TW200621291A - Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof - Google Patents
Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereofInfo
- Publication number
- TW200621291A TW200621291A TW094129583A TW94129583A TW200621291A TW 200621291 A TW200621291 A TW 200621291A TW 094129583 A TW094129583 A TW 094129583A TW 94129583 A TW94129583 A TW 94129583A TW 200621291 A TW200621291 A TW 200621291A
- Authority
- TW
- Taiwan
- Prior art keywords
- growth hormone
- human growth
- preparation
- methods
- polyethylene glycol
- Prior art date
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title abstract 6
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 6
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 6
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 title 1
- 230000006320 pegylation Effects 0.000 abstract 2
- 206010012559 Developmental delay Diseases 0.000 abstract 1
- 208000037824 growth disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60594504P | 2004-08-31 | 2004-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200621291A true TW200621291A (en) | 2006-07-01 |
Family
ID=35708806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094129583A TW200621291A (en) | 2004-08-31 | 2005-08-30 | Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1789092A2 (fr) |
JP (1) | JP2008511610A (fr) |
KR (1) | KR20070042567A (fr) |
CN (1) | CN101010105A (fr) |
AP (1) | AP2007003919A0 (fr) |
AR (1) | AR050851A1 (fr) |
AU (1) | AU2005278903A1 (fr) |
BR (1) | BRPI0515118A (fr) |
CA (1) | CA2577999A1 (fr) |
CR (1) | CR8942A (fr) |
EA (1) | EA200700380A1 (fr) |
EC (1) | ECSP077281A (fr) |
GT (1) | GT200500235A (fr) |
IL (1) | IL181085A0 (fr) |
MA (1) | MA28908B1 (fr) |
MX (1) | MX2007002441A (fr) |
NL (1) | NL1029828C2 (fr) |
NO (1) | NO20071322L (fr) |
PE (1) | PE20060654A1 (fr) |
TN (1) | TNSN07078A1 (fr) |
TW (1) | TW200621291A (fr) |
UY (1) | UY29088A1 (fr) |
WO (1) | WO2006024953A2 (fr) |
ZA (1) | ZA200701802B (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
BR9812267B1 (pt) | 1997-07-14 | 2013-11-26 | Hormônio de crescimento recombinante. | |
EP1144613B2 (fr) | 1999-01-14 | 2020-05-06 | Bolder Biotechnology, Inc. | Techniques permettant de produire des proteines contenant des residus cysteine libres |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP1834963A1 (fr) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Conjugues de proteines et de dipolymeres et leurs procedes de preparation |
MX2008014358A (es) * | 2006-05-12 | 2008-11-24 | Dong A Pharm Co Ltd | Conjugado de polietilenglicol-interferon alfa. |
JP2008069073A (ja) * | 2006-09-12 | 2008-03-27 | Yokohama Tlo Co Ltd | ラクトフェリン複合体及びその製造方法 |
KR101079993B1 (ko) | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
WO2010011096A2 (fr) * | 2008-07-23 | 2010-01-28 | Hanmi Pharmaceutical Co., Ltd. | Complexe de polypeptide comprenant un polymère non-peptidylique ayant trois extrémités fonctionnelles |
AU2009276458B2 (en) | 2008-07-31 | 2014-06-19 | Pharmaessentia Corp. | Peptide-polymer conjugates |
US8535655B2 (en) | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
PT2355853T (pt) * | 2008-10-10 | 2017-03-15 | Polyactiva Pty Ltd | Conjugados polímero biodegradável ¿ unidade bioativa |
SI2340271T1 (sl) | 2008-10-10 | 2019-08-30 | Polyactiva Pty Ltd. | Konjugati polimer-bioaktivnega sredstva |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
WO2010091122A1 (fr) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Polypeptides recombinants étendus et compositions les comprenant |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
JP6086528B2 (ja) | 2009-08-06 | 2017-03-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 長期のインビボ有効性を有する成長ホルモン |
CN101831067A (zh) * | 2010-05-31 | 2010-09-15 | 王二新 | 聚乙二醇脂类缀合物及其在制备药物中的应用 |
EP2446898A1 (fr) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de l'hormone de croissance pour améliorer la réponse immunitaire chez des patients immunodéprimés |
CN102367290B (zh) * | 2011-04-26 | 2013-05-08 | 厦门赛诺邦格生物科技有限公司 | 链官能化的多级支化聚乙二醇及其合成方法 |
WO2014110867A1 (fr) * | 2013-01-17 | 2014-07-24 | 厦门赛诺邦格生物科技有限公司 | Polyéthylèneglycol ramifié monofonctionnel et substance de type biologique modifiée par celui-ci |
CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
SI3215193T1 (sl) | 2014-11-06 | 2024-02-29 | Pharmaessentia Corporation | Dozirna shema za pegiliran interferon |
JP7227633B2 (ja) * | 2017-12-29 | 2023-02-22 | エフ. ホフマン-ラ ロシュ エージー. | Peg化タンパク質組成物を提供するための方法 |
EP3731872B1 (fr) | 2017-12-29 | 2021-11-24 | F. Hoffmann-La Roche AG | Procédé de fournir des protéines monopégylée |
JP7137625B2 (ja) * | 2017-12-29 | 2022-09-14 | エフ.ホフマン-ラ ロシュ アーゲー | Peg化タンパク質組成物を提供するための方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
JP3092531B2 (ja) * | 1996-11-05 | 2000-09-25 | 日本油脂株式会社 | コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法 |
BR9812267B1 (pt) * | 1997-07-14 | 2013-11-26 | Hormônio de crescimento recombinante. | |
JP3921781B2 (ja) * | 1998-02-12 | 2007-05-30 | 日本油脂株式会社 | カルボキシル基含有ポリオキシアルキレン化合物 |
EP1144613B2 (fr) * | 1999-01-14 | 2020-05-06 | Bolder Biotechnology, Inc. | Techniques permettant de produire des proteines contenant des residus cysteine libres |
IL162031A0 (en) * | 2001-11-20 | 2005-11-20 | Pharmacia Corp | Chemically-modified human growth hormone conjugates |
AP2005003246A0 (en) * | 2002-09-09 | 2005-03-31 | Nektar Therapeutics Al Corp | Water-soluble polymer alkanals |
JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
WO2004060406A2 (fr) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Reactifs polymeres comprenant une cetone ou un groupe fonctionnel apparente |
TR201907313T4 (tr) * | 2003-05-23 | 2019-06-21 | Nektar Therapeutics | İki PEG zinciri içeren PEG türevleri. |
-
2005
- 2005-08-25 EA EA200700380A patent/EA200700380A1/ru unknown
- 2005-08-25 CA CA002577999A patent/CA2577999A1/fr not_active Abandoned
- 2005-08-25 AU AU2005278903A patent/AU2005278903A1/en not_active Abandoned
- 2005-08-25 CN CNA2005800291171A patent/CN101010105A/zh active Pending
- 2005-08-25 MX MX2007002441A patent/MX2007002441A/es unknown
- 2005-08-25 BR BRPI0515118-0A patent/BRPI0515118A/pt not_active IP Right Cessation
- 2005-08-25 AP AP2007003919A patent/AP2007003919A0/xx unknown
- 2005-08-25 EP EP05784225A patent/EP1789092A2/fr not_active Withdrawn
- 2005-08-25 WO PCT/IB2005/002939 patent/WO2006024953A2/fr active Application Filing
- 2005-08-25 KR KR1020077004912A patent/KR20070042567A/ko not_active Application Discontinuation
- 2005-08-25 JP JP2007529040A patent/JP2008511610A/ja active Pending
- 2005-08-26 PE PE2005000991A patent/PE20060654A1/es not_active Application Discontinuation
- 2005-08-29 AR ARP050103612A patent/AR050851A1/es unknown
- 2005-08-29 UY UY29088A patent/UY29088A1/es not_active Application Discontinuation
- 2005-08-30 NL NL1029828A patent/NL1029828C2/nl not_active IP Right Cessation
- 2005-08-30 TW TW094129583A patent/TW200621291A/zh unknown
- 2005-08-30 GT GT200500235A patent/GT200500235A/es unknown
-
2007
- 2007-01-31 IL IL181085A patent/IL181085A0/en unknown
- 2007-02-26 CR CR8942A patent/CR8942A/es not_active Application Discontinuation
- 2007-02-27 TN TNP2007000078A patent/TNSN07078A1/fr unknown
