RU2227042C2 - Композиции и способы системной доставки пероральных вакцин и терапевтических агентов - Google Patents
Композиции и способы системной доставки пероральных вакцин и терапевтических агентов Download PDFInfo
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- RU2227042C2 RU2227042C2 RU2000112547/15A RU2000112547A RU2227042C2 RU 2227042 C2 RU2227042 C2 RU 2227042C2 RU 2000112547/15 A RU2000112547/15 A RU 2000112547/15A RU 2000112547 A RU2000112547 A RU 2000112547A RU 2227042 C2 RU2227042 C2 RU 2227042C2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/832—Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к химико-фармацевтической промышленности и касается композиций и способов системной доставки пероральных вакцин и терапевтических агентов. Сущность изобретения включает композиции и способы пероральной доставки антигена или терапевтического агента в общий кровоток с использованием модифицированного ботулинического токсина, который изменен с помощью модификации или делеции одной из аминокислот: His(229), Glu(230) и His(223), который способен транслоцироваться из кишечника в общий кровоток, но является нетоксичным. Преимущество изобретения заключается в снижении токсичности. 5 с. и 4 з.п. ф-лы, 2 ил.
Description
Текст описания в факсимильном виде (см. графическую часть).
Claims (9)
1. Модифицированный ботулинический токсин, содержащий ботулинический токсин, способный к транслокации из кишечника в общий кровоток, который изменен с тем, чтобы быть нетоксичным, путем устранения в значительной степени металлоэндопротеазной активности легкой цепи путем изменения цинксвязывающего мотива легкой цепи с помощью модификации или делеции одной из аминокислот His (229), Glu (230) и His (223).
2. Модифицированный ботулинический токсин по п.1, дополнительно содержащий соединенный с ним выбранный антиген.
3. Модифицированный ботулинический токсин по п.1, дополнительно содержащий связанный с ним терапевтический агент.
4. Модифицированный ботулинический токсин, содержащий ботулинический токсин, способный к транслокации из кишечника в общий кровоток, который изменен с тем, чтобы быть нетоксичным, путем устранения в значительной степени металлоэндопротеазной активности легкой цепи путем изменения цинксвязывающего мотива легкой цепи с помощью модификации или делеции всех трех аминокислот His (229), Glu (230) и His (223) .
5. Модифицированный ботулинический токсин по п.4, дополнительно содержащий соединенный с ним выбранный антиген.
6. Модифицированный ботулинический токсин по п.4, дополнительно содержащий связанный с ним терапевтический агент.
7. Пероральная вакцина против ботулизма, содержащая модифицированный ботулинический токсин по п.1 или 4 и фармацевтически приемлемый носитель.
8. Пероральная вакцина против выбранного антигена, содержащая модифицированный ботулинический токсин по п.2 или 5 и фармацевтически приемлемый носитель.
