WO1993019721A1 - Produit cosmetique nouveau - Google Patents

Produit cosmetique nouveau Download PDF

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Publication number
WO1993019721A1
WO1993019721A1 PCT/JP1992/001338 JP9201338W WO9319721A1 WO 1993019721 A1 WO1993019721 A1 WO 1993019721A1 JP 9201338 W JP9201338 W JP 9201338W WO 9319721 A1 WO9319721 A1 WO 9319721A1
Authority
WO
WIPO (PCT)
Prior art keywords
melanin
coated
pigment
coated pigment
acid
Prior art date
Application number
PCT/JP1992/001338
Other languages
English (en)
Japanese (ja)
Inventor
Shinkichi Honda
Yoichiro Takekoshi
Yoichiro Arai
Original Assignee
Kyowa Hakko Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co., Ltd. filed Critical Kyowa Hakko Kogyo Co., Ltd.
Priority to AU27717/92A priority Critical patent/AU2771792A/en
Priority to AU37685/93A priority patent/AU664262B2/en
Priority to EP93906852A priority patent/EP0587908B1/fr
Priority to DE69329764T priority patent/DE69329764T2/de
Priority to PCT/JP1993/000397 priority patent/WO1993020150A1/fr
Publication of WO1993019721A1 publication Critical patent/WO1993019721A1/fr
Priority to US08/150,114 priority patent/US5380359A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0001—Post-treatment of organic pigments or dyes
    • C09B67/0004—Coated particulate pigments or dyes
    • C09B67/0008—Coated particulate pigments or dyes with organic coatings
    • C09B67/0013—Coated particulate pigments or dyes with organic coatings with polymeric coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the present invention relates to a melanin-coated pigment obtained by coating a carrier with a natural melanin which is easily soluble and a cosmetic containing the same.
  • Melanin is a brown or black pigment and is known to have properties such as ultraviolet absorption.
  • US Pat. No. 4,961,754 discloses a powder obtained by modifying the surface of an inorganic powder with a synthetic melanin formed by an oxidative polymerization reaction of a compound having an indole skeleton and a cosmetic containing the powder.
  • Powders modified with synthetic melanin polymerized on the powder surface are used for cosmetics such as skin irritation caused by oxidation catalysts such as low molecular weight compounds, free monomers remaining in the synthesis process, and potassium iodide and hydrogen peroxide. There is a problem in safety when used as.
  • Sepia melanin is difficult to isolate and purify because it is insoluble in acids and alcohols and hardly soluble in various solvents, and is difficult to handle as a cosmetic.
  • melanin When melanin was adsorbed on a carrier, it was found to be usable for coloring purposes as a skin color or gray pigment different from the color of melanin, and was found to be particularly useful for coloring cosmetics.
  • a melanin-coated pigment obtained by coating a carrier with a readily soluble natural melanin and a cosmetic containing the pigment are provided.
  • the carrier to be used is insoluble in water, ash and the like, and can be any powder that can adsorb melanin.
  • inorganic or organic pigments are preferably used.
  • Inorganic pigments are pigments made of inorganic compounds, for example, titanium dioxide, talc, Sericite, My strength, Titanium mica, Montmorillonite, Kaolin, Alumina, Magnesium oxide, Cesium oxide, Silica, Kaolin, Muscovite, Parium sulfate, Aluminum silicate, Aluminum magnesium magnesium, Sodium magnesium magnesium , Calcium gayate, iron oxide, calcium carbonate, pumice powder, ultramarine, etc.
  • the organic pigment is a pigment composed of an organic compound, and for example, various dyes and pigments can be used.
  • resins such as nylon 6, nylon 6.6, nylon powder, silicone branch j, fife cellulose, crystal cellose, and silk powder can be used.
  • These carriers having a particle size of 0.01 to 100 microns are used singly or in combination.
  • the readily soluble natural melanin in the present invention refers to easily soluble alkali melanin derived from microorganisms and plants, and a preferred example is oleobasidium.
