EA200602137A1 - Гидрогелевые препараты интерферона - Google Patents
Гидрогелевые препараты интерферонаInfo
- Publication number
- EA200602137A1 EA200602137A1 EA200602137A EA200602137A EA200602137A1 EA 200602137 A1 EA200602137 A1 EA 200602137A1 EA 200602137 A EA200602137 A EA 200602137A EA 200602137 A EA200602137 A EA 200602137A EA 200602137 A1 EA200602137 A1 EA 200602137A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- interferon
- hydrogel preparations
- preparations
- hydrogel
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Настоящее изобретение относится к фармацевтическим гидрогелевым препаратам полоксамера, содержащим интерферон. В частности, изобретение относится к гидрогелевым препаратам интерферона-бета пролонгированного действия, способу их получения и применения.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04076496 | 2004-05-17 | ||
US57921804P | 2004-06-14 | 2004-06-14 | |
PCT/EP2005/052219 WO2005110466A1 (en) | 2004-05-17 | 2005-05-13 | Hydrogel interferon formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200602137A1 true EA200602137A1 (ru) | 2007-04-27 |
EA012205B1 EA012205B1 (ru) | 2009-08-28 |
Family
ID=34928234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200602137A EA012205B1 (ru) | 2004-05-17 | 2005-05-13 | Гидрогелевые препараты интерферона |
Country Status (14)
Country | Link |
---|---|
US (1) | US7879320B2 (ru) |
EP (1) | EP1748788A1 (ru) |
JP (1) | JP2007538048A (ru) |
KR (1) | KR20070012464A (ru) |
CN (1) | CN1984673A (ru) |
AR (1) | AR048963A1 (ru) |
AU (1) | AU2005244448B2 (ru) |
BR (1) | BRPI0510654A (ru) |
CA (1) | CA2566364A1 (ru) |
EA (1) | EA012205B1 (ru) |
NZ (1) | NZ550926A (ru) |
UA (1) | UA88300C2 (ru) |
WO (1) | WO2005110466A1 (ru) |
ZA (1) | ZA200609412B (ru) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI272948B (en) * | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
ATE526032T1 (de) * | 2003-12-11 | 2011-10-15 | Ares Trading Sa | Stabilisierte flüssige interferon-formulierungen |
EA010979B1 (ru) * | 2004-06-01 | 2008-12-30 | Арес Трейдинг С.А. | Стабилизированные жидкие препаративные формы интерферона |
WO2006122183A2 (en) * | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
BRPI0810622A2 (pt) | 2007-05-02 | 2020-10-13 | Ambrx, Inc. | polipeptídeos de interferon beta modificados e seus usos |
KR100918645B1 (ko) * | 2007-12-14 | 2009-09-25 | 포항공과대학교 산학협력단 | 하이드로겔의 상변화 원격 제어 방법 및 이를 이용한 약물전달 방법 |
RS52417B (en) * | 2007-12-20 | 2013-02-28 | Merck Serono S.A. | PEG-INTERFERON-BETA FORMULATIONS |
CN101559036B (zh) * | 2008-04-18 | 2012-02-08 | 上海医药工业研究院 | 一种***用避孕凝胶组合物及其制备方法和应用 |
ES2369101B2 (es) * | 2010-05-07 | 2012-08-02 | Universidade De Santiago De Compostela | Sistema farmacéutico acuoso para la administración de fármacos en las uñas. |
EP2622341A4 (en) * | 2010-10-01 | 2014-08-06 | Dow Agrosciences Llc | QUANTIFICATION AND CHARACTERIZATION OF ALLERGENS |
EP2734557B1 (en) * | 2011-07-20 | 2022-09-07 | UroGen Pharma Ltd. | Production of thermoreversible hydrogels for therapeutic applications |
CN102989035B (zh) * | 2011-09-10 | 2014-12-17 | 浙江海正药业股份有限公司 | 一种应用于血管吻合术的水凝胶及其制备方法 |
CN102989036B (zh) * | 2011-09-10 | 2015-10-21 | 浙江海正药业股份有限公司 | 应用于血管吻合术的含有肝素-泊洛沙姆复合物的水凝胶及其制备方法 |
RU2496478C1 (ru) * | 2012-10-19 | 2013-10-27 | Закрытое акционерное общество "ФИРН М" (ЗАО "ФИРН М") | Состав в форме геля для лечения ран и ожогов различной этиологии, обеспечивающий условия для эпителизации |
WO2014115882A1 (ja) * | 2013-01-28 | 2014-07-31 | 国立大学法人 熊本大学 | タンパク質を安定化させたゲル状製剤 |
US20140271601A1 (en) * | 2013-03-13 | 2014-09-18 | Invivo Therapeutics Corporation | Crosslinkable trehalose for the covalent incorporation in hydrogels and methods of use |
TW201609145A (zh) * | 2013-12-25 | 2016-03-16 | 參天製藥股份有限公司 | 注射劑及形成緩釋(depot)之方法 |
RU2017114350A (ru) * | 2014-10-01 | 2018-11-05 | АЛС МАУНТИН ЭлЭлСи | Фармацевтическая композиция, содержащая аспирин, метформин и серотонин вместе с поверхностно-активным веществом |
GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
KR101943160B1 (ko) * | 2016-10-06 | 2019-01-30 | 에이비온 주식회사 | 인터페론 베타 변이체의 안정화 제제 |