9. Способ пероральной доставки терапевтического агента животному, включающий введение животному модифицированного ботулинического токсина по п.3 или 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/954,302 | 1997-10-20 | ||
| US08/954,302 US6051239A (en) | 1997-10-20 | 1997-10-20 | Compositions and methods for systemic delivery of oral vaccines and therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000112547A RU2000112547A (ru) | 2002-05-20 |
| RU2227042C2 true RU2227042C2 (ru) | 2004-04-20 |
Family
ID=25495232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000112547/15A RU2227042C2 (ru) | 1997-10-20 | 1998-10-16 | Композиции и способы системной доставки пероральных вакцин и терапевтических агентов |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6051239A (ru) |
| EP (1) | EP1024827B1 (ru) |
| JP (1) | JP2001522783A (ru) |
| KR (1) | KR100594787B1 (ru) |
| CN (1) | CN1246038C (ru) |
| AT (1) | ATE355076T1 (ru) |
| AU (1) | AU756475B2 (ru) |
| BR (1) | BR9815255A (ru) |
| CA (1) | CA2306995A1 (ru) |
| DE (1) | DE69837209T2 (ru) |
| EE (1) | EE200000536A (ru) |
| HU (1) | HUP0101017A3 (ru) |
| IL (1) | IL135743A (ru) |
| NZ (1) | NZ504549A (ru) |
| RU (1) | RU2227042C2 (ru) |
| WO (1) | WO1999020306A1 (ru) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7227010B2 (en) | 1993-09-21 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
| US6967088B1 (en) * | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
| US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| US8632785B2 (en) * | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
| CN1258379C (zh) * | 2000-02-08 | 2006-06-07 | 阿勒根公司 | 肉毒杆菌毒素药物组合物 |
| US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
| US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
| DE60130266D1 (de) * | 2000-11-06 | 2007-10-11 | Us Army Med Res Mat Command | Rekombinante leichte kette des botolinum neurotoxins and fusionsproteine davon zur verwendung in forschung und klinischer therapie |
| US7273722B2 (en) * | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| JP4707254B2 (ja) * | 2001-04-24 | 2011-06-22 | クミアイ化学工業株式会社 | 粒状組成物及びその製造方法 |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| AU2003237346A1 (en) * | 2002-05-31 | 2003-12-19 | Thomas Jefferson University | Compositions and methods for transepithelial molecular transport |
| US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
| AU2003287622A1 (en) * | 2002-11-06 | 2004-06-03 | Fraunhofer Usa | Expression of foreign sequences in plants using trans-activation system |
| US7683238B2 (en) * | 2002-11-12 | 2010-03-23 | iBio, Inc. and Fraunhofer USA, Inc. | Production of pharmaceutically active proteins in sprouted seedlings |
| US7692063B2 (en) * | 2002-11-12 | 2010-04-06 | Ibio, Inc. | Production of foreign nucleic acids and polypeptides in sprout systems |
| CN100525831C (zh) * | 2002-12-20 | 2009-08-12 | 肉毒素研究同仁股份有限公司 | 改进的药用肉毒杆菌毒素组合物 |
| ES2531125T3 (es) | 2003-02-03 | 2015-03-10 | Ibio Inc | Sistema para la expresión de genes en plantas |
| US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
| US7172764B2 (en) * | 2003-11-17 | 2007-02-06 | Allergan, Inc. | Rescue agents for treating botulinum toxin intoxications |
| US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
| CA2555230A1 (en) * | 2004-02-20 | 2005-09-09 | Fraunhofer Usa Inc. | Systems and methods for clonal expression in plants |
| US7306807B2 (en) | 2004-09-13 | 2007-12-11 | Wyeth | Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease |
| CA2588758C (en) * | 2004-11-22 | 2017-01-03 | New York University | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof |
| WO2007042884A1 (en) | 2005-10-07 | 2007-04-19 | Pfizer Products Inc. | Vaccines and methods to treat canine influenza |
| EP1931379B1 (en) | 2005-10-07 | 2013-05-29 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
| WO2008150404A1 (en) * | 2007-05-30 | 2008-12-11 | Wyeth | Raccoon poxvirus expressing genes of feline antigens |
| US8445650B2 (en) * | 2007-09-25 | 2013-05-21 | Thomas Jefferson University | Mutant botulinum neurotoxin serotype A polypeptide and uses thereof |
| CA2745657C (en) | 2008-12-04 | 2022-06-21 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
| US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
| US9315549B2 (en) | 2013-01-28 | 2016-04-19 | New York University | Treatment methods using atoxic neurotoxin derivatives |
| US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| CA2969463A1 (en) | 2014-12-09 | 2016-06-16 | New York University | Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use |
| SG11202005757SA (en) | 2017-12-20 | 2020-07-29 | Allergan Inc | Botulinum toxin cell binding domain polypeptides and methods of use for skin rejuvenation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919665A (en) * | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
| DE69511860T2 (de) * | 1994-05-31 | 2000-02-10 | Allergan, Inc. | Modifizierung von clostridium-toxinen und ihre anwendung als transport proteine |
| ATE366312T1 (de) * | 1994-10-24 | 2007-07-15 | Ophidian Pharm Inc | Impfstoff und antitoxine zur behandlung und vorbeugung von c. difficile krankheiten |
| WO1996040229A1 (en) * | 1995-06-07 | 1996-12-19 | Thomas Jefferson University | Vaccines synthesized by transgenic plants |
-
1997
- 1997-10-20 US US08/954,302 patent/US6051239A/en not_active Expired - Fee Related
-
1998
- 1998-10-16 DE DE69837209T patent/DE69837209T2/de not_active Expired - Fee Related
- 1998-10-16 KR KR1020007004197A patent/KR100594787B1/ko not_active IP Right Cessation
- 1998-10-16 RU RU2000112547/15A patent/RU2227042C2/ru not_active IP Right Cessation
- 1998-10-16 BR BR9815255-6A patent/BR9815255A/pt not_active Application Discontinuation
- 1998-10-16 EP EP98953617A patent/EP1024827B1/en not_active Expired - Lifetime
- 1998-10-16 JP JP2000516701A patent/JP2001522783A/ja active Pending
- 1998-10-16 IL IL13574398A patent/IL135743A/en not_active IP Right Cessation
- 1998-10-16 NZ NZ504549A patent/NZ504549A/xx unknown
- 1998-10-16 WO PCT/US1998/021897 patent/WO1999020306A1/en active IP Right Grant
- 1998-10-16 HU HU0101017A patent/HUP0101017A3/hu unknown
- 1998-10-16 CA CA002306995A patent/CA2306995A1/en not_active Abandoned
- 1998-10-16 CN CNB988112981A patent/CN1246038C/zh not_active Expired - Fee Related
- 1998-10-16 AT AT98953617T patent/ATE355076T1/de not_active IP Right Cessation
- 1998-10-16 EE EEP200000536A patent/EE200000536A/xx unknown
- 1998-10-16 AU AU10947/99A patent/AU756475B2/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| ZHOU et al. Expression and purification of the hight chain of botulinum neurotoxin A; a single mutation abolish its clevage of SNAP-25 and neurotoxicity after reconstitution with heavy chain. Biochemistry. - 1995, v. 34, p. 15174-15181. FERRER-MONTIEL et al. Phosphorylation modulators the activity of clostridial neurotoxins. J. Biol. Chem. - 1996, v. 271, N 1, p. 18322-18325. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1290174A (zh) | 2001-04-04 |
| WO1999020306A1 (en) | 1999-04-29 |
| IL135743A (en) | 2004-03-28 |
| EP1024827A1 (en) | 2000-08-09 |
| BR9815255A (pt) | 2001-12-26 |
| JP2001522783A (ja) | 2001-11-20 |
| NZ504549A (en) | 2002-12-20 |
| EE200000536A (et) | 2002-04-15 |
| AU756475B2 (en) | 2003-01-16 |
| US6051239A (en) | 2000-04-18 |
| EP1024827A4 (en) | 2002-08-28 |
| KR20010031236A (ko) | 2001-04-16 |
| DE69837209D1 (de) | 2007-04-12 |
| AU1094799A (en) | 1999-05-10 |
| HUP0101017A3 (en) | 2003-11-28 |
| DE69837209T2 (de) | 2007-10-31 |
| EP1024827B1 (en) | 2007-02-28 |
| HUP0101017A2 (hu) | 2001-07-30 |
| CA2306995A1 (en) | 1999-04-29 |
| KR100594787B1 (ko) | 2006-07-03 |
| IL135743A0 (en) | 2001-05-20 |
| CN1246038C (zh) | 2006-03-22 |
| ATE355076T1 (de) | 2006-03-15 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20071017 |