  • microbial melanin CAureobasidium
  • Aspergillus and Streptomyces produced by microorganisms belonging to the genus include, for example, FFM. Microbiology Letters 9_, 237-240 (1980), Transactions 'Obza' Pretish 'Mycology' Society (Trans. Br. Ycol. Soc.) 70 (3), 453-455 (1978), Molecular 'and' General Genetics (Mol. Gen. Genet.) 200, 422-432 (1985).
  • the alkali-soluble natural melanin used in the present invention easily dissolves in an alkaline solution such as sodium hydroxide, hydroxylammonium or ethanolamine of 0.01 to 6.0N.
  • the melanin-coated pigment of the present invention can be produced by applying a known method for adsorbing components in a solution to a carrier, and can be obtained, for example, by the following production method.
  • the above melanin is dissolved in an alkaline solution such as sodium hydroxide (0.01 to 6.0), ⁇ -oxidizing steam or ethanolamine, and a carrier is added and stirred.
  • an acid solution such as 0.01-6.0N hydrochloric acid is added little by little to the colored suspension to be stirred to sufficiently adsorb melanin on the pigment surface. Decreasing the pH to 1-4 makes the supernatant clear.
  • the solution is filtered and washed with 5 to 10 volumes of water 2 to 5 times, and the residue is dried, and the dried material is ground to obtain a powdered melanin-coated pigment of 0.05 to 50 zm. Is obtained.
  • Alkali-soluble natural melanin is coated on the surface of the carrier at a rate of 0.01 to 50% by weight.
  • the thus obtained melanin-coated pigment can be used in paints, inks, cosmetics and the like as a pigment for flesh color or gray. Especially when used in cosmetics, the effect of ultraviolet absorption can also be expected.
  • the type of carrier and the amount of melanin coverage can be experimentally changed to obtain a melanin-coated pigment having a desired color. Such experiments can be easily performed by those skilled in the art.
  • Skin cosmetics such as milky lotions, creams, stone ages, and packs, and cosmetics for hair such as lipsticks, foundations, eye shadows, eyeliners, and the like, and W hairstyles such as IE Shamboo and rinses.
  • the cosmetic of the present invention comprises various components generally used in cosmetics, such as fats and oils, hydrocarbons, waxes, fatty acids, synthetic esters, alcohols, surfactants, thickeners, humectants, and preservatives. Agents, fragrances, pigments, UV absorbers, drugs, water, etc. can be selected and blended according to the desired dosage form.
  • oils and fats examples include jojoba shan, castor ash, olive ash, soybean oil, coconut oil, palm oil, cocoa shoot, mink shoot, turtle shoot, yashishto, fatty acid diethanolamide, sea avatar, etc. .
  • hydrocarbons examples include liquid paraffin, solid paraffin, petrolatum, microcrystalline wax, and squalane.
  • the waxes include beeswax, mokurou, lanolin, carnauba wax, candelie Larrow, hydrocarbons, etc. are released.
  • Fatty acids include myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid and the like.
  • Synthetic esters include isopropyl myristate, isopropyl palmitate, butyl oleate, myristyl myristate, octyldecyl myristate, propylene glycol mono-stearate, myristinole L, apple diisostearyl, glycerin monostearate, and chloride.
  • Distearyl dimethylammonium, acetyltributyl citrate and the like can be mentioned.
  • Fats, hydrocarbons, ⁇ ⁇ s, fatty acids, and synthetic esters are usually added together in a ratio of 0.01 to 7 O w / v ⁇ .
  • Examples of the alcohols include ethanol, 1,3-butylene glycol, propylene glycol, lauryl alcohol, ceanol, stearyl alcohol, oleyl alcohol, and denatured alcohol. It is blended in proportions.
