WO1987000523A3 - Hydroxyalkylxanthines tertiaires, leur procede de fabrication, medicaments les contenant et leur utilisation - Google Patents

Hydroxyalkylxanthines tertiaires, leur procede de fabrication, medicaments les contenant et leur utilisation

Info

Publication number
WO1987000523A3
WO1987000523A3 PCT/EP1986/000401 EP8600401W WO8700523A3 WO 1987000523 A3 WO1987000523 A3 WO 1987000523A3 EP 8600401 W EP8600401 W EP 8600401W WO 8700523 A3 WO8700523 A3 WO 8700523A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon atoms
tertiary
manufacturing process
hydroxyalkylxanthines
alkyl group
Prior art date
Application number
PCT/EP1986/000401
Other languages
German (de)
English (en)
Other versions
WO1987000523A2 (fr
Inventor
Ulrich Gebert
Ismahan Okyayuz-Baklouti
Werner Thorwart
Original Assignee
Hoechst Ag
Ulrich Gebert
Okyayuz Baklouti Ismahan
Werner Thorwart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU863670A priority Critical patent/HU198486B/hu
Priority to KR1019870700245A priority patent/KR950001019B1/ko
Priority to DE8686904158T priority patent/DE3671627D1/de
Priority to SU864355018A priority patent/RU2051918C1/ru
Priority to AT86904158T priority patent/ATE53211T1/de
Priority to JP61504113A priority patent/JPH0788382B2/ja
Application filed by Hoechst Ag, Ulrich Gebert, Okyayuz Baklouti Ismahan, Werner Thorwart filed Critical Hoechst Ag
Publication of WO1987000523A2 publication Critical patent/WO1987000523A2/fr
Publication of WO1987000523A3 publication Critical patent/WO1987000523A3/fr
Priority to DK139287A priority patent/DK157867C/da
Priority to NO871111A priority patent/NO165803C/no
Priority to FI880174A priority patent/FI89921C/fi
Priority to LV930291A priority patent/LV5703A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Hydroxyalkylxanthines tertiaires de formule générale (I), caractérisés en ce qu'au moins un des résidus R1 et R3 représente un groupe hydroxyalkyle tertiaire de formule (Ia) dans laquelle R4 représente un groupe alkyle possédant jusqu'à 3 atomes de carbone et n un nombre entier compris entre 2 et 5; l'autre résidu éventuellement restant R1 ou R3 est un atome d'hydrogène ou bien un résidu d'hydrocarbure aliphatique R5 possédant jusqu'à 6 atomes de carbone, dont la chaîne carbonée peut être interrompue par 2 atomes d'oxygène au maximum ou bien être substituée par un groupe oxo ou deux groupes hydroxy au maximum, et R2 représente un groupe alkyle possédant de 1 à 4 atomes de carbone. Est également décrit un procédé de fabrication de ces composés, lesquels sont indiqués pour la fabrication de médicaments, en particulier pour des applications de prévention et/ou de traitement de troubles de l'irrigation cérébrale et/ou périphérique.
PCT/EP1986/000401 1985-07-19 1986-07-08 Hydroxyalkylxanthines tertiaires, leur procede de fabrication, medicaments les contenant et leur utilisation WO1987000523A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
KR1019870700245A KR950001019B1 (ko) 1985-07-19 1986-07-08 3급 하이드록시 알킬크산틴의 제조방법
DE8686904158T DE3671627D1 (de) 1985-07-19 1986-07-08 Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung.
SU864355018A RU2051918C1 (ru) 1985-07-19 1986-07-08 Способ получения третичных оксиалкилксантинов
AT86904158T ATE53211T1 (de) 1985-07-19 1986-07-08 Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung.
JP61504113A JPH0788382B2 (ja) 1985-07-19 1986-07-08 第三ヒドロキシアルキルキサンチン、それらの製造法及びそれを含有する治療剤
HU863670A HU198486B (en) 1985-07-19 1986-07-08 Process for producing tertiary hydroxy-alkyl-xanthines and pharmaceutical preparations containing such active agents
DK139287A DK157867C (da) 1985-07-19 1987-03-18 Tertiaere hydroxyalkylxanthiner og deres anvendelse som laegemidler
NO871111A NO165803C (no) 1985-07-19 1987-03-18 Analogifremgangsmaate for fremstilling av terapeutisk aktive tertiaere hydroksyalkylxantiner.
FI880174A FI89921C (fi) 1985-07-19 1988-01-15 Foerfarande foer framstaellning av terapeutiskt anvaendbara tertiaera hydroxialkylxantiner
LV930291A LV5703A3 (lv) 1985-07-19 1993-05-05 Panemiens tresejo oksialkilksantinu iegusanai

