UY26427A1 - PREVENTION OF RUPTURE OF PLATE BY ACAT INHIBITORS - Google Patents

PREVENTION OF RUPTURE OF PLATE BY ACAT INHIBITORS

Info

Publication number
UY26427A1
UY26427A1 UY26427A UY26427A UY26427A1 UY 26427 A1 UY26427 A1 UY 26427A1 UY 26427 A UY26427 A UY 26427A UY 26427 A UY26427 A UY 26427A UY 26427 A1 UY26427 A1 UY 26427A1
Authority
UY
Uruguay
Prior art keywords
rupture
prevention
plate
acat inhibitors
atherosclerotic
Prior art date
Application number
UY26427A
Other languages
Spanish (es)
Inventor
Bocan Thomas Michael An Andrew
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of UY26427A1 publication Critical patent/UY26427A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención es la administración de un inhibidor ACAT para prevenir la acumulación de monocito-macrófago y la expresión MMP en las lesiones ateroscleróticas. Además, esta invención se relaciona con métodos para inhibir la desestabilización y/o ruptura de placas ateroscleróticas y el tratamiento de la angina inestable.This invention is the administration of an ACAT inhibitor to prevent monocyte-macrophage accumulation and MMP expression in atherosclerotic lesions. Furthermore, this invention relates to methods for inhibiting the destabilization and / or rupture of atherosclerotic plaques and the treatment of unstable angina.

UY26427A 1999-11-05 2000-11-03 PREVENTION OF RUPTURE OF PLATE BY ACAT INHIBITORS UY26427A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16381499P 1999-11-05 1999-11-05

Publications (1)

Publication Number Publication Date
UY26427A1 true UY26427A1 (en) 2000-12-29

Family

ID=22591694

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26427A UY26427A1 (en) 1999-11-05 2000-11-03 PREVENTION OF RUPTURE OF PLATE BY ACAT INHIBITORS

Country Status (19)

Country Link
EP (1) EP1229907A1 (en)
JP (1) JP2003513909A (en)
KR (1) KR20020050257A (en)
CN (1) CN1414848A (en)
AR (1) AR026354A1 (en)
AU (1) AU1210401A (en)
CA (1) CA2382676A1 (en)
CO (1) CO5270017A1 (en)
GT (1) GT200000193A (en)
HU (1) HUP0203160A3 (en)
IL (1) IL149145A0 (en)
PA (1) PA8506101A1 (en)
PE (1) PE20011027A1 (en)
PL (1) PL355148A1 (en)
SV (1) SV2001000207A (en)
TR (1) TR200201204T2 (en)
UY (1) UY26427A1 (en)
WO (1) WO2001034127A1 (en)
ZA (1) ZA200201755B (en)