  • surfactant examples include polyoxyethylene (60) -cured castor, sodium laurinolate sulfate, pyroglucamic acid isostearate polyoxetylene glyceryl, sodium alkylbenzene sulfonate, and polyoxyethylene (10) stearyl ether , Dialkylsulfosuccinic acid, cetylpyridinium bromide, n-octadecyltrimethylammonium chloride, monoalkylphosphoric acid, N-amrugulinic acid, sucrose fatty acid ester, glyceryl isostearate, boroxyethylene ( 20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, sorbitan sesquioleate estesole, polyoxyethylene (20) sorbitan monooleate, sorbitanses chioleate Monoglyceride stearate, polyoxyethylene cetyl ether phosphoric acid, sodium polyox
  • thickener examples include carboxyvinyl polymer, methylpolysiloxane, dextran, carboxymethylcellulose, carrageenan, hydroxymethylcellulose, butyl resin emulsion, polyacrylate emulsion, and the like. It is blended at a ratio of l to 5 w / w%.
  • humectants include glycerin, propylene glycol, 1,3-butylene glycol, pyrrolidone carboxylic acid, L-acid, hyaluronic acid, collagen, N-acetyl-L-glutamine, triethanolamine, cunic acid, and cunic acid. Sodium and the like, and are blended at a ratio of 0.01 to 30 w / w%.
  • preservatives include benzoic acid, salicylic acid, dehydroacetic acid and salts thereof, phenols such as paraoxybenzoic acid ester, 2,4,4'-trichloro- 1'-hydroxydiphenyl ether, and 3-trifluoro. Methyl 1,4'-dichlorocarnox chloride and the like are included, and are blended at a ratio of 0.01 to 0.5 w / w.
  • fragrance a fragrance usually used in cosmetics can be used.
  • Pigments added to cosmetics include titanium dioxide, talc, sericite, myriki, titanium mica, montmorillonite, kaolin, alumina, magnesium oxide, cesium oxide, silica, kaolin, muscovite, barium sulfate, aluminum gayate, Aluminum magnesium silicate, sodium magnesium gayate, calcium gayate, iron oxide, calcium carbonate, pumice powder, ultramarine, nylon 6, nylon 6.6, nylon powder, cellulose, crystalline cellulose, silk powder, etc. It is blended at a ratio of 0.01 to 90 w / w%.
  • UV absorbers include diisopropyl cinnamate, methyl diisopropyl cinnamate, mono-2-diethyl methoxycinnamate glyceryl hexylate, paraaminobenzoic acid, ethyl paraaminobenzoate, and 4-tert-butyl-4'-methoxy.
  • Sidibenzoylmethane, 2-ethylhexyl paradimethylaminobenzoate and the like are included, and are blended at a ratio of 0.01 to 10 W / W%.
  • Examples of the drug include vitamin E, vitamin C and derivatives thereof, licorice extract, dipotassium glycyrrhizinate, and bracenta liquid, which are incorporated at a ratio of 0.01 to 5 w / w%.
  • the melanin-coated pigment of the present invention is used alone or as a mixture of two or more, and is incorporated in an amount of 0.01 to 90% by weight based on the cosmetic.
  • the microorganism melanin used in the present invention is highly safe and has a wide absorption band in the ultraviolet region. Further, the pigment obtained by coating with the microbial melanin has a high color development and a high color tone, and the cosmetic containing the pigment has an excellent ultraviolet ray preventing effect.
  • FIG. I shows the survival curve of L929 fibroblast 1 upon irradiation with UVB (wavelength; the same applies to 300 rats or less).
  • FIG. 2 shows the survival rate by UV irradiation after microbial melanin treatment at each concentration of L929 fibroblasts.
  • ⁇ indicates the 50% survival rate of UVB irradiation
  • ⁇ indicates 4% survival rate of UV ⁇ irradiation.
  • Figure 3 1, 2, 3 and 4 are coated with microbial melanin film, respectively 39.6mJ / cni 2 from the top of its, the 61.2mJ / cm 2, 1 04.4mJZcm 2 and 212.4mJ cm 2 UVB intensity - of The survival rate of L929 fibroblasts by UVBj! Ft irradiation (wavelength; 25 Onm) is shown.
