TNSN04052A1 - Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladie - Google Patents
Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladieInfo
- Publication number
- TNSN04052A1 TNSN04052A1 TNP2004000052A TNSN04052A TNSN04052A1 TN SN04052 A1 TNSN04052 A1 TN SN04052A1 TN P2004000052 A TNP2004000052 A TN P2004000052A TN SN04052 A TNSN04052 A TN SN04052A TN SN04052 A1 TNSN04052 A1 TN SN04052A1
- Authority
- TN
- Tunisia
- Prior art keywords
- azabicyclic
- disease
- treatment
- heteroaryl compounds
- substituted condensed
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
LA PRESENTE INVENTION PROPOSE DES COMPOSES DE FORMULE I; DANS LAQUELLE LE SUBSTITUANT AZABICYCLO REPOND AUX FORMULES (II-VII); W REPOND AUX FORMULES (VIII-X). CES COMPOSES PEUVENT ETRE SOUS FORME DE SELS OU COMPOSITIONS PHARMACEUTIQUES; DE LEURS MELANGES RACEMIQUES OU DE LEURS ENANTIOMERES PURS. LES COMPOSES DE FORMULE I SONT UTILES DANS DES PRODUITS PHARMACEUTIQUES; EN CAS D'IMPLICATION Dα'7.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32662901P | 2001-10-02 | 2001-10-02 | |
US32656501P | 2001-10-02 | 2001-10-02 | |
US33488601P | 2001-11-15 | 2001-11-15 | |
US33963301P | 2001-12-12 | 2001-12-12 | |
PCT/US2002/029827 WO2003029252A1 (fr) | 2001-10-02 | 2002-10-01 | Composes d'heteoraryle fusionne substitues par azabicyclo utiles pour le traitement de maladies |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN04052A1 true TNSN04052A1 (fr) | 2006-06-01 |
Family
ID=27502335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2004000052A TNSN04052A1 (fr) | 2001-10-02 | 2004-04-01 | Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladie |
Country Status (31)
Country | Link |
---|---|
US (3) | US6911543B2 (fr) |
EP (1) | EP1432707B1 (fr) |
JP (1) | JP4371811B2 (fr) |
KR (1) | KR100614900B1 (fr) |
AP (1) | AP1635A (fr) |
AR (1) | AR037740A1 (fr) |
AT (1) | ATE551340T1 (fr) |
BG (1) | BG108650A (fr) |
BR (1) | BR0213612A (fr) |
CA (1) | CA2462453C (fr) |
CO (1) | CO5570667A2 (fr) |
CZ (1) | CZ2004408A3 (fr) |
DK (1) | DK1432707T3 (fr) |
EA (1) | EA007429B1 (fr) |
ES (1) | ES2383001T3 (fr) |
GE (1) | GEP20063814B (fr) |
HR (1) | HRP20040259A2 (fr) |
HU (1) | HUP0402289A2 (fr) |
IL (1) | IL160884A0 (fr) |
IS (1) | IS7188A (fr) |
MA (1) | MA27138A1 (fr) |
MX (1) | MXPA04003007A (fr) |
MY (1) | MY138252A (fr) |
NO (1) | NO20041368L (fr) |
NZ (1) | NZ531786A (fr) |
OA (1) | OA12708A (fr) |
PL (1) | PL369895A1 (fr) |
RS (1) | RS28004A (fr) |
SK (1) | SK1562004A3 (fr) |
TN (1) | TNSN04052A1 (fr) |
WO (1) | WO2003029252A1 (fr) |
Families Citing this family (53)
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AR036040A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
DE10164139A1 (de) * | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
WO2003104227A1 (fr) * | 2002-01-20 | 2003-12-18 | Bayer Healthcare Ag | 2-heteroarylcarboxamides |
EP1542999A1 (fr) * | 2002-08-01 | 2005-06-22 | Pharmacia & Upjohn Company LLC | Composes azabicyclique de 1h-pyrazole et 1h-pyrrole servant a effectuer un traitement therapeutique |
KR101129933B1 (ko) | 2002-09-25 | 2012-03-23 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸 및 벤조이소티아졸 및 그의 제조 및용도 |
BR0315056A (pt) * | 2002-11-01 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central |
AU2003269413A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
US7273872B2 (en) * | 2002-12-06 | 2007-09-25 | The Feinstein Institute For Medical Research | Inhibition of inflammation using α 7 receptor-binding cholinergic agonists |
