IL143867A0 - Antiviral nucleoside analogues - Google Patents

Antiviral nucleoside analogues

Info

Publication number
IL143867A0
IL143867A0 IL14386799A IL14386799A IL143867A0 IL 143867 A0 IL143867 A0 IL 143867A0 IL 14386799 A IL14386799 A IL 14386799A IL 14386799 A IL14386799 A IL 14386799A IL 143867 A0 IL143867 A0 IL 143867A0
Authority
IL
Israel
Prior art keywords
nucleoside analogues
antiviral nucleoside
antiviral
analogues
nucleoside
Prior art date
Application number
IL14386799A
Other languages
English (en)
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Publication of IL143867A0 publication Critical patent/IL143867A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14386799A 1998-12-23 1999-12-22 Antiviral nucleoside analogues IL143867A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11379798P 1998-12-23 1998-12-23
PCT/CA1999/001229 WO2000039143A2 (en) 1998-12-23 1999-12-22 Antiviral nucleoside analogues

Publications (1)

Publication Number Publication Date
IL143867A0 true IL143867A0 (en) 2002-04-21

Family

ID=22351590

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14386799A IL143867A0 (en) 1998-12-23 1999-12-22 Antiviral nucleoside analogues

Country Status (27)

Country Link
US (3) US6358963B1 (xx)
EP (1) EP1140937B1 (xx)
JP (1) JP2002533470A (xx)
KR (1) KR100653485B1 (xx)
CN (1) CN1117751C (xx)
AP (1) AP2001002207A0 (xx)
AT (1) ATE254126T1 (xx)
AU (1) AU760875B2 (xx)
BR (1) BR9916849A (xx)
CA (1) CA2355712C (xx)
CZ (1) CZ20012352A3 (xx)
DE (1) DE69912842T2 (xx)
DK (1) DK1140937T3 (xx)
EA (1) EA004767B1 (xx)
ES (1) ES2209532T3 (xx)
HU (1) HUP0104827A3 (xx)
ID (1) ID30477A (xx)
IL (1) IL143867A0 (xx)
MX (1) MXPA01006425A (xx)
NO (1) NO20013163L (xx)
NZ (1) NZ513094A (xx)
OA (1) OA11741A (xx)
PT (1) PT1140937E (xx)
TR (1) TR200102501T2 (xx)
UY (1) UY25878A1 (xx)
WO (1) WO2000039143A2 (xx)
ZA (1) ZA200105702B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA11741A (en) * 1998-12-23 2005-05-13 Iaf Biochem Int Antiviral nucleoside analogues.
ATE360016T1 (de) * 2000-02-11 2007-05-15 Shire Biochem Inc Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
AU2003261114A1 (en) * 2002-07-03 2004-02-09 Triangle Pharmaceuticals, Inc. Combination therapy with 1,3-dioxolanes and inosine monophosphate dehydrogenase inhibitors
ES2360096T3 (es) 2002-08-06 2011-05-31 Pharmasset, Inc. Procedimientos de preparación de nucleosidos de 1,3-dioxolano.
US7706405B2 (en) * 2002-09-12 2010-04-27 Interdigital Technology Corporation System for efficient recovery of Node-B buffered data following MAC layer reset
JP4501135B2 (ja) * 2002-11-18 2010-07-14 シェア カナダ インコーポレーテッド ジオキソランヌクレオシド類似体の立体選択的製造方法
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
US7785839B2 (en) 2004-02-03 2010-08-31 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7322412B2 (en) * 2004-08-30 2008-01-29 Halliburton Energy Services, Inc. Casing shoes and methods of reverse-circulation cementing of casing
ATE516249T1 (de) * 2008-03-20 2011-07-15 Befesa Salzschlacke Gmbh Hochtonerdehaltiger rohstoff und verfahren zur herstellung
WO2012048455A1 (zh) * 2010-10-12 2012-04-19 武汉大学 一种抗病毒透皮吸收贴片及其制备方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000137A (en) 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4041037A (en) 1975-06-10 1977-08-09 American Home Products Corporation Antitumor derivatives of periodate-oxidized cytidine
JPS5668674A (en) 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
JPS5738774A (en) 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4479942A (en) 1981-08-10 1984-10-30 Fujisawa Pharmaceutical Co., Ltd. Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
HU198933B (en) 1987-11-02 1989-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new xanthine derivatives and pharmaceutical compositions comprising same as active ingredient
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5041449A (en) 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5270315A (en) 1988-04-11 1993-12-14 Biochem Pharma Inc. 4-(purinyl bases)-substituted-1,3-dioxlanes
US4987224A (en) 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
AU3154993A (en) 1989-02-08 1994-07-19 Biochem Pharma Inc. Process for preparing substituted 1,3-oxathiolanes with antiviral properties
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
US5700937A (en) 1990-02-01 1997-12-23 Emory University Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5276151A (en) 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
GB9009861D0 (en) 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
WO1992008717A1 (en) 1990-11-13 1992-05-29 Biochem Pharma Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US5444063A (en) 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
WO1992010496A1 (en) 1990-12-05 1992-06-25 University Of Georgia Research Foundation, Inc. ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES
US5925643A (en) 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5179104A (en) 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
IL100965A (en) 1991-02-22 1999-12-31 Univ Emory 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it
WO1992018517A1 (en) 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
GB9109506D0 (en) 1991-05-02 1991-06-26 Wellcome Found Therapeutic nucleosides
GB9110874D0 (en) 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9200150D0 (en) 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
US5869461A (en) 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
GB9525606D0 (en) * 1995-12-14 1996-02-14 Iaf Biochem Int Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
US5792773A (en) 1996-11-15 1998-08-11 Yale University L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection
OA11741A (en) * 1998-12-23 2005-05-13 Iaf Biochem Int Antiviral nucleoside analogues.

Also Published As

Publication number Publication date
ID30477A (id) 2001-12-13
CN1334814A (zh) 2002-02-06
CA2355712C (en) 2009-03-17
UY25878A1 (es) 2001-08-27
DE69912842D1 (de) 2003-12-18
US6358963B1 (en) 2002-03-19
AP2001002207A0 (en) 2001-09-30
CZ20012352A3 (cs) 2001-10-17
CN1117751C (zh) 2003-08-13
EA200100711A1 (ru) 2001-12-24
US20040058893A1 (en) 2004-03-25
HUP0104827A3 (en) 2002-08-28
KR20020013485A (ko) 2002-02-20
AU1765700A (en) 2000-07-31
DK1140937T3 (da) 2004-03-22
DE69912842T2 (de) 2004-05-13
NO20013163L (no) 2001-08-20
NO20013163D0 (no) 2001-06-22
ES2209532T3 (es) 2004-06-16
WO2000039143A2 (en) 2000-07-06
MXPA01006425A (es) 2002-06-04
BR9916849A (pt) 2001-10-30
PT1140937E (pt) 2004-04-30
OA11741A (en) 2005-05-13
ZA200105702B (en) 2002-10-11
AU760875B2 (en) 2003-05-22
US6545001B2 (en) 2003-04-08
JP2002533470A (ja) 2002-10-08
KR100653485B1 (ko) 2006-12-04
US20010049372A1 (en) 2001-12-06
ATE254126T1 (de) 2003-11-15
TR200102501T2 (tr) 2002-01-21
NZ513094A (en) 2004-05-28
EP1140937A2 (en) 2001-10-10
CA2355712A1 (en) 2000-07-06
EP1140937B1 (en) 2003-11-12
EA004767B1 (ru) 2004-08-26
WO2000039143A3 (en) 2000-11-02
HUP0104827A2 (en) 2002-06-29

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