TW453893B - Encapsulation process - Google Patents
Encapsulation process Download PDFInfo
- Publication number
- TW453893B TW453893B TW086100673A TW86100673A TW453893B TW 453893 B TW453893 B TW 453893B TW 086100673 A TW086100673 A TW 086100673A TW 86100673 A TW86100673 A TW 86100673A TW 453893 B TW453893 B TW 453893B
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- TW
- Taiwan
- Prior art keywords
- item
- polymer
- scope
- pressure treatment
- patent application
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000005538 encapsulation Methods 0.000 title description 9
- 239000011162 core material Substances 0.000 claims abstract description 26
- 229920000642 polymer Polymers 0.000 claims abstract description 21
- 235000013305 food Nutrition 0.000 claims abstract description 9
- 239000011159 matrix material Substances 0.000 claims abstract description 8
- 229920005615 natural polymer Polymers 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000002775 capsule Substances 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 12
- 239000000049 pigment Substances 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 229940088594 vitamin Drugs 0.000 claims description 9
- 239000011782 vitamin Substances 0.000 claims description 9
- 229930003231 vitamin Natural products 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 8
- 235000013343 vitamin Nutrition 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 7
- 108010046377 Whey Proteins Proteins 0.000 claims description 5
- 102000007544 Whey Proteins Human genes 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 239000003981 vehicle Substances 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 230000002079 cooperative effect Effects 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 4
- 235000021119 whey protein Nutrition 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 2
- 108010076119 Caseins Proteins 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 239000008135 aqueous vehicle Substances 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 235000014103 egg white Nutrition 0.000 claims description 2
- 210000000969 egg white Anatomy 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- 235000015170 shellfish Nutrition 0.000 claims description 2
- 235000013599 spices Nutrition 0.000 claims description 2