PL1747220T3 (pl) | 2003-12-11 | 2009-09-30 | Aventis Pharma Inc | Podstawione 1H-pirolo[3,2-b, 3,2-c i 2,3-c]pirydyno-2-karboksyamidy oraz pokrewne analogi jako inhibitory kinazy kazeinowej l epsilon |
PL1697378T3 (pl) * | 2003-12-22 | 2008-04-30 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzoizoksazole i 1,2-benzoizotiazole oraz ich wytwarzanie i zastosowania |
CA2549638A1 (fr) * | 2003-12-23 | 2005-07-14 | Pfizer Products Inc. | Combinaison therapeutique d'amelioration neuro-cognitive et de traitement de troubles psychotiques |
JP4995075B2 (ja) | 2004-03-25 | 2012-08-08 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、ベンゾイソチアゾール、ベンズイソキサゾール、ならびにそれらの調製および使用 |
US7488737B2 (en) | 2004-04-22 | 2009-02-10 | Memory Pharmaceutical Corporation | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
EP1744750A2 (fr) * | 2004-05-06 | 2007-01-24 | Sandoz AG | Composition pharmaceutique comprenant un medicament hydrophobe a solubilite amelioree |
AU2005243147A1 (en) * | 2004-05-07 | 2005-11-24 | Memory Pharmaceuticals Corporation | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
DE602005019094D1 (de) | 2004-12-22 | 2010-03-11 | Memory Pharmaceutical Corp | Nikotinische alpha-7-rezeptorliganden gegen erkrankungen des zns |
WO2006101745A2 (fr) * | 2005-03-18 | 2006-09-28 | Abbott Laboratories | Ligand du recepteur nicotinique neuronal ?7 et compositions antipsychotiques |
FR2884822B1 (fr) * | 2005-04-22 | 2007-06-29 | Aventis Pharma Sa | Derives de triazines, leur preparation et leur application en therapeutique |
EP1934228A2 (fr) * | 2005-09-01 | 2008-06-25 | Array Biopharma, Inc. | Composes inhibiteurs de la raf kinase et procedes d'utilisation de ceux-ci |
US8106066B2 (en) * | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
RU2010107462A (ru) * | 2007-08-02 | 2011-09-10 | Таргасепт, Инк. (Us) | ЛЕЧЕНИЕ α7-СЕЛЕКТИВНЫМИ ЛИГАНДАМИ |
US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
CN105687190A (zh) | 2008-11-19 | 2016-06-22 | 福拉姆医药股份有限公司 | 用(R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺及其可药用盐治疗认知障碍 |
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RU2011150248A (ru) * | 2009-05-11 | 2013-06-20 | Энвиво Фармасьютикалз, Инк. | Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы |
WO2011022692A2 (fr) * | 2009-08-20 | 2011-02-24 | University Of Tennessee Research Foundation, The | Composés de cannabinoïde furanopyridine et procédés dutilisation afférents |
MX2012008082A (es) * | 2010-01-11 | 2013-02-07 | Astraea Therapeutics Llc | Moduladores del receptor nicotinico de acetilcolina. |
GB201002563D0 (en) | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
AU2011256287B2 (en) | 2010-05-17 | 2016-11-10 | Envivo Pharmaceuticals, Inc. | A crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
KR20140027939A (ko) | 2011-06-30 | 2014-03-07 | 도레이 카부시키가이샤 | 지양제 |
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WO2015116904A1 (fr) | 2014-02-03 | 2015-08-06 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de ror-gamma à base de dihydropyrrolopyridine |
WO2016012896A1 (fr) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Composés de pyrazolopyrimidine |
CN106795165B (zh) | 2014-08-06 | 2019-09-10 | 辉瑞公司 | 咪唑并哒嗪化合物 |
WO2016061160A1 (fr) | 2014-10-14 | 2016-04-21 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de ror-gamma à base de dihydropyrrolopyridine |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
AU2015362790A1 (en) | 2014-12-16 | 2017-07-20 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
