TW368397B - Oxaborole derivatives and their use as antimicrobial agent - Google Patents

Oxaborole derivatives and their use as antimicrobial agent

Info

Publication number: TW368397B
Authority: TW; Taiwan
Prior art keywords: oxaborole; group; phenyl; derivatives; antimicrobial agent
Prior art date: 1994-06-09

Application number

TW084105427A

Other languages

English (en)

Inventor

Peter William Austin

John Martin Clough

Patrick Jelf Crowley

Christopher Juan Kneale

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-09

Filing date

1995-05-30

Publication date

1999-09-01

1995-05-30 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1999-09-01 Application granted granted Critical

1999-09-01 Publication of TW368397B publication Critical patent/TW368397B/zh

Links

OHENQANLQNOMAO-UHFFFAOYSA-N oxaborole Chemical class O1B=CC=C1 OHENQANLQNOMAO-UHFFFAOYSA-N 0.000 title abstract 4
239000004599 antimicrobial Substances 0.000 title abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
ZQXCQTAELHSNAT-UHFFFAOYSA-N 1-chloro-3-nitro-5-(trifluoromethyl)benzene Chemical group [O-][N+](=O)C1=CC(Cl)=CC(C(F)(F)F)=C1 ZQXCQTAELHSNAT-UHFFFAOYSA-N 0.000 abstract 1
CPHUUWJMAOTJLB-UHFFFAOYSA-N 2-methylidenepyrrolidine Chemical group C=C1CCCN1 CPHUUWJMAOTJLB-UHFFFAOYSA-N 0.000 abstract 1
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000005245 nitryl group Chemical group [N+](=O)([O-])* 0.000 abstract 1
-1 phenoxyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0058—Biocides
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Plant Pathology (AREA)
Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Dentistry (AREA)
General Health & Medical Sciences (AREA)
Pest Control & Pesticides (AREA)
Zoology (AREA)
Agronomy & Crop Science (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Biodiversity & Conservation Biology (AREA)
Materials Engineering (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW084105427A 1994-06-09 1995-05-30 Oxaborole derivatives and their use as antimicrobial agent TW368397B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9411587A GB9411587D0 (en)	1994-06-09	1994-06-09	Compound, composition and use

Publications (1)

Publication Number	Publication Date
TW368397B true TW368397B (en)	1999-09-01

Family

ID=10756481

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW084105427A TW368397B (en)	1994-06-09	1995-05-30	Oxaborole derivatives and their use as antimicrobial agent

Country Status (14)

Country	Link
US (1)	US5880188A (zh)
EP (1)	EP0765331B1 (zh)
JP (1)	JPH10500983A (zh)
KR (1)	KR970703349A (zh)
CN (1)	CN1068005C (zh)
AT (1)	ATE195316T1 (zh)
AU (1)	AU681291B2 (zh)
BR (1)	BR9507966A (zh)
CA (1)	CA2190155A1 (zh)
DE (1)	DE69518323T2 (zh)
GB (1)	GB9411587D0 (zh)
NO (1)	NO965235L (zh)
TW (1)	TW368397B (zh)
WO (1)	WO1995033754A1 (zh)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1009415A4 (en) *	1997-06-13	2000-10-25	Univ Northwestern	INHIBITORS OF $ g (b) -LACTAMASES AND THEIR USES
US6184363B1 (en)	1997-06-13	2001-02-06	Northwestern University	Inhibitors of β-lactamases and uses therefor
BRPI0411582A (pt) *	2003-06-16	2006-08-08	Anacor Pharmaceuticals Inc	substáncias terapêuticas contendo boro hidroliticamente resistentes e método de uso
KR20050047699A (ko) *	2003-11-18	2005-05-23	주식회사 엘지생명과학	살균성 수성 액상수화제
US7767657B2 (en)	2005-02-16	2010-08-03	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
CA2597982C (en) *	2005-02-16	2014-07-08	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
MX335993B (es) *	2005-12-30	2016-01-07	Anacor Pharmaceuticals Inc	Moleculas pequeñas que contienen boro.
SI2719388T1 (sl) *	2006-02-16	2019-06-28	Anacor Pharmaceuticals, Inc.	Majhne molekule, polnjene z borom, kot učinkovine proti vnetjem
US20070197388A1 (en) *	2006-02-22	2007-08-23	Buckman Laboratories International, Inc.	Haloperoxidase treatment to control algae
RU2486914C2 (ru) *	2006-03-16	2013-07-10	Молеак Пте Лтд	Комбинированная терапия для лечения пациентов с неврологическими нарушениями и церебральным инфарктом
US8106031B2 (en) *	2006-05-02	2012-01-31	Anacor Pharmaceuticals, Inc.	Hydrolytically-resistant boron-containing therapeutics and methods of use
EP1900378A1 (en) *	2006-08-31	2008-03-19	Novartis AG	Pharmaceutical compositions for the treatment of fungal infections
JO3396B1 (ar) *	2007-06-20	2019-10-20	Anacor Pharmaceuticals Inc	جزيئات صغيرة تحتوي على البورون
JP5504454B2 (ja) *	2007-12-06	2014-05-28	国立大学法人京都大学	新規なホウ素化合物、それらの製造方法およびそれらを用いた機能性電子素子
JP5745279B2 (ja) *	2008-01-09	2015-07-08	アナコールファーマシューティカルズ，インコーポレイテッド	抗炎症剤としてのホウ素含有小分子
MX2010009765A (es)	2008-03-06	2013-07-12	Anacor Pharmaceuticals Inc	Moleculas pequeñas que contienen boro como agentes anti-inflamatorios.
EP2285384A4 (en) *	2008-05-12	2012-04-25	Anacor Pharmaceuticals Inc	BORN SMALL MOLECULES
EP2348863A4 (en) *	2008-09-04	2012-03-07	Anacor Pharmaceuticals Inc	BORN SMALL MOLECULES
WO2010028005A1 (en)	2008-09-04	2010-03-11	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
EP2343279B1 (en)	2008-10-15	2018-02-28	Kissei Pharmaceutical Co., Ltd.	Fused-ring derivative and medical application of same
US9493489B2 (en) *	2008-10-15	2016-11-15	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as anti-protozoal agents
EP2378886A4 (en) *	2008-12-17	2012-08-29	Anacor Pharmaceuticals Inc	(S) -3-Aminomethyl-7- (3-hydroxypropoxy) -3H-benzo [c] [1,2] oxaborole-1-OL-POLYMORPHS
BR112012001987A2 (pt) *	2009-07-28	2015-09-01	Anacor Pharmaceuticals Inc	Composto, combinação, formulação farmacêutica, uso de um composto, uma combinação ou um sal farmaceuticamente aceitável dos mesmos, e, métodos para tratar uma infecção bacteriana, para matar ou inibir o crescimento de uma bactéria, e para inibir uma beta-lactamase.
AP4039A (en)	2009-08-14	2017-02-28	Daitao Chen	Boron-containing small molecules as antiprotozoal agents
WO2011022337A1 (en) *	2009-08-19	2011-02-24	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
WO2011049971A1 (en)	2009-10-20	2011-04-28	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
US20110212918A1 (en) *	2009-11-11	2011-09-01	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
WO2011094450A1 (en)	2010-01-27	2011-08-04	Anacor Pharmaceuticals, Inc	Boron-containing small molecules
AP2012006482A0 (en)	2010-03-19	2012-10-31	Anacor Pharmacueticals Inc	Boron-containing small molecules as anti-protozoalagent
JP5952280B2 (ja)	2010-09-07	2016-07-13	アナコールファーマシューティカルズ，インコーポレーテッド	細菌感染治療用のベンゾオキサボロール誘導体
UY34367A (es) *	2011-10-07	2014-08-29	Syngenta Participations Ag	?método para proteger material de propagación vegetal o plantas útiles?.
WO2013057740A2 (en)	2011-10-07	2013-04-25	Syngenta Participations Ag	Method for protecting useful plants or plant propagation material
US10070649B2 (en)	2013-01-30	2018-09-11	Agrofresh Inc.	Volatile applications against pathogens
US11039617B2 (en)	2013-01-30	2021-06-22	Agrofresh Inc.	Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
CN107646865B (zh) *	2013-01-30	2020-07-03	美国陶氏益农公司	苯硼酸半酯作为挥发性抗微生物剂在肉类、植物或植物部分上的用途
US20220125049A1 (en) *	2013-01-30	2022-04-28	Agrofresh Inc.	Method and system for centralized management, monitoring, and controlled delivery of biological compounds to fruit storage rooms
US9585396B2 (en)	2013-01-30	2017-03-07	Agrofresh Inc.	Volatile applications against pathogens
US8669207B1 (en)	2013-01-30	2014-03-11	Dow Agrosciences, Llc.	Compounds and compositions
WO2014147009A1 (en) *	2013-03-18	2014-09-25	Syngenta Participations Ag	Novel microbiocides
WO2014173880A1 (en)	2013-04-22	2014-10-30	Syngenta Participations Ag	Novel microbiocides
AU2014202928B1 (en) *	2013-06-05	2014-09-11	Agrofresh Inc.	Compounds and compositions
US20170000132A1 (en) *	2013-12-23	2017-01-05	Syngenta Participations Ag	Benzoxaborole fungicides
EP3086645A1 (en) *	2013-12-23	2016-11-02	Syngenta Participations AG	Benzoxaborole fungicides
MA41495A (fr) *	2015-02-12	2017-12-19	Anacor Pharmaceuticals Inc	Composés benzoxaborole et leurs utilisations
US9730454B2 (en) *	2015-02-12	2017-08-15	Agrofresh Inc.	Fungicidal compounds and compositions
US9737075B2 (en)	2015-04-09	2017-08-22	The Penn State Research Foundation	Synergistic benzoxaborole-containing anti-fungicidal composition
WO2017024022A1 (en) *	2015-08-06	2017-02-09	The Penn State Research Foundation	Benzoxaborole-containing coating resistant to cellulose-supportable fungus
WO2017031041A1 (en) *	2015-08-17	2017-02-23	Channel Therapeutics, Inc.	Functionalized aminobenzoboroxoles
CN113321672A (zh) *	2016-03-02	2021-08-31	比尔及梅琳达盖茨基金会	含硼小分子
TW201733442A (zh)	2016-03-07	2017-10-01	農業保鮮股份有限公司	殺有害生物劑之汽化給予
TW201735792A (zh)	2016-03-07	2017-10-16	農業保鮮股份有限公司	使用苯并氧雜硼雜環戊烯化合物和防腐氣體作為作物的抗微生物劑之協同方法
US11447506B2 (en)	2016-05-09	2022-09-20	Anacor Pharmaceuticals, Inc.	Crystal forms of crisaborole in free form and preparation method and use thereof
EP3455227A1 (en)	2016-05-12	2019-03-20	Anacor Pharmaceuticals, Inc	Oxaborole esters and uses thereof
EP3704100B1 (en)	2017-11-02	2023-08-30	Halcyon Labs Private Limited	Novel process for the preparation tavaborole and its intermediates
US11834466B2 (en)	2017-11-30	2023-12-05	5Metis, Inc.	Benzoxaborole compounds and formulations thereof
WO2019173814A1 (en)	2018-03-09	2019-09-12	University Of The Sciences	Protective groups and methods for protecting benzoxaboroles or oxaboroles
AU2019325436B2 (en) *	2018-08-18	2023-10-26	5Metis, Inc.	Solid forms of substituted benzoxaborole and compositions thereof
CU20210023A7 (es)	2018-10-05	2021-10-12	Pfizer	Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4
US20210024548A1 (en) *	2019-07-25	2021-01-28	Massachusetts Institute Of Technology	Boron-containing pharmacophore
AR120504A1 (es)	2019-11-22	2022-02-16	Agrofresh Inc	Composición y método para tratar a plantas y partes de plantas con activos volátiles para el control de organismos de descomposición
CR20220369A (es)	2020-02-05	2022-10-27	Agrofresh Inc	Compuestos y composiciones antimicrobianos
CN114644645B (zh) *	2022-03-08	2023-05-26	南京农业大学	3-吲哚取代苯硼唑类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3104255A (en) *	1960-06-16	1963-09-17	Standard Oil Co	Telomerization of unsaturated hydrocarbons with alkylene glycol borates and telomeric products obtained thereby
US3361672A (en) *	1965-10-23	1968-01-02	Mobil Oil Corp	Stabilized organic compositions
GB1140399A (en) *	1966-09-16	1969-01-15	Koninklijke Pharma Fab Nv	New diphenylmethoxy derivatives
US3686398A (en) *	1970-07-20	1972-08-22	Chevron Res	10,9-boroxarophenanthrene as fungicides
GB1396904A (en) *	1972-08-11	1975-06-11	Ici Ltd	Method for the control of micro-organisms