- 239000007863 gel particle Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 abstract description 4
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 235000019197 fats Nutrition 0.000 description 13
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 239000003921 oil Substances 0.000 description 6
- 235000019868 cocoa butter Nutrition 0.000 description 5
- 229940110456 cocoa butter Drugs 0.000 description 5
- 239000003094 microcapsule Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 3
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000003505 heat denaturation Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 108010058846 Ovalbumin Proteins 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000019742 Vitamins premix Nutrition 0.000 description 2
- 235000019568 aromas Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000001055 blue pigment Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011785 micronutrient Substances 0.000 description 2
- 235000013369 micronutrients Nutrition 0.000 description 2
- 229940092253 ovalbumin Drugs 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- -1 gum or gelatin Chemical class 0.000 description 1
- 239000008173 hydrogenated soybean oil Substances 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 235000020786 mineral supplement Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/72—Encapsulation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- General Preparation And Processing Of Foods (AREA)
- Formation And Processing Of Food Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Jellies, Jams, And Syrups (AREA)
Description
經濟部中央標準局貝工消費合作社印製 453893 五、發明説明(1 ) 發明範_ 本發明係有關一種膠囊化方法,更特別地一種以天然聚 合物將核心物質膠囊化之方法。 發明背景 在食品工業中’膠囊化可用以穩定核心物質,及以控制 核心物質釋,放之適時性和速率。因此,膠囊化可能地保護 敏感之食品成份’確保避免營養損失及掩蓋或保留香味和 氣味。膠囊化亦増加維生素或礦物質補充物之穩定性,例 如其通常敏感於uv輕射、光線、氧、金屬、濕度和溫 度。再者,膠囊化亦採用於醫藥工業,以保護口和食道内 壁免於澀味之口服藥物,其在胃中由胃酸和酵素在膠囊層 上作用而釋放’或以控制經肌肉内、皮下或靜脈内途徑傳 送之藥物之釋出》 蛋白質(乳清、黃豆、明膠、卵白蛋白、醅蛋白、人血 清白蛋白等)和多醣類(澱粉、羧基甲基纖維素等)已經作 為不同組成份膠囊化之外壁物質。所用技術之整理係給定 於Gupta,P.K.和Hung,C.T ·,,,白蛋白微球:在藥物傳送之應 用,”微膠囊化會刊,(携外6,偷-仍及汉Arschady,„白蛋 白微球和微膠囊:製造技術之方法論,"控制釋出會刊, 14 (19卯)lll-lSl。典型地,活性組成份經溶解、乳化或分 散於蛋自質在水之溶液A然後蛋白質經變性及變成不溶於 水,因此網住活性組份。根據所要膠囊形狀和大小,不同 技術亦描述於文獻中,在變性前範圍自簡單研磨以在油性 媒液中形成雙乳化液H常用於所有技術中,變性過 -4 - 本紙張尺度賴t國_辟 {請先聞讀背面之注意事項再填寫本頁) i衣· ΪΤ 45389^ A7 B7 ......... 五、發明説明(2 ) 程係由熱(100-180°C )或以適當交聯劑如戊二醛化學交聯而 進行。清楚地,熱變性並不適於熱敏感之活性組成份之 例,如一些維生素、香氣、香味或藥物如甲胺噪呤、腎上 腺素、沙巴馬醇(salbumatol)係討論於Gupta和Hung"白蛋白 微球:物理化學特性,"微膠囊化會刊,(1989), 6 427-461。