TW200606147A - Indolyl derivatives as liver-X-receptor modulators - Google Patents

Indolyl derivatives as liver-X-receptor modulators

Info

Publication number: TW200606147A
Authority: TW; Taiwan
Prior art keywords: liver; receptor modulators; indolyl derivatives; indolyl; derivatives
Prior art date: 2004-05-03

Application number

TW094113966A

Other languages

English (en)

Other versions

TWI287537B (en

Inventor

Henrietta Dehmlow

Bernd Kuhn

Narendra Panday

Hasane Ratni

Tanja Schulz-Gasch

Matthew Blake Wright

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-03

Filing date

2005-04-29

Publication date

2006-02-16

2005-04-29 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-02-16 Publication of TW200606147A publication Critical patent/TW200606147A/zh

2007-10-01 Application granted granted Critical

2007-10-01 Publication of TWI287537B publication Critical patent/TWI287537B/zh

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

TW094113966A 2004-05-03 2005-04-29 Indolyl derivatives as liver-X-receptor modulators TWI287537B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04101889		2004-05-03

Publications (2)

Publication Number	Publication Date
TW200606147A true TW200606147A (en)	2006-02-16
TWI287537B TWI287537B (en)	2007-10-01

Family

ID=34970495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094113966A TWI287537B (en)	2004-05-03	2005-04-29	Indolyl derivatives as liver-X-receptor modulators

Country Status (26)

Country	Link
US (2)	US7173048B2 (zh)
EP (1)	EP1756096B1 (zh)
JP (1)	JP4682192B2 (zh)
KR (1)	KR100893449B1 (zh)
CN (1)	CN1950365A (zh)
AR (1)	AR049497A1 (zh)
AT (1)	ATE439357T1 (zh)
AU (1)	AU2005238176B2 (zh)
BR (1)	BRPI0510599A (zh)
CA (1)	CA2564563C (zh)
DE (1)	DE602005015962D1 (zh)
DK (1)	DK1756096T3 (zh)
ES (1)	ES2329489T3 (zh)
HR (1)	HRP20090533T1 (zh)
IL (1)	IL178767A0 (zh)
MX (1)	MXPA06012683A (zh)
MY (1)	MY139571A (zh)
NO (1)	NO20065503L (zh)
NZ (1)	NZ550447A (zh)
PL (1)	PL1756096T3 (zh)
PT (1)	PT1756096E (zh)
RU (1)	RU2368612C2 (zh)
SI (1)	SI1756096T1 (zh)
TW (1)	TWI287537B (zh)
WO (1)	WO2005105791A1 (zh)
ZA (1)	ZA200608886B (zh)

