DE69630972T2 (de) | 1995-10-06 | 1996-09-23 | Wachstum von adulten langenhans-zellen des pankreas mit laminin-5 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US487895P | 1995-10-06 | 1995-10-06 | |
US60/004,878 | 1995-10-06 | ||
US08/626,394 US5681587A (en) | 1995-10-06 | 1996-03-29 | Growth of adult pancreatic islet cells |
US08/626,394 | 1996-03-29 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1997012961A2 WO1997012961A2 (fr) | 1997-04-10 |
WO1997012961A3 WO1997012961A3 (fr) | 1997-05-22 |
WO1997012961B1 true WO1997012961B1 (fr) | 1997-07-10 |
Family
ID=26673609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/015167 WO1997012961A2 (fr) | 1995-10-06 | 1996-09-23 | Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5681587A (fr) |
EP (1) | EP0859830B1 (fr) |
JP (1) | JPH11513253A (fr) |
AT (1) | ATE255631T1 (fr) |
AU (1) | AU706581B2 (fr) |
CA (1) | CA2233859A1 (fr) |
DE (1) | DE69630972T2 (fr) |
ES (1) | ES2211988T3 (fr) |
WO (1) | WO1997012961A2 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6352707B1 (en) | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
USRE36844E (en) * | 1993-04-05 | 2000-08-29 | Desmos Incorporated | Cellular attachment to trans-epithelial appliances |
US5672361A (en) * | 1996-03-29 | 1997-09-30 | Desmos, Inc. | Laminin 5 for growth of pancreatic islet cells |
US6294356B1 (en) | 1998-01-16 | 2001-09-25 | Northwestern University | Methods and materials for making and using laminin-5 |
WO1999053955A1 (fr) * | 1998-04-22 | 1999-10-28 | Desmos, Inc. | Creation de surfaces bioactives par adsorption selective |
WO1999061586A1 (fr) * | 1998-05-29 | 1999-12-02 | Cythera, Inc. | Promotion de la differenciation cellulaire par des cellules ayant subi initialement plusieurs passages |
AU1093199A (en) * | 1998-10-13 | 2000-05-01 | General Hospital Corporation, The | Laminin 5, 13 and 14 and uses thereof |
US6242666B1 (en) * | 1998-12-16 | 2001-06-05 | The Scripps Research Institute | Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells |
WO2000046351A2 (fr) * | 1999-02-04 | 2000-08-10 | Mcgill University | Plate-forme de differenciation cellulaire |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
EP1177291A2 (fr) | 1999-04-30 | 2002-02-06 | Biostratum, Inc. | Laminine 8 et ses procedes d'utilisation |
US6632790B1 (en) | 1999-04-30 | 2003-10-14 | University Of Medicine And Dentistry Of New Jersey | Laminin 2 and methods for its use |
EP1177290A2 (fr) * | 1999-04-30 | 2002-02-06 | Biostratum, Inc. | Laminine 5 recombinee |
US6703363B1 (en) * | 1999-04-30 | 2004-03-09 | Biostratum, Inc. | Recombinant laminin 5 |
US6815203B1 (en) * | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
WO2000078929A1 (fr) * | 1999-06-23 | 2000-12-28 | Joslin Diabetes Center, Inc. | Fabrication d'ilots de cellules pancreatiques |
EP1224259A4 (fr) * | 1999-09-27 | 2005-04-27 | Univ Florida | Inversion de diabetes dependant de l'insuline par des cellules souches insulaires, des cellules insulaires progenitrices et des structures de type insulaire |
CA2400355A1 (fr) * | 2000-02-18 | 2001-08-23 | The Walter And Eliza Hall Institute Of Medical Research | Facteurs de croissance des cellules pancreatiques insulino-secretrices |
EP1814980B1 (fr) * | 2004-11-22 | 2015-03-25 | Ramot at Tel-Aviv University Ltd. | Populations de cellules beta adultes d'ilot de langerhans proliférées et redifferenciees permettant de produire de l'insuline et procede d'obtention associe |
US20080103606A1 (en) * | 2006-10-30 | 2008-05-01 | Cory Berkland | Templated islet cells and small islet cell clusters for diabetes treatment |
US8735154B2 (en) * | 2006-10-30 | 2014-05-27 | The University Of Kansas | Templated islet cells and small islet cell clusters for diabetes treatment |
US8895048B2 (en) * | 2010-04-06 | 2014-11-25 | The University Of Kansas | Templated islet cells and small islet cell clusters for diabetes treatment |
SG10201503582YA (en) * | 2010-05-07 | 2015-06-29 | Univ North Carolina | Method of engrafting cells from solid tissues |
KR101327630B1 (ko) * | 2012-03-05 | 2013-11-13 | 울산대학교 산학협력단 | 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장 |
WO2019098944A1 (fr) * | 2017-11-15 | 2019-05-23 | National University Of Singapore | Systèmes de développement d'îlots pancréatiques et leur transplantation |
