MX2016001134A - Derivados 1,3-disustituidos de ciclopentano. - Google Patents

Derivados 1,3-disustituidos de ciclopentano.

Info

Publication number
MX2016001134A
MX2016001134A MX2016001134A MX2016001134A MX2016001134A MX 2016001134 A MX2016001134 A MX 2016001134A MX 2016001134 A MX2016001134 A MX 2016001134A MX 2016001134 A MX2016001134 A MX 2016001134A MX 2016001134 A MX2016001134 A MX 2016001134A
Authority
MX
Mexico
Prior art keywords
cyclopentane derivatives
disubstituted
disubstituted cyclopentane
diseases
derivatives
Prior art date
Application number
MX2016001134A
Other languages
English (en)
Inventor
Wolfgang Staehle
Thomas Fuchss
Birgitta Leuthner
Christos Tsaklakidis
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2016001134A publication Critical patent/MX2016001134A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Abstract

Compuestos de la fórmula I (ver Fórmula) en donde R, Y, R1, X1, X2, X3 y q tienen los significados indicados en la reivindicación 1, son inhibidores de la ácido grasa sintasa y se pueden emplear, inter alia, para el tratamiento de enfermedades tales como cáncer, enfermedades cardiovasculares, lesión del sistema nervioso central y diferentes formas de inflamación.
MX2016001134A 2013-07-29 2014-07-11 Derivados 1,3-disustituidos de ciclopentano. MX2016001134A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003769 2013-07-29
PCT/EP2014/001912 WO2015014446A1 (en) 2013-07-29 2014-07-11 1,3-disubstituted cyclopentane derivatives

Publications (1)

Publication Number Publication Date
MX2016001134A true MX2016001134A (es) 2016-04-29

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MX2016001134A MX2016001134A (es) 2013-07-29 2014-07-11 Derivados 1,3-disustituidos de ciclopentano.

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US (1) US9718785B2 (es)
EP (1) EP3027599B1 (es)
JP (1) JP6417415B2 (es)
KR (1) KR20160037986A (es)
CN (1) CN105392785B (es)
AR (1) AR097086A1 (es)
AU (1) AU2014298959B2 (es)
BR (1) BR112016001978A2 (es)
CA (1) CA2919552C (es)
ES (1) ES2633969T3 (es)
IL (1) IL243733A0 (es)
MX (1) MX2016001134A (es)
SG (1) SG11201600726QA (es)
WO (1) WO2015014446A1 (es)

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HUE045701T2 (hu) 2013-03-13 2020-01-28 Forma Therapeutics Inc 2-Hidroxi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etán-1-on származékok és rokon vegyületek mint zsírsav szintáz (FASN) inhibitorok, rák kezelésére
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