  • [] indicates the control and indicates the survival rate.
  • Example 1 Melanin-coated pigment ⁇ preparation
  • the resulting seed culture solution 30 ⁇ capacity jar fermentans evening production medium in one (starch 5.0, i3. .096, 0.75% lysine hydrochloride, Mg 2 S0 4 ⁇ 7H 2 0 50 mg /, CuS0 4 - 5H 2 0 5 0 mg j2, ZnS0 4 ⁇ 7H 2 0 5 0 mgZ ⁇ , CaC0 3 0. 1%, was inoculated into soybean oil 4.0%) 3 0, 1 day 0 2 7 The culture was carried out by aeration and agitation (rotation speed: 4 25 rpm, aeration rate: 1 O ⁇ Zmin).
  • a carrier titanium oxide, My power, talc, nylon powder or sericite
  • 400 g of 1 N hydrochloric acid was gradually added with stirring. This was filtered, washed with water and dried, and the dried product was pulverized to obtain a 5 m melanin-coated pigment.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a solid foundation having the following composition was prepared.
  • the components (6) to (9) were uniformly dissolved in the component (5) while mixing the components CI) to (4) well with a blender, followed by pulverization. This powder was molded under pressure to obtain a solid foundation.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a liquid foundation having the following composition was prepared.
  • Components (1) to (4), (12) and (13) were mixed and uniformly dispersed by a three-roll mill (pigment part).
  • Components (5) to (11), (16) and (17) are heated and dissolved at 80 ° C, and heated to 80 ° C and uniformly mixed (14), (15), (18) And a pigment part, and emulsified and mixed with a homomixer. This was cooled to obtain a liquid foundation.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a lipstick having the following composition was prepared.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, an eyeliner having the following composition was prepared.
  • Components (5), (6) and (9) were heated and melted, and components (1) to (3) were added thereto and uniformly mixed with a colloid mill.
  • Components (4), (6) to (8), (10) and C11) were added and uniformly dispersed with a homomixer to obtain an airliner.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a mascara having the following composition was prepared.
  • component (1) dispersed by a homomixer
  • (2) was added thereto and mixed uniformly.
  • the components (3) to (7) were mixed, heated and dissolved at 70 ° C., the mixture was added, and the mixture was emulsified and dispersed with a homomixer to obtain a mascara.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a sunscreen emulsion having the following composition was prepared.
  • the components (1) to (3) were mixed and uniformly dispersed in a three-neck mill (pigment part).
  • Components (4) to (6) were heated and melted at 80 ° C (Shantou).
  • the components (7) to (11) were heated and dissolved in 8 CTC, and the pigment was added and stirred uniformly (aqueous phase).
  • the aqueous phase was added to Shantou, emulsified and mixed with a homomixer, and then cooled to obtain a sunscreen emulsion.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a sunscreen cream having the following composition was prepared.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a sunscreen composition having the following composition was prepared.
  • Example 2 Using the melanin-coated pigment obtained in Example 1, a sunscreen cream with the following cord was prepared.
  • Components (1), (2), (6), (11), (12) and (17) were mixed and uniformly dispersed by a three-roll mill (pigment part).
  • Components (3) to (5),) to (10), (13) and (14) were heated and dissolved at 80 ° C (oil phase).
  • Components (15) to (18), (21) and (23) were heated and dissolved at 80 ° C, and the pigment was added and stirred uniformly (7K phase). Hydration was added to Shantou, and the mixture was emulsified and mixed with a homomixer, then cooled, and ingredients (19), (20) and (22) were mixed to obtain a sunscreen cream.
  • the UV lamp used was FL 2 OS ⁇ E (maximum wavelength: 300 nm, manufactured by Toshiba Corporation), and the UV B5 degree was measured with an ultraviolet intensity meter UVR-1 (light receiving unit UVR-25, Tokyo Optical Machinery). It was measured.