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US20070219206A1 (en) *	2005-11-04	2007-09-20	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
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GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US20070244128A1 (en) *	2005-11-04	2007-10-18	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
US20070225285A1 (en) *	2005-11-04	2007-09-27	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (flap) inhibitors
US8399666B2 (en) *	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
EA016853B1 (ru)	2006-08-24	2012-08-30	Юниверсити Оф Теннесси Рисерч Фаундейшн	Замещенные ациланилиды и их применение
EP2079466B1 (en) *	2006-09-29	2014-01-15	GlaxoSmithKline LLC	Substituted indole compounds
US8404896B2 (en)	2006-12-01	2013-03-26	Bristol-Myers Squibb Company	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
PE20090222A1 (es)	2007-05-04	2009-03-27	Bristol Myers Squibb Co	Compuestos [6,6] y [6,7]-biciclicos como agonistas del receptor acoplado a la proteina g gpr119
ES2388315T3 (es)	2007-05-04	2012-10-11	Bristol-Myers Squibb Company	Agonistas [6,5]-bicíclicos de receptores GPR119 acoplados a la proteína G
PE20090449A1 (es)	2007-07-17	2009-04-18	Bristol Myers Squibb Co	Agonistas de receptor acoplado a proteina g gpr119 de piridona
KR100918814B1 (ko) *	2007-10-04	2009-09-25	건국대학교 산학협력단	인쇄방법을 이용한 세라믹 전자부품 고속제조방법
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JP5791500B2 (ja) *	2008-05-23	2015-10-07	パンミラファーマシューティカルズ，エルエルシー．	５−リポキシゲナーゼ活性化タンパク質阻害剤
TW201006821A (en)	2008-07-16	2010-02-16	Bristol Myers Squibb Co	Pyridone and pyridazone analogues as GPR119 modulators
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
MX2012011460A (es)	2010-04-08	2012-11-23	Squibb Bristol Myers Co	Analogos de pirimidinilpiperidiniloxipiridinona como moduladores de gpr119.
US8729084B2 (en)	2010-05-06	2014-05-20	Bristol-Myers Squibb Company	Benzofuranyl analogues as GPR119 modulators
MX2012012902A (es)	2010-05-06	2012-12-17	Bristol Myers Squibb Co	Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.
RU2598842C2 (ru) *	2011-01-20	2016-09-27	Мерк Шарп Энд Домэ Корп.	Антагонисты рецептора минералокортикоидов
WO2013173198A1 (en)	2012-05-16	2013-11-21	Bristol-Myers Squibb Company	Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
US10314807B2 (en)	2012-07-13	2019-06-11	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en)	2012-07-13	2017-08-29	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9622992B2 (en)	2012-07-13	2017-04-18	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en)	2012-07-13	2018-05-15	Gtx, Inc.	Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
DK2872482T3 (da)	2012-07-13	2020-09-21	Oncternal Therapeutics Inc	En fremgangsmåde til behandling af brystkræft med selektiv androgenreceptormodulator (sarm)
US10258596B2 (en)	2012-07-13	2019-04-16	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en)	2012-07-13	2021-04-27	University Of Tennessee Research Foundation	Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
WO2014139388A1 (en) *	2013-03-14	2014-09-18	Merck Sharp & Dohme Corp.	Novel indole derivatives useful as anti-diabetic agents
WO2015061272A1 (en)	2013-10-22	2015-04-30	Bristol-Myers Squibb Company	Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
AU2015204572B2 (en)	2014-01-10	2020-07-30	Inspirna, Inc.	LXR agonists and uses thereof
EP3402477A4 (en)	2016-01-11	2019-08-21	The Rockefeller University	METHODS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH SUPPRESSIVE CELLS DERIVED FROM MYELOID CELLS
CN106187899B (zh) *	2016-06-28	2019-07-16	绍兴文理学院	一种氟代氮杂芳烃的合成方法
JP7072557B2 (ja)	2016-07-22	2022-05-20	ブリストル－マイヤーズスクイブカンパニー	グルコキナーゼ活性化剤およびその使用方法
WO2019104062A1 (en)	2017-11-21	2019-05-31	Rgenix, Inc.	Polymorphs and uses thereof
TWI748194B (zh)	2018-06-28	2021-12-01	德商菲尼克斯Ｆｘｒ有限責任公司	含有雙環核心部分之新穎lxr調節劑
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2005
- 2005-04-26 SI SI200530765T patent/SI1756096T1/sl unknown
- 2005-04-26 DE DE602005015962T patent/DE602005015962D1/de active Active
- 2005-04-26 DK DK05751959T patent/DK1756096T3/da active
- 2005-04-26 CA CA2564563A patent/CA2564563C/en not_active Expired - Fee Related
- 2005-04-26 KR KR1020067023014A patent/KR100893449B1/ko not_active IP Right Cessation
- 2005-04-26 EP EP05751959A patent/EP1756096B1/en active Active
- 2005-04-26 AT AT05751959T patent/ATE439357T1/de active
- 2005-04-26 BR BRPI0510599-4A patent/BRPI0510599A/pt not_active IP Right Cessation
- 2005-04-26 JP JP2007511949A patent/JP4682192B2/ja not_active Expired - Fee Related
- 2005-04-26 RU RU2006142746/04A patent/RU2368612C2/ru not_active IP Right Cessation
- 2005-04-26 AU AU2005238176A patent/AU2005238176B2/en not_active Ceased
- 2005-04-26 WO PCT/EP2005/004454 patent/WO2005105791A1/en active Application Filing
- 2005-04-26 CN CNA2005800142069A patent/CN1950365A/zh active Pending
- 2005-04-26 NZ NZ550447A patent/NZ550447A/en not_active IP Right Cessation
- 2005-04-26 ES ES05751959T patent/ES2329489T3/es active Active
- 2005-04-26 PL PL05751959T patent/PL1756096T3/pl unknown
- 2005-04-26 PT PT05751959T patent/PT1756096E/pt unknown
- 2005-04-26 MX MXPA06012683A patent/MXPA06012683A/es active IP Right Grant
- 2005-04-27 US US11/115,942 patent/US7173048B2/en not_active Expired - Fee Related
- 2005-04-28 MY MYPI20051897A patent/MY139571A/en unknown
- 2005-04-29 AR ARP050101717A patent/AR049497A1/es unknown
- 2005-04-29 TW TW094113966A patent/TWI287537B/zh not_active IP Right Cessation
2006
- 2006-10-19 IL IL178767A patent/IL178767A0/en unknown
- 2006-10-25 ZA ZA200608886A patent/ZA200608886B/en unknown
- 2006-11-29 NO NO20065503A patent/NO20065503L/no not_active Application Discontinuation
- 2006-12-11 US US11/636,925 patent/US7485652B2/en not_active Expired - Fee Related
2009
- 2009-10-02 HR HR20090533T patent/HRP20090533T1/xx unknown