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3525801.2 1985-07-19
DE19853525801 DE3525801A1 (de) 1985-07-19 1985-07-19 Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
WO1987000523A2 WO1987000523A2 (fr) 1987-01-29
WO1987000523A3 true WO1987000523A3 (fr) 1987-02-26

Family

ID=6276182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000401 WO1987000523A2 (fr) 1985-07-19 1986-07-08 Hydroxyalkylxanthines tertiaires, leur procede de fabrication, medicaments les contenant et leur utilisation

Country Status (33)

Country Link
US (1) US4833146A (fr)
EP (1) EP0268585B1 (fr)
JP (1) JPH0788382B2 (fr)
KR (1) KR950001019B1 (fr)
CN (1) CN1026112C (fr)
AR (1) AR244689A1 (fr)
AT (1) ATE53211T1 (fr)
AU (1) AU588350B2 (fr)
BG (1) BG60767B2 (fr)
CA (1) CA1262248A (fr)
CS (1) CS272766B2 (fr)
DD (1) DD261156A5 (fr)
DE (2) DE3525801A1 (fr)
DK (1) DK157867C (fr)
ES (1) ES2001019A6 (fr)
FI (1) FI89921C (fr)
GR (1) GR861866B (fr)
HU (1) HU198486B (fr)
IE (1) IE59025B1 (fr)
IL (1) IL79457A0 (fr)
LT (1) LT3869B (fr)
LV (1) LV5703A3 (fr)
MA (1) MA20739A1 (fr)
MX (1) MX9254A (fr)
NO (1) NO165803C (fr)
NZ (1) NZ216888A (fr)
OA (1) OA08707A (fr)
PH (1) PH26262A (fr)
PT (1) PT83013B (fr)
RU (1) RU2051918C1 (fr)
TN (1) TNSN86111A1 (fr)
WO (1) WO1987000523A2 (fr)
ZA (1) ZA865374B (fr)

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GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
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DE3942872A1 (de) * 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
IT1240843B (it) * 1990-05-24 1993-12-17 Malesci Istituto Farmacobiologico Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
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ES2087205T3 (es) * 1990-11-07 1996-07-16 Hoechst Roussel Pharma Uso de xantinas para la preparacion de un medicamento eficaz para inhibir la replicacion de retrovirus humanos.
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
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TW209834B (fr) * 1991-12-11 1993-07-21 Hoechst Ag
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AU669702B2 (en) * 1992-03-04 1996-06-20 Cell Therapeutics, Inc. Enantiomeric hydroxylated xanthine compounds
EP0570831A2 (fr) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Utilisation de dérivés de Xanthine pour le traitement de dommages cérébraux après interruption de la circulation sanguine
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5804584A (en) * 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
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US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
DE19707655A1 (de) * 1997-02-26 1998-08-27 Hoechst Ag Kombinationspräparat zur Anwendung bei Demenz
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WO2011028820A1 (fr) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Dérivés substitués de composés [4.3.0] hétéroaryle bicycliques
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US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
FR1211333A (fr) * 1955-10-19 1960-03-15 Boehringer Sohn Ingelheim Perfectionnements apportés aux procédés pour fabriquer des oxyalcoylxanthines
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
DE2207860A1 (de) * 1972-02-19 1973-08-23 Albert Ag Chem Werke Arzneimittel, insbesondere fuer die durchblutung des gehirns, verfahren zur herstellung von dafuer geeigneten wirkstoffen und diese wirkstoffe
FR2236501A2 (fr) * 1973-07-11 1975-02-07 Albert Ag Chem Werke
DE2432702A1 (de) * 1974-07-08 1976-01-29 Hoechst Ag Verfahren zur herstellung von hydroxyalkylxanthinen