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Publication number Priority date Publication date Assignee Title
RU2358734C2 (en) 2003-08-29 2009-06-20 Кова Ко., Лтд. High-lipid plaque stabilisation method and method of destruction prevention
JP2007532617A (en) * 2004-04-15 2007-11-15 アテラ バイオテクノロジーズ エービー Annexin V to prevent atherothrombosis and plaque destruction
NZ608903A (en) 2010-11-03 2014-06-27 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
AU2012329045A1 (en) 2011-10-26 2014-04-17 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US20130291227A1 (en) 2012-04-27 2013-10-31 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004942A (en) 2013-10-17 2016-06-28 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds.
US9029554B1 (en) 2013-10-17 2015-05-12 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
BR112016007518A2 (en) 2013-10-17 2017-08-01 Dow Agrosciences Llc processes for the preparation of pesticide compounds
JP6487426B2 (en) 2013-10-17 2019-03-20 ダウ アグロサイエンシィズ エルエルシー Process for the preparation of pest control compounds
CN105636442B (en) 2013-10-17 2018-04-27 美国陶氏益农公司 The method for preparing Pesticidal compound
EP3057428A4 (en) 2013-10-17 2017-05-17 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
CN105792652A (en) 2013-10-22 2016-07-20 美国陶氏益农公司 Synergistic pesticidal compositions and related methods
US9295260B2 (en) 2013-10-22 2016-03-29 Dow Agrosciences Llc Pesticidal compositions and related methods
TW201517797A (en) 2013-10-22 2015-05-16 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9474276B2 (en) 2013-10-22 2016-10-25 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9801383B2 (en) 2013-10-22 2017-10-31 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
WO2015061140A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
JP2016535739A (en) 2013-10-22 2016-11-17 ダウ アグロサイエンシィズ エルエルシー Agrochemical compositions and related methods
MX2016005317A (en) 2013-10-22 2016-08-12 Dow Agrosciences Llc Pesticidal compositions and related methods.
RU2016119368A (en) 2013-10-22 2017-11-28 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи SYNERGETIC PESTICIDAL COMPOSITIONS AND RELATED WAYS
NZ719754A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AR098096A1 (en) 2013-10-22 2016-05-04 Dow Agrosciences Llc SYNERGIC PESTICIATED COMPOSITIONS AND RELATED METHODS
JP2016535024A (en) 2013-10-22 2016-11-10 ダウ アグロサイエンシィズ エルエルシー Synergistic pest control compositions and related methods
NZ719688A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Pesticidal compositions and related methods
KR20160074582A (en) 2013-10-22 2016-06-28 다우 아그로사이언시즈 엘엘씨 Synergistic pesticidal compositions and related methods
WO2015061163A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
JP2016538266A (en) 2013-10-22 2016-12-08 ダウ アグロサイエンシィズ エルエルシー Synergistic pest control compositions and related methods
MX2016005323A (en) 2013-10-22 2016-08-12 Dow Agrosciences Llc Pesticidal compositions and related methods.
KR20170038785A (en) 2014-07-31 2017-04-07 다우 아그로사이언시즈 엘엘씨 Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
BR112017000565A2 (en) 2014-07-31 2017-11-07 Dow Agrosciences Llc Process for the preparation of 3- (3-chloro-1h-pyrazol-1-yl) pyridine
JP2017523168A (en) 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー Method for producing 3- (3-chloro-1H-pyrazol-1-yl) pyridine
WO2016028328A1 (en) 2014-08-19 2016-02-25 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US9085552B1 (en) 2014-09-12 2015-07-21 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
EP3209671B8 (en) * 2014-10-21 2019-07-31 Council of Scientific and Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers
PE20190656A1 (en) * 2016-07-29 2019-05-08 Lupin Ltd TIAZOLO-PYRIDINE COMPOUNDS REPLACED AS INHIBITORS OF MALT1
WO2018093966A1 (en) 2016-11-16 2018-05-24 Purdue Research Foundation Compositions and methods for regulating body weight and metabolic syndromes
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
CN110139853B (en) 2016-12-29 2023-06-16 美国陶氏益农公司 Process for the preparation of pesticidal compounds
AU2018354777A1 (en) 2017-10-27 2020-04-16 Bayer Aktiengesellschaft Novel Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654688B2 (en) * 1990-10-30 1994-11-17 Warner-Lambert Company Oxysulfonyl carbamates
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
IT1270976B (en) * 1993-08-06 1997-05-26 Pierrel Spa INHIBITIVE COMPOUNDS OF ACYL ENZYME-A-CHOLESTEROL-O-ACYL TRANSFERASE TO THERAPEUTIC ACTIVITIES, THEIR USE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
JPH11510184A (en) * 1995-08-04 1999-09-07 ワーナー−ランバート・コンパニー Use of sulfamic acid derivatives, acylsulfonamides or sulfonyl carbamates for the manufacture of a medicament for reducing lipoprotein levels
CN1217656C (en) * 1995-11-02 2005-09-07 沃尼尔·朗伯公司 Method and pharmaceutical composition for regulating lipid concentration
IL140982A0 (en) * 1998-07-21 2002-02-10 Warner Lambert Co Coadministration of acat and mmp inhibitors for the treatment of atherosclerotic lesions

Also Published As

Publication number Publication date
KR20020050257A (en) 2002-06-26
PA8506101A1 (en) 2002-10-28
ZA200201755B (en) 2003-08-27
PL355148A1 (en) 2004-04-05
GT200000193A (en) 2002-04-27
WO2001034127A1 (en) 2001-05-17
AR026354A1 (en) 2003-02-05
CO5270017A1 (en) 2003-04-30
HUP0203160A2 (en) 2003-01-28
AU1210401A (en) 2001-06-06
IL149145A0 (en) 2002-11-10
HUP0203160A3 (en) 2006-02-28
CA2382676A1 (en) 2001-05-17
SV2001000207A (en) 2001-10-16
PE20011027A1 (en) 2001-10-16
CN1414848A (en) 2003-04-30
TR200201204T2 (en) 2002-08-21
JP2003513909A (en) 2003-04-15
EP1229907A1 (en) 2002-08-14

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20120529