CN112512504A (zh) * | 2018-06-22 | 2021-03-16 | 温州医科大学 | 一种水凝胶、含其的药物组合物及其应用 |
CN110655660B (zh) * | 2019-09-05 | 2020-10-20 | 北京科技大学 | 具有刺激响应性的单荧光分子白光发射水凝胶的制备方法 |
RU2768656C1 (ru) * | 2021-09-10 | 2022-03-24 | Илья Александрович Марков | Противовирусное средство в жидкой форме и способ его приготовления |
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US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
JPS5959629A (ja) * | 1982-09-27 | 1984-04-05 | Nippon Chem Res Kk | 効力持続性組成物 |
US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4469228A (en) * | 1983-05-31 | 1984-09-04 | Schering Corporation | Interferon kit |
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IT1272252B (it) | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
JP2758154B2 (ja) | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
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ES2224649T3 (es) | 1998-04-28 | 2005-03-01 | Applied Research Systems Ars Holding N.V. | Conjugados de poliol-ifn-beta. |
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ES2317843T3 (es) | 1999-07-13 | 2009-05-01 | Bolder Biotechnology, Inc. | Proteinas de fusion de eritropoyetina-inmunoglobulina. |
US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
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US6465425B1 (en) * | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
US6586785B2 (en) | 2000-06-29 | 2003-07-01 | California Institute Of Technology | Aerosol silicon nanoparticles for use in semiconductor device fabrication |
KR100396983B1 (ko) | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
DE60130580T2 (de) | 2000-12-27 | 2008-06-12 | Ares Trading S.A. | Lipidmikropartikel mittels kryogenischer mikronisierung |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
JP2005523882A (ja) * | 2001-10-16 | 2005-08-11 | アールエックスキネティックス,インコーポレイテッド | 高濃度タンパク質製剤および製造の方法 |
JP2005517012A (ja) | 2002-02-08 | 2005-06-09 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | 持続放出のためのポリマーベース組成物 |
JP4610154B2 (ja) * | 2002-05-30 | 2011-01-12 | 大塚製薬株式会社 | 注射用製剤 |
US20040037809A1 (en) | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
AR044302A1 (es) * | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
ATE526032T1 (de) | 2003-12-11 | 2011-10-15 | Ares Trading Sa | Stabilisierte flüssige interferon-formulierungen |
EA010979B1 (ru) | 2004-06-01 | 2008-12-30 | Арес Трейдинг С.А. | Стабилизированные жидкие препаративные формы интерферона |
-
2005
- 2005-05-13 CN CNA2005800237073A patent/CN1984673A/zh active Pending
- 2005-05-13 UA UAA200611710A patent/UA88300C2/ru unknown
- 2005-05-13 KR KR1020067023452A patent/KR20070012464A/ko not_active Application Discontinuation
- 2005-05-13 EA EA200602137A patent/EA012205B1/ru not_active IP Right Cessation
- 2005-05-13 US US11/596,599 patent/US7879320B2/en not_active Expired - Fee Related
- 2005-05-13 ZA ZA200609412A patent/ZA200609412B/en unknown
- 2005-05-13 JP JP2007517247A patent/JP2007538048A/ja active Pending
- 2005-05-13 WO PCT/EP2005/052219 patent/WO2005110466A1/en active Application Filing
- 2005-05-13 BR BRPI0510654-0A patent/BRPI0510654A/pt not_active IP Right Cessation
- 2005-05-13 CA CA002566364A patent/CA2566364A1/en not_active Withdrawn
- 2005-05-13 AU AU2005244448A patent/AU2005244448B2/en not_active Ceased
- 2005-05-13 EP EP05752782A patent/EP1748788A1/en not_active Withdrawn
- 2005-05-13 NZ NZ550926A patent/NZ550926A/en not_active IP Right Cessation
- 2005-05-17 AR ARP050102021A patent/AR048963A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1984673A (zh) | 2007-06-20 |
ZA200609412B (en) | 2008-07-30 |
US7879320B2 (en) | 2011-02-01 |
BRPI0510654A (pt) | 2007-11-20 |
WO2005110466A1 (en) | 2005-11-24 |
KR20070012464A (ko) | 2007-01-25 |
UA88300C2 (ru) | 2009-10-12 |
AU2005244448B2 (en) | 2011-03-17 |
US20070248674A1 (en) | 2007-10-25 |
CA2566364A1 (en) | 2005-11-24 |
AR048963A1 (es) | 2006-06-14 |
JP2007538048A (ja) | 2007-12-27 |
AU2005244448A1 (en) | 2005-11-24 |
NZ550926A (en) | 2010-01-29 |
EA012205B1 (ru) | 2009-08-28 |
EP1748788A1 (en) | 2007-02-07 |
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Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |