ES478115A1 - Procedimiento para la preparacion de derivados acilicos. - Google Patents
Procedimiento para la preparacion de derivados acilicos.Info
- Publication number
- ES478115A1 ES478115A1 ES478115A ES478115A ES478115A1 ES 478115 A1 ES478115 A1 ES 478115A1 ES 478115 A ES478115 A ES 478115A ES 478115 A ES478115 A ES 478115A ES 478115 A1 ES478115 A1 ES 478115A1
- Authority
- ES
- Spain
- Prior art keywords
- preparations
- cephalosporin derivatives
- pharmaceutical compositions
- see diagramm
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Derivados acílicos. Más particularmente el invento se refiere a derivados acílicos, a un procedimiento para su preparación y a los preparados farmacéuticos que los contienen. Los derivados acílicos proporcionados por el presente invento son compuestos de la fórmula general **fórmula** Las sales de los compuestos de la fórmula I son sales de metal alcalino tal como la sal sódica y potásica, las amónica, sales alcalino térreas tal como la sal cálcica, sales con bases orgánicas tal como sales con aminas (por ejemplo sales con N-etil-piperidina, procaina, dibencilamina, N,N''-dibenciletiletilendiamina, alquilaminas o dialquilaminas) así como sales con aminoácidos (por ejemplo sales con araginina o lisina). Las sales pueden ser mono-sales o diales. La segunda formación de sal se produce en la forma enólica tautomérica del grupo tiracínico (b), siendo dicha forma acídica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU77485 | 1977-06-03 | ||
| CH314278 | 1978-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES478115A1 true ES478115A1 (es) | 1979-06-01 |
Family
ID=25692293
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470442A Expired ES470442A1 (es) | 1977-06-03 | 1978-06-02 | procedimiento para la preparacion de derivados acilicos |
| ES478115A Expired ES478115A1 (es) | 1977-06-03 | 1979-02-27 | Procedimiento para la preparacion de derivados acilicos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470442A Expired ES470442A1 (es) | 1977-06-03 | 1978-06-02 | procedimiento para la preparacion de derivados acilicos |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0000005B1 (es) |
| JP (1) | JPS5412394A (es) |
| AR (1) | AR225134A1 (es) |
| AT (2) | AT362501B (es) |
| AU (1) | AU518648B2 (es) |
| BR (1) | BR7803565A (es) |
| CA (1) | CA1114808A (es) |
| CU (1) | CU21118A (es) |
| DE (2) | DE2824065A1 (es) |
| DK (1) | DK246878A (es) |
| ES (2) | ES470442A1 (es) |
| FI (1) | FI781754A (es) |
| FR (1) | FR2393000A1 (es) |
| GB (1) | GB1599232A (es) |
| GR (1) | GR73554B (es) |
| HU (1) | HU182498B (es) |
| IE (1) | IE46903B1 (es) |
| IL (1) | IL54803A (es) |
| IT (1) | IT1098306B (es) |
| MC (1) | MC1195A1 (es) |
| NL (1) | NL7805715A (es) |
| NO (1) | NO781934L (es) |
| NZ (1) | NZ187392A (es) |
| PH (1) | PH14653A (es) |
| PT (1) | PT68134A (es) |
| SE (1) | SE7806465L (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
| FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| MC1259A1 (fr) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | Derives acyles |
| FI782683A (fi) * | 1978-07-19 | 1980-01-20 | Hoffmann La Roche | Kefalosporinestrar och -estrar |
| US4472574A (en) * | 1981-05-22 | 1984-09-18 | Hoffman-La Roche Inc. | Process for the manufacture of a cephem carboxylic acid derivative |
| US4698338A (en) * | 1986-02-19 | 1987-10-06 | Eli Lilly And Company | 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| CH609989A5 (en) * | 1974-06-21 | 1979-03-30 | Hoffmann La Roche | Process for the preparation of acyl derivatives |