化學交聯在使用化學物並不為藥物食品法規所允准 時,亦不合適。 發明簡要 吾等設想一種膠囊化方法,藉此可克服以上使用熱和化 學物之缺點’藉使用天然聚合物作為膠囊化物質及將核心 物質和膠囊化物質之混合液在高壓下和在自〇°C至l〇(rc之 溫度下處理。 根據本發明’提供一種將核心物質膠囊化之方法,其包 括將核心物質以包含天然食品聚合物之水性媒液混合,及 在自15,000至200,000 pSi之壓力下和在自〇。至loyc之溫度下 處理生成之混合液,以形成膠基質,包括在天然聚合物内 膠囊化之核心物質,及將其乾燥a 凰,示簡單誼日日 圖1為經馬來西亞可可脂與高壓變性處理之膠囊之色素 藍色1號釋出與時間之關係。 圖2為經玉米通與高熱變性處理之膠囊之色素藍色1號釋 出與時間之關係。 圖3為由蛋白質高壓或熱變性膠囊化期間之維生素殘留 (%)。 本紙張尺度適---—------- 固家標準公幻 ^^^1 ^^^1 *1^ «m n^i tui L·Γ-ΰ^ —^J —-.I— l 1 /l\5 τ 卩 I {請先聞讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印製 5 3 893 A7 B7 五、發明説明(3 ) 發明之詳細說明 若需要時,在壓力處理前,本方法包括將生成之混合液 與熔化之脂肪混合,以形成含小液滴之水/油乳化液,將 乳化液冷卻以固化脂肪層,然後將乳化液壓力處理以將小 液滴轉變成膠粒,將膠粒自脂肪層中分開及清洗分開之膠 粒。 生成之膠囊為微膠囊,具自1微米至3毫米,較佳地自2 微米至2毫米及更佳地自5微米至0.5毫米之粒度=核心物 質可為固體或液體及可為用於食品工業之物質如香味劑、 色素、維生素、礦_物質、香辛料或油1或其可為醫藥物。 本發明係特別有利於核心物質是熱敏感或化學敏感時。 經濟部中央標準局員工消費合作社印製 (請先閱讀背面之注意事項再填寫本頁) 聚合物膠囊化物質可為多醣如果膠或膠質,例如羧基甲 基纖維素,低甲氧基果膠、褐澡酸鹽、澱粉等或其可為不 論動物或植物來源之任何蛋白質及其為水溶性或水分散性 的,例如乳清蛋白、_酪蛋白、明膠、人類血清白蛋白、卵 白或黃豆分離物。聚合物膠囊化物質較佳地應為非毒性、 在高壓處理後不溶水的、生物相容及生物可降解的,對氧 和擴散損失之良好阻隔及由法規條文所允准用於食品或醫 藥產品。 不同巨分子在高壓處理下表現之詳細整理係給定於"高 壓和生物技術”,編者 C. Balny, R. Hayashi,K. Heremans和 P. Masson,白話 INSERM/John Libey Eurotext公司,1992, 224 卷,89、105、185、195 頁。 核心物質可方便地與水性聚合物媒液混合,由將其溶 -6 - 本纸張尺度適用中國國家榡準(CNS ) A4規格(210 X 297公釐) 453893 A7 B7 五、發明説明(4 ) 解、乳化或分散於聚合物之水溶液,分散液或聚液。高壓 處理之溫度較佳地為自15°C至60°C,更佳地自20°C至40°C 及適當地在常溫下。壓力較佳地為自40,000至150,000 psi及 更佳地自60,000至120,000 psi。高壓處理可在容器内進行, 其保持内含之高壓,較佳地使用例如水和/或油作為媒液 之液壓。在置入容器前,核心物質與聚合物之混合物可封 於由橡膠或塑膠物質製成之柔軟袋中,其可由任何食品可 接受之柔軟塑膠物質例如PVC製成。可得之高壓設備及可 用於高壓整理之柔軟袋種類之整理係給定於"高壓和生物 技術,”編者C. Balny, R. Hayashi,K. Heremans 和 P. Masson,白 話 INSERM/John Libey Eurotext公司,1992,224卷,509、515 頁。高壓處理之持績時間應足以形成膠,例如至少30秒, 較佳地自1至60分鐘及更佳地自5至45分鐘。長於60分鐘之 時段可以使用,但如此做並無好處。在高壓處理期間之pH 可為自2至8,但有利地自4至7,及在聚合物為蛋白質 時,經常為蛋白質之天然pH_。 經濟部中央標準局員工消費合作社印製 {請先閲讀背面之注意事項再填寫本頁) 在膠囊化方法中,在高壓處理後,含溶解、乳化或分散 活性组成份之膠基質先磨成所要之粒度及然後由任何已知 之方法乾燥,如真空乾燥、化學脫水、冷凍乾燥、對流供 箱乾燥、吸收乾燥等。可替代地,膠基質先經乾燥及然後 磨成所要之粒度° -若想要地形成球狀之微膠囊時,可替代之程序可以依 循。核心物質在水/聚合物系統中之溶液、乳化液或分散 液經加入脂肪層,其經保持在略高於脂肪熔點(典型地30- -7- 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) 經濟部中央橒準局員工消費合作社印製 4-5389^ A7 ____B7 五、發明説明(5 ) 6〇°c)之溫度下。藉攪拌,乳化層形成想要之小滴粒度。 在此層中可加入任何合適之界面活性劑以形成穩定之乳化 層。然後,系統經封於柔軟袋中及快速冷凍,使脂肪層在 乳化小液滴允許接合前固化,袋子然後在高壓下處理。在 高壓施用想要之時間後,在脂肪層内固定之小液滴將形成 膠層,因為蛋白質變性,及將形成圍繞核心之球殼。藉升 南系統之溫度向於脂肪溶點’球狀膠囊可.自脂肪層中分開 (由任何已知之技術如過遽、離心、傾倒等)。任何食品可 接受之油和脂肪可以使用’例如可可脂、玉米油、紅花 油、橄欖油、氫化黃豆油或任何其他氫化之植物油。