- 2007-02-27 EC EC2007007281A patent/ECSP077281A/es unknown
- 2007-02-28 MA MA29724A patent/MA28908B1/fr unknown
- 2007-02-28 ZA ZA200701802A patent/ZA200701802B/xx unknown
- 2007-03-09 NO NO20071322A patent/NO20071322L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP077281A (es) | 2007-03-29 |
MX2007002441A (es) | 2007-05-04 |
IL181085A0 (en) | 2007-07-04 |
EA200700380A1 (ru) | 2007-10-26 |
GT200500235A (es) | 2006-03-21 |
ZA200701802B (en) | 2008-08-27 |
NL1029828C2 (nl) | 2006-10-20 |
NL1029828A1 (nl) | 2006-03-01 |
WO2006024953A3 (fr) | 2007-01-18 |
JP2008511610A (ja) | 2008-04-17 |
CA2577999A1 (fr) | 2006-03-09 |
NO20071322L (no) | 2007-05-29 |
KR20070042567A (ko) | 2007-04-23 |
EP1789092A2 (fr) | 2007-05-30 |
PE20060654A1 (es) | 2006-08-12 |
MA28908B1 (fr) | 2007-10-01 |
BRPI0515118A (pt) | 2008-07-01 |
CR8942A (es) | 2007-08-16 |
AP2007003919A0 (en) | 2007-02-28 |
AU2005278903A1 (en) | 2006-03-09 |
CN101010105A (zh) | 2007-08-01 |
WO2006024953A2 (fr) | 2006-03-09 |
AR050851A1 (es) | 2006-11-29 |
UY29088A1 (es) | 2006-03-31 |
TNSN07078A1 (fr) | 2008-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200621291A (en) | Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof | |
UA91512C2 (ru) | Коньюгати олигомеров инсулина, их композиция (варианты) и применение | |
WO2006004959A3 (fr) | Peg-interferon alpha-1b | |
DE602005001445D1 (de) | N-terminal monopegylierte menschliche wachstumshormon-konjugate, verfahren zu ihrer herstellung und ihre anwendung | |
RU2008145084A (ru) | Аналоги фактора ix, имеющие пролонгированное время полужизни in vivo | |
MX2009002314A (es) | Composiciones farmaceuticas que comprenden hgh para suministro oral. | |
SG161209A1 (en) | Formulations of human growth hormone comprising a non-naturally encoded amino acid | |
TW200501983A (en) | Uses of anti-insulin-like growth factor I receptor antibodies | |
WO2006138608A3 (fr) | Compositions pharmaceutiques et leur utilisation | |
EA200602137A1 (ru) | Гидрогелевые препараты интерферона | |
EA200900451A1 (ru) | Способ получения композиции эстрадиола с медленным высвобождением ( варианты ), микросферы эстрадиола и холестерина и способ для одновременной контрацепции и гормонозамещения | |
HUP0202776A2 (hu) | (+)-Tramadol, O-demetil-tramadol, (+)-O-demetil-tramadol, O-demetil-N-mono-demetil-tramadol, illetve (+)-O-demetil-N-mono-demetil-tramadol felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására | |
WO2007050121A3 (fr) | Hemoglobine pegylee a site specifique, procede de preparation afferent et utilisations associees | |
IL161670A0 (en) | Thymosin alpha 1 peptide/polymer conjugates | |
IL180900A0 (en) | Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions | |
WO2005041881A8 (fr) | Conjugues taxoide/acide gras et preparations les contenant | |
MX2008015323A (es) | Composicion farmaceutica que comprende ciclobenzaprina y aceclofenac en asociacion. | |
EP1583545A4 (fr) | Composition pharmaceutique pour administration améliorée de peptides dérivés de gp41 du vih et son utilisation en thérapie | |
WO2005048993A3 (fr) | Minimisation de l'oxydation des medicaments dans des formulations pharmaceutiques renfermant des excipients irradies | |
WO2001094386A3 (fr) | Procede de preparation et d'utilisation de peptides a efficacite antibiotique pour traiter des maladies infectieuses | |
DOP2005000172A (es) | Conjugados de hormonas del crecimiento humana y polietilenglicol ramificado con glicerol, proceso para su preparacion y metodo de uso de los mismos | |
TW200643029A (en) | Pegylated interferon alpha-1B | |
TW200615000A (en) | Use of arginase for the treatment of hepatitis |