TNSN06133A1 - Immunoglobulin variants and uses thereof - Google Patents
Immunoglobulin variants and uses thereofInfo
- Publication number
- TNSN06133A1 TNSN06133A1 TNP2006000133A TNSN06133A TNSN06133A1 TN SN06133 A1 TNSN06133 A1 TN SN06133A1 TN P2006000133 A TNP2006000133 A TN P2006000133A TN SN06133 A TNSN06133 A TN SN06133A TN SN06133 A1 TNSN06133 A1 TN SN06133A1
- Authority
- TN
- Tunisia
- Prior art keywords
- immunoglobulin variants
- immunoglobulin
- variants
- antibodies
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
THE INVENTION PROVIDES HUMANIZED AND CHIMERIC ANTI-CD20 ANTIBODIES FOR TREATMENT OF CD20 POSITIVE MALIGNANCIES AND AUTOIMMUNE DISEASES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43411502P | 2002-12-16 | 2002-12-16 | |
PCT/US2003/040426 WO2004056312A2 (fr) | 2002-12-16 | 2003-12-16 | Variants d'immunoglobuline et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN06133A1 true TNSN06133A1 (en) | 2007-11-15 |
Family
ID=36166967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2006000133A TNSN06133A1 (en) | 2002-12-16 | 2006-05-10 | Immunoglobulin variants and uses thereof |
Country Status (6)
Country | Link |
---|---|
CN (6) | CN1748143A (fr) |
CA (1) | CA2835591A1 (fr) |
CL (1) | CL2003002639A1 (fr) |
NO (1) | NO338313B1 (fr) |
TN (1) | TNSN06133A1 (fr) |
ZA (1) | ZA200504221B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2557587T3 (es) | 2004-12-28 | 2016-01-27 | Innate Pharma | Anticuerpos monoclonales contra NKG2A |
MX2008015830A (es) | 2006-06-30 | 2009-01-09 | Novo Nordisk As | Anticuerpos anti-nkg2a y usos de los mismos. |
US8796427B2 (en) * | 2008-01-24 | 2014-08-05 | Novo Nordisk A/S | Humanized anti-human NKG2A monoclonal antibody |
CN102439163A (zh) * | 2009-02-16 | 2012-05-02 | 拜奥雷克斯治疗公司 | 人源化抗cd20抗体及使用方法 |
ES2908587T3 (es) | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
CN102190728B (zh) | 2010-03-17 | 2014-07-02 | 永卓博济(上海)生物医药技术有限公司 | 一种人源化抗cd20单克隆抗体 |
DK3375284T3 (da) * | 2011-02-15 | 2023-06-12 | Univ Yale | Humaniserede M-CSF-mus og anvendelser deraf |
CN103635487B (zh) | 2011-06-17 | 2016-10-12 | 诺沃—诺迪斯克有限公司 | 选择性消除侵蚀性细胞 |
SI2771364T1 (sl) * | 2011-10-27 | 2019-10-30 | Genmab As | Produkcija heterodimernih proteinov |
CA2853138A1 (fr) | 2011-12-05 | 2013-06-13 | Immunomedics, Inc. | Utilisation therapeutique d'anticorps anti-cd22 pour induire une trogocytose |
US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
CN103936855B (zh) * | 2014-03-27 | 2016-05-04 | 合肥泰瑞生物技术有限公司 | 抗cd20抗原的抗体l4h5及其应用 |
CN103936858B (zh) * | 2014-03-27 | 2016-05-04 | 安徽大学 | 抗cd20抗原的抗体l5h6及其应用 |
CN103880957B (zh) * | 2014-03-27 | 2016-01-20 | 安徽大学 | 抗cd20抗原的抗体l1h1及其应用 |