1994
- 1994-06-09 GB GB9411587A patent/GB9411587D0/en active Pending
1995
- 1995-05-26 AU AU25348/95A patent/AU681291B2/en not_active Ceased
- 1995-05-26 DE DE69518323T patent/DE69518323T2/de not_active Expired - Fee Related
- 1995-05-26 US US08/750,081 patent/US5880188A/en not_active Expired - Fee Related
- 1995-05-26 EP EP95919572A patent/EP0765331B1/en not_active Expired - Lifetime
- 1995-05-26 WO PCT/GB1995/001206 patent/WO1995033754A1/en active IP Right Grant
- 1995-05-26 BR BR9507966A patent/BR9507966A/pt not_active Application Discontinuation
- 1995-05-26 CN CN95194519A patent/CN1068005C/zh not_active Expired - Fee Related
- 1995-05-26 CA CA002190155A patent/CA2190155A1/en not_active Abandoned
- 1995-05-26 JP JP8500489A patent/JPH10500983A/ja not_active Withdrawn
- 1995-05-26 AT AT95919572T patent/ATE195316T1/de not_active IP Right Cessation
- 1995-05-30 TW TW084105427A patent/TW368397B/zh active
1996
- 1996-12-06 NO NO965235A patent/NO965235L/no unknown
- 1996-12-07 KR KR1019960706993A patent/KR970703349A/ko not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB9411587D0 (en)	1994-08-03
BR9507966A (pt)	1997-09-02
DE69518323T2 (de)	2001-02-01
NO965235D0 (no)	1996-12-06
KR970703349A (ko)	1997-07-03
ATE195316T1 (de)	2000-08-15
AU2534895A (en)	1996-01-04
JPH10500983A (ja)	1998-01-27
NO965235L (no)	1997-01-21
CN1068005C (zh)	2001-07-04
CA2190155A1 (en)	1995-12-14
EP0765331A1 (en)	1997-04-02
WO1995033754A1 (en)	1995-12-14
US5880188A (en)	1999-03-09
EP0765331B1 (en)	2000-08-09
DE69518323D1 (de)	2000-09-14
AU681291B2 (en)	1997-08-21
CN1155286A (zh)	1997-07-23