CN113308433A (zh) * | 2021-04-27 | 2021-08-27 | 立沃生物科技(深圳)有限公司 | 一种胰岛体外培养表面杂细胞处理方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU663083B2 (en) * | 1991-03-26 | 1995-09-28 | State of Oregon acting by and through The State Board of Higher Education on behalf of The Oregon Health Sciences University, The | Product and method for improving keratinocyte adhesion to the dermis |
EP0675728B1 (fr) * | 1992-08-28 | 2001-06-13 | State Of Oregon By And Through Oregon State Board Of Higher Education On Behalf Oregon Health Sc. Univ. And Oregon State Univ. | Produits et procedes destines a ameliorer l'adhesion du keratinocyte sur le derme |
US5510263A (en) * | 1993-04-05 | 1996-04-23 | Desmos, Inc. | Growth of pancreatic islet-like cell clusters |
US5422264A (en) * | 1993-11-12 | 1995-06-06 | Desmos, Inc. | Soluble factor stimulation of attachment and hemidesmosome assembly in epithelial cells |
US5541106A (en) * | 1993-04-05 | 1996-07-30 | Desmos, Inc. | Cell matrix stimulated attachment and hemidesmosome assembly |
EP0716659A4 (fr) * | 1993-09-02 | 1998-09-02 | Hutchinson Fred Cancer Res | Epiligrine, ligand epithelial pour les integrines |
US5834308A (en) * | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
-
1996
- 1996-03-29 US US08/626,394 patent/US5681587A/en not_active Expired - Fee Related
- 1996-09-23 AT AT96935891T patent/ATE255631T1/de not_active IP Right Cessation
- 1996-09-23 JP JP9514294A patent/JPH11513253A/ja not_active Ceased
- 1996-09-23 EP EP96935891A patent/EP0859830B1/fr not_active Expired - Lifetime
- 1996-09-23 CA CA002233859A patent/CA2233859A1/fr not_active Abandoned
- 1996-09-23 AU AU73672/96A patent/AU706581B2/en not_active Ceased
- 1996-09-23 DE DE69630972T patent/DE69630972T2/de not_active Expired - Fee Related
- 1996-09-23 ES ES96935891T patent/ES2211988T3/es not_active Expired - Lifetime
- 1996-09-23 WO PCT/US1996/015167 patent/WO1997012961A2/fr active IP Right Grant
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1997012961B1 (fr) | Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5 | |
EP1312669B1 (fr) | Cellules epidermiques cultivees en couche mince, peau cultivee de facon stratifiee et procede de production associe | |
EP1093803B1 (fr) | Composition cosmétique contenant un antagoniste des récepteurs du neuropeptide Y | |
EP1666585B1 (fr) | Cellules sécrétoires macro-encapsulées | |
JP2004506598A5 (fr) | ||
JPS6133593B2 (fr) | ||
US20120210451A1 (en) | Islet cell sheet, process for production thereof, and use thereof | |
WO1997012961A3 (fr) | Augmentation du nombre de cellules adultes des ilots de langerhans du pancreas, a l'aide de laminine-5 | |
KR880700854A (ko) | 신규한 고정된 생체촉매와 그 제법 및 용도 | |
CA2334483A1 (fr) | Compositions de cellules restreintes capables de croissance rapide qui produisent des matieres supprimant la proliferation et utilisation desdites compositions | |
CA2272130A1 (fr) | Procede de prevention de rejet de greffon dans une transplantation et de production d'une cellule hote universelle de therapie genique a partir du gene d'activation des lymphocytes (lag-3) | |
RU2003121231A (ru) | Молчащие анти-cd28-антитела и их применение | |
KR101761092B1 (ko) | 췌도 세포 이식용 조성물 | |
Ohgawara et al. | Development of a method for embedded-culture of pig pancreatic islet-like cell clusters in agarose containing maltose-carrying polystyrene (HEVM) and nicotinamide | |
Zekorn et al. | Islet transplantation in immunoseparating membranes for treatment of insulin-dependent diabetes mellitus | |
Dixit et al. | Repeated transplantation of microencapsulated hepatocytes for sustained correction of hyperbilirubinemia in Gunn rats | |
JP5224440B2 (ja) | 三次元培養弾性線維組織及び三次元培養弾性線維組織の製造方法 | |
Meanna et al. | Use of cyanoacrylate glue to prepare cultured keratinocyte sheets for grafting | |
WO2019098944A1 (fr) | Systèmes de développement d'îlots pancréatiques et leur transplantation | |
Lelli et al. | Preparation and characterization of permselective, biocompatible membranes for the macroencapsulation of pancreatic islets | |
WO1995032743A1 (fr) | Pansement provisoire biologiquement actif pour lesions etendues et procede de preparation | |
AU4544299A (en) | Promotion of cell differentiation by initially passaged cells | |
CA1214389A (fr) | Cellules encapsulees, methode de preparation et utilisation | |
CN115948322A (zh) | 一种单层自组装多肽溶液培养细胞的方法 | |
Papas | Bioenergetics, metabolism, and secretion of immunoisolated endocrine cell preparations |