CN103897059B (zh) * | 2014-03-27 | 2016-03-23 | 中国人民解放军军事医学科学院生物工程研究所 | 抗cd20抗原的抗体l5h7及其应用 |
CN103880958B (zh) * | 2014-03-27 | 2016-01-20 | 安徽大学 | 抗cd20抗原的抗体l4h6及其应用 |
JP6752221B2 (ja) | 2015-04-13 | 2020-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化sirpa−il15ノックインマウス及びその使用方法 |
KR20190038613A (ko) * | 2016-08-11 | 2019-04-08 | 더 잭슨 래보라토리 | 유전자 변형된 면역결핍 비-인간 동물에서의 개선된 인간 적혈구 생존에 관한 방법 및 조성물 |
CN106872713A (zh) * | 2016-12-27 | 2017-06-20 | 许洋 | 一种微量蛋白质原位检测的免疫质谱试剂盒及制备方法 |
CN108531561A (zh) * | 2017-03-01 | 2018-09-14 | 云南序源生物技术开发有限公司 | 一种快速检测用于鉴定y染色体单倍型谱系的snp特征位点的试剂盒及方法 |
CN111705084B (zh) * | 2020-08-18 | 2020-12-08 | 江苏集萃药康生物科技有限公司 | 一种稳定表达荧光素酶及人cd20敲除鼠cd20的小鼠b细胞淋巴瘤细胞系构建方法 |
CN114990128A (zh) * | 2021-06-16 | 2022-09-02 | 百奥赛图(北京)医药科技股份有限公司 | Cd20基因人源化非人动物的构建方法及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5576195A (en) * | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
HU228180B1 (hu) * | 1998-08-11 | 2013-01-28 | Biogen Idec Inc | Anti-CD20-ellenanyag alkalmazása B-sejtes limfómák kombinációs terápiájára |
CA2422076A1 (fr) * | 2000-09-18 | 2002-03-21 | Idec Pharmaceutical Corporation | Polytherapie pour le traitement de maladies auto-immunes utilisant une combinaison d'anticorps d'immunoregulation/de depletion de cellules b |
AU2002213357A1 (en) * | 2000-10-20 | 2002-05-06 | Idec Pharmaceuticals Corporation | Variant igg3 rituxan r and therapeutic use thereof |
-
2003
- 2003-12-11 CN CNA2003801096904A patent/CN1748143A/zh active Pending
- 2003-12-11 CN CNA2003801063031A patent/CN1751236A/zh active Pending
- 2003-12-16 CA CA2835591A patent/CA2835591A1/fr not_active Abandoned
- 2003-12-16 CN CNB200380109682XA patent/CN100460421C/zh not_active Expired - Lifetime
- 2003-12-16 CN CN200810174816.0A patent/CN101418044B/zh not_active Expired - Lifetime
- 2003-12-16 CN CNA2008101748175A patent/CN101418045A/zh active Pending
- 2003-12-16 CL CL200302639A patent/CL2003002639A1/es unknown
- 2003-12-16 CN CNA2008101748156A patent/CN101418043A/zh active Pending
-
2005
- 2005-05-24 ZA ZA200504221A patent/ZA200504221B/en unknown
-
2006
- 2006-05-10 TN TNP2006000133A patent/TNSN06133A1/en unknown
-
2015
- 2015-02-20 NO NO20150245A patent/NO338313B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1748143A (zh) | 2006-03-15 |
CN101418044A (zh) | 2009-04-29 |
CL2003002639A1 (es) | 2005-04-08 |
NO20150245L (no) | 2005-08-31 |
ZA200504221B (en) | 2006-08-30 |
CN1747969A (zh) | 2006-03-15 |
CN101418045A (zh) | 2009-04-29 |
NO338313B1 (no) | 2016-08-08 |
CN100460421C (zh) | 2009-02-11 |
CN101418043A (zh) | 2009-04-29 |
CN101418044B (zh) | 2014-03-12 |
CA2835591A1 (fr) | 2004-07-08 |
CN1751236A (zh) | 2006-03-22 |
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