Also Published As

Publication number	Publication date
JP4682192B2 (ja)	2011-05-11
IL178767A0 (en)	2007-02-11
ATE439357T1 (de)	2009-08-15
NZ550447A (en)	2010-06-25
KR100893449B1 (ko)	2009-04-17
US20050245515A1 (en)	2005-11-03
US20070099916A1 (en)	2007-05-03
SI1756096T1 (sl)	2009-10-31
RU2368612C2 (ru)	2009-09-27
ES2329489T3 (es)	2009-11-26
US7485652B2 (en)	2009-02-03
KR20070008678A (ko)	2007-01-17
MY139571A (en)	2009-10-30
CN1950365A (zh)	2007-04-18
AU2005238176A1 (en)	2005-11-10
HRP20090533T1 (en)	2009-11-30
PT1756096E (pt)	2009-10-16
PL1756096T3 (pl)	2010-01-29
RU2006142746A (ru)	2008-06-10
BRPI0510599A (pt)	2007-11-20
EP1756096B1 (en)	2009-08-12
NO20065503L (no)	2007-01-24
DK1756096T3 (da)	2009-10-26
EP1756096A1 (en)	2007-02-28
DE602005015962D1 (de)	2009-09-24
US7173048B2 (en)	2007-02-06
TWI287537B (en)	2007-10-01
WO2005105791A1 (en)	2005-11-10
CA2564563A1 (en)	2005-11-10
CA2564563C (en)	2011-07-05
JP2007536300A (ja)	2007-12-13
AR049497A1 (es)	2006-08-09
AU2005238176B2 (en)	2008-11-27
MXPA06012683A (es)	2007-01-16
ZA200608886B (en)	2008-06-25

Legal Events

Date	Code	Title	Description
2013-07-01	MM4A	Annulment or lapse of patent due to non-payment of fees

Publication	Publication Date	Title
TW200606147A (en)	2006-02-16	Indolyl derivatives as liver-X-receptor modulators
NO20065904L (no)	2007-02-20	Terapeutiske forbindelser
IS8230A (is)	2006-01-12	Setið 2-amínótetralín til notkunar við meðferð á þunglyndi
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