  • Protein content of cells without UVB irradiation Figure 1 shows the survival curve of L929 fibroblasts by UVB irradiation.
  • microbial melanin 0.1 g was dissolved in 100 ml of a 0.1% aqueous sodium hydroxide solution. When completely dissolved, dissolve one PBS tablet (manufactured by Takara Shuzo) in 10 Oml of the solution, adjust the pH to 7 with hydrochloric acid, sterilize with autoclave (121 ° C, 15 minutes), and remove the microorganism melanin phosphate. A buffer (microbial melanin ZPBS) was prepared.
  • TCSA (3, 3 ', 4', 5-tetrachloro mouth salicyl alide)
  • the type of carrier (pigment) and the color tone of the microbial melanin according to the coating concentration were measured in the same manner as in Comparative Example 1 described later, and represented by L, a, and b values.
  • the UV protection effect of the cosmetic containing the melanin-coated face of the present invention was represented by an SPF (Sun Protection Factor) value.
  • sunscreen cream obtained in Example 11 was used as the SPF measurement sample of the present invention (referred to in Table 3 as sunscreen cream).
  • composition of the sunscreen cream of Example 11 components (1) and (2) were not coated with melanin, a cream was prepared in the same manner as in Example 1I, and a control SPF measurement sample was prepared. (Referred to as control in Table 3).
  • the cosmetic containing the melanin-coated pigment of the present invention has a very high
  • the color tone and coloring power of melanin, synthetic melanin, sepia melanin, black iron oxide, and carbon black (hereinafter referred to as black pigment) were compared. That is, color tone and tinctorial strength were measured in a system (dispersion system) in which titanium dioxide and each of the above black pigments were kneaded and dispersed as pigments.
  • black pigment 0.04%, titanium dioxide 1.96%, polyvinyl alcohol 2.0% of acrylic resin, 5.09 of acrylic resin, 73.0% of 1,3-butylene glycol and 18.0% of purified water were thoroughly kneaded with a three-roll mill to prepare a uniform paste-like measurement sample.
  • microbial melanin and synthetic melanin were also measured in the coating system.
  • the melanin showed a color tone close to that of synthetic melanin, and had a warm, natural color, unlike the jet black of iron oxide and Ripbon black. That is, the cosmetic containing the microbial melanin-coated pigment of the present invention has a gentle hue suitable for skin color.
  • the color tone of pigments coated with titanium dioxide with melanin is characterized by higher color development and higher saturation than when dispersed, and when microbial melanin is added to cosmetics, the coating system is more dispersed. It is understood that the stability of the product is higher than that of. Comparative Example 2
  • Purified water is added to 0.1 g of microbial melanin, synthetic melanin, or 0.1 mg of sodium hydroxide and 0.1 g of sodium hydroxide to make 100 ml, and then adjusted to pH 7 with hydrochloric acid. A solution, a synthetic melanin solution or a cameranin solution was prepared.
  • Ethanol was added to 0.1 g of di-CL-tocopherol and dissolved to prepare 100 ml of nato-tocopherol solution.
  • Purified water was added to 0.1 g of ascorbic acid and dissolved to prepare 100 ml of ascorbic acid solution.
  • CP0 cumene hydroperoxide
  • CPO As a reaction reagent, using Minaichi LPO (manufactured by Kyowa Medex), CPO reacts with a methylene blue derivative using hemoglobin as a catalyst to produce equimolar methylene blue to form a color system.
  • Microbial melanin, ascorbic acid The antioxidant activity of microbial melanin, ascorbic acid, ( ⁇ -hi-tocopherol, synthetic melanin and icaminine) was measured by adding ⁇ - ⁇ -tocopherol, synthetic melanin or imecamnin to the extent of methylene blue production inhibition.
  • Lipid peroxide elimination rate (%) 1 x 1 0 0
  • a s is the sample ⁇ Samburu absorbance
  • a B represents the absorbance of Samburu for blind.