Publication	Publication Date	Title
TW368397B (en)	1999-09-01	Oxaborole derivatives and their use as antimicrobial agent
RS50297B (sr)	2009-09-08	Fenilfenantridini sa dejstvom inhibicije pde-iv
AP9701039A0 (en)	1997-07-31	Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one.
MY125359A (en)	2006-07-31	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods.
CA2396738A1 (en)	1992-06-25	Thiazole derivatives as active superoxide radical inhibitors
YU135991A (sh)	1994-01-20	Novi derivati 3-benzil izoksazola
MXPA05012415A (es)	2006-02-13	Inhibidores de glutamina fructosa-3-fosfato amidotransferasa (gfat).
GR3036579T3 (en)	2001-12-31	5-arylindole derivatives and their use as serotonin (5-ht 1?) agonists.
AR005597A1 (es)	1999-06-23	Derivados de benzoxazina , composiciones farmaceuticas para el tratamiento de infecciones bacterianas, y metodo para la preparacion de dichos derivados.
ES8801288A1 (es)	1987-12-16	Un procedimiento para la preparacion de derivados de cefalosporina
SI1042319T1 (en)	2004-08-31	Dihydrobenzofurans
SE8107273L (sv)	1982-06-06	2-oxoazetidinderivat, sett att framstella democh anvendning derav
ATE255893T1 (de)	2003-12-15	Antikachektische zusammensetzung
NZ503710A (en)	2002-04-26	2-Substituted- 4'-hydroxy-5,9,9-trimethyl-6,7-benzomorphan derivatives useful in treating vascular diseases
CA2247946A1 (en)	1997-10-16	Anticachectic composition
ES478115A1 (es)	1979-06-01	Procedimiento para la preparacion de derivados acilicos.
EP0790247A4 (en)	2000-07-19	TETRAHYDROISOCHINOLINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
DE69914880D1 (de)	2004-03-25	Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
DK0770083T3 (da)	2000-10-16	Pyrido[3,2,1-i,j][3,1]benzoxazinderivater
EP1116486A4 (en)	2007-06-20	MEDICAL COMPOSITION CONTAINING NITROETHENAMINE DERIVATIVES OR SALTS AS ACTIVE INGREDIENTS
CA2144974A1 (en)	1994-03-31	Camphidine derivative, production thereof, and use thereof
TW257759B (en)	1995-09-21	Piperazine derivatives (2)
NZ337271A (en)	2001-01-26	4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives and their use as dopamine autoreceptor (D2) agonists