UA117780C2 - Похідні азаіндолоцтової кислоти та їх застосування як модуляторів рецепторів простагландину d2 - Google Patents

Похідні азаіндолоцтової кислоти та їх застосування як модуляторів рецепторів простагландину d2

Info

Publication number
UA117780C2
UA117780C2 UAA201610385A UAA201610385A UA117780C2 UA 117780 C2 UA117780 C2 UA 117780C2 UA A201610385 A UAA201610385 A UA A201610385A UA A201610385 A UAA201610385 A UA A201610385A UA 117780 C2 UA117780 C2 UA 117780C2
Authority
UA
Ukraine
Prior art keywords
prostaglandin
receptor modulators
acetic acid
acid derivatives
azaindole acetic
Prior art date
Application number
UAA201610385A
Other languages
English (en)
Inventor
Хамед Айссауі
Крістоф Босс
Патрік Буа
Жульєн Аземанн
Ромен Зігріст
Original Assignee
Ідорсія Фармасьютікалз Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ідорсія Фармасьютікалз Лтд filed Critical Ідорсія Фармасьютікалз Лтд
Publication of UA117780C2 publication Critical patent/UA117780C2/uk

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/08—Antiseborrheics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Даний винахід стосується похідних азаіндолоцтової кислоти формули (І) EMBED ISISServer , (І) у якій R1 і R2 є такими, як визначено в описі, та їх застосування як модуляторів рецепторів простагландину, особливо переважно як модуляторів рецепторів простагландину D2, при лікуванні різних опосередкованих простагландином захворювань і порушень, фармацевтичних композицій, що містять такі сполуки, і способу їх одержання.
UAA201610385A 2014-03-17 2015-03-16 Похідні азаіндолоцтової кислоти та їх застосування як модуляторів рецепторів простагландину d2 UA117780C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2014059883 2014-03-17
PCT/IB2015/051895 WO2015140684A1 (en) 2014-03-17 2015-03-16 Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators

Publications (1)

Publication Number Publication Date
UA117780C2 true UA117780C2 (uk) 2018-09-25

Family

ID=52808086

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201610385A UA117780C2 (uk) 2014-03-17 2015-03-16 Похідні азаіндолоцтової кислоти та їх застосування як модуляторів рецепторів простагландину d2

Country Status (31)

Country Link
US (2) US9879006B2 (uk)
EP (1) EP3119779B1 (uk)
JP (1) JP6152489B2 (uk)
KR (1) KR101864060B1 (uk)
CN (1) CN106103435B (uk)
AR (1) AR099767A1 (uk)
AU (1) AU2015233029B2 (uk)
BR (1) BR112016021471B1 (uk)
CA (1) CA2939892C (uk)
CL (1) CL2016002321A1 (uk)
CY (1) CY1120744T1 (uk)
DK (1) DK3119779T3 (uk)
EA (1) EA030159B1 (uk)
ES (1) ES2687279T3 (uk)
HR (1) HRP20181555T1 (uk)
HU (1) HUE039614T2 (uk)
IL (1) IL247705B (uk)
LT (1) LT3119779T (uk)
MA (1) MA39750B1 (uk)
MX (2) MX368179B (uk)
MY (1) MY179356A (uk)
PE (1) PE20161177A1 (uk)
PH (1) PH12016501764A1 (uk)
PL (1) PL3119779T3 (uk)
PT (1) PT3119779T (uk)
RS (1) RS57867B1 (uk)
SG (1) SG11201607708RA (uk)
SI (1) SI3119779T1 (uk)
TW (1) TWI649321B (uk)
UA (1) UA117780C2 (uk)
WO (1) WO2015140684A1 (uk)

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MY179356A (en) 2014-03-17 2020-11-05 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
CA2938107A1 (en) 2014-03-18 2015-09-24 Actelion Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
TWI711616B (zh) * 2015-09-15 2020-12-01 瑞士商愛杜西亞製藥有限公司 結晶型式
KR102480088B1 (ko) * 2016-03-17 2022-12-23 삼성디스플레이 주식회사 양자점 발광 소자

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