其想 要地在鬲壓處理期間使脂肪固化,以使微膠囊並不接合及 此可以任何油達成’衹要生成之乳化液在處理期間之全程 係穩定的。製備水/油乳化液之合適親脂.性乳化劑為甘油 單油骏酯.、丙二醇單硬脂酸酯、甘油單硬脂酸酯、卵磷脂 和山梨醇單硬脂酸酯等。 在具水性聚合物媒液之混合液中核心物質之量可基於混 合液總重量,為自0.5至30重量%,較佳地自1至10%及更佳 地自2至8%。聚合物在水性聚合物媒液中之量可基於水性 聚合物媒液之總重量,為自1至50重量%及較佳地自5至 30%。 在想要時,防腐劑如檸檬酸鈉或亞硫酸氫鈉可加入核心 物質與水性聚合物之混合液中,以防止核心物質之氧化。 貫施例 本發明現將以參閱以下之實施例進一步說明,其中份量 -8- 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) -- I —^n : 1^1. (請先聞讀背面之注意事項再填寫本買) 訂 經濟部中央橾準局員工消費合作社印製 453893 A7 ____________B7 五、發明説明(6 ) 和百分率係為重量比。 實施例1 1份卵白蛋白與0' 1份食用色素藍色1號混合及溶於3份水 中。落液經加入200份馬來西亞可可脂,含〇丨份吐溫8〇作 為乳化劑及在35 C之溫度下在3〇〇 rpm下連績攪拌。乳化液 然後置入柔軟之PVC袋中。其然後立即經冷卻,以期將可 可脂層固化及防止小液滴之接合。柔軟袋經置入Quintus QFP-6高壓處理機,由abb殺菌釜系統公司所供給,及加壓 至128,000 psi下40分鐘。.在加壓期間,溫度自16。〇增至42 C。生成之膠囊自脂肪層中過濾及以乙酸清洗表面脂肪。
自膠囊中釋出之藍色色素由將〇.〇5份膠囊在連績攪拌下加 入1000份室溫水而測試。Spectronic 21D吸收計對已知濃度 之藍色色素標準物校準及用以測定色素隨時間之釋出。圖 1顯示色素快速釋出(可能地表面色素),接著極慢之釋 出。在最初8小時期間釋出約50%及在2天後釋出僅55%。 比較實施例A 藉依循實質相似於實施例1中所述之程序,但使用玉米 油替代馬來西亞可可脂及排除柔軟袋之高壓處理,如圖2 所示在8小時後約70%色素(可能地表面色素)自膠囊释出 及在2天後釋出90%。當與實施例1之膠囊比較時,其中乳 化液經過高壓處理,此指示著極差之膠囊化。 t施例2 25份乳清蛋白(Bi_pro,95%,生物分離物公司)經溶於100 份水中及加入〇.〇6份微營養維生素預混料。實驗在pH 5和7 -9- 本紙浪尺度適用中國國家標準(CNS ) A4規格(2丨0X297公釐) --------'L,w — (讀先聞讀背面之注意事項再填寫本頁) 訂 A7 B7 53893 五、發明説明(7 ) 下進行。溶液經置入柔軟袋及在室溫下在6〇,〇〇〇 psi下加壓 20分鐘。生成之膠基質經研磨及真空乾燥。乾燥粒子之維 生素含量分析指示著其内所含之所有維生素E和維生素B1 在兩種pH值下殘留於高壓處理=變性蛋白質在pH 7下之質 地為更有彈性、光亮和透明’而pH 5的則更脆和不透明 實施例3 35〇份水、.100份乳清蛋白(相同於實施例2 )和5〇份微營養 維生万預混料(相同於實施例2 )之溶液經置入塑膠袋及在 高壓(60,000 psi)下在宣溫和pH 7下變性20分鐘。生成之膠 基質經研磨及冷凍乾燥。生成之微膠囊經分析維生素含量 及圖3顯示所有維生素之滯留皆極高。
比較實施例B 依循相似於實施例3中所述之程序,除了替代塑膠袋之 高壓處理’變性由加熱組合物在95°C下進行15分鐘。圖3 顯示當與實施例3高壓處理之樣品比較時,5種維生素中 之4種滯留顯著地較低。 iij(3-- (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印裝 -10- 本紙伕尺度通用中國國家標準(CNS } A4規格(2〗〇X 29*7公釐)
Claims (1)
- 公 >1* -1» ΐΐϊίΑ8 Β8 C8 D8 六'申請專利範圍 經濟部中央裙隼局員Η消費合作社印¾ 1_ 一種將核心物質膠囊化之方法,其包括將核心物質與 包含天然聚合物之水性媒液混合,在自15,〇〇〇至200,000 psi疋壓力下和在自〇。至ι〇〇^之溫度下處理生成之混合 液’以形成一種膠基質,包含在天然食品聚合物内膠 囊化之核心物質’然後乾燥及研磨生成物。 2. 如令s青專利範圍第丨項之方法,其在壓力處理前,包 括將生成之混合液與熔化之脂肪混合,以形成含小液 滴之水/油乳化液,將乳化液冷卻以固化脂肪層,然 後將乳化液壓力處理以轉換小液滴成膠粒,將膠粒自 脂肪層中分開及清洗分開之膠粒。 3. 如申請專利範圍第1項之.方法,其中核心物質為香味 劑、色素、維生素、礦物質、香辛料、油或醫藥物。 4. 如申请專利範圍第1項之方法,其中核心物質為熱敏 感或化學敏感的。 5. 如申請專利範圍第1項之方法,其中天然聚合物為乳 清蛋白、酪蛋白、明膠、人類血清白蛋白、卵白、黃 豆分離物、果膠或羧基甲基纖維素。 6. 如申請專利範圍第1項之方法,其中天然聚合物在高 壓處理後不溶於水。 7. 如申請專利範圍第1項之方法,其中核心物質係與水 性聚合物媒液混合,藉由將其溶解、乳化或分散至聚 合物之水溶液或分散液,或漿液中。 8. 如申請專利範圍第1項之方法,其中高壓處理之溫度 係自15°至60°C。 11 本紙張尺度適用中國國家標準(CNS ) A4規格(2丨0X297公釐) (請先閱讀背面之注意事項再填寫本頁) k. 訂-453893 ---- ,、,丫砑寻刑範圍 9.