UY33449A - Nuevo Proceso De Preparación De N-[2-(7-Metoxi-1-Naftil)-011] Acetam Forma Cristalina - Google Patents

Nuevo Proceso De Preparación De N-[2-(7-Metoxi-1-Naftil)-011] Acetam Forma Cristalina

Info

Publication number
UY33449A
UY33449A UY0001033449A UY33449A UY33449A UY 33449 A UY33449 A UY 33449A UY 0001033449 A UY0001033449 A UY 0001033449A UY 33449 A UY33449 A UY 33449A UY 33449 A UY33449 A UY 33449A
Authority
UY
Uruguay
Prior art keywords
methoxy
naphthyl
crystalline form
acetam
preparation process
Prior art date
Application number
UY0001033449A
Other languages
English (en)
Inventor
Dora Graciela Tombari
Contanza Pia Mangone
Maria Beatriz Garcia
Vecchioli Adriana
Rafael Alberto Labriola
Burton German
Eduardo Miguel Rustoy
Original Assignee
Gador Sa
Conicet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44509830&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY33449(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gador Sa, Conicet filed Critical Gador Sa
Publication of UY33449A publication Critical patent/UY33449A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un nuevo procedimiento utilizando 7-metoxi-tetralona como material de partida para la preparación de N-[2-(7-metoxi-1-naftil)etil]acetamida, también conocida como agomelatina. Resulta un primer objeto de la invención, el compuesto 7-metoxi-tetralona utilizando de acuerdo con el Esquema I para la formación de Agomelatina. El segundo objeto de la invención, el compuesto 7-metoxi-tetralona utilizado de acuerdo con el Esquema II para la formación de Agomelatina. Además la invención también se refiere a una nueva forma cristalina X de agomelatina y a sus procesos de preparación.
UY0001033449A 2010-06-10 2011-06-10 Nuevo Proceso De Preparación De N-[2-(7-Metoxi-1-Naftil)-011] Acetam Forma Cristalina UY33449A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35326610P 2010-06-10 2010-06-10

Publications (1)

Publication Number Publication Date
UY33449A true UY33449A (es) 2012-01-31

Family

ID=44509830

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033449A UY33449A (es) 2010-06-10 2011-06-10 Nuevo Proceso De Preparación De N-[2-(7-Metoxi-1-Naftil)-011] Acetam Forma Cristalina

Country Status (4)

Country Link
EP (1) EP2580183B1 (es)
CL (1) CL2011001405A1 (es)
UY (1) UY33449A (es)
WO (1) WO2011154140A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101781226B (zh) * 2009-12-23 2012-03-28 天津泰普药品科技发展有限公司 阿戈美拉汀及其药物组合物
CN102690209A (zh) * 2011-03-23 2012-09-26 上海医药工业研究院 阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
CN102875408B (zh) * 2012-10-09 2014-07-16 江西同和药业有限责任公司 一种阿戈美拉汀的制备方法
CN102942501B (zh) * 2012-12-10 2015-08-19 天津泰普药品科技发展有限公司 一种氢化制备阿戈美拉汀的生产方法
CN103655499B (zh) * 2013-12-23 2015-07-22 天津泰普药品科技发展有限公司 一种稳定的晶x型阿戈美拉汀片剂及其制备方法
CN104016874A (zh) * 2014-06-16 2014-09-03 鹤飞扬科技发展（天津）有限公司 N-[2-(7-甲氧基-1,2,3,4-四氢-1-萘基)乙基]乙酰胺及其制备方法与应用
CN105777572A (zh) * 2014-12-26 2016-07-20 辽宁药联制药有限公司 一种阿戈美拉汀混晶的制备方法及其在片剂中的应用
EP3466923A1 (en) 2017-10-09 2019-04-10 KRKA, d.d., Novo mesto Process for the preparation of agomelatine in crystalline form
CN111807968B (zh) * 2020-07-01 2022-05-20 复旦大学 一种2-(1-环己烯基)乙胺的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE69517433T2 (de) * 1994-09-12 2001-02-08 Takeda Chemical Industries Ltd Benzozykloalkenverbindungen, deren herstellung und verwendung
US7498465B2 (en) 2004-02-13 2009-03-03 Les Laboratoires Servier Process for the synthesis and crystalline form of agomelatine
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
US7498466B2 (en) 2004-02-13 2009-03-03 Les Laboratoires Servier Process for the synthesis and crystalline form of agomelatine
FR2866337B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'aglomelatine
FR2866336B1 (fr) 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR2866334B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
FR2889522B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
US7635721B2 (en) 2005-08-03 2009-12-22 Les Laboratoires Servier Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it
FR2889523B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889521B1 (fr) 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2919606B1 (fr) 2007-08-03 2010-09-17 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine.
FR2934855B1 (fr) 2008-08-05 2010-08-13 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934857B1 (fr) 2008-08-05 2010-08-27 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934859B1 (fr) 2008-08-05 2010-08-13 Servier Lab Nouveau procede de synthese de l'agomelatine
WO2011006387A1 (zh) 2009-07-11 2011-01-20 浙江华海药业股份有限公司 阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法

Also Published As

Publication number Publication date
EP2580183A2 (en) 2013-04-17
EP2580183B1 (en) 2014-07-23
WO2011154140A2 (en) 2011-12-15
CL2011001405A1 (es) 2012-03-30
WO2011154140A3 (en) 2012-07-26

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Effective date: 20200807