EA200870223A1 - Производные бензоизоиндола для лечения боли - Google Patents
Производные бензоизоиндола для лечения болиInfo
- Publication number
- EA200870223A1 EA200870223A1 EA200870223A EA200870223A EA200870223A1 EA 200870223 A1 EA200870223 A1 EA 200870223A1 EA 200870223 A EA200870223 A EA 200870223A EA 200870223 A EA200870223 A EA 200870223A EA 200870223 A1 EA200870223 A1 EA 200870223A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzoizoindol
- pain
- derivatives
- treatment
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Соединение формулы (I) или его фармацевтически приемлемое производное, где R, Rи R, Х и Y имеют указанные в описании значения, способ получения таких соединений, фармацевтическая композиция, содержащая такие соединения, и применение таких соединений в медицине.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0602238A GB0602238D0 (en) | 2006-02-03 | 2006-02-03 | Novel compounds |
GB0615094A GB0615094D0 (en) | 2006-07-28 | 2006-07-28 | Novel compounds |
PCT/EP2007/050991 WO2007088189A1 (en) | 2006-02-03 | 2007-02-01 | Benzoisoindole derivatives for the treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200870223A1 true EA200870223A1 (ru) | 2009-02-27 |
EA014428B1 EA014428B1 (ru) | 2010-12-30 |
Family
ID=38042653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870223A EA014428B1 (ru) | 2006-02-03 | 2007-02-01 | Производные бензоизоиндола для лечения боли |
Country Status (15)
Country | Link |
---|---|
US (1) | US8207213B2 (ru) |
EP (1) | EP1979317B1 (ru) |
JP (1) | JP5118063B2 (ru) |
KR (1) | KR20080098597A (ru) |
AU (1) | AU2007211483B2 (ru) |
BR (1) | BRPI0708025A2 (ru) |
CA (1) | CA2640274A1 (ru) |
CR (1) | CR10210A (ru) |
EA (1) | EA014428B1 (ru) |
ES (1) | ES2393800T3 (ru) |
IL (1) | IL192933A0 (ru) |
MA (1) | MA30308B1 (ru) |
NO (1) | NO20083441L (ru) |
SG (1) | SG169378A1 (ru) |
WO (1) | WO2007088189A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8110681B2 (en) | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
GB0620619D0 (en) * | 2006-10-17 | 2006-11-29 | Glaxo Group Ltd | Novel compounds |
GB0623203D0 (en) * | 2006-11-21 | 2007-01-03 | Glaxo Group Ltd | Novel compounds |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
EP2338485A1 (de) * | 2009-12-14 | 2011-06-29 | Grünenthal GmbH | Substituierte 1,3-Dioxoisoindoline als Arzneimittel |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0030541D0 (en) * | 2000-12-14 | 2001-01-31 | Glaxo Group Ltd | Medical uses |
GB0031295D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
GB0103269D0 (en) * | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
-
2007
- 2007-02-01 SG SG201100786-1A patent/SG169378A1/en unknown
- 2007-02-01 EA EA200870223A patent/EA014428B1/ru not_active IP Right Cessation
- 2007-02-01 BR BRPI0708025-5A patent/BRPI0708025A2/pt not_active IP Right Cessation
- 2007-02-01 EP EP07704312A patent/EP1979317B1/en active Active
- 2007-02-01 WO PCT/EP2007/050991 patent/WO2007088189A1/en active Application Filing
- 2007-02-01 AU AU2007211483A patent/AU2007211483B2/en not_active Ceased
- 2007-02-01 US US12/278,013 patent/US8207213B2/en not_active Expired - Fee Related
- 2007-02-01 ES ES07704312T patent/ES2393800T3/es active Active
- 2007-02-01 JP JP2008552808A patent/JP5118063B2/ja not_active Expired - Fee Related
- 2007-02-01 CA CA002640274A patent/CA2640274A1/en not_active Abandoned
- 2007-02-01 KR KR1020087018902A patent/KR20080098597A/ko not_active Application Discontinuation
-
2008
- 2008-07-21 IL IL192933A patent/IL192933A0/en unknown
- 2008-08-06 MA MA31160A patent/MA30308B1/fr unknown
- 2008-08-06 NO NO20083441A patent/NO20083441L/no not_active Application Discontinuation
- 2008-08-14 CR CR10210A patent/CR10210A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2640274A1 (en) | 2007-08-09 |
KR20080098597A (ko) | 2008-11-11 |
JP2010517925A (ja) | 2010-05-27 |
IL192933A0 (en) | 2009-02-11 |
MA30308B1 (fr) | 2009-04-01 |
EP1979317B1 (en) | 2012-08-22 |
JP5118063B2 (ja) | 2013-01-16 |
EP1979317A1 (en) | 2008-10-15 |
US8207213B2 (en) | 2012-06-26 |
WO2007088189A1 (en) | 2007-08-09 |
ES2393800T3 (es) | 2012-12-28 |
AU2007211483B2 (en) | 2012-08-16 |
NO20083441L (no) | 2008-09-30 |
CR10210A (es) | 2008-10-29 |
BRPI0708025A2 (pt) | 2011-05-17 |
AU2007211483A1 (en) | 2007-08-09 |
EA014428B1 (ru) | 2010-12-30 |
US20110092561A1 (en) | 2011-04-21 |
SG169378A1 (en) | 2011-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |