TN2010000230A1 - Agonistes nouveaux des recepteurs de glucocorticoides - Google Patents
Agonistes nouveaux des recepteurs de glucocorticoidesInfo
- Publication number
- TN2010000230A1 TN2010000230A1 TN2010000230A TN2010000230A TN2010000230A1 TN 2010000230 A1 TN2010000230 A1 TN 2010000230A1 TN 2010000230 A TN2010000230 A TN 2010000230A TN 2010000230 A TN2010000230 A TN 2010000230A TN 2010000230 A1 TN2010000230 A1 TN 2010000230A1
- Authority
- TN
- Tunisia
- Prior art keywords
- glucocorticoid receptors
- new agonists
- relates
- agonists
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cette invention concerne des agonistes nouveaux des récepteurs de glucocorticoïdes de formule (I) et des procédés et intermédiaires pour leur préparation. La présente invention concerne également des compositions pharmaceutiques contenant ces composés, leur association avec un ou plusieurs autres agents thérapeutiques, ainsi que leur utilisation pour le traitement d'un certain nombre de maladies, troubles et affections inflammatoires et allergiques.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99135407P | 2007-11-30 | 2007-11-30 | |
US5724108P | 2008-05-30 | 2008-05-30 | |
US7955508P | 2008-07-10 | 2008-07-10 | |
PCT/IB2008/054801 WO2009069032A2 (fr) | 2007-11-30 | 2008-11-17 | Nouveaux agonistes des récepteurs des glucocorticoïdes |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000230A1 true TN2010000230A1 (fr) | 2011-11-11 |
Family
ID=40427125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2010000230A TN2010000230A1 (fr) | 2007-11-30 | 2010-05-21 | Agonistes nouveaux des recepteurs de glucocorticoides |
Country Status (33)
Country | Link |
---|---|
US (2) | US8822439B2 (fr) |
EP (1) | EP2225256B1 (fr) |
JP (1) | JP4686650B2 (fr) |
KR (1) | KR101295998B1 (fr) |
CN (1) | CN101878221B (fr) |
AP (1) | AP2010005267A0 (fr) |
AR (1) | AR069490A1 (fr) |
AU (1) | AU2008331187B2 (fr) |
BR (1) | BRPI0820447A2 (fr) |
CA (1) | CA2706180C (fr) |
CL (1) | CL2008003549A1 (fr) |
CO (1) | CO6280401A2 (fr) |
CR (1) | CR11393A (fr) |
DK (1) | DK2225256T3 (fr) |
DO (1) | DOP2010000161A (fr) |
EA (1) | EA201070535A1 (fr) |
EC (1) | ECSP10010209A (fr) |
ES (1) | ES2399945T3 (fr) |
GT (1) | GT201000153A (fr) |
HK (1) | HK1144821A1 (fr) |
IL (1) | IL205356A0 (fr) |
MA (1) | MA31867B1 (fr) |
MX (1) | MX2010005861A (fr) |
NI (1) | NI201000090A (fr) |
NZ (1) | NZ585434A (fr) |
PA (1) | PA8805801A1 (fr) |
PE (1) | PE20091072A1 (fr) |
SV (1) | SV2010003580A (fr) |
TN (1) | TN2010000230A1 (fr) |
TW (1) | TW200930378A (fr) |
UY (1) | UY31496A1 (fr) |
WO (1) | WO2009069032A2 (fr) |
ZA (1) | ZA201003439B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5858929B2 (ja) * | 2010-01-15 | 2016-02-10 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Dexおよびgdf8を用いたスクリーニングアッセイ |
TW201139369A (en) | 2010-02-05 | 2011-11-16 | Chiesi Farma Spa | Pyrrolidine derivatives |
KR20140039161A (ko) * | 2011-03-15 | 2014-04-01 | 키에시 파르마슈티시 엣스. 피. 에이. | 이소옥사졸리딘 유도체 |
SG193262A1 (en) * | 2011-03-15 | 2013-10-30 | Chiesi Farma Spa | Isoxazolidine derivatives |
FR2984325A1 (fr) * | 2011-12-14 | 2013-06-21 | Sanofi Sa | Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique |
TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
WO2014094357A1 (fr) | 2012-12-21 | 2014-06-26 | Abbvie Inc. | Modulateurs hétérocycliques des récepteurs nucléaires aux hormones |
AU2014228990B2 (en) * | 2013-03-15 | 2017-02-02 | Aprecia Pharmaceuticals LLC | Rapid disperse dosage form containing levetiracetam |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
WO2016133967A2 (fr) | 2015-02-18 | 2016-08-25 | Parion Sciences, Inc. | Bloqueurs de canaux sodiques pour le traitement de troubles de la peau |
CA3025377A1 (fr) | 2016-06-02 | 2017-12-07 | Abbvie Inc. | Agoniste du recepteur des glucocorticoides et immunoconjugues de celui-ci |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN114732910A (zh) | 2017-10-05 | 2022-07-12 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
EP3716982A4 (fr) * | 2017-12-01 | 2021-08-11 | AbbVie Inc. | Conjugués médicament-anticorps anti-cd40 |
RU2020117698A (ru) * | 2017-12-01 | 2022-01-04 | Эббви Инк. | Агонист глюкокортикоидного рецептора и его иммуноконъюгаты |
