TNSN04090A1 - Conjugues de l'hormone de croissance humaine chimiquement modifies - Google Patents
Conjugues de l'hormone de croissance humaine chimiquement modifiesInfo
- Publication number
- TNSN04090A1 TNSN04090A1 TNP2004000090A TNSN04090A TNSN04090A1 TN SN04090 A1 TNSN04090 A1 TN SN04090A1 TN P2004000090 A TNP2004000090 A TN P2004000090A TN SN04090 A TNSN04090 A TN SN04090A TN SN04090 A1 TNSN04090 A1 TN SN04090A1
- Authority
- TN
- Tunisia
- Prior art keywords
- growth hormone
- human growth
- chemically modified
- modified human
- hormone conjugates
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 3
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 3
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 3
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENTION DECRIT UNE HORMONE DE CROISSANCE HUMAINE (hGH) MODIFIEE CHIMIQUEMENT PAR LIAISON DE LA PROTEINE AVEC UN POLYMERE SOLUBLE DANS L'EAU. LA PROTEINE MODIFIEE AU SENS DE L'INVENTION; PRESENTE UNE ACTIVITE hGH QUI DURE BEAUCOUP PLUS LONGTEMPS QUE CELLE DE L'HORMONE NON MODIFIEE; CE QUI PERMET D'EN REDUIRE LA DOSE ET LA FREQUENCE D'ADMINISTRATION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33190701P | 2001-11-20 | 2001-11-20 | |
PCT/US2002/037270 WO2003044056A2 (fr) | 2001-11-20 | 2002-11-20 | Conjugues de l'hormone de croissance humaine chimiquement modifiee |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN04090A1 true TNSN04090A1 (fr) | 2006-06-01 |
Family
ID=23295870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2004000090A TNSN04090A1 (fr) | 2001-11-20 | 2004-05-20 | Conjugues de l'hormone de croissance humaine chimiquement modifies |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1453859A2 (fr) |
JP (2) | JP2005525302A (fr) |
KR (2) | KR20050044858A (fr) |
CN (1) | CN1608079A (fr) |
AP (1) | AP2004003050A0 (fr) |
AU (1) | AU2002356990A1 (fr) |
BR (1) | BR0214451A (fr) |
CA (1) | CA2467731A1 (fr) |
CO (1) | CO5580794A2 (fr) |
EA (2) | EA200700431A1 (fr) |
EC (1) | ECSP045114A (fr) |
GE (1) | GEP20063860B (fr) |
HR (1) | HRP20040448A2 (fr) |
HU (1) | HUP0500997A2 (fr) |
IL (1) | IL162031A0 (fr) |
IS (1) | IS7268A (fr) |
MA (1) | MA27544A1 (fr) |
MX (1) | MXPA04004809A (fr) |
NO (1) | NO20042182L (fr) |
OA (1) | OA13063A (fr) |
PL (1) | PL374354A1 (fr) |
RS (1) | RS53104A (fr) |
TN (1) | TNSN04090A1 (fr) |
WO (1) | WO2003044056A2 (fr) |
ZA (1) | ZA200403907B (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
AU2002357806A1 (en) * | 2001-12-11 | 2003-06-23 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
ME00239B (me) * | 2002-01-18 | 2011-05-10 | Biogen Ma Inc | Polimerna jedinjenja polialkilena i njihova upotreba |
EP1591467A1 (fr) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugue d un polyethylene glycol comprenant un group terminal alcanal et un hormone de croissance humaine |
ES2897470T3 (es) | 2002-09-09 | 2022-03-01 | Nektar Therapeutics | Alcanales poliméricos solubles en agua |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
CN100580087C (zh) * | 2003-10-10 | 2010-01-13 | 诺和诺德医疗保健公司 | 肽的缀合 |
US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
EP2368579A1 (fr) * | 2004-01-21 | 2011-09-28 | Novo Nordisk Health Care AG | Conjugaison au moyen de transglutaminase de peptides |
AU2005278903A1 (en) * | 2004-08-31 | 2006-03-09 | Pharmacia & Upjohn Company Llc | Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof |
CN103290084A (zh) * | 2004-12-22 | 2013-09-11 | Ambrx公司 | 表达和纯化重组人类生长激素的方法 |
US7638491B2 (en) | 2004-12-22 | 2009-12-29 | Ambrx, Inc. | Therapies using non-natural amino acids and polypeptides |
CN103690936A (zh) * | 2004-12-22 | 2014-04-02 | Ambrx公司 | 经修饰的人类生长激素 |
US20090105134A1 (en) | 2005-02-10 | 2009-04-23 | Novo Nordisk A/S | C-Terminally Pegylated Growth Hormones |
EP1877439B1 (fr) | 2005-04-18 | 2011-02-09 | Novo Nordisk A/S | Variantes de l'il-21 |
US8293708B2 (en) | 2005-08-30 | 2012-10-23 | Novo Nordisk Health Care A/G | Liquid formulations N-terminal serine of pegylated growth hormone |
AU2006311568B2 (en) | 2005-11-08 | 2010-11-11 | Ambrx, Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
US20080317670A1 (en) | 2005-12-14 | 2008-12-25 | Ambrx, Inc. | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides |
KR20100014215A (ko) | 2006-07-07 | 2010-02-10 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 신규 단백질 접합체 및 그것의 제조 방법 |
CN101108895B (zh) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
JP2010507382A (ja) | 2006-10-26 | 2010-03-11 | ノヴォ ノルディスク アクティーゼルスカブ | Il−21変異体 |
CL2008002399A1 (es) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
CA2720306C (fr) | 2008-04-03 | 2016-03-15 | Biosteed Gene Expression Tech. Co., Ltd. | Hormone de croissance modifiee par polyethyleneglycol double brin, son procede de preparation et son application |
KR101104574B1 (ko) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도 |
KR101533757B1 (ko) * | 2008-07-31 | 2015-07-03 | 파마이센시아 코퍼레이션 | 펩티드-중합체 접합체 |
WO2010015668A1 (fr) | 2008-08-06 | 2010-02-11 | Novo Nordisk A/S | Protéines conjuguées à efficacité in vivo prolongée |
RU2409669C9 (ru) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
JP5766118B2 (ja) * | 2008-09-11 | 2015-08-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法 |
EP2389389B1 (fr) | 2009-01-22 | 2015-04-15 | Novo Nordisk Health Care AG | Composés d'hormone de croissance stables |
CN105963710A (zh) | 2009-08-06 | 2016-09-28 | 诺沃—诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
CN102711733A (zh) | 2009-12-15 | 2012-10-03 | 阿森迪斯药物股份有限公司 | 瞬时连接于聚合物载体的干生长激素组合物 |
US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
KR101813595B1 (ko) | 2010-01-22 | 2017-12-29 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 장기적 생체 내 효능을 갖는 성장 호르몬 |
NZ603399A (en) * | 2010-05-17 | 2014-09-26 | Cebix Inc | Pegylated c-peptide |
EP2446898A1 (fr) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de l'hormone de croissance pour améliorer la réponse immunitaire chez des patients immunodéprimés |
EA019967B1 (ru) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Ковалентный конъюгат полиэтиленгликоля с гормоном роста человека |
EP2981282B1 (fr) | 2013-04-05 | 2020-11-04 | Novo Nordisk Health Care AG | Formulation d'un composé d'hormone de croissance |
WO2016073825A1 (fr) | 2014-11-06 | 2016-05-12 | Pharmaessentia Corporation | Régime posologique pour l'interféron pégylé |
ES2896971T3 (es) | 2014-11-21 | 2022-02-28 | Ascendis Pharma Endocrinology Div A/S | Formas de administración de hormona del crecimiento de acción prolongada |
US20190290733A1 (en) * | 2015-03-11 | 2019-09-26 | Nektar Therapeutics | Conjugates of an il-7 moiety and a polymer |
RU2738416C2 (ru) * | 2015-09-18 | 2020-12-14 | Юниверсити Оф Миязаки | Длительно действующее производное адреномедуллина |
CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
ES2113354T3 (es) * | 1990-05-04 | 1998-05-01 | American Cyanamid Co | Estabilizacion de somatotropinas y otras proteinas por modificacion de residuos de cisteina. |