MX2017016231A (es) * | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
RU2018121946A (ru) | 2015-11-20 | 2019-12-23 | Вайтаи Фармасьютиклз, Ллк | Модуляторы ror-гамма |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
AU2017221404A1 (en) * | 2016-02-16 | 2018-08-23 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
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WO2018063552A1 (fr) | 2016-09-30 | 2018-04-05 | Vanderbilt University | Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m1 |
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MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
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SE9900100D0 (sv) * | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
WO2000073431A2 (fr) | 1999-05-27 | 2000-12-07 | Pharmacia & Upjohn Company | Techniques et compositions permettant de mesurer la conductance du canal ionique |
SE9904176D0 (sv) * | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
TWI256314B (en) * | 2000-02-09 | 2006-06-11 | Mitsubishi Pharma Corp | Preventive-therapeutical medicament for gastroesophageal reflux disease |
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
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-
2002
- 2002-10-01 PL PL02369895A patent/PL369895A1/xx not_active Application Discontinuation
- 2002-10-01 RS YUP-280/04A patent/RS28004A/sr unknown
- 2002-10-01 AP APAP/P/2004/003002A patent/AP1635A/en active
- 2002-10-01 EA EA200400387A patent/EA007429B1/ru unknown
- 2002-10-01 MX MXPA04003007A patent/MXPA04003007A/es unknown
- 2002-10-01 EP EP02778286A patent/EP1432707B1/fr not_active Expired - Lifetime
- 2002-10-01 DK DK02778286.1T patent/DK1432707T3/da active
- 2002-10-01 KR KR1020047004871A patent/KR100614900B1/ko not_active IP Right Cessation
- 2002-10-01 ES ES02778286T patent/ES2383001T3/es not_active Expired - Lifetime
- 2002-10-01 AT AT02778286T patent/ATE551340T1/de active
- 2002-10-01 OA OA1200400087A patent/OA12708A/en unknown
- 2002-10-01 CA CA002462453A patent/CA2462453C/fr not_active Expired - Fee Related
- 2002-10-01 IL IL16088402A patent/IL160884A0/xx unknown
- 2002-10-01 CZ CZ2004408A patent/CZ2004408A3/cs unknown
- 2002-10-01 US US10/262,257 patent/US6911543B2/en not_active Expired - Fee Related
- 2002-10-01 GE GE5551A patent/GEP20063814B/en unknown
- 2002-10-01 NZ NZ531786A patent/NZ531786A/en unknown
- 2002-10-01 HU HU0402289A patent/HUP0402289A2/hu unknown
- 2002-10-01 BR BR0213612-0A patent/BR0213612A/pt not_active IP Right Cessation
- 2002-10-01 SK SK156-2004A patent/SK1562004A3/sk unknown
- 2002-10-01 JP JP2003532500A patent/JP4371811B2/ja not_active Expired - Fee Related
- 2002-10-01 WO PCT/US2002/029827 patent/WO2003029252A1/fr active Application Filing
- 2002-10-02 AR ARP020103718A patent/AR037740A1/es unknown
- 2002-10-02 MY MYPI20023689A patent/MY138252A/en unknown
-
2004
- 2004-03-17 HR HR20040259A patent/HRP20040259A2/hr not_active Application Discontinuation
- 2004-03-18 IS IS7188A patent/IS7188A/is unknown
- 2004-03-24 BG BG108650A patent/BG108650A/xx unknown
- 2004-03-30 CO CO04030193A patent/CO5570667A2/es not_active Application Discontinuation
- 2004-04-01 TN TNP2004000052A patent/TNSN04052A1/fr unknown
- 2004-04-01 MA MA27603A patent/MA27138A1/fr unknown
- 2004-04-01 NO NO20041368A patent/NO20041368L/no not_active Application Discontinuation
-
2005
- 2005-05-26 US US11/139,066 patent/US20050234092A1/en not_active Abandoned
- 2005-05-26 US US11/137,912 patent/US20050222196A1/en not_active Abandoned
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