  • Table 6 shows the elimination rate of the lipid peroxides at a concentration of 0.014% for the microorganisms melanin, ascorbic acid, sodium tocopherol, synthetic melanin, and imagenine.
  • the antioxidant ability of microorganisms such as melanin, ascorbic acid, d- ⁇ -tocopherol, synthetic melanin and icaminin can be represented by the lipid peroxide elimination rate. From the above results, it is understood that the microorganism melanin used in the present invention has an antioxidant ability. Availability of SJi
  • a melanin-coated cosmetic having high safety, high color development, and high color tone and a cosmetic containing the same are provided.
  • 'Melanin-coated pigments can be used in paints, inks, cosmetics, etc. as flesh-colored or gray pigments.
  • UV absorption and antioxidant food can be expected to be effective when used in cosmetics.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

On décrit un pigment recouvert de mélanine, préparé en recouvrant un excipient de mélanine naturelle facilement soluble en liquide alcalin, ainsi qu'un produit cosmétique contenant ce pigment. Le pigment ainsi recouvert se révèle très sûr et donne une coloration très marquée et très saturée, et le produit cosmétique devrait présenter à la fois des effets d'absorption des ultraviolets et des effets anti-oxydants.
PCT/JP1992/001338 1992-03-31 1992-10-15 Produit cosmetique nouveau WO1993019721A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU27717/92A AU2771792A (en) 1992-03-31 1992-10-15 Novel cosmetic
AU37685/93A AU664262B2 (en) 1992-03-31 1993-03-30 Melanin-coated pigments
EP93906852A EP0587908B1 (fr) 1992-03-31 1993-03-30 Produit cosmetique nouveau
DE69329764T DE69329764T2 (de) 1992-03-31 1993-03-30 Neues kosmetisches präparat
PCT/JP1993/000397 WO1993020150A1 (fr) 1992-03-31 1993-03-30 Produit cosmetique nouveau
US08/150,114 US5380359A (en) 1992-03-31 1993-11-24 Cosmetics based on naturally derived melanin-coated pigments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7784892 1992-03-31
JP4/77848 1992-03-31

Publications (1)

Publication Number Publication Date
WO1993019721A1 true WO1993019721A1 (fr) 1993-10-14

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WO (1) WO1993019721A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0847747A1 (fr) * 1996-12-16 1998-06-17 L'oreal Pigment mélanique composite sous forme de particules comprenant un noyau sphérique à base de cire, procédé de préparation et utilisations en cosmétique
CN113069372A (zh) * 2021-04-07 2021-07-06 广州慈康生物科技有限公司 一种基于黑色素包覆粒子的防晒组合物及制备方法

Citations (5)

* Cited by examiner, † Cited by third party
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JPS5553211A (en) * 1978-10-13 1980-04-18 Shiseido Co Ltd Make-up cosmetic
JPS55102659A (en) * 1979-01-30 1980-08-06 Sanyo Kokusaku Pulp Co Ltd Deep red coloring composition and its preparation
JPS57145159A (en) * 1981-03-04 1982-09-08 Pola Chem Ind Inc Natural coloring matter pigment
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EP0847747A1 (fr) * 1996-12-16 1998-06-17 L'oreal Pigment mélanique composite sous forme de particules comprenant un noyau sphérique à base de cire, procédé de préparation et utilisations en cosmétique
FR2757054A1 (fr) * 1996-12-16 1998-06-19 Oreal Pigment melanique composite sous forme de particules comprenant un noyau spherique a base de cire, procedes de preparation et utilisations en cosmetique
US5954871A (en) * 1996-12-16 1999-09-21 L'oreal Composite melanin pigment in the form of particles comprising a wax-based spherical core, preparation processes and cosmetic uses
CN113069372A (zh) * 2021-04-07 2021-07-06 广州慈康生物科技有限公司 一种基于黑色素包覆粒子的防晒组合物及制备方法

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