JPH06506217A (ja) * | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体 |
AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
DE69638117D1 (de) * | 1995-09-21 | 2010-03-04 | Genentech Inc | Varianten des menschlichen Wachstumshormons |
WO1999003887A1 (fr) * | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derives d'hormone de croissance et proteines associees |
IL144259A0 (en) * | 1999-01-14 | 2002-05-23 | Bolder Biotechnology Inc | Methods for making proteins containing free cysteine residues |
ATE246202T1 (de) * | 1999-01-29 | 2003-08-15 | Hoffmann La Roche | Gcsf konjugate |
AU2001289307A1 (en) * | 2000-04-06 | 2001-10-23 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
JP2004524020A (ja) * | 2001-01-11 | 2004-08-12 | マキシゲン・エイピーエス | 改良された成長ホルモン分子 |
-
2002
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/es not_active Application Discontinuation
- 2002-11-20 EA EA200700431A patent/EA200700431A1/ru unknown
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/fr not_active Abandoned
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/fr not_active Application Discontinuation
- 2002-11-20 EP EP02803695A patent/EP1453859A2/fr not_active Withdrawn
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/ja active Pending
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/pt not_active IP Right Cessation
- 2002-11-20 RS YU53104A patent/RS53104A/sr unknown
- 2002-11-20 CN CNA028259289A patent/CN1608079A/zh active Pending
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/ko active IP Right Grant
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 PL PL02374354A patent/PL374354A1/xx unknown
- 2002-11-20 EA EA200400565A patent/EA008505B1/ru unknown
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/ko not_active Application Discontinuation
- 2002-11-20 IL IL16203102A patent/IL162031A0/xx unknown
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/hu unknown
-
2004
- 2004-05-17 IS IS7268A patent/IS7268A/is unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/fr unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/hr not_active Application Discontinuation
- 2004-05-20 CO CO04046633A patent/CO5580794A2/es not_active Application Discontinuation
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/es unknown
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/fr unknown
- 2004-05-26 NO NO20042182A patent/NO20042182L/no not_active Application Discontinuation
-
2006
- 2006-07-14 JP JP2006193577A patent/JP2006321808A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EA200700431A1 (ru) | 2008-02-28 |
HRP20040448A2 (en) | 2006-02-28 |
PL374354A1 (en) | 2005-10-17 |
KR20070072924A (ko) | 2007-07-06 |
CA2467731A1 (fr) | 2003-05-30 |
EA008505B1 (ru) | 2007-06-29 |
BR0214451A (pt) | 2006-05-30 |
MXPA04004809A (es) | 2004-08-11 |
MA27544A1 (fr) | 2005-10-03 |
ZA200403907B (en) | 2007-12-27 |
WO2003044056A2 (fr) | 2003-05-30 |
CN1608079A (zh) | 2005-04-20 |
NO20042182L (no) | 2004-08-11 |
JP2005525302A (ja) | 2005-08-25 |
ECSP045114A (es) | 2004-07-23 |
WO2003044056A3 (fr) | 2003-08-21 |
OA13063A (en) | 2006-11-10 |
GEP20063860B (en) | 2006-06-26 |
KR20050044858A (ko) | 2005-05-13 |
HUP0500997A2 (en) | 2007-11-28 |
CO5580794A2 (es) | 2005-11-30 |
EA200400565A1 (ru) | 2005-06-30 |
AP2004003050A0 (en) | 2004-06-30 |
EP1453859A2 (fr) | 2004-09-08 |
JP2006321808A (ja) | 2006-11-30 |
AU2002356990A1 (en) | 2003-06-10 |
IL162031A0 (en) | 2005-11-20 |
IS7268A (is) | 2004-05-17 |
RS53104A (en) | 2006-10-27 |
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