TNSN06133A1 - Immunoglobulin variants and uses thereof - Google Patents

Immunoglobulin variants and uses thereof

Info

Publication number
TNSN06133A1
TNSN06133A1 TNP2006000133A TNSN06133A TNSN06133A1 TN SN06133 A1 TNSN06133 A1 TN SN06133A1 TN P2006000133 A TNP2006000133 A TN P2006000133A TN SN06133 A TNSN06133 A TN SN06133A TN SN06133 A1 TNSN06133 A1 TN SN06133A1
Authority
TN
Tunisia
Prior art keywords
immunoglobulin variants
immunoglobulin
variants
antibodies
treatment
Prior art date
Application number
TNP2006000133A
Other languages
French (fr)
Inventor
C Chan Andrew
W Crowley Craig
B Lowman Henry
R Nakamura Gerald
G Presta Leonard
W Adams Camellia
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36166967&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN06133(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2003/040426 external-priority patent/WO2004056312A2/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of TNSN06133A1 publication Critical patent/TNSN06133A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

THE INVENTION PROVIDES HUMANIZED AND CHIMERIC ANTI-CD20 ANTIBODIES FOR TREATMENT OF CD20 POSITIVE MALIGNANCIES AND AUTOIMMUNE DISEASES.
TNP2006000133A 2002-12-16 2006-05-10 Immunoglobulin variants and uses thereof TNSN06133A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43411502P 2002-12-16 2002-12-16
PCT/US2003/040426 WO2004056312A2 (en) 2002-12-16 2003-12-16 Immunoglobulin variants and uses thereof

Publications (1)

Publication Number Publication Date
TNSN06133A1 true TNSN06133A1 (en) 2007-11-15

Family

ID=36166967

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000133A TNSN06133A1 (en) 2002-12-16 2006-05-10 Immunoglobulin variants and uses thereof

Country Status (6)

Country Link
CN (6) CN1748143A (en)
CA (1) CA2835591A1 (en)
CL (1) CL2003002639A1 (en)
NO (1) NO338313B1 (en)
TN (1) TNSN06133A1 (en)
ZA (1) ZA200504221B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2557587T3 (en) 2004-12-28 2016-01-27 Innate Pharma Monoclonal antibodies against NKG2A
MX2008015830A (en) 2006-06-30 2009-01-09 Novo Nordisk As Anti-nkg2a antibodies and uses thereof.
US8796427B2 (en) * 2008-01-24 2014-08-05 Novo Nordisk A/S Humanized anti-human NKG2A monoclonal antibody
CN102439163A (en) * 2009-02-16 2012-05-02 拜奥雷克斯治疗公司 Humanized anti-cd20 antibodies and methods of use
ES2908587T3 (en) 2009-10-06 2022-05-03 Regeneron Pharma Genetically modified mice and graft
CN102190728B (en) 2010-03-17 2014-07-02 永卓博济(上海)生物医药技术有限公司 Novel humanized anti-CD20 monoclonal antibody
DK3375284T3 (en) * 2011-02-15 2023-06-12 Univ Yale Humanized M-CSF mice and uses thereof
CN103635487B (en) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 Selectivity eliminates aggressivity cell
SI2771364T1 (en) * 2011-10-27 2019-10-30 Genmab As Production of heterodimeric proteins
CA2853138A1 (en) 2011-12-05 2013-06-13 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
US8883979B2 (en) * 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
CN103936855B (en) * 2014-03-27 2016-05-04 合肥泰瑞生物技术有限公司 Antibody L4H5 and the application thereof of anti-CD20 antigen
CN103936858B (en) * 2014-03-27 2016-05-04 安徽大学 Antibody L5H6 and the application thereof of anti-CD20 antigen
CN103880957B (en) * 2014-03-27 2016-01-20 安徽大学 The antibody L1H1 of anti-CD20 antigen and application thereof
CN103897059B (en) * 2014-03-27 2016-03-23 中国人民解放军军事医学科学院生物工程研究所 The antibody L5H7 of anti-CD20 antigen and application thereof
CN103880958B (en) * 2014-03-27 2016-01-20 安徽大学 The antibody L4H6 of anti-CD20 antigen and application thereof
JP6752221B2 (en) 2015-04-13 2020-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Humanized SIRPA-IL15 knock-in mouse and its usage
KR20190038613A (en) * 2016-08-11 2019-04-08 더 잭슨 래보라토리 Methods and compositions for improved human red blood cell survival in genetically modified immunodeficient non-human animals
CN106872713A (en) * 2016-12-27 2017-06-20 许洋 A kind of immunomic mass spectrometry kit and preparation method of trace protein in situ detection
CN108531561A (en) * 2017-03-01 2018-09-14 云南序源生物技术开发有限公司 A kind of quick detection is used to identify the kit and method in the SNP features site of Y chromosome haplotype pedigree
CN111705084B (en) * 2020-08-18 2020-12-08 江苏集萃药康生物科技有限公司 Construction method of mouse B cell lymphoma cell line stably expressing luciferase and knocking out mouse CD20 from human CD20
CN114990128A (en) * 2021-06-16 2022-09-02 百奥赛图(北京)医药科技股份有限公司 Construction method and application of CD20 gene humanized non-human animal

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576195A (en) * 1985-11-01 1996-11-19 Xoma Corporation Vectors with pectate lyase signal sequence
HU228180B1 (en) * 1998-08-11 2013-01-28 Biogen Idec Inc Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
CA2422076A1 (en) * 2000-09-18 2002-03-21 Idec Pharmaceutical Corporation Combination therapy for treatment of autoimmune diseases using b cell depleting/immunoregulatory antibody combination
AU2002213357A1 (en) * 2000-10-20 2002-05-06 Idec Pharmaceuticals Corporation Variant igg3 rituxan r and therapeutic use thereof

Also Published As

Publication number Publication date
CN1748143A (en) 2006-03-15
CN101418044A (en) 2009-04-29
CL2003002639A1 (en) 2005-04-08
NO20150245L (en) 2005-08-31
ZA200504221B (en) 2006-08-30
CN1747969A (en) 2006-03-15
CN101418045A (en) 2009-04-29
NO338313B1 (en) 2016-08-08
CN100460421C (en) 2009-02-11
CN101418043A (en) 2009-04-29
CN101418044B (en) 2014-03-12
CA2835591A1 (en) 2004-07-08
CN1751236A (en) 2006-03-22

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