EP3768324A1 (fr) | 2018-03-22 | 2021-01-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de modulation de l'activité des cellules lymphoïdes innées, conjugués anticorps-médicaments et leurs utilisations en thérapie |
CN109575097A (zh) * | 2019-01-20 | 2019-04-05 | 湖南科瑞生物制药股份有限公司 | 一种16a-羟基***龙产品的新的制备方法 |
CN109651474A (zh) * | 2019-01-20 | 2019-04-19 | 湖南科瑞生物制药股份有限公司 | 一种16a-羟基***龙的新的制备方法 |
CN109734763A (zh) * | 2019-01-20 | 2019-05-10 | 湖南科瑞生物制药股份有限公司 | 一种16a-羟基醋酸***龙产品的制备方法 |
CN109575095A (zh) * | 2019-01-20 | 2019-04-05 | 湖南科瑞生物制药股份有限公司 | 一种16a-羟基醋酸***龙的制备方法 |
TW202304462A (zh) | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | 糖皮質素受體激動劑 |
AR125079A1 (es) | 2021-03-23 | 2023-06-07 | Lilly Co Eli | Agonistas de receptores de glucocorticoides sustituidos con carboxi |
CN117580849A (zh) * | 2021-06-24 | 2024-02-20 | 江苏先声药业有限公司 | 甾体类化合物、其药物组合物及其应用 |
JP2023184489A (ja) * | 2022-06-16 | 2023-12-28 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | 抗cd19抗体薬物コンジュゲート |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3197469A (en) * | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
CA2528776A1 (fr) | 2002-10-24 | 2004-05-06 | G & R Pharmaceuticals, Llc | Preparations antifongiques |
WO2005044759A2 (fr) * | 2003-08-14 | 2005-05-19 | Sun Pharmaceutical Industries Limited | Acetalisation pour preparation de composes steroides |
WO2005028495A1 (fr) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Glucocorticoïdes anti-inflammatoires |
GB0402797D0 (en) | 2004-02-09 | 2004-03-10 | Novartis Ag | Organic compounds |
US20050227927A1 (en) | 2004-03-31 | 2005-10-13 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis |
-
2008
- 2008-11-17 NZ NZ585434A patent/NZ585434A/en not_active IP Right Cessation
- 2008-11-17 AU AU2008331187A patent/AU2008331187B2/en not_active Ceased
- 2008-11-17 JP JP2010535483A patent/JP4686650B2/ja not_active Expired - Fee Related
- 2008-11-17 CN CN200880118275.8A patent/CN101878221B/zh not_active Expired - Fee Related
- 2008-11-17 DK DK08854982.9T patent/DK2225256T3/da active
- 2008-11-17 AP AP2010005267A patent/AP2010005267A0/en unknown
- 2008-11-17 KR KR1020107011610A patent/KR101295998B1/ko not_active IP Right Cessation
- 2008-11-17 ES ES08854982T patent/ES2399945T3/es active Active
- 2008-11-17 CA CA2706180A patent/CA2706180C/fr not_active Expired - Fee Related
- 2008-11-17 MX MX2010005861A patent/MX2010005861A/es active IP Right Grant
- 2008-11-17 EA EA201070535A patent/EA201070535A1/ru unknown
- 2008-11-17 EP EP08854982A patent/EP2225256B1/fr active Active
- 2008-11-17 BR BRPI0820447-0A patent/BRPI0820447A2/pt not_active IP Right Cessation
- 2008-11-17 WO PCT/IB2008/054801 patent/WO2009069032A2/fr active Application Filing
- 2008-11-24 US US12/276,925 patent/US8822439B2/en not_active Expired - Fee Related
- 2008-11-27 PA PA20088805801A patent/PA8805801A1/es unknown
- 2008-11-28 UY UY31496A patent/UY31496A1/es not_active Application Discontinuation
- 2008-11-28 AR ARP080105201A patent/AR069490A1/es not_active Application Discontinuation
- 2008-11-28 CL CL2008003549A patent/CL2008003549A1/es unknown
- 2008-11-28 TW TW097146518A patent/TW200930378A/zh unknown
- 2008-11-28 PE PE2008001996A patent/PE20091072A1/es not_active Application Discontinuation
-
2010
- 2010-04-26 CR CR11393A patent/CR11393A/es not_active Application Discontinuation
- 2010-04-26 IL IL205356A patent/IL205356A0/en unknown
- 2010-05-14 ZA ZA2010/03439A patent/ZA201003439B/en unknown
- 2010-05-21 TN TN2010000230A patent/TN2010000230A1/fr unknown
- 2010-05-24 GT GT201000153A patent/GT201000153A/es unknown
- 2010-05-25 NI NI201000090A patent/NI201000090A/es unknown
- 2010-05-26 CO CO10063356A patent/CO6280401A2/es not_active Application Discontinuation
- 2010-05-28 SV SV2010003580A patent/SV2010003580A/es not_active Application Discontinuation
- 2010-05-28 MA MA32873A patent/MA31867B1/fr unknown
- 2010-05-28 EC EC2010010209A patent/ECSP10010209A/es unknown
- 2010-05-28 DO DO2010000161A patent/DOP2010000161A/es unknown
- 2010-12-09 HK HK10111448.3A patent/HK1144821A1/xx not_active IP Right Cessation
-
2014
- 2014-07-23 US US14/338,434 patent/US20140336160A1/en not_active Abandoned
Also Published As
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