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CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
CA1075690A (fr) * 1974-12-13 1980-04-15 Hoechst Aktiengesellschaft Derives de la xanthine
DE3062499D1 (en) * 1979-04-05 1983-05-05 Beecham Wuelfing Gmbh & Co Kg Dialkoxy- and dioxacycloalkyl-alkyltheobromines, pharmaceutical compositions containing them and their preparation
JPS5838284A (ja) * 1981-09-01 1983-03-05 Teikoku Chem Ind Corp Ltd １−（５′−オキソヘキシル）−３，７−ジメチルキサンチンの製造方法
DE3138397A1 (de) * 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
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DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
FR1211333A (fr) * 1955-10-19 1960-03-15 Boehringer Sohn Ingelheim Perfectionnements apportés aux procédés pour fabriquer des oxyalcoylxanthines
DE2207860A1 (de) * 1972-02-19 1973-08-23 Albert Ag Chem Werke Arzneimittel, insbesondere fuer die durchblutung des gehirns, verfahren zur herstellung von dafuer geeigneten wirkstoffen und diese wirkstoffe
FR2236501A2 (fr) * 1973-07-11 1975-02-07 Albert Ag Chem Werke
DE2432702A1 (de) * 1974-07-08 1976-01-29 Hoechst Ag Verfahren zur herstellung von hydroxyalkylxanthinen

Also Published As

Publication number Publication date
PT83013A (de) 1986-08-01
IE861917L (en) 1987-01-19
NO165803C (no) 1991-04-10
JPS63501149A (ja) 1988-04-28
PH26262A (en) 1992-04-01
NZ216888A (en) 1989-05-29
AU588350B2 (en) 1989-09-14
CS545386A2 (en) 1990-04-11
ATE53211T1 (de) 1990-06-15
RU2051918C1 (ru) 1996-01-10
DK157867C (da) 1990-07-30
CA1262248A (fr) 1989-10-10
DK139287A (da) 1987-03-18
HUT47274A (en) 1989-02-28
MA20739A1 (fr) 1987-04-01
FI89921B (fi) 1993-08-31
DE3671627D1 (de) 1990-07-05
CS272766B2 (en) 1991-02-12
TNSN86111A1 (fr) 1990-01-01
EP0268585A1 (fr) 1988-06-01
IL79457A0 (en) 1986-10-31
WO1987000523A2 (fr) 1987-01-29
DK157867B (da) 1990-02-26
PT83013B (pt) 1989-01-30
EP0268585B1 (fr) 1990-05-30
KR870700623A (ko) 1987-12-30
CN1026112C (zh) 1994-10-05
FI880174A0 (fi) 1988-01-15
FI89921C (fi) 1993-12-10
AR244689A1 (es) 1993-11-30
BG60767B2 (bg) 1996-02-29
GR861866B (en) 1986-11-17
HU198486B (en) 1989-10-30
NO871111D0 (no) 1987-03-18
LV5703A3 (lv) 1995-02-20
MX9254A (es) 1993-06-01
DE3525801A1 (de) 1987-01-22
LT3869B (en) 1996-04-25
OA08707A (en) 1989-03-31
ES2001019A6 (es) 1988-04-16
FI880174A (fi) 1988-01-15
KR950001019B1 (ko) 1995-02-07
ZA865374B (en) 1987-02-25
LTIP1467A (en) 1995-05-25
US4833146A (en) 1989-05-23
JPH0788382B2 (ja) 1995-09-27
NO165803B (no) 1991-01-02
DD261156A5 (de) 1988-10-19
IE59025B1 (en) 1993-12-15
DK139287D0 (da) 1987-03-18
AU6143986A (en) 1987-02-10
CN86105835A (zh) 1987-01-14
NO871111L (no) 1987-03-18

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