如令請專利範圍第丨項之方法,其中高溫處理係在水 壓中進行。 1〇·如申請專利範圍第之方法,其令在高壓處理前核 。物貝與食品聚合物之混合液經封於由橡膠或塑膠物 質製成之柔軟袋中。 u.如申请專利範圍第丄項之方法,其中高壓處理方法之 持續期間係自1至60分鐘。 12. 如争請專利範圍第1項之方法,其令在高壓處理後膠 基質先經乾燥後研磨’或先經研磨再乾燥,以形成具 想要粒度之膠囊> 13. 如申請專利範圍第1項之方法,其中在具水性聚合_ 媒液之混合液中核心物質之量,基於混合液之總重 量,係自0.5至15重量%,及在水性聚合物媒液中聚合 物之量,基於水性聚合物媒液之總重量,係自1至50重 量%。 {請先閲讀背面之注意事項再填寫本買) ;,.ί赛· Γ 經濟部中央標準局員工消費合作社印裝 本紙張尺度適用中國國家標準(CNS)Α4規格(210x297公釐)
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-
1996
- 1996-06-18 DE DE69616167T patent/DE69616167T2/de not_active Expired - Fee Related
- 1996-06-18 AT AT96201691T patent/ATE207312T1/de not_active IP Right Cessation
- 1996-06-18 EP EP96201691A patent/EP0750854B1/en not_active Expired - Lifetime
- 1996-06-18 PT PT96201691T patent/PT750854E/pt unknown
- 1996-06-18 ES ES96201691T patent/ES2164205T3/es not_active Expired - Lifetime
- 1996-06-24 IN IN1115MA1996 patent/IN182483B/en unknown
- 1996-06-27 MX MX9602503A patent/MX9602503A/es unknown
- 1996-06-27 BR BR9602914A patent/BR9602914A/pt not_active Application Discontinuation
- 1996-06-28 US US08/673,227 patent/US6048562A/en not_active Expired - Fee Related
- 1996-06-28 CN CN96111076A patent/CN1081946C/zh not_active Expired - Fee Related
- 1996-06-28 ZA ZA9605532A patent/ZA965532B/xx unknown
- 1996-06-28 AR ARP960103388A patent/AR002649A1/es unknown
- 1996-06-28 RU RU96112775/14A patent/RU2164406C2/ru not_active IP Right Cessation
- 1996-06-28 PL PL96315020A patent/PL182026B1/pl unknown
- 1996-06-29 SG SG1996010180A patent/SG74562A1/en unknown
- 1996-06-29 MY MYPI96002681A patent/MY132266A/en unknown
-
1997
- 1997-01-22 TW TW086100673A patent/TW453893B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR002649A1 (es) | 1998-03-25 |
ATE207312T1 (de) | 2001-11-15 |
CN1081946C (zh) | 2002-04-03 |
MY132266A (en) | 2007-09-28 |
EP0750854B1 (en) | 2001-10-24 |
PL315020A1 (en) | 1997-01-06 |
IN182483B (zh) | 1999-04-17 |
SG74562A1 (en) | 2000-08-22 |
DE69616167T2 (de) | 2002-06-20 |
EP0750854A2 (en) | 1997-01-02 |
ZA965532B (en) | 1997-12-29 |
MX9602503A (es) | 1997-06-28 |
BR9602914A (pt) | 1999-06-15 |
US6048562A (en) | 2000-04-11 |
PL182026B1 (pl) | 2001-10-31 |
RU2164406C2 (ru) | 2001-03-27 |
EP0750854A3 (en) | 1998-04-08 |
DE69616167D1 (de) | 2001-11-29 |
ES2164205T3 (es) | 2002-02-16 |
CN1141211A (zh) | 1997-01-29 |
PT750854E (pt) | 2002-04-29 |
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