| CA1100129A (en) * | 1974-08-02 | 1981-04-28 | William H.W. Lunn | Cephalosporin compounds |
| GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
| GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
| GB1596278A (en) * | 1976-11-30 | 1981-08-26 | Glaxo Operations Ltd | 7-(-oxyimino-acetamino)cephalosporin derivatives |
-
1978
- 1978-05-25 NL NL7805715A patent/NL7805715A/xx not_active Application Discontinuation
- 1978-05-25 GB GB22499/78A patent/GB1599232A/en not_active Expired
- 1978-05-26 MC MC781305A patent/MC1195A1/xx unknown
- 1978-05-26 IE IE1056/78A patent/IE46903B1/en unknown
- 1978-05-26 NZ NZ187392A patent/NZ187392A/en unknown
- 1978-05-29 IL IL54803A patent/IL54803A/xx unknown
- 1978-05-29 AU AU36588/78A patent/AU518648B2/en not_active Expired
- 1978-05-31 HU HU78HO2077A patent/HU182498B/hu unknown
- 1978-06-01 GR GR56409A patent/GR73554B/el unknown
- 1978-06-01 FI FI781754A patent/FI781754A/fi not_active Application Discontinuation
- 1978-06-01 FR FR7816468A patent/FR2393000A1/fr active Granted
- 1978-06-01 JP JP6501078A patent/JPS5412394A/ja active Pending
- 1978-06-01 SE SE7806465A patent/SE7806465L/xx unknown
- 1978-06-01 DE DE19782824065 patent/DE2824065A1/de not_active Withdrawn
- 1978-06-01 EP EP78100078A patent/EP0000005B1/de not_active Expired
- 1978-06-01 DE DE7878100078T patent/DE2860248D1/de not_active Expired
- 1978-06-02 AR AR272437A patent/AR225134A1/es active
- 1978-06-02 BR BR787803565A patent/BR7803565A/pt unknown
- 1978-06-02 PT PT68134A patent/PT68134A/pt unknown
- 1978-06-02 ES ES470442A patent/ES470442A1/es not_active Expired
- 1978-06-02 IT IT24165/78A patent/IT1098306B/it active
- 1978-06-02 AT AT403578A patent/AT362501B/de not_active IP Right Cessation
- 1978-06-02 PH PH21225A patent/PH14653A/en unknown
- 1978-06-02 DK DK246878A patent/DK246878A/da not_active Application Discontinuation
- 1978-06-02 NO NO781934A patent/NO781934L/no unknown
- 1978-06-02 CA CA304,644A patent/CA1114808A/en not_active Expired
- 1978-07-03 CU CU7834929A patent/CU21118A/es unknown
-
1979
- 1979-02-27 ES ES478115A patent/ES478115A1/es not_active Expired
-
1980
- 1980-07-02 AT AT0345980A patent/AT365197B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3658878A (en) | 1979-12-06 |
| IE46903B1 (en) | 1983-11-02 |
| SE7806465L (sv) | 1978-12-04 |
| BR7803565A (pt) | 1979-02-20 |
| NL7805715A (nl) | 1978-12-05 |
| IL54803A (en) | 1982-01-31 |
| EP0000005A1 (de) | 1978-12-20 |
| PH14653A (en) | 1981-10-14 |
| ES470442A1 (es) | 1979-10-01 |
| ATA345980A (de) | 1981-05-15 |
| HU182498B (en) | 1984-01-30 |
| CA1114808A (en) | 1981-12-22 |
| AT365197B (de) | 1981-12-28 |
| CU21118A (es) | 1983-04-06 |
| FR2393000B1 (es) | 1982-10-29 |
| IE781056L (en) | 1978-12-03 |
| NZ187392A (en) | 1984-05-31 |
| NO781934L (no) | 1978-12-05 |
| AR225134A1 (es) | 1982-02-26 |
| DK246878A (da) | 1978-12-04 |
| FI781754A (fi) | 1978-12-04 |
| GB1599232A (en) | 1981-09-30 |
| GR73554B (es) | 1984-03-14 |
| DE2824065A1 (de) | 1978-12-14 |
| MC1195A1 (fr) | 1979-02-23 |
| PT68134A (en) | 1978-07-01 |
| IT7824165A0 (it) | 1978-06-02 |
| FR2393000A1 (fr) | 1978-12-29 |
| IL54803A0 (en) | 1978-07-31 |
| ATA403578A (de) | 1980-10-15 |
| IT1098306B (it) | 1985-09-07 |
| AT362501B (de) | 1981-05-25 |
| JPS5412394A (en) | 1979-01-30 |
| AU518648B2 (en) | 1981-10-15 |
| DE2860248D1 (en) | 1981-01-29 |
| EP0000005B1 (de) | 1980-10-29 |
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